nitrosoproline: RN given refers to 1-nitroso-L-proline [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 24141 |
| CHEMBL ID | 75995 |
| SCHEMBL ID | 4416268 |
| MeSH ID | M0046322 |
| Synonym |
|---|
| CHEMBL75995 , |
| 1-nitrosoproline |
| nitrosoproline |
| nsc109546 |
| nsc-109546 |
| 2571-28-0 |
| nsc109545 |
| 1-nitrosopyrrolidine-2-carboxylic acid |
| bdbm50403310 |
| FT-0672990 |
| FT-0672991 |
| SCHEMBL4416268 |
| nitroso-l-proline |
| 1-nitrosoproline (acd/name 4.0) |
| DTXSID50860015 |
| EN300-202860 |
| 1-nitrosopyrrolidine-2-carboxylicacid |
| mfcd01698777 |
| SY343119 |
| Z1508917222 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Only diet was given in between dosing days to ensure baseline levels of NAA excretion." | ( Influence of fruit and vegetable juices on the endogenous formation of N-nitrosoproline and N-nitrosothiazolidine-4-carboxylic acid in humans on controlled diets. Helser, MA; Hotchkiss, JH; Roe, DA, 1992) | 0.28 |
| "A logarithmic dose-response relationship between ascorbic acid dose and N-nitrosoproline (NPRO) excretion in humans on a controlled diet was established." | ( Relationship between ascorbic acid dose and N-nitrosoproline excretion in humans on controlled diets. Hotchkiss, JH; Leaf, CD; Roe, DA; Vecchio, AJ, 1987) | 0.27 |
| " A dose-response relationship was established for the formation of NPRO in rats in vivo, after concurrent administration of various concentrations of the precursors, L-proline and sodium nitrite." | ( Monitoring endogenous nitrosamine formation in man. Bartsch, H; Ohshima, H, 1984) | 0.27 |
| "A dose-response study on the endogenous formation of N-nitrosoproline in rats was carried out by feeding various doses of L-proline in the diet and sodium nitrite in the drinking water." | ( Dose-response study of N-nitrosoproline formation in rats and a deduced kinetic model for predicting carcinogenic effects caused by endogenous nitrosation. Bartsch, H; Mahon, GA; Ohshima, H; Wahrendorf, J, 1983) | 0.27 |
| "Various amounts of lyophilized beer were administered to rats dosed with proline and sodium nitrite." | ( Inhibition of endogenous nitrosation of proline in rats by lyophilized beer constituents. Bartsch, H; Descotes, G; Pignatelli, B; Scriban, R, 1983) | 0.27 |
| " The amounts of NPRO formed (as estimated from the amounts excreted within 24 hr) after dosing 325 mg nitrate (NO3-) followed by 500 mg proline, ranged from 16." | ( Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine. Bartsch, H; Ohshima, H, 1981) | 0.26 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID226733 | Carcinogenic potency modelled in silico, (- = non-carcinogen) | 1982 | Journal of medicinal chemistry, Jul, Volume: 25, Issue:7 | Computer-assisted studies of structure-activity relationships of N-nitroso compounds using pattern recognition. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 79 (68.10) | 18.7374 |
| 1990's | 27 (23.28) | 18.2507 |
| 2000's | 6 (5.17) | 29.6817 |
| 2010's | 4 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 7 (5.38%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 123 (94.62%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|---|---|---|---|---|
| adenine [no description available] | 4.5 | 4 | 0 | 6-aminopurines; purine nucleobase | Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
| chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion. | 2.67 | 3 | 0 | halide anion; monoatomic chlorine | cofactor; Escherichia coli metabolite; human metabolite |
| dimethylamine [no description available] | 1.97 | 1 | 0 | methylamines; secondary aliphatic amine | metabolite |
| pipecolic acid pipecolic acid: RN given refers to cpd without isomeric designation. pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.. pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid. | 1.96 | 1 | 0 | piperidinemonocarboxylic acid | |
| nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical. | 6.96 | 41 | 0 | monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species | |
| nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed) | 6.06 | 23 | 0 | monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species | human metabolite |
| sarcosine cocobetaine: N-alkyl-betaine; cause of shampoo dermatitis | 1.95 | 1 | 0 | N-alkylglycine zwitterion; N-alkylglycine; N-methyl-amino acid; N-methylglycines | Escherichia coli metabolite; glycine receptor agonist; glycine transporter 1 inhibitor; human metabolite; mouse metabolite |
| cimetidine Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. | 3.75 | 3 | 0 | aliphatic sulfide; guanidines; imidazoles; nitrile | adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor |
| nipecotic acid nipecotic acid: RN given refers to cpd without isomeric designation. nipecotic acid : A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group. | 1.96 | 1 | 0 | beta-amino acid; piperidinemonocarboxylic acid | |
| omeprazole Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.. 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5. | 1.97 | 1 | 0 | aromatic ether; benzimidazoles; pyridines; sulfoxide | |
| hydroxyproline Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group. | 2.63 | 3 | 0 | 4-hydroxyproline; L-alpha-amino acid zwitterion | human metabolite; mouse metabolite; plant metabolite |
| diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | 3.48 | 8 | 0 | nitrosamine | carcinogenic agent; hepatotoxic agent; mutagen |
| aminopyrine Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.. aminophenazone : A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties. | 1.97 | 1 | 0 | pyrazolone; tertiary amino compound | antipyretic; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic |
| n-nitrosomorpholine N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | 3.07 | 5 | 0 | nitrosamine | carcinogenic agent; mutagen |
| tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring. | 3.48 | 2 | 0 | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical |
| dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. | 3.67 | 10 | 0 | nitrosamine | geroprotector; mutagen |
| mannitol [no description available] | 2.01 | 1 | 0 | mannitol | allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent |
| trichloroethylene Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups. | 1.96 | 1 | 0 | chloroethenes | inhalation anaesthetic; mouse metabolite |
| n-nitrosodiphenylamine N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source | 1.96 | 1 | 0 | phenylhydrazines | |
| n-nitrosopiperidine N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | 2.38 | 2 | 0 | nitrosamine; piperidine | apoptosis inducer; carcinogenic agent; environmental contaminant; mutagen |
| caprolactam Caprolactam: Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.. epsilon-caprolactam : A member of the class of caprolactams that is azepane substituted by an oxo group at position 2. | 2.01 | 1 | 0 | caprolactams | human blood serum metabolite |
| diethylamine [no description available] | 1.99 | 1 | 0 | secondary aliphatic amine | |
| morpholine [no description available] | 2.38 | 2 | 0 | morpholines; saturated organic heteromonocyclic parent | NMR chemical shift reference compound |
| framycetin Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. | 1.96 | 1 | 0 | aminoglycoside | allergen; antibacterial drug; Escherichia coli metabolite |
| 4-nitrosodimethylaniline 4-nitrosodimethylaniline: structure; RN given refers to parent cpd. N,N-dimethyl-4-nitrosoaniline : A member of the class of dimethylanilines that is N,N-dimethylaniline having a nitroso group at the 4-position. | 2.01 | 1 | 0 | dimethylaniline; nitroso compound; tertiary amino compound | |
| n,n'-dinitrosopiperazine N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd | 1.96 | 1 | 0 | ||
| catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite. | 1.96 | 1 | 0 | catechin | antioxidant; plant metabolite |
| thiazoles [no description available] | 5.98 | 21 | 0 | 1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene | |
| thiocyanate thiocyanate: RN given refers to parent cpd. thiocyanate : A pseudohalide anion obtained by deprotonation of the thiol group of thiocyanic acid. | 2.37 | 2 | 0 | pseudohalide anion; sulfur molecular entity | human metabolite |
| thiazolidine-4-carboxylic acid thiazolidine-4-carboxylic acid: active against thimerosal intoxication; acts on cell membranes of tumor cells causing reverse transformation to normal cells; RN given refers to parent cpd | 2.38 | 2 | 0 | alpha-amino acid zwitterion; non-proteinogenic alpha-amino acid; sulfur-containing amino acid; thiazolidinemonocarboxylic acid | antidote; antioxidant; hepatoprotective agent |
| thiazolidines Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES. | 5.98 | 21 | 0 | thiazolidine | |
| tetranitromethane [no description available] | 1.97 | 1 | 0 | organonitrogen compound | |
| methylurea N-methyl urea : A member of the class of ureas that is urea substituted by a methyl group at one of the nitrogen atoms. | 2.11 | 1 | 0 | ureas | |
| diisopropylnitrosamine [no description available] | 1.96 | 1 | 0 | ||
| n-methyl-n-nitrosoaniline N-methyl-N-nitrosoaniline: structure | 1.96 | 1 | 0 | ||
| n-nitroso(di-n-propyl)amine [no description available] | 2.38 | 2 | 0 | nitroso compound | |
| methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. | 2.11 | 1 | 0 | N-nitrosoureas | alkylating agent; carcinogenic agent; mutagen; teratogenic agent |
| dibutylnitrosamine dibutylnitrosamine: structure | 1.96 | 1 | 0 | nitroso compound | |
| n-nitrosopyrrolidine N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism. | 3.07 | 5 | 0 | pyrrolidines | |
| n-nitrosoperhydroazepine [no description available] | 1.96 | 1 | 0 | ||
| nitrosobenzylmethylamine nitrosobenzylmethylamine: structure | 2.67 | 3 | 0 | ||
| n-nitrosodiethanolamine [no description available] | 1.96 | 1 | 0 | nitroso compound | |
| d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils. | 3.07 | 5 | 0 | alpha-tocopherol | algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite |
| n-nitroso-2,6-dimethylmorpholine N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation | 1.96 | 1 | 0 | ||
| butylhydroxybutylnitrosamine Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. | 1.96 | 1 | 0 | nitrosamine; primary alcohol | carcinogenic agent |
| dimethylnitramine [no description available] | 1.95 | 1 | 0 | ||
| n-nitroso-n-methylvinylamine N-nitroso-N-methylvinylamine: structure given in first source | 1.96 | 1 | 0 | nitroso compound | |
| n-nitrosodibenzylamine N-nitrosodibenzylamine: structure | 1.96 | 1 | 0 | ||
| n-nitroso-n-methylcyclohexylamine [no description available] | 1.96 | 1 | 0 | ||
| 1-nitrosopiperazine [no description available] | 2.37 | 2 | 0 | phytanoyl-CoAs | |
| ammonium nitrate ammonium nitrate: structure. ammonium nitrate : The ammonium salt of nitric acid. | 1.96 | 1 | 0 | ammonium salt; inorganic molecular entity; inorganic nitrate salt | explosive; fertilizer; oxidising agent |
| nitrosomethyl-n-butylamine nitrosomethyl-N-butylamine: RN given refers to parent cpd | 1.96 | 1 | 0 | ||
| sodium nitrate sodium nitrate : The inorganic nitrate salt of sodium. | 3.47 | 8 | 0 | inorganic nitrate salt; inorganic sodium salt | fertilizer; NMR chemical shift reference compound |
| methylethylnitrosamine [no description available] | 1.96 | 1 | 0 | nitroso compound | |
| n-ethyl-n-hydroxyethylnitrosamine N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents. | 1.96 | 1 | 0 | nitrosamine; primary alcohol | carcinogenic agent |
| n-amyl-n-methylnitrosamine N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent |
| vinylethylnitrosamine [no description available] | 1.96 | 1 | 0 | ||
| n-nitrososarcosine N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. | 3.67 | 10 | 0 | nitrosamine; non-proteinogenic amino acid derivative | carcinogenic agent |
| trinitrosotrimethylenetriamine [no description available] | 1.96 | 1 | 0 | 1,3,5-triazinanes; nitrosamine | |
| diallylnitrosamine [no description available] | 1.96 | 1 | 0 | ||
| n-nitroso-n'-methylpiperazine [no description available] | 1.96 | 1 | 0 | ||
| n'-nitrosonornicotine N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals | 1.96 | 1 | 0 | pyridines; pyrrolidines | |
| n-nitrosoephedrine [no description available] | 2.37 | 2 | 0 | ||
| n-nitrosoheptamethyleneimine [no description available] | 1.96 | 1 | 0 | nitrosamine | |
| fluorescamine Fluorescamine: A nonfluorescent reagent for the detection of primary amines, peptides and proteins. The reaction products are highly fluorescent. | 1.95 | 1 | 0 | ||
| diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney. | 1.96 | 1 | 0 | diol; nitrosamine; secondary alcohol | carcinogenic agent |
| n-nitrosomethyldodecylamine N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid | 1.96 | 1 | 0 | ||
| n,n-dinitrosohomopiperazine [no description available] | 1.96 | 1 | 0 | ||
| methyl(acetoxymethyl)nitrosamine methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source | 1.96 | 1 | 0 | ||
| nitrosobis(2-oxopropyl)amine nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible). | 1.96 | 1 | 0 | ketone; nitrosamine | carcinogenic agent |
| nitrosocimetidine nitrosocimetidine: possible metabolite of cimetidine | 3.46 | 2 | 0 | ||
| n-nitrosothiazolidine N-nitrosothiazolidine: structure given in first source | 2.37 | 2 | 0 | nitrosamine; thiazolidines | |
| n-nitroso-4-hydroxyproline N-nitroso-4-hydroxyproline: RN given refers to cpd without isomeric designation | 3.06 | 5 | 0 | L-proline derivative | |
| n-nitrosoguvacoline N-nitrosoguvacoline: formed by nitrosation of arecoline | 1.96 | 1 | 0 | citraconoyl group | |
| n-nitrososarcosine ethyl ester [no description available] | 1.96 | 1 | 0 | ||
| nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. | 1.96 | 1 | 0 | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic |
| 2-hydroxypropyl-n-propylnitrosamine [no description available] | 1.96 | 1 | 0 | ||
| 2-oxopropyl-n-propylnitrosamine [no description available] | 1.96 | 1 | 0 | ||
| n-nitrosothiazolidine-4-carboxylic acid N-nitrosothiazolidine-4-carboxylic acid: found in human urine | 5.83 | 18 | 0 | organonitrogen compound; organooxygen compound | |
| procyanidin Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways. | 1.96 | 1 | 0 | proanthocyanidin | |
| proanthocyanidin proanthocyanidin: RN given refers to proanthocyanidin A; Cannabinoid Receptor CB1 antagonist. proanthocyanidin : A flavonoid oligomer obtained by the the condensation of two or more units of hydroxyflavans. | 1.96 | 1 | 0 | ||
| 3-nitrosomethylaminopyridine 3-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | ||
| n-nitrosothioproline N-nitrosothioproline: found in normal human urine | 2.66 | 3 | 0 | ||
| 4-nitrophenyl myo-inositol-1-phosphate 4-nitrophenyl myo-inositol-1-phosphate: structure given in first source; a chromogenic substrate for phosphatidylinositol-specific phospholipase C; RN given refers to monoammonium salt | 2.01 | 1 | 0 | ||
| proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. | 5.95 | 35 | 0 | amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid | algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite |
| 2-nitrosomethylaminopyridine 2-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | ||
| 4-nitrosomethylaminopyridine 4-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | ||
| n-acetyl-s-allylcysteine N-acetyl-S-allylcysteine: found in urine after consumption of onions & garlic; structure given in first source | 2.05 | 1 | 0 | N-acyl-L-amino acid | |
| 3-nitrotyrosine 3-nitrotyrosine: RN given refers to parent cpd without isomeric designation. 3-nitrotyrosine : A nitrotyrosine comprising tyrosine having a nitro group at the 3-position on the phenyl ring. | 3.48 | 2 | 0 | 2-nitrophenols; C-nitro compound; nitrotyrosine; non-proteinogenic alpha-amino acid | |
| n,n-diamylnitrosamine [no description available] | 1.96 | 1 | 0 | ||
| cotinine Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.. (-)-cotinine : An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum. | 2.65 | 3 | 0 | N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid | antidepressant; biomarker; human xenobiotic metabolite; plant metabolite |
| 1,3-dimethylthiourea [no description available] | 2.11 | 1 | 0 | ||
| thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur. | 2.11 | 1 | 0 | one-carbon compound; thioureas; ureas | antioxidant; chromophore |
| ranitidine Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.. ranitidine : A member of the class of furans used to treat peptic ulcer disease (PUD) and gastroesophageal reflux disease. | 1.96 | 1 | 0 | C-nitro compound; furans; organic sulfide; tertiary amino compound | anti-ulcer drug; drug allergen; environmental contaminant; H2-receptor antagonist; xenobiotic |
| nitrogen dioxide Nitrogen Dioxide: Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface. | 1.96 | 1 | 0 | nitrogen oxide | |
| cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3. | 2.05 | 1 | 0 | cysteinium | fundamental metabolite |
| selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE. | 1.99 | 1 | 0 | chalcogen; nonmetal atom | micronutrient |
| chlorhexidine Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. | 1.97 | 1 | 0 | biguanides; monochlorobenzenes | antibacterial agent; antiinfective agent |
| mesna Mesna: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE. | 1.97 | 1 | 0 | organosulfonic acid | |
| sodium nitrite Sodium Nitrite: Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.. sodium nitrite : An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning. | 2.88 | 4 | 0 | inorganic sodium salt; nitrite salt | antidote to cyanide poisoning; antihypertensive agent; antimicrobial food preservative; food antioxidant; poison |
| ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms. | 4.45 | 23 | 0 | ascorbic acid; vitamin C | coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent |
| tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. | 1.96 | 1 | 0 | ||
| guanine [no description available] | 2.38 | 2 | 0 | 2-aminopurines; oxopurine; purine nucleobase | algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
| 3-methyladenine N3-methyladenine: structure in first source | 4.5 | 4 | 0 | ||
| 7-methylguanine 7-methylguanine: RN given refers to unlabeled cpd; structure. 7-methylguanine : A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.. 2-imino-7-methyl-1,2,3,7-tetrahydro-6H-purin-6-one : A 7-methylguanine that is 1,2,3,7-tetrahydro-6H-purin-6-one substituted by an imino group at position 2 and a methyl group at position 7.. 2-amino-7-methyl-7H-purin-6-ol : A 7-methylguanine that is 7H-purine substituted by an amino group at position 2, a methyl group at position 7 and a hydroxy group at position 6.. 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one : A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7. | 2.38 | 2 | 0 | 7-methylguanine | |
| methylnitronitrosoguanidine Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position | 2.37 | 2 | 0 | nitroso compound | alkylating agent |
| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 2.21 | 1 | 0 |
| Pigmentary Retinopathy [description not available] | 0 | 2.21 | 1 | 0 |
| Retinitis Pigmentosa Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina. | 0 | 2.21 | 1 | 0 |
| Experimental Hepatoma [description not available] | 0 | 2.01 | 1 | 0 |
| Condition, Preneoplastic [description not available] | 0 | 3.07 | 5 | 0 |
| Precancerous Conditions Pathological conditions that tend eventually to become malignant. | 0 | 3.07 | 5 | 0 |
| Cancer of Esophagus [description not available] | 0 | 4.14 | 6 | 0 |
| Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS. | 0 | 4.14 | 6 | 0 |
| Curling Ulcer Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns. | 0 | 1.96 | 1 | 0 |
| Duodenal Ulcer A PEPTIC ULCER located in the DUODENUM. | 0 | 1.96 | 1 | 0 |
| Alloxan Diabetes [description not available] | 0 | 1.96 | 1 | 0 |
| Addison's Anemia [description not available] | 0 | 2.88 | 4 | 0 |
| Cancer of Stomach [description not available] | 0 | 5.03 | 16 | 0 |
| Gastritis, Atrophic GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis. | 0 | 2.66 | 3 | 0 |
| Stomach Neoplasms Tumors or cancer of the STOMACH. | 0 | 5.03 | 16 | 0 |
| Experimental Neoplasms [description not available] | 0 | 3.97 | 5 | 0 |
| Cancer of Gastrointestinal Tract [description not available] | 0 | 1.96 | 1 | 0 |
| Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 2.37 | 2 | 0 |
| Cancer of Liver [description not available] | 0 | 2.36 | 2 | 0 |
| Cancer of Nasopharynx [description not available] | 0 | 1.95 | 1 | 0 |
| Liver Neoplasms Tumors or cancer of the LIVER. | 0 | 2.36 | 2 | 0 |
| Nasopharyngeal Neoplasms Tumors or cancer of the NASOPHARYNX. | 0 | 1.95 | 1 | 0 |
| Metaplasia A condition in which there is a change of one adult cell type to another similar adult cell type. | 0 | 1.98 | 1 | 0 |
| Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders. | 0 | 2.67 | 3 | 0 |
| Hepatocellular Carcinoma [description not available] | 0 | 1.95 | 1 | 0 |
| Cancer of Kidney [description not available] | 0 | 1.95 | 1 | 0 |
| Cancer of Lung [description not available] | 0 | 1.95 | 1 | 0 |
| Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. | 0 | 1.95 | 1 | 0 |
| Kidney Neoplasms Tumors or cancers of the KIDNEY. | 0 | 1.95 | 1 | 0 |
| Lung Neoplasms Tumors or cancer of the LUNG. | 0 | 1.95 | 1 | 0 |
| Deficiency, Ascorbic Acid [description not available] | 0 | 1.98 | 1 | 0 |
| Ascorbic Acid Deficiency A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177) | 0 | 1.98 | 1 | 0 |
| Adenocarcinoma, Basal Cell [description not available] | 0 | 1.97 | 1 | 0 |
| Adenoma, Basal Cell [description not available] | 0 | 1.97 | 1 | 0 |
| Bladder Cancer [description not available] | 0 | 1.97 | 1 | 0 |
| Cancer of Colon [description not available] | 0 | 1.97 | 1 | 0 |
| Adenocarcinoma A malignant epithelial tumor with a glandular organization. | 0 | 1.97 | 1 | 0 |
| Adenoma A benign epithelial tumor with a glandular organization. | 0 | 1.97 | 1 | 0 |
| Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. | 0 | 1.97 | 1 | 0 |
| Colonic Neoplasms Tumors or cancer of the COLON. | 0 | 1.97 | 1 | 0 |
| Chronic Illness [description not available] | 0 | 1.97 | 1 | 0 |
| Gastric Diseases [description not available] | 0 | 2.66 | 3 | 0 |
| Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 1.97 | 1 | 0 |
| Benign Neoplasms [description not available] | 0 | 4.92 | 6 | 0 |
| Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 4.92 | 6 | 0 |
| Achlorhydria A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion. | 0 | 1.97 | 1 | 0 |
| Bacterial Disease [description not available] | 0 | 2.89 | 1 | 0 |
| Parasite Infections [description not available] | 0 | 2.89 | 1 | 0 |
| Bacterial Infections Infections by bacteria, general or unspecified. | 0 | 2.89 | 1 | 0 |
| Complication, Postoperative [description not available] | 0 | 1.97 | 1 | 0 |
| Postgastrectomy Syndromes Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies. | 0 | 1.97 | 1 | 0 |
| Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. | 0 | 1.97 | 1 | 0 |
| Starvation Lengthy and continuous deprivation of food. (Stedman, 25th ed) | 0 | 1.97 | 1 | 0 |
| Opisthorchis felineus Infection [description not available] | 0 | 1.97 | 1 | 0 |
| Opisthorchiasis Infection with flukes of the genus Opisthorchis. | 0 | 1.97 | 1 | 0 |
| Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. | 0 | 2.88 | 1 | 0 |
| Poisoning, Lead [description not available] | 0 | 1.96 | 1 | 0 |
| Cadmium Poisoning Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis. | 0 | 1.96 | 1 | 0 |
| Lead Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds. | 0 | 1.96 | 1 | 0 |
| Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 1.96 | 1 | 0 |