An increased sensation of pain or discomfort produced by minimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
| Excerpt | Reference |
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| "Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)." | ( Paalzow, GH, 1992) |
| "Adenosine-induced hyperalgesia is mimicked by the A2-agonists, 5'-(N-ethyl)-carboxamido-adenosine and 2-phenylaminoadenosine but not by the A1-agonist, N6-cyclopentyladenosine and antagonized by the adenosine A2-receptor antagonist, PD 081360-0002 but not by the A1-antagonist, 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine." | ( Levine, JD; Taiwo, YO, 1990) |
| "This hyperalgesia is prevented by sympathectomy and suppressed by the calcium antagonists Quin 2 and verapamil." | ( Heller, PH; Levine, JD; Taiwo, YO, 1990) |
| "This hyperalgesia is antagonized by yohimbine (an alpha 2-adrenergic antagonist) but not prazosin (an alpha 1-adrenergic antagonist) as well as by inhibitors of the cyclooxygenase pathway of arachidonic acid metabolism." | ( Levine, JD; Taiwo, YO, 1989) |
| "Hyperalgesia is also transiently depressed for at least 30 min during the postischaemic period, well beyond the duration of paraesthesiae or overt hyperaemia." | ( Cline, M; Culp, WJ; Dotson, R; Ochoa, J, 1989) |
| "In this work, hyperalgesia is described following stressful but non-noxious manipulations consisting of inescapable holding or exposure to a novel environment." | ( Jacob, J; Vidal, C, 1982) |
| "This hyperalgesia is mediated in part by sympathetic neurotransmitters." | ( Romm, MA; Tracey, DJ; Yao, NN, 1995) |
| "Hyperalgesia is not mediated solely by circuitry intrinsic to the spinal cord, but rather involves activation of centrifugal pathways originating within the brain and descending to the spinal cord via pathway(s) outside of the dorsolateral funiculus." | ( Furness, LE; Horan, R; Maier, SF; Martinez, J; Watkins, LR; Wiertelak, EP, 1994) |
| "The mechanical hyperalgesia is reproducible enough to reveal a clear dependency on the dose of NGF." | ( Dawson, AJ; Mendell, LM; Rueff, A, 1996) |
| "Illness-induced hyperalgesia is abolished by unilateral (left) NTS lesions, whereas formalin-induced hyperalgesia remains unaffected by this procedure." | ( Maier, SF; Roemer, B; Watkins, LR; Wiertelak, EP, 1997) |
| "Antihyperalgesia is defined as the ability to block enhanced sensitivity, usually produced by nerve injury or inflammation, to nociceptive stimuli." | ( Caudle, RM; Dubner, R; Ho, J; Mannes, AJ, 1997) |
| "We conclude that ET hyperalgesia is mediated by both prostaglandin-sensitive and prostaglandin-independent mechanisms." | ( Abdelnoor, AM; Atweh, SF; Haddad, JJ; Jabbur, SJ; Kanaan, SA; Saadé, NE; Safieh-Garabedian, B, 1997) |
| "The hyperalgesia is proposed to result either from inhibition of these neurons or from disinhibition of a serotonergic pain facilitatory pathway that also originates in this area of the ventromedial medulla." | ( Hammond, DL; Nelson, V; Thomas, DA, 1998) |
| "Secondary hyperalgesia is thought to reflect changes in central neurons and is thus a measure of activity of central neurons." | ( Bailey, K; Bogush, J; Olson, R; Ricketts, A; Sluka, KA, 1998) |
| "Secondary hyperalgesia is characterized by increased sensitivity to noxious mechanical stimuli in the area surrounding injured skin." | ( Segerdahl, M; Sjölund, KF; Sollevi, A, 1999) |
| "It is thought that mechanical hyperalgesia is maintained by the sensitization of spinal dorsal horn neurons." | ( Sakashita, Y; Yamamoto, T, 1999) |
| "As far as early hyperalgesia is concerned, the preventive effect of the N-butyl tetracaine was much longer than that of lidocaine and continued for approximately 1 wk." | ( Bradley, EL; Kissin, I; Lee, SS, 1999) |
| "Hyperalgesia is characterized by intensified pain with a reduced threshold to somatic stimulation, and it is involved in chronic inflammatory disease." | ( Inoue, A; Morioka, N; Nakata, Y, 2000) |
| "This hyperalgesia is blocked by the oxidizing agent 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB) and the T channel antagonist mibefradil." | ( Jevtovic-Todorovic, V; Mennerick, S; Meyenburg, A; Olney, JW; Perez-Reyes, E; Romano, C; Todorovic, SM; Zorumski, CF, 2001) |
| "The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in the damaged skin." | ( Chung, JM; Kim, HT; Lee, DH; Lee, SE; Park, SK, 2001) |
| "However, allodynia is now expressed both in the ipsilateral as well as contralateral hindpaws." | ( Armstrong, C; Chacur, M; Gazda, LS; Maier, SF; Milligan, ED; Tracey, KJ; Wang, H; Watkins, LR, 2001) |
| "The lack of observed thermal hyperalgesia is surprising especially in light of the capsaicin-associated blockade, however, it is consistent with several other immune system related models of pain." | ( Doom, CM; Junger, H; Sorkin, LS; Yu, AL, 2002) |
| "The spread of secondary hyperalgesia is mediated peripheral nerve fibers, but when secondary hyperalgesia has fully developed, it becomes less dependent on or even independent of peripheral neural activity originating from the injured site." | ( Kawamata, M; Kawamata, T; Kozuka, Y; Namiki, A; Nishikawa, K; Omote, K; Takahashi, T; Watanabe, H, 2002) |
| "Since hyperalgesia is a behavioral consequence of central sensitization, it should be attenuated at the level of the dorsal horn with NMDA receptor antagonists." | ( Hama, A; Sagen, J; Woon Lee, J, 2003) |
| "Mirror-image allodynia is a mysterious phenomenon that occurs in association with many clinical pain syndromes." | ( Biedenkapp, J; Chacur, M; Maier, SF; Martin, D; Milligan, ED; O'Connor, K; Poole, S; Tracey, K; Twining, C; Watkins, LR, 2003) |
| "Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain." | ( Jørum, E; Stubhaug, A; Warncke, T, 2003) |
| "This hyperalgesia is mediated partly by prostaglandin(s) produced in the CNS through the cyclooxygenase-2 (COX-2) dependent pathway." | ( Ibuki, T; Kobayashi, S; Matsumura, K; Nozaki, T; Tanaka, Y; Yamazaki, Y, 2003) |
| "This type of hyperalgesia is probably mediated by central sensitization to Adelta-fibre high-threshold mechanoreceptor input, a hallmark sign of the hyperalgesia type of neuropathic pain." | ( Magerl, W; Möller, JC; Oertel, WH; Stiasny-Kolster, K; Treede, RD, 2004) |
| "Since thermal hyperalgesia is a common symptom of axonal injury, locally applied oxidizing agents could be used as a novel treatment to ameliorate neuropathic pain." | ( Jevtovic-Todorovic, V; Meyenburg, A; Todorovic, SM, 2004) |
| "dynamic-mechanical allodynia, is one of the most distressing symptoms of neuropathic pain." | ( Forster, C; Handwerker, HO; Maihöfner, C; Neundörfer, B; Schmelz, M, 2004) |
| "Acute hyperalgesia is detected at the remaining part of the tail as well as hindpaw." | ( J Kim, S; Zhuo, M, 2004) |
| "This hyperalgesia is evident in people with a history of heroin use and is not modified by methadone or buprenorphine treatment but is reduced by long-term abstinence from opioids." | ( White, JM, 2004) |
| "Hyperalgesia is now thought to be an important component of the illness response, yet the specific mechanisms through which the MPO acts to facilitate nociception have not been established." | ( Gonçalves, L; Heinricher, MM; Martenson, ME; Neubert, MJ, 2004) |
| "PAF-evoked tactile allodynia is suggested to be mediated by ATP and the following NMDA and NO cascade through capsaicin-sensitive fiber, different from exogenously injected alpha,beta-methylene ATP which is insensitive to capsaicin treatment." | ( Abdin, J; Dohi, T; Kitayama, S; Morioka, N; Morita, K; Nakata, Y, 2004) |
| "Opioid-induced hyperalgesia is characterized by hypersensitivity to innocuous or noxious stimuli during sustained opiate administration." | ( Gardell, LR; Herman, DS; Lai, J; Ossipov, MH; Porreca, F; Stiller, CO; Vanderah, TW; Xie, JY, 2005) |
| "Visceral hyperalgesia is associated with other behavioral manifestations of stress sensitization but was only associated with minor colonic immune activation arguing against a primary role of mucosal immune activation in the maintenance of this phenomenon." | ( Bradesi, S; Ennes, HS; Fanselow, M; Lamy, CM; Mayer, EA; McRoberts, JA; Ohning, G; Pothoulakis, C; Schwetz, I, 2005) |
| "PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK)." | ( Dina, OA; Hucho, T; Levine, JD; Malik-Hall, M; Reichling, DB; Yeh, J, 2005) |
| "thermal hyperalgesia, is a key feature of primary hyperalgesia, whereas secondary hyperalgesia is characterized by hypersensitivity towards mechanical (e." | ( Handwerker, HO; Maihöfner, C, 2005) |
| "Cold hyperalgesia is a major clinical phenomenon, but validated experimental models are still lacking for humans." | ( Attal, N; Bouhassira, D; Hatem, S; Willer, JC, 2006) |
| "This hyperalgesia is extensively conceptualized to be a consequence of opioid receptor activity, perhaps providing an adaptive response to analgesia, and to utilize N-methyl-D-aspartate (NMDA) receptors." | ( Juni, A; Kest, B; Klein, G; Pintar, JE, 2007) |
| "Once allodynia is established, triptans are less effective." | ( Bradley, KC; Gebeline-Myers, C; Hopkins, MM; Silberstein, SD; Young, WB, 2007) |
| "Visceral hyperalgesia is prevented by pre-emptive administration of the CRF1 receptor antagonist, antalarmin." | ( Miranda, A; Nordstrom, E; Sengupta, JN; Smith, C, 2007) |
| "Nocebo hyperalgesia is a phenomenon that is opposite to placebo analgesia and whereby expectation of pain increase plays a crucial role." | ( Benedetti, F; Colloca, L, 2007) |
| "Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops through largely unknown mechanisms." | ( Bandell, M; Huynh, T; Hwang, SW; Jegla, T; Olney, N; Patapoutian, A; Peier, AM; Petrus, M, 2007) |
| "Thermal hyperalgesia is one hallmark of neuropathic pain conditions." | ( Engert, S; Petersen, M; Schwab, A; Wendland, JR, 2008) |
| "Mechanical allodynia is mainly mediated by Abeta fibers, whereas mu-opioid receptors are present in C and Adelta fibers." | ( Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I, 2008) |
| "EphrinB1-Fc-induced hyperalgesia is accompanied with the NMDA receptor-mediated increase of expression in peripheral and spinal phosphorylated mitogen-activated protein kinases (phospho-MAPKs) including p-p38, pERK and pJNK, and also is prevented or reversed by the inhibition of peripheral and spinal MAPKs." | ( Bao, Q; Cao, JL; Guan, XH; Ling, DY; Ruan, JP; Song, XJ; Yuan, Y; Zeng, YM; Zhang, LC, 2008) |
| "Allodynia is a marker for sensitization of central trigeminal neurons." | ( Diener, HC; Schürks, M, 2008) |
| "Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy." | ( Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL, 2009) |
| "The hyperalgesia is characterized by mechanical and thermal hyperalgesia in the abdominal and pelvic regions as well as by visceral hypersensitivity." | ( Cervero, F; Sanoja, R, 2010) |
| "Visceral hyperalgesia is a major pathophysiological mechanism in IBS-C." | ( Beaufrand, C; Bradesi, S; Bryant, AP; Bueno, L; Cohen, M; Currie, MG; Eutamene, H; Fioramonti, J; Kurtz, C; Larauche, M; Mayer, EA; Ohning, G; Theodorou, V, 2010) |
| "Hyperalgesia is one of the debilitating complications of diabetes." | ( Ghazi-Khansari, M; Jaberi, E; Mohammadi-Farani, A; Sahebgharani, M; Sepehrizadeh, Z, 2010) |
| "Ongoing hyperalgesia is maintained by spinal microglial/macrophage activity, fractalkine signaling, p38 activation and IL-1 signaling." | ( Dantzer, R; Dorn, GW; Eijkelkamp, N; Heijnen, CJ; Kavelaars, A; Kelley, KW; Wang, H; Willemen, HLDM, 2010) |
| "This hyperalgesia is mitochondrial-dependent but PKCε-independent." | ( Ferrari, LF; Levine, JD, 2010) |
| "Opioid-induced hyperalgesia is defined as an increased sensitivity to pain or a decreased pain threshold in response to opioid therapy." | ( Zöllner, C, 2010) |
| "Cold hyperalgesia is 1 of the characteristic signs in neuropathic pain." | ( Baron, R; Binder, A; Klebe, O; Stengel, M; Wasner, G, 2011) |
| "Opioid-induced hyperalgesia is recognized in the laboratory and the clinic, generating central hyperexcitability in the absence of peripheral pathology." | ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| "Mechanical allodynia is a common symptom found in neuropathic patients." | ( Ahn, DK; Chung, G; Davies, AJ; Hwang, JH; Jung, SJ; Kim, JS; Kim, YH; Oh, SB; Park, MK; Yeon, KY, 2011) |
| "Opioid-induced hyperalgesia is a paradoxical response to opioid agonists resulting in an increased perception of pain rather than an antinociceptive effect." | ( Gupta, A; Ramasubbu, C, 2011) |
| "This hyperalgesia is strongly associated with the duration of exposure to remifentanil." | ( Hashimoto, T; Ishida, R; Nikai, T; Saito, Y; Tsumori, T, 2012) |
| "Visceral hyperalgesia is a multifactorial gastrointestinal disorder which featured with alterations of abdominal motility and/or gut sensitivity, and is believed to be triggered by environmental stressor or psychological factors." | ( Bian, ZX; Sung, JJ; Tsang, SW; Wu, J; Zhao, M, 2012) |
| "Mechanical hyperalgesia is a common and potentially disabling complication of many inflammatory and neuropathic conditions." | ( Chandra, D; Dadgar, J; Dib-Hajj, SD; Kharazia, VN; Liang, YJ; McMahon, T; Messing, RO; Wang, D; Waxman, SG; Wu, DF, 2012) |
| "Inflammatory hyperalgesia is one of the most important events of acute inflammation." | ( Barbosa, AL; Moraes, MO; Oliveira, GJ; Pinheiro, CA; Ribeiro, RA; Souza, MH; Torres, JN; Vale, ML, 2012) |
| "This hyperalgesia is reflected by increased blood flow in brain regions that are involved in pain processing." | ( Babes, A; Bierhaus, A; Brownlee, M; Cooper, ME; Dehmer, T; Eberhardt, M; Edelstein, D; Elvert, R; Fleming, T; Forbes, J; Haberkorn, U; Humpert, PM; Kichko, TI; Konrade, I; Lasischka, F; Lasitschka, F; Leffler, A; Lukic, IK; Mier, W; Morcos, M; Nau, C; Nawroth, PP; Neacsu, C; Neuhuber, WL; Pirags, V; Rabbani, N; Reeh, PW; Sauer, SK; Schnölzer, M; Schwaninger, M; Stern, DM; Stoyanov, S; Thornalley, PJ; Ziegler, D, 2012) |
| "Post-operative hyperalgesia is associated with an increased risk for persistent post-surgical pain; however, there are no data on whether residual scar hyperalgesia (SHA) from a previous Caesarean delivery (CD) persists until the next delivery." | ( Bollag, L; Cardoso, M; Granot, M; Landau, R; Ortner, CM; Richebé, P, 2013) |
| "Antihyperalgesia is at least in part mediated by peripheral μ-opioid, α2A,C-adrenergic, A1 adenosine, and 5-HT1B/1D receptors, but not by GABAA receptors." | ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA; Ugrešić, ND, 2012) |
| "The mechanical allodynia is reversed by suppression of microglial activation." | ( Lyons, D; Ma, F; Westlund, KN; Zhang, L, 2012) |
| "Mechanical dynamic allodynia is a hallmark symptom of postherpetic neuralgia, but the mechanisms are unclear." | ( Andoh, T; Inomata, Y; Kuraishi, Y; Sasaki, A; Serizawa, K, 2013) |
| "Hyperalgesia is a cardinal symptom of opioid withdrawal." | ( Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C, 2013) |
| "As cold allodynia is frequently observed in individuals experiencing toothache pain, we tested whether mice with DPI demonstrate an aversion to drinking cold liquids using a cold-sucrose consumption test." | ( Basbaum, AI; Gibbs, JL; Urban, R, 2013) |
| "Nocebo hyperalgesia is an increase in subjective pain perception after a patient or subject underwent an inert treatment without any active ingredient." | ( Büchel, C; Geuter, S, 2013) |
| "Chronic NTG-induced hyperalgesia is a mouse model that may be useful for the study of mechanisms underlying progression of migraine from an episodic to a chronic disorder, and for the identification and characterization of novel acute and preventive migraine therapies." | ( Charles, A; Evans, CJ; McGuire, B; Pradhan, AA; Smith, ML; Tarash, I, 2014) |
| "The allodynia is associated with an up-regulation of activation transcription factor 3 (ATF3) in the dorsal root ganglia (DRG), a factor, which is activated by Toll-like receptors (TLRs)." | ( Corr, M; Park, HJ; Stokes, JA; Yaksh, TL, 2014) |
| "Carrageenan-induced hyperalgesia is a widely used pain model in rodents." | ( Ko, MC; Lee, H; Rice, KC; Sukhtankar, DD, 2014) |
| "This hyperalgesia is reversed by nitric oxide synthase inhibitors, suggesting the possibility of involvement of nitric oxide pathway." | ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014) |
| "Orofacial cold hyperalgesia is known to cause severe persistent pain in the face following trigeminal nerve injury or inflammation, and transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankylin 1 (TRPA1) are thought to be involved in cold hyperalgesia." | ( Furukawa, A; Honda, K; Iwata, K; Kita, K; Noma, N; Shinoda, M, 2014) |
| "Mechanical hyperalgesia is one distressing symptom of neuropathic pain which is explained by central sensitization of the nociceptive system." | ( Baron, R; Gierthmühlen, J; Jansen, O; Rempe, T; Riedel, C; Stroman, PW; Wolff, S, 2014) |
| "Hyperalgesia and allodynia are among the common manifestations of painful diabetic neuropathy." | ( Fazeli, F; Hasanein, P, 2014) |
| "Opioid-induced hyperalgesia is a clinical syndrome whereby patients on long-term opioids become more sensitive to pain while taking opioids." | ( Edwards, RR; Katz, NP; Paillard, FC, 2015) |
| "Opioid-induced hyperalgesia is well known complication of acute high dose and chronic opioid therapy." | ( Cinar, S; Doganci, S; Dogrul, A; Eksert, S; Eskin, MB; Ince, ME; Ozkan, G; Yildirim, V, 2014) |
| "Hyperalgesia is one of the negative consequences following intraoperative analgesia with remifentanil." | ( Li, N; Shu, RC; Wang, CY; Wang, GL; Wang, HY; Xie, KL; Yu, YH; Zhang, LL, 2015) |
| "Inflammatory hyperalgesia is a complex process that depends on the sensitization of primary nociceptive neurons triggered by proinflammatory mediators, such as interleukin 1β (IL-1β)." | ( Cunha, FQ; Cunha, TM; França, RO; Lima, JB; Lopes, AH; Mascarenhas, DP; Ryffel, B; Silva, RL; Talbot, J; Verri, WA; Zamboni, DS, 2015) |
| "Opioid-induced hyperalgesia is a phenomenon defined by increasing pain after opioid exposure with the worsening of pain occurring when opioid doses are increased." | ( Kane-Gill, SL; Lyons, PJ; Nery, JP; Rivosecchi, RM, 2015) |
| "Morphine-induced hyperalgesia is a pharmacological phenomenon often hindering its prolonged applications in the clinic." | ( Galeotti, N; Ghelardini, C; Mello, T; Sanna, MD, 2015) |
| "Secondary hyperalgesia is believed to be a key feature of "central sensitization" and is characterized by enhanced pain to mechanical nociceptive stimuli." | ( Groneberg, AH; Klein, T; Mouraux, A; Pfau, DB; Treede, RD; van den Broeke, EN, 2015) |
| "This allodynia is associated with the activation of a neuronal network encompassing lamina I-outer lamina III, including interneurons expressing the γ isoform of protein kinase C (PKCγ) within inner lamina II (IIi) of MDH." | ( Artola, A; Bourgois, N; Dallel, R; Peirs, C, 2016) |
| "Hyperalgesia is an exaggerated response to noxious stimuli produced by peripheral or central plasticity." | ( Baiamonte, BA; Baynes, BB; Gilpin, NW; Itoga, CA; Lu, YL; Richardson, HN; Roltsch Hellard, EA; Schreiber, AL; Whitaker, AM, 2016) |
| "Cold allodynia is also a common complaint of patients chronically treated with opioids, yet its molecular mechanisms remain to be understood." | ( Gong, K; Jasmin, L, 2017) |
| "Cold allodynia is a common symptom of neuropathic and inflammatory pain following peripheral nerve injury." | ( Gómez-Sánchez, JA; González, A; Herrera, G; Madrid, R; Orio, P; Pertusa, M; Piña, R; Restrepo, C; Ugarte, G, 2017) |
| "Facial allodynia is a migraine symptom that is generally considered to represent a pivotal point in migraine progression." | ( Bastos, LF; Brown, K; Cady, S; Ellis, A; Johnson, K; Maier, SF; McFadden, A; Rezvani, N; Rice, KC; Sprunger, D; Stone, K; Watkins, LR; Wieseler, J, 2017) |
| "Allodynia is due in part to the sensitization of articular nociceptors to mechanical stimuli." | ( Christin, M; Davidova, A; He, BH; Mouchbahani-Constance, S; Sharif-Naeini, R, 2017) |
| "Ongoing LMWH and A6 hyperalgesia are reversed by HMWH." | ( Araldi, D; Ferrari, LF; Khomula, EV; Levine, JD, 2018) |
| "capsaicin-induced thermal allodynia) are unknown." | ( Banks, ML; Cornelissen, JC; Nicholson, KL; Rice, KC; Steele, FF, 2018) |
| "Hyperalgesia is particularly problematic as further opioid prescribing is largely futile." | ( Bull, F; Colvin, LA; Hales, TG, 2019) |
| "Cold hyperalgesia is an indicator of widespread pain sensitivity and is associated with poor clinical outcomes." | ( Benson, HAE; Moss, P; Wright, A, 2019) |
| "Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management." | ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018) |
| "Opioid-induced hyperalgesia is a state of nociceptive sensitisation secondary to opioid administration." | ( Albrecht, E; Frauenknecht, J; Grape, S; Kilchoer, L; Kirkham, KR, 2020) |
| "Stress-induced hyperalgesia is a problematic condition that lacks an effective therapeutic measure, and hence impairs health-related quality of life." | ( An, H; Cao, DY; Li, YX; Tao, ZY; Wen, Z, 2020) |
| "In rodents, mechanical allodynia is a common phenotype of painful neuropathy for 3 chemotherapeutics." | ( Bai, XH; Deng, J; Ding, HH; Liu, M; Luo, DX; Mai, JW; Ruan, XC; Xin, WJ; Xu, T; Yang, YL; Zhang, SB; Zhang, XQ; Zhang, XZ, 2020) |
| "Hyperalgesia is a heightened pain response to a noxious stimulus and is a hallmark of many common neuropathic and chronic pain conditions." | ( Dunn, JS; Mahns, DA; Nagi, SS, 2020) |
| "However, allodynia is the major dose-limiting side effect, hindering its use for neuroblastoma patients at higher doses and for other GD2-expressing malignancies." | ( Diccianni, MB; Gangoti, JA; Kempińska, K; Sorkin, LS; Yu, AL, 2020) |
| "Opioid induced hyperalgesia is likely an underrecognized phenomenon in patients with cancer-related pain." | ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
| "Allodynia is a state in which pain is elicited by innocuous stimuli." | ( Chen, H; Hachisuka, J; Ibinson, J; Koerber, HR; Ross, SE; Salsovic, J; Sheahan, TD; Smith, KM; Warwick, C, 2022) |
| "Allodynia and hyperalgesia are common signs in individuals with complex regional pain syndrome (CRPS), mainly attributed to sensitization of the nociceptive system." | ( Brunner, F; Curt, A; De Schoenmacker, I; Hubli, M; Rosner, J; Scheuren, PS, 2023) |
| "Visceral hyperalgesia is common among children with complex medical conditions." | ( Allen, CC; Bartlett, H; Canada, K; Schlueter, S; Zhang, X, 2023) |
| "Hyperalgesia is an occult complication during the treatment of cancer pain, not only related to opioids, but also pertaining to the tumor itself and cancer therapeutic drugs." | ( Li, BL; Li, HX; Wang, TH; Yan, T; Zheng, H, 2022) |
| "Although allodynia is often resistant to analgesics, the antidepressant duloxetine has been used as an effective therapeutic option." | ( Ishibashi, T; Koga, K; Sueto, D; Tsuda, M; Yamaura, K; Yoshikawa, Y, 2022) |
| "Stress-induced hyperalgesia is a health-threatening condition that lacks effective therapeutic intervention, impairing the quality of life." | ( Ding, J; Fu, D; Han, Y; Li, W; Wu, J; Xu, R; Yuan, T, 2023) |
| Excerpt | Reference |
|---|
| "Thermal hyperalgesia to radiant heat was assessed by using a foot-withdrawal test and NMDA/non-NMDA receptor antagonists were administered intrathecally onto the lumbar spinal cord before and after nerve injury." | ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
| "These same treatments blocked the thermal hyperalgesia in rats with chromic gut ligatures for a period of 2 and 4 h, respectively." | ( Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS, 1992) |
| "Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)." | ( Paalzow, GH, 1992) |
| "To clarify the mechanism of the hyperalgesia in SART mice and the mode of the antinociceptive action of neurotropin in this model, the influence of systemically administered neurotransmitter related drugs was studied." | ( Hata, T; Kawamura, M; Miura, T; Namimatsu, A; Ohara, H; Yoneda, R, 1991) |
| "In contrast, thermal hyperalgesia failed to develop in capsaicin-treated rats following partial nerve injury." | ( Seltzer, Z; Shir, Y, 1990) |
| "This hyperalgesia can be inhibited by prior administration of either indomethacin or delta 1-THC-7-oic acid, presumably because of their ability to inhibit eicosanoid synthesis." | ( Burstein, SH; Hull, K; Hunter, SA; Latham, V, 1988) |
| "Skin hyperalgesia persisted for at least 30 minutes in both strychnine and glycine treated rats." | ( Beyer, C; Komisaruk, BR; Roberts, LA, 1985) |
| "To assess the magnitude of hyperalgesia, the animals were also challenged with several concentrations of saline administered at the time of peak sensitivity and a saline EC50 was thereby derived." | ( Lewis, RA; VonVoigtlander, PF, 1983) |
| "4 Prostaglandin E2-induced hyperalgesia, once established, is not relieved by systemically administered drugs." | ( Ferreira, SH, 1980) |
| "The prostaglandin hyperalgesia and tail immersion tests were used to evaluate the analgesic action of morphine, codeine, d-propoxyphene and pentazocine following intraperitoneal, intraplantar and intracerebroventricular administration to rats." | ( Ferreira, SH; Lorenzetti, BB; Molina, N; Vettore, O, 1983) |
| "During the last ten years hyperalgesia (H), allodynia (A) and myoclonia (M) has been reported at an increased frequency in human beings treated with morphine." | ( Jacobsen, LS; Jensen, NH; Olsen, AK; Sjøgren, P, 1995) |
| "The thermal hyperalgesia but not the NGF elevation produced by intraplantar IL-1 beta (1 ng) was prevented by administration of a polyclonal neutralizing anti-NGF serum." | ( Allchorne, A; Poole, S; Safieh-Garabedian, B; Winter, J; Woolf, CJ, 1995) |
| "Persistent hyperalgesia induced by chronic constrictive injury (CCI) to the sciatic nerve was significantly reduced for up to 14 days by prophylactic administration of memantine (3." | ( Eisenberg, E; LaCross, S; Strassman, AM, 1995) |
| "The results support the hypothesis that hyperalgesia is a property of different anaesthetic agents when administered at sub-hynotic concentrations." | ( Archer, DP; Ewen, A; Roth, SH; Samanani, N, 1995) |
| "The effect of lidocaine pretreatment on thermal hyperalgesia and thermal skin asymmetries provoked by experimental mononeuropathy was investigated in rats." | ( Castagna, A; Lacerenza, M; Marchettini, P; Sotgiu, ML, 1995) |
| "administration of PGE2 exerts allodynia through EP1 in the mouse spinal cord and that ONO-NT-012 is a highly potent, simple competitive antagonist for the PGE2-induced allodynia." | ( Hayaishi, O; Hyodo, M; Ito, S; Minami, T; Nishihara, I; Sakamoto, K, 1995) |
| "To address the mechanisms of hyperalgesia and dorsal horn plasticity following peripheral tissue inflammation, the effects of adjuvant-induced inflammation of the rat hindpaw on behavioral nociception and nociceptive neuronal activity in the superficial dorsal horn were examined in neonatally capsaicin-treated rats 6-8 weeks of age." | ( Dubner, R; Ren, K; Ruda, MA; Williams, GM, 1994) |
| "Hyperalgesia and allodynia in 4 cancer patients treated with morphine disappeared after discontinuing or substituting morphine with other opioid agonists." | ( Jensen, NH; Jensen, TS; Sjøgren, P, 1994) |
| "After the development of mechanical hyperalgesia in the neuropathic limb, the responses of medial bulboreticular neurons to noxious skin stimulation were determined, and the attenuation of the responses was attempted by administering systemically medetomidine, a highly specific alpha 2-adrenoceptor agonist." | ( Luukko, M; Pertovaara, A, 1993) |
| "This hyperalgesia was antagonized by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)-MK-801, suggesting involvement of NMDA receptors." | ( Paalzow, GH, 1994) |
| "The allodynia, hyperalgesia and after-sensation present in 5 patients improved after the administration of ketamine." | ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
| "The rhIL-1 beta-induced hyperalgesia was completely abolished by pretreatment with an IL-1 receptor antagonist (IL-1ra) or Na salicylate." | ( Aou, S; Hori, T; Oka, T, 1993) |
| "Bradykinin-induced hyperalgesia was abolished by HOE 140 and by treatment of the paws with anti-TNF-alpha antisera." | ( Cunha, FQ; Ferreira, SH; Lorenzetti, BB; Poole, S, 1993) |
| "This hyperalgesia peaked 15 to 45 min after administration and lasted for approximately 2 hr." | ( Al, Y; Butelman, ER; Negus, SS; Woods, JH, 1993) |
| "Nerve growth factor-induced thermal hyperalgesia in rodents was prevented by co-administration of the non-selective opiate antagonist naloxone, as well as by the kappa-selective antagonist nor-binaltorphimine." | ( Apfel, SC; Dormia, C; Kessler, JA; Newel, M, 1995) |
| "Both the development of thermal hyperalgesia and the increase in PKC gamma immunoreactivity in CCI rats were prevented by once daily intrathecal administration with 10 nmol MK-801 for 7 days." | ( Lu, J; Mao, J; Mayer, DJ; Phillips, LL; Price, DD, 1995) |
| "The BK-induced hyperalgesia was abolished by concomitant intradermal administration of either a guanylate cyclase inhibitor, methylene blue (10 nmol), or LY83583 (1 nmol)." | ( Fujita, M; Nakamura, A; Shiomi, H, 1996) |
| "Finally, the hyperalgesia produced by sustained noxious thermal stimulation of the tip of the tail was unaffected by intrathecal administration of SR 48968; thus, it remains to find a physiological response in which endogenous neurokinin A and NK2 receptors at the spinal level are involved in the rat in vivo." | ( Henry, JL; Hui-Chan, CW; Yashpal, K, 1996) |
| "Thermal hyperalgesia produced by N-methyl-D-aspartate (1 pmol) was attenuated by intrathecal administration of the N-methyl-D-aspartate receptor-selective antagonist 2-amino-5-phosphonopentanoate (100 pmol), but not by the AMPA receptor-selective antagonist 6,7-dinitroquinoxaline-2,3-dione (1 nmol) or the metabotropic receptor antagonist 2-amino-3-phosphonoproprionate (10 nmol)." | ( Dykstra, C; Gebhart, GF; Meller, ST, 1996) |
| "In contrast, naloxone-precipitated hyperalgesia in DAMGO-tolerant paws, a measure of dependence, was blocked by pretreatment with chelerythrine but not by NMLA, ddA, TMB-8, or Quin-2." | ( Aley, KO; Levine, JD, 1997) |
| "Mechanical hyperalgesia increased and was persistent after plantar incision and was not decreased by intrathecal administration of 4, 14, or 40 nmol MK-801 or 10 nmol AP5." | ( Brennan, TJ; Zahn, PK, 1998) |
| "Prevention of late hyperalgesia can be provided not only by the preinjury block but also by the postinjury block administered when hyperalgesia is already well established." | ( Bradley, EL; Kissin, I; Lee, SS, 1998) |
| "In the long-term models of hyperalgesia, intrathecally administered lamotrigine produced a dose-dependent and long-lasting (24-48 h) antihyperalgesic effect." | ( Klamt, JG, 1998) |
| "The intensity of thermal hyperalgesia differed significantly across the following treatments: saline (heat pain threshold 1." | ( Drummond, PD, 1998) |
| "The following observations were made: 1) Thermal hyperalgesia otherwise observed during the first 170 min was blocked in a dose-dependent manner by S(+)-ibuprofen or SC58125 administered i." | ( Dirig, DM; Isakson, PC; Yaksh, TL, 1998) |
| "This hyperalgesia, as assessed by behavioral and neuronal responses, was blocked by pretreatment with IL-1 receptor antagonist (IL-1Ra), Na salicylate, or alpha melanocyte-stimulating hormone, indicating the involvement of IL-1 receptors and the synthesis of prostanoids." | ( Aou, S; Hori, T; Hosoi, M; Oka, T, 1998) |
| "This study demonstrated that hyperalgesia resulting from an intraneural injection of the cytokine tumor necrosis factor-alpha (TNF) was prevented by preemptive administration of a single dose of the prosaptide TX14(A) (200 microg/kg)." | ( Myers, RR; O'Brien, JS; Wagner, R, 1998) |
| "MK-801 treatment reduced hyperalgesia by 57% (p=0." | ( Birch, PJ; Bountra, C; Elliot, PJ; Harrisson, S; Hudspith, MJ; Hunt, SP; Munglani, R; Smith, G, 1999) |
| "Epinephrine-induced hyperalgesia was attenuated significantly by intradermal pretreatment with propranolol, a beta-adrenergic receptor antagonist, but not by phentolamine, an alpha-adrenergic receptor antagonist." | ( Khasar, SG; Levine, JD; McCarter, G, 1999) |
| "Thermal hyperalgesia intensified during arterial occlusion; however, sites of noradrenaline iontophoresis were more sensitive to heat than elsewhere in the capsaicin-treated skin, even when noradrenaline was administered during arterial occlusion." | ( Drummond, PD, 1999) |
| "After 5 days of treatment, heat pain hyperalgesia persisted on both forearms; however, it was significantly less on the EMLA-treated forearm vs the vehicle-treated site (p < 0." | ( Maibach, HI; Rowbotham, MC; Yosipovitch, G, 1999) |
| "Midazolam caused hyperalgesia when administered intracerebroventricularly (i." | ( Duarte, ID; Francischi, JN; Salgado, JV; Tatsuo, MA; Yokoro, CM, 1999) |
| "This hyperalgesia was dose-dependently and reversibly attenuated by intrathecal administration of the nonselective NO* synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (100-800 nmol) as well as by the selective neuronal NOS inhibitor ARL 17477 (30-600 nmol)." | ( Coutinho, SV; Gebhart, GF, 1999) |
| "Mechanical allodynia induced by stimulation with an electronic toothbrush was rated at the end of each treatment period with a similar scale." | ( Andersen, G; Brøsen, K; Jensen, TS; Madsen, C; Sindrup, SH; Smith, T, 1999) |
| "The CFA-treated paw displayed hyperalgesia as early as 4 h after CFA injection and hyperalgesia was maintained until day 4 but had disappeared by day 21." | ( Angelici, O; Bonanno, G; Carità, F; Clarke, GD; Raiteri, M; Schmid, G; Zaratin, P, 2000) |
| "The area of pin-prick hyperalgesia was significantly reduced by systemic lidocaine, whereas the inhibition of hyperalgesia was absent during regional administration of lidocaine." | ( Koppert, W; Ostermeier, N; Schmelz, M; Sittl, R; Weidner, C, 2000) |
| "Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i." | ( Domont, GB; Frutuoso, VS; Martins, MA; Moussatché, H; Perales, J; Rocha, SL, 2000) |
| "OFQ/N antagonism of the hyperalgesia may have significance for the treatment of opioid withdrawal and sensitized pain." | ( Fields, HL; Hirakawa, N; Pan, Z, 2000) |
| "Behavioral analysis revealed thermal hyperalgesia and perturbation of accurate paw placement on grid-walking tasks for both FGF-2- and NGF-treated animals." | ( Garry, MG; Li, L; Lightfoot, E; Rangappa, N; Romero, MI; Smith, GM, 2000) |
| "Prolonged hyperalgesia was induced by OVX, and the antinociceptive effect of ECT was proved because peripherally and repeatedly administered ECT improved hyperalgesia." | ( Yoshimura, M, 2000) |
| "Interestingly, only the mechanical allodynia evoked by alpha(beta)meATP selectively remained in neonatal capsaicin-treated adult rats that had selectively lost the capsaicin-sensitive neurons." | ( Inoue, K; Kita, A; Koizumi, S; Shigemoto, Y; Tsuda, M; Ueno, S, 2000) |
| "We conclude that hyperalgesia associated with opioid withdrawal can be blocked by spinally administered ibuprofen, and suggest that there may be a role for spinal prostaglandins in the enhancement of nociception observed in association with the opioid abstinence syndrome." | ( Buerkle, H; Dunbar, SA; Karamov, IG, 2000) |
| "No thermal hyperalgesia was observed to either CGRP or ADM, when given as single or repeated treatments." | ( Brain, SD; Cao, T; Choy, M; Chu, DQ; Foster, P, 2000) |
| "All three drugs decreased hyperalgesia when administered prior to carrageenan injection." | ( Abarca, C; Contreras, E; Oliva, P; Sepúlveda, MJ; Silva, E, 2000) |
| "Muscle hyperalgesia (post-operative decrease in threshold with respect to pre-stone implantation) was significantly reduced in extent and duration in ketoprofen with respect to saline-injected animals but no difference was found between the pre- and post-operative treatment." | ( Affaitati, G; Giamberardino, MA; Lerza, R; Vecchiet, L, 2000) |
| "The time course of the heat hyperalgesia identified in the paw pad of the bee venom-treated side was shorter and lasted for less than 48 h, which was in parallel with the reduction in thermal latency of the withdrawal reflex identified in the non-injected hind paw." | ( Chen, HS; Chen, J, 2000) |
| "However, OFQ dose-dependently produced hyperalgesia in rats pretreated with naloxone, implying that OFQ can indeed produce hyperalgesia once an endogenous opioidergic tone is inhibited." | ( Lutfy, K; Maidment, NT, 2000) |
| "Mechanical hyperalgesia was significantly reduced by the pre-treatment of 150 mg/kg, but not 50 mg/kg aspirin." | ( Fuchs, PN; LaBuda, CJ, 2001) |
| "This hyperalgesia was markedly diminished or absent in mice lacking the NK-1 receptor, preprotachykinin-A or PAR2 genes, or in rats treated with a centrally acting cyclooxygenase inhibitor or treated by spinal cord injection of NK-1 antagonists." | ( Andrade-Gordon, P; Basbaum, AI; Brussee, V; Bunnett, NW; Cirino, G; Compton, SJ; Gerard, N; Grady, EF; Hollenberg, MD; Sharkey, KA; Vergnolle, N; Wallace, JL, 2001) |
| "Furthermore, fenvalerate-induced thermal allodynia and hyperalgesia were inhibited by the pretreatment with calphostin C." | ( Kamei, J; Morita, K; Sasaki, M; Tanaka, S; Zushida, K, 2001) |
| "Reversal effects on tactile allodynia have been demonstrated after the intrathecal administration of gamma-aminobutyric acid (GABA) receptor agonists or cholinesterase inhibitors in rats." | ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001) |
| "Acutely, Taxol induced hyperalgesia that was significant within 1 h, maximal after 6 h and resolved completely by 24 h after a single treatment." | ( Chen, X; Dina, OA; Levine, JD; Reichling, D, 2001) |
| "The long-lasting hyperalgesia induced by the first carrageenan injection was dose-dependently enhanced in both duration and magnitude in 4 x 60 or 4 x 100 microg/kg fentanyl-treated rats: 5 or 10 days, respectively, as compared with 2 days in saline-treated rats." | ( Célèrier, E; Corcuff, JB; Laulin, JP; Pain, L; Rivat, C; Simonnet, G, 2002) |
| "This reduction in hyperalgesia appears to be a local peripheral effect, reducing nerve fibers within the subepidermal treatment area." | ( McLoon, LK; Nockleby, KJ; Sandnas, AM; Wirtschafter, JD, 2002) |
| "Murine anti-GD(2) elicited mechanical allodynia when administered into either the vasculature or the intrathecal space." | ( Doom, CM; Junger, H; Sorkin, LS; Yu, AL, 2002) |
| "Pretreatment with PAT prevented the hyperalgesia and maintained the body temperature within the normal range and was accompanied by a down-regulation of the levels of pro-inflammatory cytokines and PGE(2) in the liver." | ( Dardenne, M; Pléau, JM; Saadé, NE; Safieh-Garabedian, B, 2002) |
| "Mechanical hyperalgesia was assessed by measuring the withdrawal thresholds to mechanical stimuli (von Frey filaments) before the first and second intramuscular injection, 24 h after the second intramuscular injection, and for 1 h after administration of the opioid agonist or vehicle." | ( Bussey, RA; Eikenberry, SA; Rohlwing, JJ; Sluka, KA; Wilken, JM, 2002) |
| "Allodynia and hyperalgesia evoked by intrathecal administration of Noc/OFQ (50 pg/mouse) were dose dependently blocked by simultaneous administration of JTC-801 with IC(50) values of 32." | ( Enomoto, U; Ito, S; Kiyokane, K; Minami, T; Mori, H; Muratani, T; Okuda-Ashitaka, E; Sakai, M, 2002) |
| "Opioid-abstinence hyperalgesia (OAH) is a phenomenon characterized by thermal and mechanical hyperalgesia that occurs between intermittent doses of opioids or after the chronic administration of these drugs when administration is abruptly stopped." | ( Clark, JD; Li, X, 2002) |
| "These studies provide evidence that the hyperalgesia induced by chronic opioid administration may be in part to spinal neuroplastic changes." | ( Clark, JD; Li, X, 2002) |
| "Movement-related hyperalgesia, known clinically as a specific type of 'breakthrough pain', is a common feature of bone cancer and is thought to be a predictor of poor response to conventional analgesic pharmacotherapy (Bruera et al." | ( Beitz, AJ; Kehl, LJ; Ramnaraine, ML; Trempe, TM; Wacnik, PW; Wilcox, GL, 2003) |
| "In PTX-treated rats, thermal hyperalgesia was observed, and the PKCgamma content of both the synaptosomal membrane and cytosolic fractions was significantly increased." | ( Chang, YC; Guo, YW; Wen, ZH; Wong, CS, 2003) |
| "PGI(2) agonist-induced hyperalgesia in neonatal capsaicin-treated injured mice." | ( Bakoshi, S; Inoue, M; Kawashima, T; Kondo, S; Rashid, MH; Ueda, H, 2003) |
| "Mice exhibited a persistent hyperalgesia after either systemic application of KA or topical treatment with KA on vagal afferents." | ( Jasmin, L; Larson, AA; Ohara, PT; Tien, D, 2003) |
| "The induction of hyperalgesia upon capsaicin administration requires activation of specific sub-classes of nociceptive afferent C-fibres providing nociceptive input to the central nervous system." | ( Dvorak, M; McGlone, F; Rukwied, R; Watkinson, A, 2003) |
| "This thermal hyperalgesia was prevented by the systemic administration of morphine (15 mg/kg)." | ( Baamonde, A; Fresno, MF; Hidalgo, A; Lastra, A; Llames, S; Meana, A; Menéndez, L, 2003) |
| "At the time of peak hyperalgesia, WIN55,212-2 (1-30mg/kg) or vehicle was administered intraperitoneally and forelimb grip force was measured 0." | ( Croft, DL; Hamamoto, DT; Kehl, LJ; Norsted, BD; Simone, DA; Wacnik, PW; Wilcox, GL, 2003) |
| "In another group of rats, hyperalgesia was induced by intrathecal administration of NMDA." | ( Kuno, Y; Sato, E; Sato, I; Takano, M; Takano, Y, 2003) |
| "Bilateral mechanical hyperalgesia of the paw was induced by administering two injections of acidic saline, 5 d apart, into the gastrocnemius muscle of male Sprague Dawley rats." | ( Hoeger-Bement, MK; Sluka, KA, 2003) |
| "We show here that this type of hyperalgesia is also abolished by the local administration of morphine given at low doses (10 nmol), or the peripheral acting opioid receptor agonist loperamide (146 nmol)." | ( Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2003) |
| "Its antihyperalgesic effect on mechanical hyperalgesia (paw pressure test) in rats induced by chronic constriction injury of the sciatic nerve was assessed after repeated administrations (five injections every half-life, a regimen close to clinical use)." | ( Alloui, A; Ardid, D; Chapuy, E; Eschalier, A; Jourdan, D; Marchand, F, 2003) |
| "Gabapentin was poorly active against mechanical hyperalgesia in both the rat and guinea-pig following a single oral administration (100 mg x kg(-1)), although upon repeated administration it produced up to 70 and 90% reversal in rat and guinea-pig, respectively." | ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003) |
| "In contrast, hyperalgesia after remifentanil was more pronounced than hyperalgesia after naloxone administration and did not correlate to the observed anti-analgesic effects, suggesting the involvement of additional receptors systems other than the endorphin system." | ( Albrecht, S; Alsheimer, M; Angst, M; Koppert, W; Schmelz, M; Schüttler, J; Sittl, R, 2003) |
| "We examined the time course (7 weeks) of thermal hyperalgesia and light touch allodynia in rats after intradermal administration of Mycobacterium butyricum." | ( Arévalo, MI; Calpena, A; Domenech, J; Escribano, E; Queralt, J, 2003) |
| "Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult to treat." | ( Breese, NM; Price, MP; Sluka, KA; Stucky, CL; Welsh, MJ; Wemmie, JA, 2003) |
| "Mechanical allodynia and thermal hyperalgesia induced by CCI was moderately, but consistently attenuated by early (day -2 or 12 h after CCI), but not late (7 days after CCI) ibuprofen and celecoxib treatment." | ( Marziniak, M; Schäfers, M; Sommer, C; Sorkin, LS; Yaksh, TL, 2004) |
| "Mechanical hyperalgesia, measured as the reduction in weight-bearing of the ipsilateral limb, and the development of static and dynamic allodynia were significantly inhibited by repeated lumaricoxib administration." | ( Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L, 2004) |
| "This treatment produced profound thermal hyperalgesia in both Adelta and C-fiber thermonociceptive tests lasting at least 6 weeks." | ( Jones, T; Laurito, CE; Lu, Y; Wilson, SP; Yeomans, DC, 2004) |
| "Patients with mechanical allodynia may be good candidates for treatment with local anesthetic-like drugs and possibly with other sodium-channel blockers." | ( Attal, N; Bouhassira, D; Brasseur, L; Chauvin, M; Rouaud, J, 2004) |
| "This blockade of PGE2 mechanical hyperalgesia induced by diclofenac (100 microg/paw) was antagonized in a dose-dependent manner by intraplantar administration of the sulphonylureas glibenclamide (40, 80 and 160 microg) and tolbutamide (80, 160 and 320 microg), specific blockers of ATP-sensitive K+ channels, and it was observed even when the hyperalgesic agent used was carrageenin, while the antinociceptive action of indomethacin (200 microg/paw), a typical cyclo-oxygenase inhibitor, over carrageenin-induced hyperalgesia was not affected by this treatment." | ( Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA, 2004) |
| "In carrageenan-induced tactile allodynia, coadministration of weak analgesic doses of nefopam (10 and 30 mg/kg) with a nonanalgesic dose (1 mg/kg) or moderately analgesic dose (3 mg/kg) of morphine significantly reduced or reversed allodynia, respectively." | ( Gillardin, JM; Girard, P; Pansart, Y, 2004) |
| "In CCI, treatment with TPM attenuated mechanical hyperalgesia and cold allodynia." | ( Bischofs, S; Sommer, C; Zelenka, M, 2004) |
| "Mechanical hyperalgesia was observed after intrathecal PGE2 administration." | ( Kawamata, T; Nakayama, Y; Namiki, A; Omote, K, 2004) |
| "Since thermal hyperalgesia is a common symptom of axonal injury, locally applied oxidizing agents could be used as a novel treatment to ameliorate neuropathic pain." | ( Jevtovic-Todorovic, V; Meyenburg, A; Todorovic, SM, 2004) |
| "This hyperalgesia is evident in people with a history of heroin use and is not modified by methadone or buprenorphine treatment but is reduced by long-term abstinence from opioids." | ( White, JM, 2004) |
| "Clinically detectable allodynia, which occurs with high frequency in migraineurs, should become part of the clinical evaluation because of its implications in early treatment with triptans, recurrence of headache, consistency of response to triptans, and development of chronicity of migraine." | ( Kailasam, J; Mathew, NT; Seifert, T, 2004) |
| "In addition, formalin-induced secondary hyperalgesia was locally prevented by pre-but not post-celecoxib treatment." | ( Avila, MN; da Motta, PG; Duarte, ID; Francischi, JN; Tatsuo, MA; Veiga, AP, 2004) |
| "Both punctate allodynia and a weight bearing deficit were observed in MIA-treated rats for up to 10 weeks." | ( Bramwell, S; Combe, R; Field, MJ, 2004) |
| "In the test phase, hyperalgesia before morphine injection in the same context and antinociception after morphine injection in the different context were evident in the saline-pretreated group in the training phase, but they were not observed in those contexts in the dizocilpine-pretreated groups." | ( Nakama-Kitamura, M, 2005) |
| "Opioid-induced hyperalgesia is characterized by hypersensitivity to innocuous or noxious stimuli during sustained opiate administration." | ( Gardell, LR; Herman, DS; Lai, J; Ossipov, MH; Porreca, F; Stiller, CO; Vanderah, TW; Xie, JY, 2005) |
| "On day 11 after arthritis induction, mechanical hyperalgesia was assessed by the modified Randall Selitto paw pressure test following acute treatment with lacosamide." | ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "Morphine-induced hyperalgesia was reversed by spinal administration of an NK-1 receptor antagonist in rats and mice, and was observed in wildtype (NK-1(+/+)), but not NK-1 receptor knockout (NK-1(-/-)), mice." | ( Gardell, LR; Hruby, VJ; Hunt, SP; King, T; Lai, J; Malan, PT; Ossipov, MH; Porreca, F; Vanderah, TW; Vardanyan, A; Wang, R, 2005) |
| "On SCS treatment, both deep pain and allodynia could be permanently reduced from 10 to 0-2 on a 10 cm visual analogue scale (VAS) (p<0." | ( Gretenkort, P; Harke, H; Ladleif, HU; Rahman, S, 2005) |
| "Secondary allodynia was obliterated, and secondary hyperalgesia attenuated by this treatment." | ( Duarte, AM; Hamaya, Y; Mujenda, F; Pospisilova, E; Reilly, E; Strichartz, GR, 2005) |
| "IL-1beta-induced hyperalgesia was blocked by pretreatment with IL-1 receptor antagonist." | ( Ahn, DK; Bae, YC; Chae, JM; Choi, HS; Kwon, OW; Kyung, HM; Park, HS; Youn, DH, 2005) |
| "Mechanical hyperalgesia was observed in the sham and saline groups, but not in the OP-1 treated group." | ( Chubinskaya, S; Hashizume, H; Kawakami, M; Kuribayashi, K; Matsumoto, T; Yoshida, M, 2005) |
| "The magnitude of pain and the area of secondary hyperalgesia following transcutaneous stimulation were repetitively assessed before and up to 150 min after administration of (1) 0." | ( Ihmsen, H; Koppert, W; Körber, N; Schmelz, M; Schüttler, J; Sittl, R; Wehrfritz, A, 2005) |
| "As a measure of referred hyperalgesia, tail-flick latency was measured daily, before and 4 h after analgesia administration." | ( Cooper, DM; Hoffman, W; Lee, HY; Wheat, N, 2005) |
| "This L-NAME-induced thermal hyperalgesia was dose-dependently attenuated by pretreatment with mexiletine (10 and 30 mg/kg, i." | ( Kamei, J; Nozaki, C; Saitoh, A, 2006) |
| "Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236." | ( Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC, 2006) |
| "Imetit-induced hyperalgesia was completely prevented by treatment with a dose ineffective per se of thioperamide (H(3) receptor antagonist, 5 mg/kg i." | ( Farzin, D; Nosrati, F, 2007) |
| "Opioid-induced hyperalgesia (OIH) is a syndrome of increased sensitivity to noxious stimuli, seen after both the acute and chronic administration of opioids, that has been observed in humans and rodent models." | ( Clark, JD; Guo, Y; Liang, DY; Liao, G; Peltz, G; Usuka, J; Wang, J, 2006) |
| "Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days." | ( Elekes, K; Engström, M; Helyes, Z; Pintér, E; Sándor, K; Szabó, A; Szolcsányi, J; Wurster, S, 2006) |
| "Cizolirtine-induced antihyperalgesia was compared before and after pretreatment with ADO A(1)-A(2A) and 5-HT(1B/1D) receptor ligands in rats rendered diabetic by streptozotocin pretreatment and suffering from neuropathic pain." | ( Aubel, B; Bourgoin, S; Farré, A; Hamon, M; Kayser, V, 2007) |
| "Opioid-induced hyperalgesia (OIH) is a state of paradoxically increased nociceptive sensitivity seen in both humans and rodents following the resolution of the acute opioid antinociceptive effects or during periods of chronic opioid administration." | ( Clark, DJ; Liang, DY; Liao, G; Lighthall, GK; Peltz, G, 2006) |
| "The degree of opioid-induced hyperalgesia displayed in response to a thermal stimulus applied to the hind paw was measured in 16 strains of inbred mice after 4 days of morphine administration." | ( Clark, DJ; Liang, DY; Liao, G; Lighthall, GK; Peltz, G, 2006) |
| "Thermal hyperalgesia and mechanical allodynia induced by chronic constriction nerve injury (CCI) in rats were attenuated by the short-acting benzodiazepine midazolam (20=10>5 mug>vehicle) administered intrathecally once daily for 7 postoperative days." | ( Lim, G; Lim, J; Mao, J; Sung, B; Wang, S, 2006) |
| "Caffeine-treated rats showed hyperalgesia in hot-plate test, less anxiety than controls in the elevated plus-maze and dark-light transition, and impairment in step-through avoidance learning test." | ( Chen, HH; Pan, HZ, 2007) |
| "Cold allodynia and mechanical hypersensitivity were strongly attenuated with similar absolute potency after intravenous administration of tramadol and morphine." | ( Christoph, T; Kögel, B; Schug, SA; Strassburger, W, 2007) |
| "Muscle hyperalgesia (withdrawal threshold to compression of the muscle) and cutaneous hyperalgesia of the paw (withdrawal threshold to von Frey filaments) were measured before and after induction of hyperalgesia and after treatment with pregabalin (saline, 10 to 100 mg/kg i." | ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Headaches without allodynia were aborted when treated early or late, and headaches with allodynia were aborted only when allodynia was not present after treatment." | ( Landy, SH; McDonald, SA; McGinnis, JE, 2007) |
| "Bradykinin-induced hyperalgesia was abolished by co-administration with the B(2) receptor antagonist Hoe 140 (5 pmol/site), the NMDA antagonist MK-801 (5 nmol/site), the cyclooxygenase inhibitor indomethacin (10 nmol/site) and the glial metabolic inhibitor fluorocitrate (1 nmol/site)." | ( Bellé, NA; Calixto, JB; Dalmolin, GD; Ferreira, J; Mello, CF; Rubin, MA; Silva, CR, 2007) |
| "TX14(A) did not prevent tactile allodynia when injected directly into the foot pad whereas intrathecal administration of TX14(A) both prevented and alleviated gp120-induced tactile allodynia." | ( Calcutt, NA; Dacunha, JM; Esch, FS; Jolivalt, CG, 2008) |
| "In addition, CFA-induced thermal hyperalgesia was significantly reversed by intrathecal administration of 1-100 microg of BCTC and SB-366791." | ( Hara, T; Imai, A; Kanai, Y; Sakakibara, A, 2007) |
| "Subjective cutaneous allodynia started to decline after 30 minutes postdose in the early treated group and after 120 minutes postdose in the late-treated group." | ( Bradley, KC; Gebeline-Myers, C; Hopkins, MM; Silberstein, SD; Young, WB, 2007) |
| "We have shown that the hyperalgesia in our model of postoperative pain is responsive to treatment with the analgesic tramadol, but it is not responsive to the selective COX-2 inhibitor parecoxib at the doses we used." | ( Kamerman, P; Koller, A; Loram, L, 2007) |
| "In this study, opioid-induced hyperalgesia was measured by the tail-flick test when acute abstinence was precipitated by administering naloxone to drug naive rats that had experienced morphine analgesia for only 30 min." | ( Hamlin, AS; McNally, GP; Osborne, PB, 2007) |
| "Visceral hyperalgesia is prevented by pre-emptive administration of the CRF1 receptor antagonist, antalarmin." | ( Miranda, A; Nordstrom, E; Sengupta, JN; Smith, C, 2007) |
| "A PD diet strongly reduced long-lasting hyperalgesia induced by inflammation or incision, especially in fentanyl-treated rats." | ( Havouis, R; Laboureyras, E; Laulin, JP; Moulinoux, JP; Noble, F; Richebé, P; Rivat, C; Simonnet, G, 2008) |
| "To avoid a cutaneous allodynia it is necessary to introduce as soon as possible the treatment with triptans." | ( Dewarrat, A; Regli, F, 2007) |
| "Similarly, mechanical allodynia was partially reduced after ropivacaine treatment." | ( Ikeda, Y; Sakai, A; Sakamoto, A; Sato, C; Suzuki, H, 2008) |
| "To this end, persistent hyperalgesia was induced by administration of capsaicin in the tail of gonadally intact F344 rats, following which the tail was immersed in a mildly noxious thermal stimulus, and tail-withdrawal latencies measured." | ( Lomas, LM; Picker, MJ; Terner, JM, 2008) |
| "Thermal hyperalgesia, a decrease in paw withdrawal latency (PWL) to a noxious thermal stimulus, and mechanical hyperalgesia, a decrease in paw withdrawal pressure threshold (PWPT), was measured at baseline and 20min after the EA treatment." | ( Berman, BM; Lao, L; Li, A; Liu, B; Qiao, JT; Ren, K; Wang, L; Xin, J; Zhang, RX, 2008) |
| "Mechanical hyperalgesia (von Frey filaments) was significantly alleviated from 7 days to 4 weeks after capsaicin treatment, but cold allodynia (acetone) was unchanged." | ( Hwang, SJ; Kim, E; Kim, J; Kim, SM; Lee, SE; Shin, HK, 2008) |
| "Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia." | ( Andoh, T; Kuraishi, Y; Sasaki, A; Shiraki, K; Takahata, H; Takasaki, I; Takeshima, H, 2008) |
| "The PPADS administration decreased both tactile allodynia and thermal hyperalgesia in a time and dose dependent manner." | ( Albertini, R; Borsani, E; Colleoni, M; Labanca, M; Lonati, C; Panerai, AE; Rezzani, R; Rodella, LF; Sacerdote, P; Trovato, AE, 2008) |
| "In rat carrageenan-induced tactile allodynia, single administration of nefopam or ketoprofen only partially reduced allodynia." | ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| "Administration of AIDA reduced thermal hyperalgesia and mechanical allodynia at 3 and 7 days post-CCI; administration of JNJ16259685 reduced thermal hyperalgesia at 3 and 7 days post-CCI, but not mechanical allodynia." | ( de Novellis, V; Ferraraccio, F; Fuccio, C; Giordano, C; Luongo, L; Maione, S; Rossi, F; Roth, KA; Siniscalco, D, 2008) |
| "Saline-treated CCI rats developed thermal hyperalgesia on Day 3 with a more pronounced effect on Day 7." | ( Miletic, G; Miletic, V; Shih, A; Smith, LJ, 2008) |
| "Inoculation of SCC-158 induced marked mechanical allodynia, thermal hyperalgesia, and signs of spontaneous nocifensive behavior, which were diminished by systemic morphine administration." | ( Hironaka, K; Ogino, A; Ozaki, N; Shinoda, M; Sugiura, Y; Urano, H; Yasui, M, 2008) |
| "Thermal hyperalgesia provoked by phenylephrine was inhibited by terazosin administered after the burn injury, but not by terazosin administered before the burn injury." | ( Drummond, PD, 2009) |
| "1) The hyperalgesia induced by chrysin was significantly and dose-dependently blocked by pretreatment with flumazenil (0." | ( Chen, J; Chen, Q; Fu, CY; Hu, L; Zhai, K, 2008) |
| "Ethanol-induced hyperalgesia was attenuated by systemic and local peripheral administration of inhibitors of MAO-A, reduction of norepinephrine transporter (NET) in sensory neurons and a NET inhibitor." | ( Alessandri-Haber, N; Bogen, O; Chen, X; Dina, OA; Green, PG; Khasar, SG; Levine, JD; Messing, RO; Reichling, DB, 2008) |
| "Zymosan-induced primary hyperalgesia, measured as a decrease in hindpaw withdrawal latency in response to a thermal stimulus, is long-lasting and is not inhibited by pre-treatment with the systemic COX-2 selective inhibitor, parecoxib (20 mg/kg)." | ( Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I, 2008) |
| "Thermal hyperalgesia at day 3, but not at 6 hours, after CFA injection was blocked by intrathecal administration of anti-dynorphin antiserum or by bradykinin receptor antagonists." | ( Chen, Q; Lai, J; Luo, MC; Ossipov, MH; Porreca, F; Rankin, DR, 2008) |
| "This hyperalgesia was significantly attenuated by local administration of the AT(1) antagonist losartan." | ( Albino-Teixeira, A; Marques-Lopes, J; Morato, M; Patinha, D; Pinho, D; Pinto, M; Tavares, I, 2009) |
| "Ongoing CION-induced heat hyperalgesia (on Day 4) was reduced transiently, but significantly, by systemic or local treatment with antagonists of endothelin ET(A) receptors (atrasentan, 10 mg/kg, i." | ( Cabrini, DA; Chichorro, JG; Franco, CR; Rae, GA; Zampronio, AR, 2009) |
| "Thermal hyperalgesia was also decreased by intraplantar treatment with morphine (10 microg) or diclofenac (100 microg)." | ( Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J, 2009) |
| "Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy." | ( Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL, 2009) |
| "Sevoflurane effects on hyperalgesia were evaluated in Sprague-Dawley rats: opioid-naive rats, rats treated with fentanyl (4 x 60 microg kg(-1)) and rats with inflammatory pain (carrageenan) treated with fentanyl (4 x 60 microg kg(-1))." | ( Janvier, G; Laulin, JP; Maurette, P; Richebé, P; Rivalan, B; Rivat, C; Simonnet, G, 2009) |
| "Furthermore, both hyperalgesia and nociceptive responses were enhanced after the co-administration with NOP receptor antagonist [Nphe(1)]N/OFQ(1-13)-NH(2)." | ( Chang, M; Gao, YH; Han, RW; Li, W; Peng, YL; Wang, R; Yao, J, 2009) |
| "After induction of pin-prick hyperalgesia lidocaine or placebo was administered systemically using a double-blinded design." | ( Bschorer, K; De Col, R; Filitz, J; Koppert, W; Maihöfner, C; Peltz, E; Seifert, F, 2009) |
| "Daily stavudine administration induced mechanical hyperalgesia within three weeks, which was sustained until week six, but the hyperalgesia was not associated with neuronal apoptosis or necrosis, or elevated IL-6 concentrations in the spinal cord." | ( Kamerman, PR; Mitchell, B; Mitchell, D; Veliotes, D; Weber, J, 2009) |
| "Mechanical hyperalgesia induced by Freund's Complete Adjuvant (CFA) was attenuated by 3-ASP administration to mice (maximal inhibition of 42+/-11%)." | ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| "MK-801 blocked and reversed hyperalgesia caused by the acute injection and continuous infusion of fentanyl, respectively, in naltrexone-treated CD-1 mice, indicating the contribution of NMDA receptors to fentanyl hyperalgesia." | ( Arout, C; Caldwell, M; Dahan, A; Kest, B; Waxman, AR, 2009) |
| "An understanding of how the hyperalgesia may fit in with other manifestations of ethanol withdrawal may be an important variable in determining treatment outcome." | ( Gatch, MB, 2009) |
| "Pretreatment of mice with FBP reduced hyperalgesia induced by intraplantar injection of carrageenin (up to 54%), tumour necrosis factor alpha (40%), interleukin-1 beta (46%), CXCL1 (33%), prostaglandin E(2) (41%) or dopamine (55%)." | ( Alves-Filho, JC; Cunha, FQ; Cunha, TM; De Oliveira, JR; Ferreira, FI; Ferreira, SH; Lima, FO; Queiroz, RH; Valério, DA; Verri, WA, 2009) |
| "Pretreatment with DGPP blocked both mechanical allodynia and ipsilateral hyperalgesia." | ( Ahn, DK; Bae, YC; Han, SR; Ju, JS; Lee, MK; Lee, SY; Yang, GY; Youn, DH, 2009) |
| "Fentanyl-induced hyperalgesia and antinociception after systemic administration has been shown in previous clinical and experimental studies." | ( Gunay, I; Gunes, Y; Mert, T; Ozcengiz, D, 2009) |
| "The mechanical allodynia and the evoked activity of WDR neurons is attenuated by intrathecal and topical administration of SB203580, an inhibitor of p-38 MAPK activation, dose dependently (p<0." | ( Gwak, YS; Hulsebosch, CE; Unabia, GC, 2009) |
| "The anti-allodynia/antihyperalgesia caused by TTX in these neuropathic rats was promoted by combined treatment with naloxone (0." | ( Bernard, JF; Bourgoin, S; Buschmann, H; Hamon, M; Ioannidi, M; Kayser, V; Latrémolière, A; Michot, B; Vela, JM; Viguier, F, 2010) |
| "PSL-induced thermal hyperalgesia was significantly attenuated by treatment with U0126 on Days 3, 7, and 14 after PSL." | ( Fukazawa, Y; Kiguchi, N; Kishioka, S; Kobayashi, Y; Maeda, T, 2009) |
| "Unlike ziconotide, powerful antihyperalgesia without side effects can be achieved by intravenous administration of leconotide thus avoiding the need for an intrathecal injection." | ( Cooke, I; Goodchild, CS; Kolosov, A, 2010) |
| "Selective inhibition of disease-related hyperalgesia by tapentadol suggests a possible advantage in the treatment of chronic neuropathic pain when compared with classical opioids, such as morphine." | ( Christoph, T; De Vry, J; Tzschentke, TM, 2010) |
| "Opioid-induced hyperalgesia was produced by repeated morphine administration or pellet implantation in mice." | ( Chen, Y; Wang, ZJ; Yang, C, 2010) |
| "Allodynia and hyperalgesia were assessed after intraperitoneal administration of each drug alone or in combination." | ( Obara, I; Przewlocka, B; Wordliczek, J; Wrzosek, A, 2009) |
| "The concept of opioid-induced hyperalgesia has recently gained prominence as a contributing factor for long-term treatment failure." | ( Freye, E; Levy, JV, 2010) |
| "Under SP-induced thermal hyperalgesia, the number of scratchings following SP administration was time-dependently suppressed, whereas the number of scratchings after NMDA or AMPA administration was markedly enhanced and SP-induced thermal hyperalgesia was attenuated by pretreatment with NMDA or AMPA receptor antagonist." | ( Ikeda, T; Nakayama, T; Naono, R; Nishimori, T, 2010) |
| "Mechanical hyperalgesia and allodynia of both skin and muscle were observed in cisplatin-treated animals." | ( Hori, K; Ozaki, N; Sugiura, Y; Suzuki, S, 2010) |
| "Mechanical allodynia and thermal hyperalgesia induced by CCI were markedly attenuated by celecoxib from 5 to 14 days after surgery, and relieved by ibuprofen treatment from 7 to 10 days after surgery." | ( Guo, QL; Huang, CS; Wang, Y; Yan, JQ; Zhang, X; Zou, WY, 2010) |
| "Prostaglandin E(2) (PGE(2))-induced hyperalgesia is short lived in naïve rats, while it is prolonged in psiepsilonRACK pre-treated rats, a phenomenon referred to as priming." | ( Joseph, EK; Levine, JD, 2010) |
| "Ongoing hyperalgesia in GRK2(+/-) mice is reversed by minocycline administration at days 1 and 2 after IL-1beta injection." | ( Dantzer, R; Dorn, GW; Eijkelkamp, N; Heijnen, CJ; Kavelaars, A; Kelley, KW; Wang, H; Willemen, HLDM, 2010) |
| "However, there was a trend to reduced hyperalgesia and allodynia after propofol treatment." | ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| "The development of mechanical and cold allodynia was assessed in injured male rats treated with daily injections of progesterone or vehicle." | ( Coronel, MF; De Nicola, AF; González, SL; Labombarda, F; Villar, MJ, 2011) |
| "The SP-induced hyperalgesia was both GABA(A) and NMDA receptor-dependent after pre- and post-treatment with selective antagonists at the spinal level." | ( Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K, 2010) |
| "Thermal hyperalgesia was significantly ameliorated in a dose-dependent manner with systemically administered WIN." | ( Ahmed, MM; Allcock, B; Gerovac, TA; McChesney, S; Miranpuri, GS; Patel, AU; Rajpal, S; Resnick, DK; Sweeney, C; Tilghman, JI, 2010) |
| "The established referred allodynia/hyperalgesia following cerulein treatment was abolished by post-treatment with nafamostat mesilate, a proteinase inhibitor, and with capsazepine, a TRPV1 antagonist, in mice." | ( Akashi, R; Ishikura, H; Kawabata, A; Kitamura, T; Matsumura, K; Matsunami, M; Naruse, M; Nishimura, S; Sekiguchi, F; Shinozaki, Y, 2010) |
| "Opioid-induced hyperalgesia is defined as an increased sensitivity to pain or a decreased pain threshold in response to opioid therapy." | ( Zöllner, C, 2010) |
| "The mechanical allodynia was significantly attenuated by intrathecally administrated l-α-aminoadipate (astrocytic specific inhibitor) whereas minocycline (microglial specific inhibitor) did not have any effect on mechanical allodynia, which indicated that spinal astrocytic activation contributed to allodynia in db/db mice." | ( Cao, DY; Dou, KF; Gao, CJ; He, F; He, Y; Jia, D; Liao, YH; Qian, NS; Tao, KS; Wang, DS; Wang, P; Yang, YL; Zeng, XT; Zhang, GH; Zhang, Y, 2011) |
| "Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV." | ( Kawamata, T; Kiya, T; Namiki, A; Yamakage, M, 2011) |
| "In mice with LPS-induced hyperalgesia vehicle, indomethacin (10 mg/kg) or minocycline (50 mg/kg) did not produce significant changes, however, coadministration of minocycline plus indomethacin resulted in antinociceptive activity." | ( Abu-Ghefreh, AA; Masocha, W, 2010) |
| "At doses producing already maximal antihyperalgesia, HZ166 was devoid of sedation and motor impairment, and showed no loss of analgesic activity during a 9-day chronic treatment period (i." | ( Benke, D; Besson, M; Cook, JM; Daali, Y; Desmeules, J; Di Lio, A; Edwankar, R; Wang, ZJ; Zeilhofer, HU, 2011) |
| "Chronic pain and hyperalgesia can be difficult to treat with classical opioids acting predominately at the µ-opioid receptor." | ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Mansikka, H; Oksche, A; Staahl, C, 2011) |
| "minocycline treatment reversed the mechanical hyperalgesia, increased Fos expression and decreased the KCC2 expression detected in STZ-diabetic rats to control levels." | ( Cruz, CD; Morgado, C; Pereira-Terra, P; Tavares, I, 2011) |
| "Threshold for mechanical allodynia was measured with the digital von Frey test and responses to cold stimuli with the acetone test, before surgery and every other day after it 1h before drug administration." | ( Käenmäki, M; Kalso, EA; Kambur, O; Kontinen, VK; Männistö, PT; Pusa, AM, 2011) |
| "In a rat incision model of postoperative thermal hyperalgesia, coadministration of nefopam at a non-analgesic dose (3 mg/kg) with paracetamol at a low analgesic dose (300 mg/kg) showed the appearance of a strong antihyperalgesic effect, maintained for at least 3 h." | ( Coppé, MC; Girard, P; Niedergang, B; Pansart, Y; Verleye, M, 2011) |
| "Furthermore, G-CSF-induced hyperalgesia was inhibited in a dose-dependent manner by intrathecal pre-treatment with ERK (PD98059), JNK (SB600125), p38 (SB202190) or PI(3)K (wortmanin) inhibitors." | ( Batistela, AP; Carvalho, TT; Cunha, FQ; Cunha, TM; Ferreira, SH; Flauzino, T; Otaguiri, ES; Verri, WA; Zarpelon, AC, 2011) |
| "CFA-induced mechanical hyperalgesia in CD1 mice was attenuated by AP-18 (administered by intraarticular injection 22 hours after the administration of CFA)." | ( Bevan, S; Brain, SD; Fernandes, ES; Gentry, C; Graepel, R; Keeble, JE; Malcangio, M; McDougall, JJ; Mountford, DM; Russell, FA; Spina, D; Staniland, AA, 2011) |
| "Verbascoside was also effective against mechanical hyperalgesia after oral administration at doses of 300 and 600 mg/kg." | ( Bergonzi, MC; Bilia, AR; Galeotti, N; Ghelardini, C; Iacopi, R; Isacchi, B; Norcini, M; Vincieri, FF; Vivoli, E, 2011) |
| "Early after streptozotocin treatment, thermal hyperalgesia developed that was corrected by electroacupuncture." | ( Aloe, L; Florenzano, F; Manni, L, 2011) |
| "Chemotherapy-evoked hyperalgesia was induced by i." | ( Bento, AF; Calixto, JB; Costa, R; Dutra, RC; Malinsky, FR; Manjavachi, MN; Motta, EM; Pesquero, JB, 2011) |
| "Mechanical allodynia developed in a temporal manner in the rat hindpaws, such that it was fully developed by 6 weeks and persisted for at least 24 weeks post-STZ administration." | ( Cabot, PJ; Otto, KJ; Smith, MT; Wyse, BD, 2011) |
| "Administration of cisplatin evoked mechanical allodynia, an effect that was reduced in TRPA1-deficient mice." | ( Cavazzini, A; De Siena, G; Failli, P; Gees, M; Geppetti, P; Harrison, S; Mancini, F; Marchetti, N; Materazzi, S; Moretto, N; Nassini, R; Nilius, B; Patacchini, R; Pedretti, P; Preti, D, 2011) |
| "The phenomenon of opioid-induced hyperalgesia (OIH), an increased sensitivity to pain attributed to the very opioid drugs administered to manage the pain, is well established in animal models, and there is concern that it also occurs in patients." | ( Pergolizzi, JV; Raffa, RB, 2012) |
| "Blockade of neuronal FAAH reverses allodynia through the activation of both cannabinoid receptors and represents a promising target to treat inflammatory pain." | ( Abdullah, RA; Blankman, JL; Boger, DL; Booker, L; Cravatt, BF; Ezzili, C; Kinsey, SG; Lichtman, AH; Long, JZ, 2012) |
| "Administration of FCA induced hyperalgesia, which was significantly reduced by estradiol treatment compared to controls." | ( Hagiwara, S; Iwasaka, H; Noguchi, T; Okuda, K; Takatani, J; Takeshima, N; Uchino, T, 2011) |
| "The accompanying mechanical allodynia may be reduced by the intrathecal administration of adenosine." | ( Hahm, KD; Jeong, SM; Kim, YK; Lee, C; Leem, JG; Park, PH; Shin, JW; Song, JG, 2011) |
| "Paclitaxel produced allodynia that was largely dose independent and more robust in female mice, and this effect was prevented by treatment with cannabidiol." | ( Neelakantan, H; Ramirez, MD; Walker, EA; Ward, SJ, 2011) |
| "Once secondary allodynia was established, treatment with chromaffin cells produced a significant reduction in the nociceptive behavior in both hind paws." | ( Ambriz-Tututi, M; Drucker-Colín, R; Sánchez-González, V, 2011) |
| "Lidocaine plaster effectively treats mechanical hyperalgesia and cold pain." | ( Draxler, J; Gustorff, B; Hauer, D; Seis, A; Thaler, J, 2011) |
| "The cobra venom-treated rats developed mechanical allodynia 3 days after surgery that lasted for 60 days postoperatively at the ipsilateral side." | ( An, JX; Cope, DK; Guo, QL; He, Y; Qian, XY; Williams, JP; Wu, JP; Xie, YK, 2011) |
| "Remarkably, hyperalgesia evoked by Bjv or carrageenan was completely blocked in animals treated with ARPI or busulfan, or pre-treated with aspirin or clopidogrel." | ( Cirillo, MC; Giorgi, R; Gonçalves, LR; Nogueira, TO; Sano-Martins, IS; Santoro, ML; Senise, LV; Yamashita, KM, 2011) |
| "In addition, relief from mechanical allodynia, induced by ICS exposure, was also observed at day 9 after the cessation of antidepressant treatment." | ( Araki, K; Kishioka, S; Mukae, T; Nagai, J; Nishiyori, M; Uchida, H; Ueda, H, 2011) |
| "Mechanical allodynia was measured in mice receiving single intrathecal administration of Phα1β, ω-conotoxin MVIIA or morphine before or after the incisional plantar procedure." | ( Cordeiro, MN; da Silva, JF; de Castro Junior, CJ; de Souza, AH; Drewes, CC; Ferreira, J; Gomez, MV; Gomez, RS; Lima, MC; Pereira, EM; Richardson, M; Romano-Silva, MA; Torres, KC; Vieira, LB, 2011) |
| "SalB was effective against mechanical hyperalgesia when administered intraperitoneally at the dose of 100mg/kg, 15 min after administration." | ( Bergonzi, MC; Bilia, AR; Fabbri, V; Galeotti, N; Ghelardini, C; Isacchi, B; Karioti, A; Vannucchi, MG, 2011) |
| "Morphine can induce tolerance and hyperalgesia after long-term administration." | ( Chun, W; Ling, L; Wei, W; Xin, W, 2012) |
| "At the time of treatment, allodynia was present in 216 patients treated with MAP0004 and 202 patients treated with placebo." | ( Borland, SW; Hu, B; Kori, SH; Mathew, NT; Silberstein, SD; Tepper, SJ; Wang, MH, 2012) |
| "Patients were also more likely to be allodynia-free following treatment of a migraine with MAP0004." | ( Borland, SW; Hu, B; Kori, SH; Mathew, NT; Silberstein, SD; Tepper, SJ; Wang, MH, 2012) |
| "Paclitaxel potentiation of cold hyperalgesia in diabetes may result from the combination of increased mitochondrial ROS production and poor radical detoxification induced by paclitaxel treatment and diabetes-related overexpression of TRPA1." | ( Barrière, DA; Busserolles, J; Chanteranne, D; Chapuis, L; Chauvin, MA; Dubray, C; Morio, B; Rieusset, J; Salles, J, 2012) |
| "NPC-treated animals showed decreased hyperalgesia and allodynia 1-3week post-transplantation; vehicle-injected CCI rats continued displaying pain behaviors." | ( Gajavelli, S; Hentall, ID; Jergova, S; Sagen, J; Varghese, MS, 2012) |
| "Mechanical hyperalgesia was measured using the Randall-Selitto apparatus after injecting 5% formalin solution into the gastrocnemius muscle in mice treated with selective antagonists for B(1) or B(2) receptors." | ( Calixto, JB; Campos, R; Costa, R; da Silva, K; Meotti, FC; Paszcuk, AF, 2012) |
| "Mechanical hyperalgesia continued for 28 days at a lesion in the BLG, 21 days in PLG and 5 days in SLG after treatments, respectively." | ( Hayashi, K; Hori, K; Ichiyanagi, M; Ozaki, N; Shiraishi, Y; Sugiura, Y; Yasui, M, 2012) |
| "In inflammatory hyperalgesia induced by carrageenan, LPS, CFA or PGE(2), the inhibition values obtained with the PCME treatment were 68 ± 3%, 89 ± 5%, 43 ± 3% and 40 ± 4%, respectively." | ( Bresolin, TM; Cechinel-Filho, V; Klein-Júnior, LC; Meira, NA; Quintão, NL, 2012) |
| "Because thermal hyperalgesia was observed after both drugs, 8 of the original 19 subjects returned for an additional session without drug administration." | ( Coghill, RC; Eisenach, JC; Martucci, KT; Tong, C, 2012) |
| "PSL-induced tactile allodynia on days 4 to 7 was prevented by the administration of MIP-1β neutralizing antibody (anti-MIP-1β; on days 0, 3 and 6)." | ( Fukazawa, Y; Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F, 2012) |
| "Thermal hyperalgesia, mechanical and cold allodynia were examined at preadministration and at 15, 30, 60, 90, 120, 180, 240 and 360 min after administering the drug." | ( Im, KS; Joo, CH; Jung, HJ; Kim, JB; Lee, JM; Moon, DE; Park, HJ, 2012) |
| "Behavioral analysis indicated that mechanical allodynia began to develop after 2 days of capsaicin treatment and persisted for at least 6 days after the onset of the repetitive capsaicin injection." | ( Funakubo, M; Iwashita, T; Koizumi, K; Kuroi, T; Sato, H; Shibata, M; Shimizu, T; Suzuki, N; Toriumi, H, 2012) |
| "Paclitaxel-induced mechanical allodynia and hyperalgesia began 1 day after administration of paclitaxel and resolved within 7 days." | ( Katsuyama, S; Kishikawa, Y; Komatsu, T; Kuwahata, H; Nakamura, H; Sakurada, T; Yagi, T, 2012) |
| "SA daily treatment significantly reduced mechanical allodynia in KOR and cannabinoid receptor 1 (CB1R) sensitive manner." | ( Aviello, G; Boccella, S; Capasso, R; De Chiaro, M; de Novellis, V; Gatta, L; Guida, F; Izzo, AA; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Zjawiony, JK, 2012) |
| "The percentage allodynia relief was only 60% for carbamazepine and 80% for pregabalin by single administration, whereas their co-administration relieved allodynia by 100%." | ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Thermal hyperalgesia was also inhibited by the peritumoral administration of a neutralizing CCL2 antibody." | ( Baamonde, A; González-Rodríguez, S; Hidalgo, A; Lastra, A; Menéndez, L; Pevida, M, 2012) |
| "The mechanical allodynia was reversed by P2X(3)R antagonist, A-317491 administration into whisker pad skin." | ( Honda, K; Iwata, K; Kaji, K; Kimoto, S; Kiyomoto, M; Shinoda, M; Suzuki, A; Tamagawa, T; Yasuda, M, 2012) |
| "Both treatments resulted in cold and mechanical allodynia." | ( Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K, 2012) |
| "Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment." | ( Arout, C; Beijnen, JH; Dahan, A; den Hartigh, J; Kest, B; Mooren, RA; Swartjes, M; van de Wetering, K; Waxman, AR, 2012) |
| "Less mechanical allodynia was observed in ppt-A(-/-) mice compared to wild types (wt) after morphine treatment both before and after incision." | ( David Clark, J; Guo, TZ; Kingery, WS; Li, X; Liang, D; Qiao, Y; Sahbaie, P; Shi, X; Yeomans, DC, 2012) |
| "However, thermal hyperalgesia was reduced in rats given high-dose remifentanil: mean (standard deviation) area under the curve 426 (53) compared with 363 (34) and 342 (24) in saline or low-dose remifentanil treated rats, respectively (P<0." | ( Ihmsen, H; Manering, NA; Reuter, T; Tzabazis, A; Yeomans, DC, 2013) |
| "Ankle joint mobilization decreased mechanical hyperalgesia, and this effect was reversed by pretreatment of the animals with caffeine given by intraperitoneal, intraplantar, and intrathecal routes." | ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| "To induce hyperalgesia, rat paws were treated with intraplantar prostaglandin E2 (PGE2, 2μg)." | ( Duarte, ID; Pacheco, Dda F; Romero, TR, 2013) |
| "Zymosan-induced articular hyperalgesia, oedema and neutrophil migration were dose-dependently reduced following pretreatment with selective PAFR antagonists, UK74505 (5, 10 and 20 mg/kg) and PCA4248 (3, 10, 30 mg/kg)." | ( Cunha, FQ; Cunha, TM; Ferreira, SH; Guerrero, AT; Pinto, LG; Verri, WA; Vieira, SM; Zaperlon, AC; Zarpelon, AC, 2013) |
| "Identifying mechanisms underlying hyperalgesia could contribute to the development of new treatment strategies for the management of TMD and other muscle pain conditions." | ( Chung, MK; Ro, JY; Saloman, JL, 2013) |
| "Cisplatintreated mice display allodynia and an activation of DRG activated transcription factor 3, which is paralleled by its effects on behavior in the CPP system, wherein gabapentin, but not ketorolac, in the presence of the cisplatin polyneuropathy, is positively rewarding, confirming that this neuropathy is an aversive (painful) state that is ameliorated by gabapentin." | ( Park, HJ; Pirie, E; Shtaerman, Y; Skahen, J; Stokes, JA; Yaksh, TL, 2013) |
| "Diabetic rats exhibited significant hyperalgesia, and these rats were left untreated for the first four weeks." | ( Balaji, B; Prathab Balaji, S; Ramanathan, M; Ramesh, RV; Ranjithkumar, R, 2013) |
| "We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K(+)-Cl(-) co-transporter KCC2, impairing Cl(-) homeostasis in rat spinal lamina l neurons." | ( Beaulieu, JM; Beggs, S; Cahill, CM; Castonguay, A; De Koninck, Y; Del'Guidice, T; Doyon, N; Ferrini, F; Godin, AG; Laffray, S; Lorenzo, LE; Mattioli, TA; Mohr, D; Salter, MW; Trang, T; Vandal, K; Zhang, W, 2013) |
| "Cisplatin-treated mice developed heat hyperalgesia and mechanical allodynia while oxaliplatin-treated mice exhibited cold hyperalgesia and mechanical allodynia." | ( Bieber, AJ; Brederson, JD; Loprinzi, CL; Low, PA; Schmelzer, JD; Sieck, GC; Ta, LE; Windebank, AJ, 2013) |
| "Spinal-nerve ligation induced mechanical allodynia in saline-treated rats, with OX-42 and GFAP immunoreactivity being significantly increased on the ipsilateral side of the spinal cord." | ( Choi, YS; Jun, IG; Kim, SH; Park, JY, 2013) |
| "Thermal and mechanical hyperalgesia was evoked in mouse knee joints by intraplantar injection of tumor necrosis factor α and intraarticular infusion of Freund's complete adjuvant, and the analgesic effects of cortistatin, administered centrally, peripherally, and systemically, were assessed." | ( Caro, M; de Lecea, L; Delgado, M; Forte-Lago, I; Gonzalez-Rey, E; Morell, M; O'Valle, F; Souza-Moreira, L, 2013) |
| "Mechanical hyperalgesia was evaluated using a modified Randall and Selitto method in rats, cytokine production by ELISA and nitroxyl was determined by confocal microscopy in DAF (a cell permeable reagent that is converted into a fluorescent molecule by nitrogen oxides)-treated dorsal root ganglia neurons in culture." | ( Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Marchesi, M; Miranda, KM; Pinge-Filho, P; Schivo, IR; Souza, GR; Verri, WA; Zarpelon, AC, 2013) |
| "The mechanical allodynia was dose-dependently attenuated by intrathecal administratration of L-α-aminoadipate (astrocytic specific inhibitor); whereas minocycline (microglial specific inhibitor) had no such effect, indicating that spinal astrocytic activation contributes to allodynia in CNP rat." | ( Fei, Z; Huang, G; Ji, XT; Jia, D; Li, JM; Li, XK; Niu, L; Qian, NS; Wang, P; Zhang, L; Zhang, T; Zhao, DS, 2013) |
| "Heat hypoalgesia, but not mechanical hyperalgesia, was markedly attenuated by this treatment (P<0." | ( Lei, J; You, HJ, 2013) |
| "TENS treatment significantly alleviated mechanical hyperalgesia caused by CFA." | ( Du, JY; Fang, JF; Fang, JQ; Liang, Y, 2013) |
| "The tactile allodynia induced by nerve ligation was attenuated by prophylactic and chronic administration of neutralizing antibody against CCL-1 and by knocking down of CCR-8." | ( Akimoto, N; Beppu, K; Honda, K; Imoto, K; Kido, MA; Matsuzaki, Y; Nakashima, S; Noda, M; Takano, Y; Ushijima, Y; Uta, D, 2013) |
| "Our results demonstrate that the thermal hyperalgesia induced by intrathecal administration of NMDA is associated with spinal nitration of GluN1 and GluN2B receptor subunits, GS, that normally convert glutamate into nontoxic glutamine, and glutamate transporter GLT1." | ( Bardhi, E; Dagostino, C; Gliozzi, M; Ilari, S; Lauro, F; Mollace, V; Muscoli, C; Palma, E; Salvemini, D, 2013) |
| "Nocebo hyperalgesia is an increase in subjective pain perception after a patient or subject underwent an inert treatment without any active ingredient." | ( Büchel, C; Geuter, S, 2013) |
| "Mechanical hyperalgesia was assessed after acute treatment with TAT-2ASCV or/and fluoxetine (SSRI) 2." | ( Aissouni, Y; Chalus, M; Courteix, C; Dupuis, A; Eschalier, A; Hernández, A; Marin, P; Pelissier, T; Pichon, X; Privat, AM; Wattiez, AS, 2013) |
| "Mechanical allodynia was assessed daily 30 minutes before/after injection, 1 hour after injection of BQ-123 from post-SNL day 4 to day 6, and once on day 7 (without BQ-123 administration) before rats were sacrificed." | ( Cheung, CW; Chung, SK; Hung, VK; Mei, W; Qiu, Q; Tai, LW, 2013) |
| "This chronic basal hyperalgesia occurred in a dose-dependent fashion and persisted for days after cessation of NTG administration." | ( Charles, A; Evans, CJ; McGuire, B; Pradhan, AA; Smith, ML; Tarash, I, 2014) |
| "IANX induced mechanical allodynia, which was diminished by intra-TG administration of selective nNOS inhibitors." | ( Echizenya, S; Honda, K; Ito, R; Iwata, K; Kaji, K; Lee, J; Ohara, K; Shinoda, M; Sugiyama, T; Takahashi, O; Urata, K; Watase, T, 2013) |
| "Cold allodynia [evaluated by immersing the tail into cold water (4 °C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i." | ( Bae, H; Kim, SK; Lee, DI; Lee, G; Lim, BS; Min, BI; Moon, HJ; Na, HS; Ye, MS, 2014) |
| "(1) WT cisplatin-treated mice showed tactile allodynia from day 3 through day 30." | ( Corr, M; Park, HJ; Stokes, JA; Yaksh, TL, 2014) |
| "Ovariectomy attenuated the mechanical hyperalgesia induced by recombinant leptin, in rats treated with vehicle compared to those treated with 17β-estradiol replacement, at 1 and 24 h after leptin injection." | ( Alvarez, P; Bogen, O; Chen, X; Giudice, LC; Levine, JD, 2014) |
| "Moreover, in these mice, thermal hyperalgesia was counteracted following the peritumoral (10-30μg) but not spinal (3-5μg) administration of J113863." | ( Baamonde, A; Hidalgo, A; Lastra, A; Meana, Á; Menéndez, L; Pevida, M, 2014) |
| "Moreover, CXCL10-induced mechanical allodynia was rescued by minocycline treatment during the late-stage of CIBP, days 10-14." | ( Bu, H; Cao, F; Gao, F; Guan, X; Hinton, AO; Ke, C; Liu, C; Shu, B; Tian, X; Tian, Y; Xiang, H; Yang, H, 2014) |
| "Mechanical allodynia in paclitaxel-treated Sprague Dawley (SD) rats was measured using a dynamic plantar aesthesiometer before and after treatment with E139 (10 and 20 mg/kg) or its vehicle for four consecutive days from day 7 after first administration of paclitaxel (16 mg/kg on two alternate days)." | ( Edafiogho, IO; Masocha, W; Thangamani, D, 2013) |
| "Since hyperalgesia remains after cessation of paclitaxel therapy and becomes chronic, we hypothesize that alteration in memory and the cognitive process of pain underlies hyperalgesia." | ( Akita, H; Noda, K; Ogata, M; Saji, M, 2014) |
| "Visceral hyperalgesia was assessed by comparing the viscero-motor response (VMR) to graded colorectal distension (CRD) prior and post 7 days after TNBS treatment." | ( Banerjee, B; Bruckert, M; Kannampalli, P; Pochiraju, S; Sengupta, JN; Shaker, R, 2014) |
| "Mechanical allodynia was evaluated just before (preventive or alleviative effect) and 1 h after (analgesic effect) drug administration." | ( Asakura, K; Isami, K; Kaneko, S; Maeda, S; Nakagawa, T; Sakakiyama, M; Shirakawa, H; So, K, 2014) |
| "Thermal hyperalgesia and mechanical allodynia tests were conducted to observe the analgesic effect of chronic administration with ferulic acid on CCI mice." | ( Chen, SZ; Lv, WH; Pan, JC; Wu, SJ; Zhang, L; Zhu, XB, 2013) |
| "However, orofacial heat and cold hyperalgesia, induced by carrageenan injected into the upper lip (50 µg/50 μl), was abolished by previous intraganglionar RTX treatment." | ( Chichorro, JG; Cruz, LS; Kopruszinski, CM, 2014) |
| "JTC-801 treatment reversed SPS-induced mechanical allodynia, thermal hyperalgesia, anxiety-like behaviour and hypocortisolism." | ( Simpson-Durand, CD; Standifer, KM; Zhang, Y, 2015) |
| "The results show that thermal hyperalgesia and mechanical allodynia were reduced in the KMUP-1 treated group as compared to that in the CCI group." | ( Chen, IJ; Chen, JY; Cheng, KI; Chu, LW; Dai, ZK; Lin, TC; Liou, JC; Wu, BN, 2014) |
| "Intense acute swimming-induced muscle mechanical hyperalgesia was dose-dependently inhibited by IL-1ra treatment." | ( Alves-Filho, JC; Borghi, SM; Cardoso, RD; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Pinho-Ribeiro, FA; Verri, WA; Zarpelon, AC, 2014) |
| "Moreover, bladder hyperalgesia was reversed by acute treatment with the TRPA1 antagonist HC-030031 (300 mg/kg, i." | ( Davis, BM; DeBerry, JJ; Schwartz, ES, 2014) |
| "Carrageenan-induced allodynia and edema were largely reduced by the pretreatment with GA." | ( Athayde, ML; Boligon, AA; Ferreira, J; Hoffmeister, C; Klafke, JZ; Pinheiro, FV; Pinheiro, KV; Rosa, F; Rossato, MF; Tonello, R; Trevisan, G, 2014) |
| "Visceral hyperalgesia was measured by the intracolonic administration of TRPM8 agonist, WS-12, in control and dextran sodium sulfate (DSS)-induced colitis mice." | ( Fujino, H; Horie, S; Hosoya, T; Matsumoto, K; Murayama, T; Nakamura, H; Tashima, K, 2014) |
| "Opioid-induced hyperalgesia was defined as an increase in mechanical nociceptive thresholds after opioid administration." | ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Gómez de Segura, IA, 2015) |
| "Also the effect of venlafaxine on heat hyperalgesia was reversed by pretreatment with yohimbine at all-time intervals." | ( Abed, A; Banafshe, HR; Hajhashemi, V; Mesdaghinia, A; Minaiyan, M, 2014) |
| "Thermal hyperalgesia and mechanical allodynia were measured before and after administration of inhibitor of cGMP-cGKs pathway (Rp-8-pCPT-cGMPS)." | ( Chen, LP; Liu, GJ; Liu, S; Liu, YP; Zhang, MY, 2014) |
| "mechanical and cold allodynia) developed equivalently in all pretreatment groups and was similarly reversed by either morphine (6 mg/kg i." | ( Deng, L; Fan, B; Guindon, J; Hohmann, AG; Wager-Miller, J, 2014) |
| "The spinal action of luteolin on mechanical hyperalgesia was inhibited by intrathecal pretreatment with the γ-aminobutyric acidA (GABAA) receptor antagonist bicuculline and μ-opioid receptor antagonist naloxone, but not by intrathecal pretreatment with either the benzodiazepine receptor antagonist flumazenil or glycine receptor antagonist strychnine." | ( Hara, K; Haranishi, Y; Nakamura, M; Sata, T; Takahashi, Y; Terada, T, 2014) |
| "Chronic visceral hyperalgesia was induced in rats by intracolonic administration of zymosan for 3 days during postnatal day 14-16 (P14-P16)." | ( Berg, BM; Bruckert, M; Chichlowski, M; Kannampalli, P; Miranda, A; Pochiraju, S; Rudolph, C; Sengupta, JN, 2014) |
| "Previous studies reported development of thermal hyperalgesia in mice treated with paclitaxel." | ( Masocha, W, 2014) |
| "Rats exhibited significant mechanical allodynia following 2 weeks of chronic oxaliplatin administration." | ( Hasegawa, M; Kanbara, T; Kanemasa, T; Mori, T; Nakamura, A; Ogawa, K; Sakaguchi, G; Shibasaki, M; Suzuki, T; Takasu, K, 2014) |
| "Diabetic rats exhibited hyperalgesia and allodynia and remifentanil treatment aggravated the hyperalgesia and allodynia." | ( Bilgin, R; Kilinc, M; Mert, T; Oksuz, H; Senoglu, N; Tugtag, B, 2014) |
| "Opioid-induced hyperalgesia is well known complication of acute high dose and chronic opioid therapy." | ( Cinar, S; Doganci, S; Dogrul, A; Eksert, S; Eskin, MB; Ince, ME; Ozkan, G; Yildirim, V, 2014) |
| "G-CSF-induced mechanical hyperalgesia was inhibited by systemic and local treatment with etanercept and IL-1 receptor antagonist (IL-1ra) or TNF receptor 1 (TNFR1) deficiency and increased in IL-10 deficient mice." | ( Borghi, SM; Carvalho, TT; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Pinho-Ribeiro, FA; Verri, WA, 2015) |
| "However, these cold and mechanical allodynia were markedly alleviated by berberine administration in a dose-dependent manner." | ( Kim, HJ, 2015) |
| "Administration of KO2 induced mechanical hyperalgesia, thermal hyperalgesia, paw edema, leukocyte recruitment, the writhing response, paw flinching, and paw licking in a dose-dependent manner." | ( Calixto-Campos, C; Carvalho, TT; Casagrande, R; Ferraz, CR; Guazelli, CF; Hohmann, MS; Maioli, NA; Manchope, MF; Mizokami, SS; Pinho-Ribeiro, FA; Verri, WA; Zarpelon, AC, 2015) |
| "Male WT mice develop a persistent tactile allodynia resulting from cisplatin administration." | ( Corr, M; Woller, SA; Yaksh, TL, 2015) |
| "Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment." | ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| "Vincristine-induced cold allodynia, mechanical hyperalgesia and thermal hyperalgesia were measured pre-vincristine administration and on days 15, 17 and 19 post-vincristine administration." | ( Adjei, S; Ahedor, B; Ameyaw, EO; Amoateng, P; N'guessan, BB; Nyarko, AK; Osei-Safo, D, 2015) |
| "This morphine-induced mechanical and thermal hyperalgesia were greatly attenuated by co-administration of morphine with melatonin." | ( Song, L; Wu, C; Zuo, Y, 2015) |
| "Mechanical allodynia was observed in rats with LDH not treated with FLL; however, not in FLL‑treated rats." | ( Han, XR; Han, YX; Liang, D; Liang, DY, 2015) |
| "RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500 ng and RTX 1 μg groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine." | ( Choi, SS; Choi, YS; Huh, BK; Hur, WS; Kim, HS; Kim, HZ; Lee, DK; Lee, MG; Lee, MK; Lim, BG, 2015) |
| "The intensity of tactile allodynia in STZ-induced diabetic mice was alleviated by the oral administration of PGN; however, the antiallodynic effect varied according to its dosing time." | ( Akamine, T; Hashimoto, H; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Taniguchi, M, 2015) |
| "We found that mechanical allodynia was significantly inhibited by a continuous application of high dose and a single treatment of a super high dose of MeCbl." | ( Han, W; Hu, S; Jiao, X; Meng, F; Xu, H; Zhang, M; Zheng, J, 2015) |
| "Orofacial cold hyperalgesia was induced in rats either by the administration of oxaliplatin or by infraorbital nerve chronic constrictive injury." | ( Abd-Elsayed, AA; Gu, JG; Ikeda, R; Jia, Z; Li, M; Ling, J; Zuo, X, 2015) |
| "Acute CS1 therapy attenuated mechanical allodynia (pain from innocuous stimulation) but not thermal hyperalgesia and reduced the levels of IL-17A expression in the injured nerve." | ( Angert, M; Chernov, AV; Dolkas, J; Hoang, K; Liu, H; Nishihara, T; Remacle, AG; Shiryaev, SA; Shubayev, VI; Strongin, AY, 2015) |
| "Thermal hyperalgesia and mechanical allodynia were assessed 60 and 120 min post injection on each day of TTX treatment." | ( Clifford, JL; Korz, W; McIntyre, MK; Petz, LN; Salas, MM; Wong, D, 2015) |
| "And the mechanical allodynia induced by PK2 was prevented by co-administration of TNP-ATP, a selective P2X receptor antagonist." | ( Gan, X; Hu, WP; Liu, TT; Qiu, CY; Qu, ZW; Rao, Z; Ren, C, 2015) |
| "In addition, hyperalgesia to sharp stimulation was lower at the prazosin- than vehicle-treated site in the CRPS-affected limb, and allodynia to brushing was lower at the prazosin-treated than vehicle-treated site in patients with an adrenergic component of pain." | ( Birklein, F; Drummond, ES; Drummond, PD; Finch, PM; Maker, G, 2016) |
| "However, the prolongation of PGE2 hyperalgesia induced by repeated administration of CPA depends on G-protein αi subunit activation, differently from DAMGO-induced type II priming, in which it depends on the β/γ subunit." | ( Araldi, D; Ferrari, LF; Levine, JD, 2016) |
| "Mice significantly present an anti-allodynia effect in a dose-related manner after the PX-12 administration." | ( Hsiao, HT; Lin, YC; Liu, YC; Tsai, YC; Wang, JC, 2016) |
| "Cold (acetone test) and mechanical hyperalgesia (electronic von Frey analysis) responses were evaluated for 15 days in rats treated with oral EEPA (100mg/kg) in the spared nerve injury (SNI) model." | ( Balen, E; Barison, A; da Silva Arrigo, J; da Silva Mota, J; Iwamoto, RD; Júnior, UL; Leite Kassuya, CA; Sugizaki, MM, 2016) |
| "Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain." | ( Hu, X; Huang, F; Liu, Y; Szymusiak, M; Tian, X; Wang, ZJ, 2016) |
| "TCI treatment induced significant thermal hyperalgesia and mechanical allodynia." | ( Liu, GJ; Liu, S; Liu, YP; Qi, DY; Yue, DM; Zhang, LY; Zhang, MY, 2015) |
| "After confirming hyperalgesia, male mice were treated with βCP-βCD (10 or 20mg/kg; p." | ( Araújo, AA; Brito, RG; Brogden, NK; Carvalho, FM; Menezes, PP; Quintans, JS; Quintans-Júnior, LJ; Santos, PL; Serafini, MR; Silva, GF; Sluka, KA, 2016) |
| "Nitrous oxide significantly reduced hyperalgesia, allodynia and pain intensity aggravated after remifentanil administration in a human volunteer model." | ( Apiou-Sbirlea, G; Bessiere, B; Noel, N; Richebé, P; Schaefer, S; Schuettler, J; Simonnet, G; Troester, A; Wehrfritz, A, 2016) |
| "Additionally, tongue heat hyperalgesia following complete Freund's adjuvant injection was completely suppressed by the administration of SB366791, a transient receptor potential vanilloid 1 antagonist, in the tongue." | ( Honda, K; Iwata, K; Shinoda, M; Shirakawa, T; Suzuki, A, 2016) |
| "After confirming hyperalgesia, male mice were treated with αTPN-βCD (25, 50 or 100 mg/kg; p." | ( Almeida, JR; Araújo, AA; Araújo-Filho, HG; Brito, RG; Carvalho, YM; Menezes, PP; Oliveira, MG; Quintans, JS; Quintans-Júnior, LJ; Santos, PL; Scotti, L; Scotti, MT; Serafini, MR; Shanmugam, S; Silva, JC; Thangaraj, P, 2016) |
| "We show that IB-MECA alleviated mechanical hyperalgesia and thermal hypoalgesia in mice 2 weeks but not 4 weeks after streptozocin (STZ) treatment." | ( Feng, C; Yan, H; Zhang, E; Zhao, X, 2016) |
| "CT-βCD reduced mechanical hyperalgesia on all days of treatment (p <0." | ( Araújo, AA; Brito, RG; Coutinho, HD; Guimarães, AG; Menezes, IR; Menezes, PP; Oliveira, MA; Quintans, JS; Quintans-Júnior, LJ; Santos, MR; Santos, PL; Serafini, MR, 2016) |
| "Mechanical allodynia in the whisker pad skin in adulthood was induced by MS and was significantly suppressed by successive postnatal subcutaneous administration of the glucocorticoid receptor antagonist mifepristone." | ( Fujita, M; Honda, K; Iwata, K; Kawata, A; Kimoto, S; Nagashima, H; Shinoda, M; Shoji, N; Takahashi, O; Watanabe, M; Yasuda, M, 2016) |
| "Mechanical hyperalgesia and increased P2X3 expression in ovariectomized (OVX) CFA-treated rats were reversed by estrogen replacements." | ( Burnstock, G; Fan, J; Jiang, Q; Li, WX; Ma, B; Sun, JR; Yang, H; Yu, LH; Zhu, TT, 2017) |
| "Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Daily treatment with AS inhibited mechanical hyperalgesia and inflammation (edema, leukocyte migration, cytokines release and NF-κB activation, and oxidative stress) resulting in reduced disease severity (clinical course, histopathological changes, proteoglycan levels in the joints, and osteoclastogenesis)." | ( Bordignon, J; Casagrande, R; Domiciano, TP; Fattori, V; Figueiredo, F; Miranda, KM; Mizokami, SS; Pelayo, JS; Pinho-Ribeiro, FA; Ruiz-Miyazawa, KW; Staurengo-Ferrari, L; Verri, WA, 2017) |
| "ERK inhibitor attenuated NP-induced hyperalgesia compared to the dimethyl sulfoxide-(vehicle control) administered group (p < 0." | ( Cao, MH; He, QL; Li, MN; Sun, LB; Wang, YM; Wei, M; Wu, HX; Xu, H, 2017) |
| "Tianeptine administered i." | ( Han, SM; Jo, HU; Kim, YH; Kwak, JA; Park, HJ, 2017) |
| "Both CBD and THC alone attenuated mechanical allodynia in mice treated with paclitaxel." | ( King, KM; Myers, AM; Soroka-Monzo, AJ; Tallarida, RJ; Tuma, RF; Walker, EA; Ward, SJ, 2017) |
| "Mechanical allodynia was reversed on day 7 in the groups treated with BBG and PPADS." | ( Almeida, FM; de Andrade, GM; Marques, SA; Martinez, AMB; Melo, PA; Oliveira, JT; Ribeiro, T; Tomaz, MA, 2017) |
| "Chronic pain and hyperalgesia, as well as pain resulting from episodes of vaso-occlusion, are characteristic features of sickle cell disease (SCD) and are difficult to treat." | ( Gupta, K; Simone, DA; Uhelski, ML, 2017) |
| "Rats with stable signs of static allodynia were selected 2 weeks after the surgery and drug treatments were started (day 0)." | ( Miura, A; Morimoto, K; Tanaka, K, 2017) |
| "After induction of hyperalgesia, the oral administration of LIM-βCD (50mg/kg) significantly increased the paw withdrawal threshold compared to uncomplexed limonene." | ( Albuquerque, TR; Alcantara, IS; Araújo, AAS; Araújo-Filho, HG; Barreto, RSS; Coutinho, HDM; Martins, AOBPB; Menezes, IRA; Menezes, PP; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Rezende, MM; Silva, BAF, 2017) |
| "Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment." | ( Jeong, KY; Kang, JH, 2018) |
| "Furthermore, it markedly attenuated the mechanical allodynia caused by surgical incision (after acute treatment with stigmasterol, preventive and curative effects were observed) and partial sciatic nerve ligation (after acute treatment with stigmasterol) and complete Freund's adjuvant (after acute or repeated treatment with stigmasterol)." | ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "AEPM and MEPM significantly reversed the mechanical hyperalgesia caused by CFA in acute and chronic treatment." | ( Bomba, FDT; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Piegang, BN; Wandji, BA, 2018) |
| "A distinct area of hyperalgesia or allodynia around the surgical incision was found in more patients in the control group than in the treated group." | ( Arcioni, R; D'Andrilli, A; De Blasi, RA; Massullo, D; Mercieri, M; Naccarato, A; Palmisani, S; Rocco, M; Silvestri, B; Tigano, S, 2017) |
| "In order to evaluate the hyperalgesia of the ASD, sciatic nerve crush injury (NCI) was induced in mice followed by administration of the ASD, where three parameters were evaluated: mechanical and thermal hyperalgesia as well as grip strength." | ( Barbosa, EG; da Silva-Júnior, WF; de Azevedo, EP; de França Almeida Moreira, CDL; de Lima, ÁAN; de Oliveira Pinheiro, JG; de Souza Araújo, AA; de Souza Siqueira Quintans, J; Lavra, ZMM; Pereira, EWM; Quintans-Júnior, LJ; Resende, MM, 2018) |
| "CoPP treatment inhibited allodynia, hyperglycemia and body weight gain in db/db mice by enhancing HO-1/NQO1 levels and reducing JNK phosphorylation." | ( Leánez, S; McDonnell, C; Pol, O, 2017) |
| "Furthermore, the mechanical allodynia was significantly attenuated after PUR administration." | ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018) |
| "Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various pain states, and remain difficult to treat." | ( Alpár, A; Balázsa, T; Barta, B; Bölcskei, K; Fekete, C; Gerber, G; Helyes, Z; Király, K; Kozsurek, M; Lukácsi, E; Pap, K; Puskár, Z; Szabon, J; Tékus, V; Tóth, ZE, 2018) |
| "Puerarin treatment alleviated mechanical hyperalgesia and cartilage damage in osteoarthritis rats." | ( Pan, C; Shan, H; Wang, B; Wang, F; Wang, L; Wang, N; Zhou, Z, 2018) |
| "Mice treated with VCR showed high mechanical allodynia but no modifications of motor performance or mechanical/thermal nociception." | ( Bessaguet, F; Bouchenaki, H; Danigo, A; Demiot, C; Desmoulière, A; Duchesne, M; Magy, L; Richard, L; Sturtz, F, 2018) |
| "Development of mechanical and thermal allodynia was prevented completely in paclitaxel-treated hHsp27 transgenic mice." | ( Au, NPB; Chine, VB; Kumar, G; Ma, CHE, 2019) |
| "Oxaliplatin-induced cold allodynia is a frequent complication appearing in patients treated with this anti-tumor drug." | ( Fijałkowski, Ł; Furgała, A; Nowaczyk, A; Sałat, K; Sałat, R, 2018) |
| "Intrathecal KLA-induced tactile allodynia was completely prevented by spinal pretreatment with the 12/15-lipoxygenase inhibitor CDC or a selective antibody targeting rat 15-LOX-1." | ( Buczynski, MW; Dennis, EA; Dumlao, DS; Fitzsimmons, BL; Gregus, AM; Jadhav, A; Maloney, DJ; Norris, PC; Rai, G; Simeonov, A; Wei, SC; Xu, Q; Yaksh, TL, 2018) |
| "Seven days of treatment with CBD reduced mechanical allodynia, decreased anxiety-like behavior, and normalized 5-HT activity." | ( Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L, 2019) |
| "Paclitaxel treatment developed mechanical allodynia in mice, as assessed by von Frey test, which was prevented by an anti-HMGB1-neutralizing antibody or thrombomodulin alfa capable of inactivating HMGB1." | ( Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D, 2018) |
| "Females developed more severe mechanical allodynia than males after LPA treatment." | ( McDougall, JJ; O'Brien, MS; Philpott, HTA, 2019) |
| "Furthermore, long-lasting bilateral hyperalgesia could be reversed by pharmacological inhibition of over-expressed spinal PKCγ; however, pretreating with intrathecal KIG31-1 showed no antinociceptive effects on short-term spontaneous pain behaviors." | ( Chen, DS; Chen, GZ; Ding, T; Guo, XJ; Liang, JC; Tang, K; Wang, Y; Wu, HH; Yin, JB; Zhao, YQ, 2018) |
| "Opioid-induced hyperalgesia and analgesic tolerance can lead to dose escalation and inadequate pain treatment with μ-opioid receptor agonists." | ( Chen, H; Chen, SR; Deng, M; Dong, Y; Luo, Y; Pan, HL, 2019) |
| "Cisplatin produced mechanical and cold hyperalgesia and decreased electrical thresholds of Aδ and C fibers, which were attenuated by coadministration of pioglitazone (10 mg/kg, intraperitoneally [i." | ( Albino-Ramírez, AM; Khasabov, SG; Khasabova, IA; Kim, AH; Olson, JK; Seybold, VS; Simone, DA; Uhelski, ML; Wagner, CL, 2019) |
| "Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy." | ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "MCS reversed the hyperalgesia induced by peripheral neuropathy in the rats with chronic sciatic nerve constriction and induced a significant increase in the glycine and GABA levels in the PAG in comparison with the naive and sham-treated rats." | ( Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL, 2019) |
| "Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management." | ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018) |
| "Nicotine treatment reduced mechanical allodynia, cartilage degradation, and the upregulation of matrix metalloproteinase-9 (MMP-9), a hallmark of joint inflammation in OA, in mice treated with monosodium iodoacetate." | ( Dai, Y; Hu, J; Liu, WT; Liu, Y; Teng, P; Zhang, H, 2019) |
| "Furthermore, this hyperalgesia was attenuated by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid treatment." | ( Akbari, A; Pandey, SC; Pradhan, AA; Tipton, AF; Zhang, H, 2019) |
| "We observed significant hindpaw allodynia in TBI rats that was reduced after DHT but not vehicle treatment." | ( Clark, JD; Ferguson, AR; Irvine, KA; Sahbaie, P, 2019) |
| "Tactile allodynia and sciatic, tibial, and peroneal functional indices were assessed before the knee joint immobilization, 24 hours after the knee cast removal, and 24 hours after 3 weeks of lumbar therapy with the Activator Adjusting Instrument, model 4 (AAI 4)." | ( Belló-Klein, A; Duarte, FCK; Kolberg, C; Partata, WA; Riffel, APK; Souza, JA, 2019) |
| "The CCI-induced development of mechanical allodynia was attenuated by administration of either ketoconazole (10 nmol) or the p38 MAPK inhibitor, SB203580 (5 nmol)." | ( Beitz, AJ; Choi, SR; Lee, JH, 2019) |
| "Mechanical and cold allodynia were evaluated after acute or repeated dacarbazine administration in naive mice or after inoculation of B16-F10 melanoma cells in C57BL/6 mice." | ( Brusco, I; Camponogara, C; Chiepe, KB; da Silva Brum, E; de Almeida, AS; de Andrade, VM; de David Antoniazzi, CT; De Logu, F; Ferreira, J; Geppetti, P; Li Puma, S; Nassini, R; Oliveira, SM; Silva, CR; Trevisan, G, 2020) |
| "FST-induced hyperalgesia in the hindpaw was prevented by repeated SL and SLX treatments." | ( Kakihara, Y; Nakatani, Y; Okamoto, K; Saeki, M; Shimizu, S; Taiyoji, M; Takagi, R; Yamamura, K, 2020) |
| "Opioid-induced hyperalgesia is a state of nociceptive sensitisation secondary to opioid administration." | ( Albrecht, E; Frauenknecht, J; Grape, S; Kilchoer, L; Kirkham, KR, 2020) |
| "The degree of allodynia and the effects of systemic morphine or intrathecal endomorphin-1 administration were determined." | ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020) |
| "WAS caused visceral allodynia and colonic hyperpermeability, and intragastric administration of GSE (100 mg/kg, once daily for 11 days) inhibited these changes." | ( Arie, H; Ida, M; Izumo, T; Miyagishi, S; Nozu, T; Shibata, H, 2019) |
| "Celecoxib had no effect on muscular mechanical hyperalgesia, when orally administered 24 h after lengthening contractions." | ( Mikoshiba, S; Shimodaira, T; Taguchi, T, 2019) |
| "The areas of hyperalgesia and allodynia were lower during placebo treatment compared to no treatment (hyperalgesia, 30 cm [17 to 47] vs." | ( Bandschapp, O; Luethi, J; Mauermann, E; Ruppen, W; Schneider, T, 2020) |
| "Administration of CFA induced mechanical allodynia associated with reduced spinal GSK3β phosphorylation, increased spinal SAPK/JNK phosphorylation, and increased plasma SOD levels." | ( Anselmo-Franci, JA; Branco, LGS; Carolino, ROG; Mota, CMD; Rodrigues-Santos, C, 2020) |
| "Paclitaxel produced mechanical hyperalgesia, over the 4-day course of administration, peaking by day 7, and still present by day 28, with no significant difference between male and female rats." | ( Araldi, D; Ferrari, LF; Green, PG; Levine, JD, 2020) |
| "Treatment with ANA-12 could attenuate mechanical allodynia, restrain activation of astrocytes and microglia and alleviate neuroinflammation." | ( Chen, J; Ding, H; Huang, Y; Li, W; Lin, Z; Liu, B; Liu, X; Su, M; Xie, J; Yang, F; Zhan, H; Zhou, X, 2020) |
| "Thermal hyperalgesia and mechanical allodynia were reduced in the loganin-treated group as compared to the CCI group." | ( Chang, YC; Chen, JY; Cheng, KI; Cheng, YC; Chu, LW; Dai, ZK; Hsu, JH; Wu, BN; Yeh, JL, 2020) |
| "Nociception and tactile allodynia were measured with von Frey filaments after acute and chronic treatments." | ( Ahlström, FHG; Blomqvist, KJ; Jokinen, V; Kalso, EA; Lilius, TO; Rauhala, PV; Sidorova, YA; Suleymanova, I; Viisanen, H, 2020) |
| "Although several studies demonstrate hyperalgesia as a result of barbiturate administration, others show analgesia." | ( Acampora, G; Arout, CA; DeNegre, D; Koretski, J; Newcomb, J; Perrino, AC; Petrakis, IL; Ralevski, E, 2020) |
| "Moreover, opioid-induced hyperalgesia was observed after repeated administration of morphine, but not BN-9." | ( Chen, D; Fang, Q; Li, N; Niu, J; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R; Zhao, G; Zhu, H, 2020) |
| "FMNT treatment also reduced thermal hyperalgesia and mechanical allodynia significantly." | ( Kulkarni, YA; Oza, MJ, 2020) |
| "Mechanical allodynia, which develops in patients of diabetes mellitus as a neuropathic manifestation, remains without an effective treatment." | ( Cui, Y; Gou, X; Li, L; Li, Y; Mi, Y; Ning, J; Qiu, Z; Wang, X, 2020) |
| "Diabetic mechanical allodynia (DMA) is a common manifestation in patients with diabetes mellitus, and currently, no effective treatment is available." | ( Cui, YY; Gou, XC; Li, MY; Li, YQ; Li, YT; Ning, JY; Shi, J, 2020) |
| "Sumatriptan elicited cutaneous allodynia in both cephalic and hindpaw regions; cutaneous allodynia resolved to baseline levels after cessation of drug administration (14 days)." | ( Banerjee, P; Behravesh, S; Dodick, DW; Navratilova, E; Oyarzo, J; Porreca, F, 2020) |
| "The main symptoms of neuropathy: tactile allodynia and cold hyperalgesia, appear in more than 80% of patients on oxaliplatin therapy and are due to the overexpression of neuronal sodium channels (Navs) and neuroinflammation." | ( Fijałkowski, Ł; Furgała-Wojas, A; Kowalska, M; Nowaczyk, A; Sałat, K, 2020) |
| "Mechanical allodynia and axonal degeneration, but not cold hyperalgesia, were ameliorated by daily co-administration of Cystine [200 mg/kg orally (p." | ( Egashira, N; Kawashiri, T; Kobayashi, D; Shimazoe, T; Tsuchiya, T, 2020) |
| "The treatments reduced oedema, cold and mechanical hyperalgesia, leukocyte migration and protein exudation." | ( Ferrari, IC; Kassuya, CAL; Leitão, MM; Mota, JDS; Negrão, FJ; Oliveira, RJ; Radai, JAS; Silva-Filho, SE, 2020) |
| "Then, tactile allodynia was determined, and animals were treated with logarithmic doses of PhAR-DBH-Me (3." | ( González-Anduaga, GM; López-Ortíz, M; Navarrete, A; Palomino-Hernández, O; Quiñonez-Bastidas, GN; Regla, I; Rocha-González, HI, 2020) |
| "Conversely, at 7 days both CFA-evoked mechanical allodynia and paw edema were not affected by SP treatment." | ( Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K, 2020) |
| "The treatment decreased allodynia (p < 0." | ( Mousa, AMA; Nadar, MS; Qabazard, B; Renno, WM; Shayea, AMF; Yousif, MHM, 2020) |
| "PTX-treated rats showed mechanical allodynia and neurophysiological alterations consistent with a severe sensory axonal polyneuropathy." | ( Alberti, P; Ballarini, E; Canta, A; Cavaletti, G; Chiorazzi, A; Fumagalli, G; Guarnieri, C; Marmiroli, P; Meregalli, C; Monza, L; Oggioni, N; Pozzi, E; Rodriguez-Menendez, V; Scali, C, 2021) |
| "HA and HA/βCD reduced mechanical hyperalgesia in relation to the vehicle group until the fourth and fifth hours, respectively, in the acute evaluation, with a superior effect of the complexed form over the pure form in the second and third hour after treatment (p < 0." | ( Antunes de Souza Araújo, A; Barbosa Gomes de Carvalho, YM; Barreto, RSS; Guedes da Silva Almeida, JR; Heimfarth, L; Melo Coutinho, HD; Monteiro, BS; Pereira, EWM; Picot, L; Quintans, JSS; Quintans-Júnior, LJ; Santos Passos, FR; Siqueira-Lima, PS, 2021) |
| "However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment." | ( Al-Khrasani, M; Balogh, M; Barsi, S; Benyhe, S; Galambos, AR; Harsing, LG; Karádi, DÁ; Király, K; Köles, L; Lakatos, PP; Mohammadzadeh, A; Riba, P; Szökő, É; Tábi, T; Zádor, F; Zádori, ZS, 2021) |
| "Moreover, the effectiveness of treating hyperalgesia with a combination of polyalthic acid and naproxen was analyzed, as well as the type of drug-drug interaction involved." | ( Arrieta, J; Flores-Murrieta, FJ; López-Lorenzo, Y; Quiñonez-Bastidas, GN; Reyes-García, JG; Rocha-González, HI; Rodríguez-Silverio, J; Sánchez-Mendoza, ME, 2021) |
| "On the other hand, persistent allodynia and overexpression of Sprr1a and Anxa10 after electrocautery were dramatically suppressed by systemic administration of GSK-J4, which is a selective H3K27 demethylase inhibitor." | ( Hamada, Y; Inada, E; Iseki, M; Katsuda, Y; Kondo, T; Kuzumaki, N; Matsufuji, M; Mori, T; Narita, M; Sato, D; Takeshima, H; Tanaka, K; Ushijima, T; Yamabe, Y; Yamaguchi, K, 2021) |
| "The behavior tests for hyperalgesia and tolerance were performed in male Wistar rats before and after morphine administration." | ( Chen, Y; Fan, R; Gong, X; Ye, X; Zhang, M; Zhu, Q, 2021) |
| "Nitroglycerin-induced hyperalgesia was evaluated in mice with different gut microbiota statuses as follows: Specific pathogen-free mice; germ-free mice; specific pathogen-free mice treated with antibiotics to deplete the gut microbiome (ABX mice); and germ-free mice transplanted with the gut microbial profile from specific pathogen-free mice (GFC mice)." | ( Kang, L; Kong, S; Li, Y; Liu, J; Tang, W; Yu, S; Zhang, M; Zhang, Y; Zhao, D, 2022) |
| "Moreover, significant hyperalgesia was induced by nitroglycerin administration in GFC mice." | ( Kang, L; Kong, S; Li, Y; Liu, J; Tang, W; Yu, S; Zhang, M; Zhang, Y; Zhao, D, 2022) |
| "After the treatment period, the area of hyperalgesia was significantly reduced (P < 0." | ( Bauer, M; Bessiere, B; Ihmsen, H; Noel, N; Prottengeier, J; Ramirez-Gil, JF; Schüttler, J; Wehrfritz, A, 2021) |
| "In the model of mechanical allodynia and paw edema induced by carrageenan, metformin also exhibited activity when administered after (1 h) the inflammatory stimulus." | ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "Opioid-induced hyperalgesia (OIH) is a problem associated with prolonged use of opioids in chronic pain management, and its effective treatment has been hampered by lack of mechanistic evidence." | ( Cui, LL; Gan, SF; Li, CH; Luo, F; Wang, XX; Xiao, J; Zhang, ZR, 2022) |
| "Resveratrol administration alleviated hyperalgesia, motor disfunction and allodynia." | ( Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Genovese, T; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R, 2022) |
| "Mechanical allodynia has been studied in chronic naltrexone-treated people (N." | ( Dieb, W; Durif, F; Hafidi, A; Hamdi, D; Lashin, M; Omara-Reda, H; Ouachikh, O, 2022) |
| "However, GBCA administration induced mechanical hyperalgesia in sham and tMCAO mice although in the same level, which may be an important consideration for patients with central post-stroke pain and those who are sensitive to pain and about to receive multiple GBCA administrations." | ( Huang, XX; Jiang, RH; Li, L; Liu, S; Shi, HB; Sun, YQ; Wang, W; Xu, XQ, 2023) |
| "The exaggerated mechanical allodynia in the oral ulcerative region was largely inhibited by topical treatment with the antioxidative drug, ɑ-lipoic acid, or the blocker of N-formyl peptide receptor 1, N-t-butoxycarbonyl-methionyl-leucyl-phenylalanine." | ( Harano, N; Hitomi, S; Hsu, CC; Iwata, K; Nakatomi, C; Ono, K; Yamaguchi, K, 2022) |
| "SNI-induced allodynia was reduced by chemogenetic inhibition of Y1-INs, or intrathecal administration of a Y1-selective agonist." | ( Jukkola, P; McCarson, KE; Nelson, TS; Prasoon, P; Santos, DFS; Sinha, GP; Smith, BN; Taylor, BK; Winter, MK, 2022) |
| "The duration of mechanical allodynia in male rats was shortened by intracisternal administration of minocycline." | ( Hayashi, Y; Hitomi, S; Iwata, K; Otsuji, J; Shibuta, I; Shinoda, M; Shirakawa, T; Soma, C; Soma, K, 2022) |
| "Interestingly, the anti-allodynia was associated with a decrease in the PFC expression level of GFAP under the drugs' co-administration." | ( Alijanpour, S; Asgharpour-Masouleh, N; Delphi, L; Rezayof, A, 2023) |
| "Opioid-induced hyperalgesia (OIH) is a state of paradoxically enhanced pain transmission, termed nociceptive sensitization, described to occur in both humans and animals after repeated administration of opioid drugs, including rapidly acting remifentanil." | ( Todorovic, SM, 2022) |
| "Opioid-induced hyperalgesia (OIH) is a state of paradoxically enhanced pain transmission, termed nociceptive sensitization, described to occur in both humans and animals after repeated administration of opioid drugs, including rapidly acting remifentanil." | ( Todorovic, SM, 2022) |
| "Umbellulone-induced allodynia was prevented by cabergoline co-treatment during priming with KOR agonists in female, but not male, mice." | ( de Souza, LHM; Dodick, DW; Kopruszinski, CM; Martinez, AL; Moutal, A; Navratilova, E; Neugebauer, V; Porreca, F; Watanabe, M, 2023) |
| "In rats with CCI, mechanical allodynia, cold allodynia, and thermal hyperalgesia developed, which improved when the rats were administered CNPs." | ( Darroudi, M; Forouzanfar, F; Ghazavi, H; Khorrami, MB; Mashhad, NM; Moghadam, OF; Pourbagher-Shahri, AM; Sadeghi, M; Vafaee, F, 2023) |
| "Mechanical and thermal hyperalgesia were evaluated at baseline (24 h prior to remifentanil infusion) and 2, 6, 12, and 24 h following remifentanil administration." | ( Gao, Y; Li, J; Li, Q; Li, Y; Ma, W; Sun, Z; Wang, C; Wang, Q; Yu, Y, 2023) |
| "CCI increased mechanical allodynia, cold allodynia, and thermal hyperalgesia in rats which were reduced by treatment with EA (50 or 100 mg/kg), gabapentin, or their combination." | ( Esmaeili, M; Forouzanfar, F; Ghazavi, H; Mahdianpour, S; Pourbagher-Shahri, AM; Tanha, NK, 2023) |
| "BTZ-treated mice showed enhanced mechanical hyperalgesia, decreased tail nerve conduction and sciatic nerve demyelination." | ( Li, X; Wang, H; Wang, K; Wu, J; Wu, Z; Xu, G; Yan, W; Yang, M; Zhang, X; Zhu, D, 2023) |
| "Indeed, neuropathic allodynia was attenuated after conditional knockout of miR-21 and restored by TGF-βR inhibitor (SB431542) administration." | ( Al-Mudaris, S; Chambers, D; Fox, S; Malcangio, M; Picco, F; Sideris-Lampretsas, G; Silva, R; Zeboudj, L, 2023) |
| "Importantly, periorbital mechanical allodynia by both ethanol and acetaldehyde is abrogated by pretreatment with the CGRP receptor antagonist, olcegepant, and a selective silencing of RAMP1 in Schwann cells." | ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "The mechanical allodynia and thermal hyperalgesia following CFA were alleviated by the treatment of intrathecal injection of GSK-J4, and by microinjection of AAV-EGFP-KDM6B shRNA in the sciatic nerve or in lumbar 5 dorsal horn." | ( Bai, L; Gao, Y; Li, L; Liang, Z; Qiao, Y; Wang, L; Wang, X; Xu, JT; Yang, Y, 2023) |
| "Mechanical allodynia caused by PTX treatment was alleviated in PAR2 knockout mice of both sexes." | ( Ahmad, A; Boitano, S; DeFea, KA; Dussor, G; Kume, M; Price, TJ; Vagner, J, 2023) |
| "We evaluated mechanical hyperalgesia after intrathecal administration of GR and MR agonists." | ( Beyer, A; Hong, X; Mousa, SA; Schäfer, M; Shaqura, M; Tafelski, S; Wandrey, JD, 2023) |
| "Moreover, CSD-induced hyperalgesia was attenuated by local NADA administration to the TRN." | ( Akeju, O; Borsook, D; Chen, P; Chen, Q; Choi, JH; Ding, W; Feng, G; Gao, L; Hu, K; Kim, B; Low, S; Luo, A; Mao, J; Ran, C; Schreiber, KL; Shen, S; Shi, E; Wang, C; Yang, J; Yang, L, 2023) |