1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine profile

## 1,2-Bis(10,12-tricosadiynoyl)phosphatidylcholine: A Synthetic Phospholipid for Research

**1,2-Bis(10,12-tricosadiynoyl)phosphatidylcholine (DC₈PC)** is a synthetic phospholipid with two long, unsaturated fatty acid chains containing diyne moieties (two triple bonds) at the 10th and 12th positions. This unique structure makes it a valuable tool in various research areas, particularly in studying membrane dynamics and biophysics.

**Importance in Research:**

1. **Membrane Dynamics and Fluidity:** DC₈PC acts as a **molecular ruler** in membrane studies. Its diyne moieties have specific absorption properties that allow researchers to probe membrane properties like:
* **Lateral diffusion:** The diyne groups can be excited with UV light, causing them to fluoresce. This fluorescence can be measured to track their movement within the membrane, providing information about lateral diffusion rates.
* **Membrane fluidity:** Changes in the fluidity of the membrane can affect the mobility of DC₈PC molecules. Researchers can monitor these changes through fluorescence anisotropy measurements, which reflect the rotational freedom of the probes.

2. **Membrane Structure and Organization:** DC₈PC can be used to study:
* **Lipid packing:** The unique structure of DC₈PC allows it to interact with other lipids in specific ways, influencing lipid packing and membrane organization.
* **Domain formation:** DC₈PC can help identify and characterize lipid domains or rafts within membranes, which are enriched in specific lipids and proteins and play crucial roles in cellular processes.

3. **Lipid-Protein Interactions:** DC₈PC can be incorporated into membranes to study:
* **Protein association with specific lipid domains:** This can provide insights into how proteins interact with membranes and how they are localized within different cellular compartments.
* **Effects of lipids on protein function:** By modifying the lipid composition of membranes with DC₈PC, researchers can study how lipid changes influence the activity and behavior of membrane-bound proteins.

4. **Drug Delivery and Nanocarriers:** DC₈PC is a versatile molecule for creating liposomes, which are nano-sized vesicles used for:
* **Drug delivery:** Liposomes containing DC₈PC can encapsulate and transport drugs to specific targets within the body, improving drug efficacy and reducing side effects.
* **Nanocarrier design:** DC₈PC can be incorporated into nanocarriers to tune their properties, such as stability, targeting ability, and drug release kinetics.

**Overall, 1,2-Bis(10,12-tricosadiynoyl)phosphatidylcholine (DC₈PC) is a powerful tool for studying membrane dynamics, structure, and interactions. Its unique properties make it invaluable for advancing research in diverse fields, including biophysics, cell biology, and drug delivery.**

1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine: constituent of lipid tubules [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3080938
SCHEMBL ID	415281
MeSH ID	M0152570

Synonym
dc(8,9)pc
1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine
1,2-ditricosa-10,12-diynoyl-sn-glycero-3-phosphocholine
1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine
3,5,9-trioxa-4-phosphadotriaconta-19,21-diyn-1-aminium, 4-hydroxy-n,n,n-trimethyl-10-oxo-7-((1-oxo-10,12-tricosadinyl)oxy)-, hydroxide, inner salt, 4-oxide, (r)-
1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine
76078-28-9
1,2-btpc
[(2r)-2,3-di(tricosa-10,12-diynoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
SCHEMBL415281
DTXSID40226969
23:2 diyne pc [dc(8,9)pc]
23:2 diyne pc [dc(8,9)pc], 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine, powder
(r)-2,3-bis(tricosa-10,12-diynoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
BP-28327

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (19.23)	18.7374
1990's	10 (38.46)	18.2507
2000's	5 (19.23)	29.6817
2010's	6 (23.08)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.85%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (96.15%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	2.06	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
phosphorylcholine Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.. phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.	2.01	1	phosphocholines	allergen; epitope; hapten; human metabolite; mouse metabolite
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	2.1	1	pentacarboxylic acid	copper chelator
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.48	2
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	2.92	4
acetylene [no description available]	1.97	1	alkyne; gas molecular entity; terminal acetylenic compound
trehalose alpha,alpha-trehalose : A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.	1.97	1	trehalose	Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
gadolinium Gadolinium: An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.	2.1	1	f-block element atom; lanthanoid atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.06	1	copper group element atom; elemental gold
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.97	1	dihydrogen
sodium azide Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).	2.08	1	inorganic sodium salt	antibacterial agent; explosive; mitochondrial respiratory-chain inhibitor; mutagen
fluorexon fluorexon: structure	2.06	1	xanthene dye	fluorochrome
organophosphonates hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.	2.01	1	divalent inorganic anion; phosphite ion
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.02	1	organic sodium salt	detergent; protein denaturant
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	2.69	3	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.13	1	carbon group element atom; metalloid atom; nonmetal atom
1-palmitoyl-2-oleoylphosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine: RN given refers to (Z)-isomer	2.08	1
technetium tc 99m mebrofenin technetium Tc 99m mebrofenin: hepatobiliary radiopharmaceutical	2.06	1
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	5.7	26	1,2-diacyl-sn-glycero-3-phosphocholine
chitosan [no description available]	2.1	1
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.08	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	2.72	3

Condition	Relationship Strength	Studies
Diffuse Mixed Small and Large Cell Lymphoma [description not available]	2.11	1
Lymphoma, Non-Hodgkin Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.	2.11	1
Extravascular Hemolysis [description not available]	2.06	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.06	1
Breast Cancer [description not available]	2.06	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.06	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	1.97	1

1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine

Description

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Synonyms (15)

Research

Studies (26)

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