Compounds > alpha,beta,gamma,delta-tetrakis(4-n-trimethylaminophenyl)porphine

Page last updated: 2024-10-15

alpha,beta,gamma,delta-tetrakis(4-n-trimethylaminophenyl)porphine

Description

alpha,beta,gamma,delta-tetrakis(4-N-trimethylaminophenyl)porphine: for colorimetric determination of serum copper; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	135433388
CHEMBL ID	2171697
SCHEMBL ID	266547
MeSH ID	M0095182

Synonyms (8)

Synonym
alpha,beta,gamma,delta-tetrakis(4-n-trimethylaminophenyl)porphine
ttap
tetrakis(p-trimethylammoniumphenyl)porphyrin
benzenaminium, 4,4',4'',4'''-(21h,23h-porphine-5,10,15,20-tetrayl)tetrakis(n,n,n-trimethyl-
tetra(4-(trimethylammoniophenyl))porphine
69458-19-1
CHEMBL2171697
SCHEMBL266547

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID701796	Photocytotoxicity against Candida albicans PC31 assessed as release of intracellular DNA and protein at 5 uM preincubated for 30 mins in dark followed by irradiation measured after 30 mins by UV-vis spectroscopic analysis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701805	Binding affinity to calf thymus DNA by spectrophotometric analysis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701804	Binding affinity to calf thymus DNA assessed as DNA cleavage at 20 uM after 1 hr irradiation by agarose gel electrophoresis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701798	Binding affinity to Candida albicans PC31 DNA assessed as genomic DNA cleavage at 5 uM preincubated for 30 mins in dark followed by irradiation measured after 30 mins by agarose gel electrophoresis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701794	Antifungal activity against 10'6 CFU/mL Candida albicans PC31 assessed as cell survival at 5 uM preincubated for 30 mins in dark followed by irradiation measured after 30 mins	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701795	Binding affinity to calf thymus DNA assessed as DNA cleavage at 20 uM after 2 hrs irradiation by agarose gel electrophoresis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701800	Antifungal activity against 10'7 CFU/mL Candida albicans PC31 assessed as cell survival at 5 uM preincubated for 30 mins in dark followed by irradiation measured after 30 mins	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID701799	Antifungal activity against 10'7 CFU/mL Candida albicans PC31 preincubated for 30 mins in dark followed by irradiation measured after 30 mins	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
AID1845447	Photocytotoxicity against human WiDr cells assessed as lethal dose incubated for 18 hrs followed by replacement of medium containing compound with 48 hrs incubation and subsequent light irradiation of 13.5 mW/cm2 at 435 nm measured after 48 hrs by MTT ass	2021	Bioorganic & medicinal chemistry, 01-15, Volume: 30	Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer.
AID701797	Photocytotoxicity against Candida albicans PC31 assessed as change in cell morphology at 5 to 10 uM preincubated for 30 mins in dark followed by irradiation measured after 30 mins by transmission electron microscopy	2012	European journal of medicinal chemistry, Dec, Volume: 58	Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (25.00)	18.7374
1990's	2 (16.67)	18.2507
2000's	3 (25.00)	29.6817
2010's	3 (25.00)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
protoporphyrin ix protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685. protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.	2.47	2	0
temoporfin temoporfin: used as PHOTOCHEMOTHERAPY	2.31	1	0
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	2.06	1	0	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
tetraphenylphosphonium tetraphenylphosphonium: RN given refers to parent cpd; structure. tetraphenylphosphonium : A polyatomic cation consisting of four phenyl groups attached to a central phosphonium.	2.46	2	0	heteroorganic entity; phosphorus molecular entity; polyatomic cation
indium Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum.	1.96	1	0	boron group element atom
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.03	1	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
tetracarboxyphenylporphine [no description available]	2.31	1	0
tetra(4-n-methylpyridyl)porphine tetra(4-N-methylpyridyl)porphine: structure in first source	2.69	3	0
5,10,15,20-tetra(4-hydroxyphenyl)porphyrin 5,10,15,20-tetra(4-hydroxyphenyl)porphyrin: structure in first source; tumor localizer; do not confuse with THPP	2.31	1	0
insulin [no description available]	2.31	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Experimental Neoplasms [description not available]	0	2.31	1	0
Colorectal Cancer [description not available]	0	2.31	1	0
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	0	2.31	1	0
Benign Neoplasms [description not available]	0	2.01	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	0	2.01	1	0
Coagulation Disorders, Blood [description not available]	0	1.97	1	0
Bleeding [description not available]	0	1.97	1	0
Envenomation, Snakebite [description not available]	0	1.97	1	0
Blood Coagulation Disorders Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.	0	1.97	1	0
Hemorrhage Bleeding or escape of blood from a vessel.	0	1.97	1	0