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spiroketal

A cyclic ketal in which the ketal carbon is the only common atom of two rings.

ChEBI ID: 72600

Members (18)

MemberDefinitionRole
2',3'-o-(2,4,6-trinitrophenyl)adenosine 5'-triphosphateA sprioketal resulting from the formal condensation of the 2'- and 3'- hydroxy groups of ATP with picric acid.TNP-ATP
22,23-dihydroavermectin b(1)aA macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.22,23-dihydroavermectin B1a
amcinonideamcinonide
aplysiatoxinThe parent member of the class of aplysiatoxins. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs.aplysiatoxin
avenacoside bA steroid saponin obtained from grain and leaves of oats (Avena sativa) that is nuatigenin in which the hydroxy group at position 26 is converted to its beta-D-glucoside and in which the hydroxy group at position 3 is converted into its methyl alpha-L-rhamnopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)-beta-D-glucopyranosyl-(1->4)]-beta-D-glucopyranoside derivative.avenacoside B
chrysopineA spiroketal and delta-lactone resulting from the formal condensation of the carboxy group of L-glutamine with the anomeric hydroxy group of D-fructose and substitution of the 1-hydroxy group of the fructose by the alpha-amino group of the glutamine. It is found in crown gall tumours induced in chrysanthemums by Agrobacterium tumefaciens.chrysopine
debromoaplysiatoxinA member of the class of aplysiatoxins that has the structure of the parent aplysiatoxin, but is lacking the bromo substituent on the benzene ring at the position para to the phenolic hydroxy group. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs.debromoaplysiatoxin
dioscinA spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.dioscin
diosgeninA sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.diosgenin
diosgenin glucosideA sterol 3-beta-D-glucoside having diosgenin as the sterol component.diosgenin 3-O-beta-D-glucoside
guanadrelA spiroketal resulting from the formal condensation of the keto group of cyclohexanone with the hydroxy groups of 1-(2,3-dihydroxypropyl)guanidine. A postganglionic adrenergic blocking agent formerly used (generally as the sulfate salt) for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching).guanadrel
monensinA spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.monensin A
ossamycinA macrolide antibiotic that was originally isolated from the culture broths of Streptomyces hygroscopicus var. ossamyceticus.ossamycin
pectenotoxin 1Pectenotoxin 1
pectenotoxin 2Pectenotoxin 2
pectenotoxin 6Pectenotoxin 7
salinomycinSalinomycin
spiroxamineThe spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powdery mildew in the production of cereals, bananas and grapes.spiroxamine

Research

Studies (5,370)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19901,497 (27.88)18.7374
1990's1,183 (22.03)18.2507
2000's928 (17.28)29.6817
2010's1,287 (23.97)24.3611
2020's475 (8.85)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials170 (2.86%)5.53%
Reviews178 (2.99%)6.00%
Case Studies44 (0.74%)4.05%
Observational0 (0.00%)0.25%
Other5,556 (93.41%)84.16%