One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
| Member | Definition | Class |
|---|
| 16,16-dimethylprostaglandin e2 | A prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. | 16,16-dimethylprostaglandin E2 |
| 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one | A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol. | rohitukine |
| alpha-methylene gamma-butyrolactone | A butan-4-olide having a methylene group at the 3-position. | alpha-methylene gamma-butyrolactone |
| amlexanox | A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position. | amlexanox |
| azuletil | A member of the class of azulenes carrying sulfo, ethyl and isopropyl substituents at positions 1, 3 and 7 respectively. Used (in the form of its sodium salt) for treatment of gastric ulcers. | egualen |
| azuletil sodium | An organic sodium salt having 3-ethyl-7-isopropylazulene-1-sulfonate as the counterion. Used for treatment of gastric ulcers. | egualen sodium |
| cimetidine | A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. | cimetidine |
| eupatilin | A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities. | eupatilin |
| famotidine | | famotidine |
| famotidine | | famotidine |
| lansoprazole | | lansoprazole |
| nizatidine | A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4. | nizatidine |
| octotropine methylbromide | A quaternary ammonium salt resulting from the reaction of the amino group of anisotropine with methyl bromide. | anisotropine methylbromide |
| oxmetidine | A 2-aminopyrimidin-4(1H)-one derivative bearing a 1,3-benzodioxol-5-ylmethyl group at the 5-position and with a 4-(5-methyl-(1H)imidazol-4-yl)-3-thiabutyl substituent attached to the 2-amino group. It is a specific histamine H2-receptor antagonist. | oxmetidine |
| pantoprazole | A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2. | pantoprazole |
| pantoprazole sodium | | pantoprazole sodium |
| pibutidine | An aromtic ether that is 4-(piperidin-1-ylmethyl)pyridin-2-ol in which the hydroxy group has been substituted by a {(2Z)-4-[(2-amino-3,4-dioxocyclobut-1-en-1-yl)amino]but-2-en-1-yl}oxy group. It is a H2 receptor antagonist which was developed for the treatment of peptic ulcers and duodenal ulcers. | pibutidine |
| pibutidine hydrochloride | The hydrochloride salt of pibutidine. It is a H2 receptor antagonist which was developed for the treatment of peptic ulcers and duodenal ulcers. It was in phase III clinical trials in Japan (now discontinued). | pibutidine hydrochloride |
| pirenzepine | | pirenzepine |
| plaunotol | A diterpenoid that is geranylgeraniol carrying an additional hydroxy substituent at position 18. | plaunotol |
| proglumide | A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. | N(2)-benzoyl-N,N-dipropyl-alpha-glutamine; proglumide |
| rabeprazole | | rabeprazole |
| ranitidine | A member of the class of furans used to treat peptic ulcer disease (PUD) and gastroesophageal reflux disease. | ranitidine |
| s 1743 | A magnesium salt resulting from the formal reaction of magnesium hydroxide with 2 mol eq. of esomeprazole. An inhibitor of gastric acid secretion, it is used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome. | esomeprazole magnesium |
| sofalcone | A member of the class of chalcones that is benzene in which the hydrogens at positions 1,2 and 5 are replaced by carboxymethoxy, (1E)-1-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-oxoprop-1-en-3-yl, and (3-methylbut-2-en-1-yl)oxy groups, respectively. It is a gastrointestinal drug currently used for treatment of gastritis and gastric ulcers in Japan and South Korea. | sofalcone |
| succinic acid | An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. | succinic acid |
| tiquizium bromide | A organic bromide salt of tiquizium. It is an antispasmodic drug used for the treatment of convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis. | tiquizium bromide |
| tridihexethyl | | tridihexethyl |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 21.0257 | 1 | 6 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 16.3600 | 3 | 9 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 7.5624 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.4538 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 19.6740 | 3 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.2191 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 14.6253 | 10 | 33 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 8.0960 | 2 | 13 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.4230 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 3.7746 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 18.3516 | 1 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 5.1233 | 2 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 18.4927 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 13.0474 | 3 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 62.3032 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 1.1883 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 1.1883 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 17.3431 | 2 | 6 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 27.8104 | 1 | 6 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 48.5342 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 18.3844 | 2 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.2637 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 13.1842 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 13.7342 | 2 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 19.4361 | 1 | 5 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 39.4723 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.2637 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 67.0064 | 2 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 18.1981 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 17.2697 | 1 | 7 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 13.4667 | 1 | 10 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 25.2783 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 24.3493 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 13.7648 | 2 | 12 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.8439 | 1 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.6359 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 33.4613 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 31.8326 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 14.1254 | 1 | 1 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.9329 | 9 | 38 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 19.0801 | 2 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 11.1010 | 8 | 25 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.2873 | 2 | 14 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 24.8614 | 4 | 10 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 34.0273 | 2 | 3 |
| G | Vesicular stomatitis virus | Potency | 17.2697 | 1 | 7 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| GALC protein | Homo sapiens (human) | Potency | 0.0708 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 24.3493 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 4.4739 | 2 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 13.8845 | 3 | 6 |
| GLS protein | Homo sapiens (human) | Potency | 6.8460 | 1 | 4 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 7.5624 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 39.6649 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 25.0900 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 34.3761 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 24.8041 | 1 | 4 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 0.4088 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 46.5191 | 2 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 17.2697 | 1 | 7 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 15.8489 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 9.2578 | 2 | 6 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 17.2697 | 1 | 14 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 4.7904 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 19.2019 | 3 | 11 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.7396 | 1 | 12 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 13.8169 | 3 | 7 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 24.0353 | 2 | 4 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 45.5995 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.6625 | 2 | 11 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 3.2440 | 2 | 5 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 24.0353 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 24.0353 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.7079 | 2 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.3566 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 18.2076 | 2 | 15 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 9.5205 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 14.0857 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 9.2961 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.1724 | 3 | 15 |
| Parkin | Homo sapiens (human) | Potency | 2.0596 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 13.9154 | 2 | 6 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 95.2834 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 25.3000 | 3 | 5 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 22.6490 | 3 | 4 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 41.1811 | 2 | 10 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 9.0000 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 29.4107 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 16.2246 | 2 | 7 |
| progesterone receptor | Homo sapiens (human) | Potency | 20.7641 | 2 | 4 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 7.0795 | 2 | 3 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 14.1254 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 12.8769 | 2 | 13 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 2.4889 | 1 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 9.0854 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 11.7723 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 12.9016 | 2 | 5 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 25.2288 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 20.2309 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 20.2309 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 23.9063 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 8.9672 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.8360 | 2 | 13 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 33.7556 | 2 | 8 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 10.6541 | 3 | 9 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 41.5097 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 32.5475 | 2 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 36.0844 | 1 | 7 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 39.6649 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0479 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.6146 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 3.2190 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 1.8200 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | Ki | 155.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.2190 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.8200 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.2190 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.8200 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.7370 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.7930 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 46.1400 | 4 | 5 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 50.0000 | 4 | 4 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 420.2500 | 4 | 12 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 9.6000 | 2 | 4 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 28.4408 | 2 | 3 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0453 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.1715 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 0.6772 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 28.1526 | 2 | 3 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 0.9388 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 1.4295 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 5.3282 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 0.0982 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.1263 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | IC50 | 800.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | IC50 | 250.0000 | 1 | 1 |
| Cyclin-A2 | Homo sapiens (human) | IC50 | 7.3000 | 3 | 3 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 7.3000 | 3 | 3 |
| Cyclin-dependent kinase 9 | Homo sapiens (human) | IC50 | 0.3000 | 3 | 3 |
| Cyclin-T1 | Homo sapiens (human) | IC50 | 0.3000 | 3 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.3367 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 5.3148 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 77.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 507.5000 | 2 | 2 |
| Cytosolic endo-beta-N-acetylglucosaminidase | Homo sapiens (human) | IC50 | 14.4250 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 2.3260 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.7900 | 1 | 1 |
| Delta-aminolevulinic acid dehydratase | Escherichia coli K-12 | Ki | 12,500.0000 | 1 | 1 |
| Egl nine homolog 1 | Homo sapiens (human) | IC50 | 3,362.7667 | 3 | 3 |
| Fatty acid synthase | Homo sapiens (human) | IC50 | 70.3800 | 3 | 5 |
| Fatty acid synthase | Homo sapiens (human) | Ki | 4.2500 | 2 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 1.0200 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.0484 | 8 | 9 |
| Histamine H2 receptor | Rattus norvegicus (Norway rat) | IC50 | 2,500.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.3020 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 0.9161 | 5 | 7 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 3 |
| Histone-lysine N-methyltransferase 2A | Homo sapiens (human) | IC50 | 3.1950 | 1 | 2 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 101.5000 | 1 | 2 |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | IC50 | 10.4000 | 1 | 2 |
| Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Homo sapiens (human) | IC50 | 5.1143 | 1 | 2 |
| Insulin-degrading enzyme | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 710.0000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Ki | 0.0025 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 8.3800 | 5 | 7 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 154.6000 | 3 | 4 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 100.3000 | 1 | 4 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0657 | 2 | 2 |
| Muscarinic acetylcholine receptor DM1 | Drosophila melanogaster (fruit fly) | Ki | 0.4100 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0291 | 14 | 14 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.6134 | 33 | 44 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0566 | 13 | 13 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0524 | 4 | 5 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.6891 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Mus musculus (house mouse) | IC50 | 0.5100 | 3 | 6 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.6281 | 35 | 45 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.3744 | 4 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 4.8286 | 3 | 4 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.9556 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.6222 | 34 | 44 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.2453 | 3 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.1533 | 2 | 3 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.5856 | 4 | 4 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.6227 | 33 | 43 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2163 | 3 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.1462 | 3 | 4 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.3406 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.6227 | 33 | 43 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.2305 | 3 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 2 |
| N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase | Homo sapiens (human) | Ki | 5,000.0000 | 1 | 1 |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Homo sapiens (human) | IC50 | 55.6667 | 2 | 3 |
| NAD(+) hydrolase SARM1 | Homo sapiens (human) | IC50 | 3.2500 | 2 | 2 |
| phosphoethanolamine/phosphocholine phosphatase isoform 1 | Homo sapiens (human) | IC50 | 0.4340 | 1 | 1 |
| Potassium-transporting ATPase alpha chain 1 | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| Potassium-transporting ATPase subunit beta | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| Prolyl 4-hydroxylase | Paramecium bursaria Chlorella virus 1 | IC50 | 1,000.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 0.9950 | 1 | 2 |
| Serine/threonine-protein kinase TBK1 | Homo sapiens (human) | IC50 | 0.8506 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit beta-2 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit beta-3 | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Sodium/potassium-transporting ATPase subunit gamma | Homo sapiens (human) | IC50 | 119.6684 | 1 | 2 |
| Solute carrier family 13 member 3 | Homo sapiens (human) | IC50 | 107.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | IC50 | 0.5900 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 329.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 5.7000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 262.2500 | 3 | 4 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 166.0000 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | IC50 | 2,000.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 20.2000 | 2 | 3 |
| Solute carrier family 22 member 2 | Mus musculus (house mouse) | IC50 | 8.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 373.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 928.5000 | 1 | 2 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 103.7000 | 2 | 2 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 73.8500 | 1 | 2 |
| Solute carrier family 22 member 4 | Rattus norvegicus (Norway rat) | IC50 | 1,500.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 492.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | IC50 | 92.4000 | 1 | 1 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | IC50 | 166.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 176.5000 | 1 | 2 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | Ki | 46.8000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 0.2900 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 0.2900 | 1 | 1 |
| WD repeat-containing protein 5 | Homo sapiens (human) | IC50 | 3.1950 | 1 | 2 |