Page last updated: 2024-11-05

calcium propionate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Calcium propionate is a white, crystalline salt with the formula Ca(C3H5O2)2. It is a food additive used as a mold inhibitor and preservative, particularly in baked goods. It is synthesized by reacting propionic acid with calcium hydroxide. Calcium propionate is generally considered safe for human consumption. Its primary effect is to inhibit the growth of mold and bacteria, thus extending the shelf life of food products. Research on calcium propionate often focuses on its effectiveness as a food preservative, its safety, and potential environmental impacts. It is a commonly studied compound due to its wide use in the food industry.'

Cross-References

ID SourceID
PubMed CID19999
CHEMBL ID3186661
SCHEMBL ID52363
MeSH IDM0094456

Synonyms (47)

Synonym
bioban-c
caswell no. 151
calcium propanoate
calcium propionate
propionic acid, calcium salt
hsdb 907
einecs 223-795-8
propanoic acid, calcium salt
epa pesticide chemical code 077701
calcium dipropanoate
4075-81-4
P0503
propionic acid calcium salt
NCGC00259981-01
cas-4075-81-4
tox21_202432
dtxcid607556
dtxsid1027556 ,
unii-8ai80040kw
ec 223-795-8
propanoic acid, calcium salt (2:1)
calcium propionate [nf]
8ai80040kw ,
FT-0623409
AKOS015903218
calcium propionate [fcc]
ins-282
calcium propionate (e 282)
ins no.282
e-282
calcium propionate [mi]
calcium propionate [inci]
ca-propionate
calcium propionate [hsdb]
calcium propionate [mart.]
calcium propionate [who-dd]
SCHEMBL52363
BCZXFFBUYPCTSJ-UHFFFAOYSA-L
CHEMBL3186661
Q417394
calcium;propanoate
AMY37013
calcium propionate;bioban-c; calcium dipropionate
propanoate (calcium)
calcium propinate
propionic acid calcium 1000 microg/ml in acetonitrile:water
calciumpropionate

Research Excerpts

Effects

ExcerptReferenceRelevance
"Calcium propionate has been widely used as a preservative in bakery and in bread. "( Fast and simple method for semiquantitative determination of calcium propionate in bread samples.
Phechkrajang, CM; Yooyong, S, 2017
)
2.14

Treatment

ExcerptReferenceRelevance
"Each calcium propionate treatment tube supplied 37 g of calcium."( Field trials of an oral calcium propionate paste as an aid to prevent milk fever in periparturient dairy cows.
Borelli, C; Goff, JP; Horst, RL; Jardon, PW; Wedam, J, 1996
)
1.06

Dosage Studied

ExcerptRelevanceReference
" Dosing with 349 g calcium propionate in molasses increased plasma total calcium (Catot) concentration by 10% in lactating and non-lactating cows for periods less than 7 h, and this was not augmented by simultaneous administration of MgO or treatment 24 h earlier with 349 g calcium propionate in molasses."( Effects of oral dosing with calcium propionate on total calcium and glucose concentrations in the plasma of the cow.
Daniel, RC; Jonsson, NN; Mayer, D; Verrall, R, 1998
)
0.92
" amstelodami within the recommended dosage range for application in bakery products."( Antifungal properties of fermentates and their potential to replace sorbate and propionate in pound cake.
Devlieghere, F; Eeckhout, M; Samapundo, S; Vroman, A, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (207 Items)

ItemProcessFrequency
Plant-based foodscore-ingredient1,139
Plant-based foods and beveragescore-ingredient1,138
Cereals and potatoescore-ingredient1,132
Breadscore-ingredient1,118
Special breadscore-ingredient169
Mealscore-ingredient132
Pizzascore-ingredient123
Pizzas pies and quichescore-ingredient122
White breadscore-ingredient121
Wheat breadscore-ingredient74
Mexican Dinner Mixescore-ingredient70
Snackscore-ingredient63
Frozen foodscore-ingredient53
Sweet snackscore-ingredient51
Cheesescore-ingredient50
Fermented milk productscore-ingredient50
Fermented foodscore-ingredient50
Dairiescore-ingredient50
Bagel breadscore-ingredient49
Flatbreadscore-ingredient49
Sliced breadscore-ingredient44
Hamburger bunscore-ingredient43
Biscuits and cakescore-ingredient43
Sandwichescore-ingredient41
Hot dog bunscore-ingredient33
Pitascore-ingredient29
Aliments d'origine végétalecore-ingredient24
Aliments et boissons à base de végétauxcore-ingredient24
Céréales et pommes de terrecore-ingredient23
Painscore-ingredient21
Pastriescore-ingredient20
Cereals and their productscore-ingredient19
Cakescore-ingredient19
Pie doughcore-ingredient17
Wheat flatbreadscore-ingredient16
Groceriescore-ingredient13
English muffinscore-ingredient12
Condimentscore-ingredient12
Pains spéciauxcore-ingredient11
Wrapscore-ingredient11
Cooking helperscore-ingredient9
Stuffingcore-ingredient9
Saucescore-ingredient9
Meats and their productscore-ingredient9
Wholemeal breadscore-ingredient9
Appetizerscore-ingredient8
Salty snackscore-ingredient8
Meatscore-ingredient8
Viennoiseriescore-ingredient8
Dipscore-ingredient6
Pains Bagelcore-ingredient6
Pastry helperscore-ingredient5
Pains platscore-ingredient5
Croissantscore-ingredient5
Sweet pastries and piescore-ingredient5
Frozen meatscore-ingredient5
Filled croissantscore-ingredient5
Whole wheat breadcore-ingredient4
Breadcore-ingredient4
Garlic breadscore-ingredient4
Tortillacore-ingredient4
Piescore-ingredient3
Sweet piescore-ingredient3
Tortillas de blécore-ingredient3
Pains de blécore-ingredient3
Pains blancscore-ingredient3
Rye breadscore-ingredient3
Naanscore-ingredient3
Wholemeal sliced breadscore-ingredient3
Corn chipscore-ingredient3
Crispscore-ingredient3
Chips and friescore-ingredient3
en:breadscore-ingredient3
Bunscore-ingredient3
Apple piescore-ingredient2
Canned foodscore-ingredient2
Seafoodcore-ingredient2
Frozen breadscore-ingredient2
Pains Burgercore-ingredient2
Sausagescore-ingredient2
Prepared meatscore-ingredient2
Meal kitscore-ingredient2
Garlic baguettescore-ingredient2
Pains Pitacore-ingredient2
Bran sliced breadscore-ingredient2
Pains de miecore-ingredient2
Sausage rollscore-ingredient2
Stuffed olivescore-ingredient2
Olivescore-ingredient2
Plant-based picklescore-ingredient2
Olive tree productscore-ingredient2
Picklescore-ingredient2
Multigrain sliced breadscore-ingredient2
tortillascore-ingredient2
Vegetarian wrapscore-ingredient2
Gluten-free breadscore-ingredient2
Sourdough breadcore-ingredient2
Croissant filled with creamcore-ingredient2
Whole wheatcore-ingredient1
Pizza Crustcore-ingredient1
Cake mixescore-ingredient1
Dessert mixescore-ingredient1
Baking Mixescore-ingredient1
Sandwich loafcore-ingredient1
Frozen seafoodcore-ingredient1
White Pittacore-ingredient1
en:hot-dog-bunscore-ingredient1
Doughnutscore-ingredient1
Empanizadorcore-ingredient1
Bread crumbscore-ingredient1
Cheddar cheesecore-ingredient1
Cheeses from Englandcore-ingredient1
Cheeses from the United Kingdomcore-ingredient1
Cow cheesescore-ingredient1
Margherita Pizzacore-ingredient1
Vegetarian pizzascore-ingredient1
Cinnamon Raisin English Muffinscore-ingredient1
Smoked sausagescore-ingredient1
en:Tortillascore-ingredient1
Cheddar baguettescore-ingredient1
Farinescore-ingredient1
Pains à l'ailcore-ingredient1
Amuse-gueulescore-ingredient1
saléscore-ingredient1
No synthetic colourscore-ingredient1
No artificial flavourscore-ingredient1
Low saltcore-ingredient1
Bread white from wheat flour of the highest grade GOST 26987-86core-ingredient1
210core-ingredient1
Muffins anglais au blé entiercore-ingredient1
Whole grain English muffinscore-ingredient1
en:special-breadscore-ingredient1
Whole-wheat English muffinscore-ingredient1
Salted snackscore-ingredient1
Canned meatscore-ingredient1
Kaiser bunscore-ingredient1
Mexican-dinner-mixescore-ingredient1
Dutch apple piescore-ingredient1
Pepperoni pizzascore-ingredient1
pancore-ingredient1
Fatscore-ingredient1
Salad dressingscore-ingredient1
Teff Wrapscore-ingredient1
Gluten-free-wrapscore-ingredient1
Chocolate cakescore-ingredient1
Flat beanscore-ingredient1
Vegetables based foodscore-ingredient1
Legumescore-ingredient1
Fruits and vegetables based foodscore-ingredient1
Legumes and their productscore-ingredient1
Corned-beefcore-ingredient1
Beef dishescore-ingredient1
Meals with meatcore-ingredient1
White pita breadcore-ingredient1
Whole Wheat Naancore-ingredient1
Pumpkin piescore-ingredient1
sliced breadcore-ingredient1
Biscuitscore-ingredient1
Cinnamon stickscore-ingredient1
Cinnamoncore-ingredient1
Spicescore-ingredient1
en:flatbreadscore-ingredient1
Flour tortillascore-ingredient1
Pains de seigle et de blécore-ingredient1
Miffinscore-ingredient1
Blueberry muffinscore-ingredient1
Fruit muffinscore-ingredient1
Muffinscore-ingredient1
Pizza saucescore-ingredient1
Multigrain Breadcore-ingredient1
Multi-Seed Breedcore-ingredient1
Frozen dessertscore-ingredient1
Dessertscore-ingredient1
Wraps/Tortillascore-ingredient1
Bagelcore-ingredient1
Bagelscore-ingredient1
Tandoori Baked Naan breadcore-ingredient1
Pastascore-ingredient1
Wraps with beefcore-ingredient1
Beef wrapcore-ingredient1
Baguettescore-ingredient1
Pains Hot Dogcore-ingredient1
Omelettes espagnoles sans oeufcore-ingredient1
Omelettes de pommes de terrecore-ingredient1
Plats préparéscore-ingredient1
en:muffinscore-ingredient1
en:wheat-flatbreadscore-ingredient1
en:white-breadscore-ingredient1
Whole Wheat breadscore-ingredient1
Fish sandwichescore-ingredient1
Enriched white breadscore-ingredient1
Products without glutencore-ingredient1
Products for specific dietscore-ingredient1
Specific productscore-ingredient1
Naan breadcore-ingredient1
Chicken wrapscore-ingredient1
Chocolate croissant prepackedcore-ingredient1
Chocolate croissantcore-ingredient1
Wholemeal-wrapscore-ingredient1
Baguette made with type T55-T110 flourcore-ingredient1
Cream puffcore-ingredient1
Chocolate sandwich cookiescore-ingredient1
Biscuitcore-ingredient1
Breads with corncore-ingredient1
Wheatscore-ingredient1
Cereal grainscore-ingredient1
Seedscore-ingredient1

Drug Classes (1)

ClassDescription
dicarboxylic acidAny carboxylic acid containing two carboxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency58.81200.003041.611522,387.1992AID1159552; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency61.37930.001530.607315,848.9004AID1224841
estrogen nuclear receptor alphaHomo sapiens (human)Potency0.19580.000229.305416,493.5996AID743075
thyroid stimulating hormone receptorHomo sapiens (human)Potency1.37410.001628.015177.1139AID1259385
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency30.76250.000323.4451159.6830AID743066
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (64)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (3.13)18.7374
1990's8 (12.50)18.2507
2000's20 (31.25)29.6817
2010's28 (43.75)24.3611
2020's6 (9.38)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 74.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index74.55 (24.57)
Research Supply Index4.37 (2.92)
Research Growth Index5.16 (4.65)
Search Engine Demand Index127.76 (26.88)
Search Engine Supply Index2.03 (0.95)

This Compound (74.55)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials11 (16.42%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other56 (83.58%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]