Sulfhemoglobinemia

A morbid condition due to the presence of sulfmethemoglobin in the blood. It is marked by persistent cyanosis, but the blood count does not reveal any special abnormality in the blood. It is thought to be caused by the action of hydrogen sulfide absorbed from the intestine. (Stedman, 25th ed)

Synonym
Sulfhemoglobinemia

Excerpt	Reference
"Sulfhemoglobinemia is suspected when a cyanotic patient has normal to near-normal oxygen tension, laboratory reports of elevated methemoglobin, and does not respond to methylene blue therapy."	( Bharadwaj, P; Bowie, VL; Gopalachar, AS, 2005)
"Sulfhemoglobinemia is a rare dyshemoglobinemia that presents similarly to methemoglobinemia."	( Brown, W; Checinski, P; Morales, A; Walsh, R; Williams, SR, 2021)
"Sulfhemoglobinemia is an incurable disease caused by an overdose of sulfur-containing drugs with oxidizing properties."	( Czajkowski, A; Dybas, J; Górecki, A; Marzec, KM; Rutkowska, W; Stepanenko, T; Zając, G, 2023)
"Sulfhemoglobinemia is mainly associated with drugs or intestinal bacterial overgrowth."	( Aguirre, H; Benavente, R; Meneses, R; Parada, N; Peña, C; Pineda, C; Sánchez, B; Torres, S, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	43 (65.15)	23.3326
1990's	9 (13.64)	12.5806
2000's	8 (12.12)	18.1394
2010's	3 (4.55)	28.8240
2020's	3 (4.55)	9.53

Drug	Relationship Strength	Studies
quinacrine	low	1
carbon monoxide	low	2
hydrogen sulfide	low	5
dimethyl sulfoxide	low	1
nitrites	low	1
thiosulfates	low	3
sulfuric acid	low	1
sulfur dioxide	low	1
toluene	low	1
urea	low	1
acetaminophen	low	2
benzocaine	low	1
cimetidine	low	1
dapsone	low	2
flutamide	low	1
ibuprofen	low	1
metoclopramide	low	3
phenacetin	low	12
phenazopyridine	low	5
sulfanilamide	low	1
sulfisoxazole	low	1
sumatriptan	low	1
tiopronin	low	1
urethane	low	1
zopiclone	low	2
methylene blue	low	6
aniline	low	1
colchicine	low	1
nitrobenzene	low	1
4-chloroaniline	low	1
trinitrotoluene	low	1
framycetin	low	3
acetylcysteine	low	1
sodium sulfate	low	1
copper sulfate	low	2
sodium thiosulfate	low	1
methotrexate	low	1
naproxen	low	1
morphine	low	1
ergothioneine	low	1
sulfur	low	8
thiocolchicoside	low	1
calcium sulfide	low	1
ascorbic acid	low	2
nitrophenols	low	1

Protein Targets (661)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	10	0	0	10
AR protein	17	0	0	17
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
estrogen-related nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	20	0	0	20
G	6	0	0	6
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
aryl hydrocarbon receptor	8	0	0	8
activating transcription factor 6	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
thyroid hormone receptor beta isoform 2	12	0	0	12
histone deacetylase 9 isoform 3	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Cellular tumor antigen p53	11	0	0	11
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Histone acetyltransferase KAT8	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
ATAD5 protein, partial	7	0	0	7
GLS protein	5	0	0	5
Microtubule-associated protein tau	7	0	0	7
Smad3	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
thyroid stimulating hormone receptor	10	0	0	10
EWS/FLI fusion protein	6	0	0	6
retinoid X nuclear receptor alpha	13	0	0	13
chromobox protein homolog 1	11	0	0	11
peripheral myelin protein 22	8	0	0	8
cytochrome P450 3A4 isoform 1	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	8	1	0	9
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Solute carrier family 22 member 6	0	7	0	7
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	19	0	19
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	7	0	8
Carbonic anhydrase 2	0	7	2	10
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	3
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	4	1	5
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2C9	0	6	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	8	1	0	9
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	0	9
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	0	9
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	6	0	6
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	0	9
Carbonic anhydrase 5A, mitochondrial	0	6	0	7
Prostaglandin G/H synthase 2	0	2	0	3
Carbonic anhydrase 7	0	4	0	4
Nuclear receptor ROR-gamma	4	0	0	4
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-2	8	1	0	9
Carbonic anhydrase 9	0	5	0	5
GABA theta subunit	8	1	0	9
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 15	0	3	0	3
Carbonic anhydrase 13	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	8	1	0	9
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	4	0	5
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	4	0	0	4
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	4	0	0	4
USP1 protein, partial	8	0	0	8
NFKB1 protein, partial	2	0	0	2
Thrombopoietin	2	0	0	2
regulator of G-protein signaling 4	2	0	0	2
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
Bloom syndrome protein isoform 1	3	0	0	3
D(1A) dopamine receptor	4	0	0	4
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	2	0	0	2
flap endonuclease 1	6	0	0	6
geminin	14	0	0	14
survival motor neuron protein isoform d	5	0	0	5
muscarinic acetylcholine receptor M1	6	0	0	6
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	8	0	0	8
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Steroid C26-monooxygenase	0	0	1	1
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	9	0	0	9
thioredoxin glutathione reductase	2	0	0	2
IDH1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	4	0	0	4
lamin isoform A-delta10	16	0	0	16
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	3
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	4	0	0	4
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
glp-1 receptor, partial	2	0	0	2
peroxisome proliferator-activated receptor delta	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	3	0	0	3
TAR DNA-binding protein 43	4	0	0	4
ATPase family AAA domain-containing protein 5	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
interleukin 8	5	0	0	5
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
DNA polymerase kappa isoform 1	4	0	0	4
M-phase phosphoprotein 8	4	0	0	4
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	4	0	5
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	3	1	5
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Histamine H2 receptor	0	4	0	4
Histamine H1 receptor	0	0	1	1
Histamine H2 receptor	5	2	1	8
Potassium-transporting ATPase subunit beta	0	1	0	1
Aldehyde oxidase	0	2	0	2
Solute carrier family 22 member 6	0	4	0	5
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Solute carrier family 22 member 8	0	3	0	5
Multidrug and toxin extrusion protein 1	0	4	0	4
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Chain A, Beta-lactamase	4	0	0	4
Chain A, Ferritin light chain	5	0	0	5
Luciferase	5	0	0	5
endonuclease IV	2	0	0	2
PAX8	0	0	0	1
thioredoxin reductase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Fumarate hydratase	4	0	0	4
PPM1D protein	2	0	0	2
TDP1 protein	10	0	0	10
polyprotein	4	0	0	4
67.9K protein	8	0	0	8
glucocerebrosidase	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C9 precursor	5	0	0	5
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	7	0	0	7
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
Myeloperoxidase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
5-hydroxytryptamine receptor 6	0	3	0	3
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
nonstructural protein 1	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
huntingtin isoform 2	2	0	0	2
mitogen-activated protein kinase 1	4	0	0	4
DNA polymerase iota isoform a (long)	5	0	0	5
Cocaine esterase	0	1	0	2
Androgen receptor	0	2	0	2
Androgen receptor	0	2	0	2
Arylacetamide deacetylase	0	0	0	2
Alpha-synuclein	2	0	0	2
Arylacetamide deacetylase	0	0	0	2
Arylacetamide deacetylase	0	0	0	2
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Cruzipain	1	0	0	1
Albumin	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	1	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	5	0	5
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	0	2	2
Cholinesterase	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	5
UDP-glucuronosyltransferase 2B7	0	1	0	2
Acetylcholinesterase	0	5	0	5
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	2	0	2
Caspase-1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	2	0	2
Caspase-3	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Mu-type opioid receptor	0	4	0	4
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	4
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Histone H2A.x	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	4	0	5
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	1	9
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
caspase-3	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	5
Glycoprotein hormones alpha chain	1	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	1	3
Cruzipain	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Inositol monophosphatase 1	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
5-hydroxytryptamine receptor 3E	0	1	1	2
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Alpha-2A adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	3	0	3
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	1	4
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 1D	0	2	1	3
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 3A	0	3	0	3
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3D	0	1	1	2
5-hydroxytryptamine receptor 3C	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	3	0	3
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Cytochrome P450 1A2	0	0	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
hemoglobin subunit beta	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Replicase polyprotein 1ab	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
N	0	1	0	1
NPYLR7B	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	0	1	1
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Trypanothione reductase	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Protein argonaute-2	0	0	1	1
Endothelin-1 receptor	0	2	0	2
Endothelin-1 receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	1	3
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	1	4
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	0	1	1
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Endolysin	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (66)

Protein Targets (661)

Sulfhemoglobinemia

Synonyms(1)

Research Excerpts

Overview

Research

Studies (66)

Drugs Studied (55)

Protein Targets (661)