A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
| Member | Definition | Class |
|---|
| (R)-fluoxetine | An N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine that has R configuration. [The antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine]. | (R)-fluoxetine |
| (R)-fluoxetine hydrochloride | A hydrochloride obtained by reaction of (R)-fluoxetine with one equivalent of hydrochloric acid. | (R)-fluoxetine hydrochloride |
| (S)-fluoxetine hydrochloride | A hydrochloride obtained by reaction of (S)-fluoxetine with one equivalent of hydrochloric acid. | (S)-fluoxetine hydrochloride |
| amoxapine | A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position. | amoxapine |
| chlorpheniramine | A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. | chlorphenamine |
| clomipramine | A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias. | clomipramine |
| cocaine | A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. | cocaine |
| desipramine | A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. | desipramine |
| dexfenfluramine | The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects. | (S)-fenfluramine |
| dexfenfluramine hydrochloride | The hydrochloride salt of (S)-fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike the racemate it does not possess catecholamine agonist activity. It was formerly given by mouth in the treatment of obesity, but, like the racemate, was withdrawn wolrdwide following reports of valvular heart defects. | (S)-fenfluramine hydrochloride |
| fenfluramine | A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. | fenfluramine |
| fluoxetine | An N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine that has S configuration. [The antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine]. | (S)-fluoxetine |
| fluvoxamine | An oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder. | fluvoxamine |
| ly 367265 | A fluoroindole that is 1H-indole in which the hydrogens at positions 3 and 6 are replaced by 1-[2-(2,2-dioxo-5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinolin-1(2H)-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl and fluoro groups, respectively. It is an inhibitor of the 5-hydroxytryptamine transporter (Ki = 2.3 nM) and an antagonist of 5-hydroxytryptamine(2A) receptor (Ki = 0.81 nM). | LY-367,265 |
| minaprine | | minaprine |
| nefazodone | | nefazodone |
| noribogaine | An organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a hydroxy group. It is the primary (and long-lived) metabolite of ibogaine, the psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe iboga. | noribogaine |
| olanzapine | A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4. | olanzapine |
| paroxetine | A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. | paroxetine |
| paroxetine hydrochloride | The hydrochloride salt of paroxetine. It is an antidepressant drug. | paroxetine hydrochloride |
| paroxetine maleate | A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. | paroxetine maleate |
| sertraline | A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder. | sertraline |
| sertraline hydrochloride | A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder. | sertraline hydrochloride |
| sibutramine | | sibutramine |
| tramadol | A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol |
| tramadol hydrochloride | A hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol hydrochloride |
| trazodone | An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group. | trazodone |
| trazodone hydrochloride | A hydrochloride salt prepared from equimolar amounts of trazodone and hydrogen chloride. | trazodone hydrochloride |
| venlafaxine | A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group. | venlafaxine |
| vilazodone | A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder. | vilazodone |
| vilazodone hydrochloride | A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder. | vilazodone hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 26.1096 | 1 | 4 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 20.0203 | 1 | 3 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 0.0478 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 10.7893 | 2 | 9 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 15.9807 | 2 | 7 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.9883 | 1 | 6 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 31.4658 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 28.2946 | 9 | 31 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.4915 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 3.7189 | 1 | 7 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 19.9204 | 3 | 10 |
| Ataxin-2 | Homo sapiens (human) | Potency | 21.1992 | 2 | 11 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 12.9422 | 2 | 10 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 30.0474 | 1 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 6.6180 | 1 | 3 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 16.1722 | 1 | 8 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0005 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.3404 | 1 | 3 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 23.4124 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 23.4124 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.8233 | 2 | 10 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 19.1041 | 2 | 16 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 21.6303 | 1 | 7 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 18.2951 | 2 | 5 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 26.3783 | 2 | 6 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 26.0533 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 30.0377 | 1 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 5.3828 | 2 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 13.6724 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 26.0533 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 58.1018 | 2 | 16 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.9624 | 1 | 6 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 11.7450 | 1 | 7 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.1021 | 1 | 12 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 6.4208 | 1 | 15 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.6793 | 2 | 32 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.6655 | 2 | 10 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 26.3359 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.8980 | 3 | 16 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 23.7428 | 1 | 6 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 19.9526 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 19.6222 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.7181 | 8 | 27 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 26.0806 | 2 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.5152 | 10 | 30 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 26.6480 | 1 | 18 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 17.6839 | 4 | 15 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 31.7670 | 3 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 10.9041 | 2 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 34.6004 | 1 | 7 |
| G | Vesicular stomatitis virus | Potency | 11.7450 | 1 | 7 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.6793 | 1 | 16 |
| geminin | Homo sapiens (human) | Potency | 10.5365 | 4 | 25 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.8406 | 2 | 14 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.6280 | 2 | 10 |
| GLS protein | Homo sapiens (human) | Potency | 12.0841 | 2 | 6 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 17.7082 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.1770 | 2 | 10 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 19.6442 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 1.8356 | 1 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 46.4515 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 36.1430 | 2 | 5 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 16.8524 | 2 | 30 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 14.2566 | 1 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 59.6865 | 2 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 47.2456 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 11.7450 | 1 | 7 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 24.8363 | 2 | 5 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 15.2172 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 14.1622 | 1 | 8 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 27.7013 | 2 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 11.7450 | 1 | 14 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 8.7077 | 2 | 7 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 23.9060 | 1 | 6 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 23.9060 | 1 | 6 |
| Interferon beta | Homo sapiens (human) | Potency | 19.7064 | 3 | 18 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 14.6171 | 1 | 11 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 21.6729 | 1 | 5 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 36.3984 | 1 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.5710 | 2 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.8185 | 2 | 11 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 8.3448 | 2 | 17 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 9.1745 | 2 | 10 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.3842 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 33.6854 | 2 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 19.4365 | 1 | 5 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.5267 | 2 | 6 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.7164 | 3 | 11 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 66.8968 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.9875 | 1 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 41.0252 | 1 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 25.1592 | 2 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.2102 | 3 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 25.1189 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.7604 | 1 | 6 |
| polyprotein | Zika virus | Potency | 34.6004 | 1 | 7 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 14.7858 | 1 | 12 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 9.0652 | 1 | 12 |
| PPM1D protein | Homo sapiens (human) | Potency | 23.6401 | 1 | 6 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 14.2171 | 2 | 7 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.8565 | 2 | 10 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.1240 | 2 | 7 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 23.9364 | 1 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.9421 | 3 | 12 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 22.4007 | 2 | 4 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 22.4624 | 4 | 17 |
| Smad3 | Homo sapiens (human) | Potency | 29.5872 | 1 | 8 |
| snurportin-1 | Homo sapiens (human) | Potency | 27.7013 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 27.1496 | 2 | 7 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 18.2709 | 1 | 7 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 23.8770 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.8018 | 2 | 39 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 89.1251 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 35.4597 | 2 | 14 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5387 | 2 | 16 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 20.3893 | 2 | 15 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 12.5595 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.2053 | 6 | 15 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 19.9526 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.7604 | 1 | 6 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.7604 | 1 | 6 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 46.5283 | 1 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 16.9596 | 2 | 13 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 23.0371 | 3 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 76.1230 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 19.6442 | 1 | 2 |
| Vpr | Human immunodeficiency virus 1 | Potency | 31.6228 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 1 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.0002 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.8139 | 3 | 5 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 1.6839 | 13 | 13 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 1.1713 | 6 | 7 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.8138 | 3 | 5 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.8558 | 3 | 4 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 1.4517 | 2 | 3 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 2.6505 | 2 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.1775 | 1 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 2.6505 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.3983 | 4 | 8 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.2646 | 6 | 8 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0330 | 25 | 32 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0432 | 8 | 8 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.7613 | 1 | 5 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.1146 | 4 | 5 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.4047 | 2 | 6 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.1073 | 3 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.2466 | 1 | 5 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.4288 | 5 | 6 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0546 | 9 | 13 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.1073 | 3 | 3 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 1.5517 | 2 | 3 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 1.5517 | 2 | 3 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.2343 | 2 | 6 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.1291 | 1 | 5 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 0.2023 | 2 | 3 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 0.1775 | 1 | 2 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 0.1775 | 1 | 2 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.1113 | 1 | 3 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 1.1183 | 2 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0211 | 18 | 21 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 38.0500 | 1 | 4 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.8726 | 6 | 6 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 1.1183 | 2 | 3 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 600.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 43.0185 | 2 | 2 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 21.3000 | 1 | 1 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 21.3000 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.0850 | 1 | 1 |
| Advanced glycosylation end product-specific receptor | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.5880 | 1 | 6 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | Ki | 0.0004 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.5749 | 1 | 6 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 1.9800 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0938 | 2 | 3 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0291 | 5 | 6 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.8207 | 4 | 4 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 1.9800 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1422 | 2 | 2 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0251 | 4 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.4704 | 5 | 5 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.5646 | 2 | 5 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2810 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0642 | 5 | 8 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.8207 | 4 | 4 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.3084 | 3 | 8 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.2797 | 4 | 8 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6055 | 3 | 4 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.1156 | 3 | 9 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.2769 | 3 | 8 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6055 | 3 | 4 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 2.1922 | 3 | 8 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2659 | 4 | 8 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6055 | 3 | 4 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 36.6491 | 1 | 4 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 12.7251 | 1 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 10 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 22.1000 | 2 | 3 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0270 | 1 | 1 |
| Beta-adrenergic receptor kinase 1 | Bos taurus (cattle) | IC50 | 1.1533 | 3 | 3 |
| Beta-adrenergic receptor kinase 1 | Homo sapiens (human) | IC50 | 4.5600 | 6 | 6 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 127.6118 | 6 | 28 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 17.4000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| Chloroquine resistance transporter | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 54.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Rattus norvegicus (Norway rat) | Ki | 57.4000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.6550 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 26.1667 | 2 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 8.5000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 3.2694 | 3 | 5 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 8.6750 | 3 | 4 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 34.2500 | 1 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 11.0500 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.6024 | 2 | 5 |
| D | Rattus norvegicus (Norway rat) | IC50 | 1.3769 | 2 | 5 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.0711 | 7 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.5257 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.1500 | 6 | 8 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2825 | 1 | 4 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 1.3040 | 2 | 4 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3017 | 3 | 7 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0615 | 23 | 27 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0744 | 10 | 15 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 1.0235 | 1 | 4 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2402 | 2 | 5 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.1357 | 10 | 13 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.1730 | 1 | 1 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9060 | 2 | 5 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.0310 | 7 | 7 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | IC50 | 0.3670 | 1 | 1 |
| G protein-coupled receptor kinase 5 | Bos taurus (cattle) | IC50 | 150.7250 | 4 | 4 |
| G protein-coupled receptor kinase 5 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 497.2000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.1248 | 2 | 5 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 4 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0126 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0076 | 9 | 13 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 2.2600 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 2.0490 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 2.0150 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 5.0120 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 3 | Homo sapiens (human) | IC50 | 42.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| MBT domain-containing protein 1 | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | IC50 | 4.5980 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | Ki | 4.3132 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0003 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 126.8000 | 1 | 10 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.6790 | 1 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.9663 | 6 | 9 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 61.3985 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.5409 | 1 | 4 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.4436 | 2 | 5 |
| Muscarinic acetylcholine receptor M2 | Sus scrofa (pig) | Ki | 0.2344 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.6305 | 1 | 4 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.1122 | 2 | 5 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.9716 | 1 | 5 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1024 | 3 | 7 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.3159 | 1 | 5 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.1936 | 2 | 6 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 36.6491 | 1 | 4 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 12.7251 | 1 | 3 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 2.8067 | 3 | 3 |
| P2X purinoceptor 4 | Rattus norvegicus (Norway rat) | IC50 | 2.4500 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.7680 | 1 | 1 |
| Potassium voltage-gated channel subfamily A member 3 | Homo sapiens (human) | IC50 | 31.9000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 8.7943 | 15 | 33 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 22.0350 | 3 | 5 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 0.1600 | 1 | 1 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 160.0000 | 2 | 2 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Quinolone resistance protein NorA | Staphylococcus aureus | IC50 | 7.0000 | 1 | 1 |
| Rhodopsin kinase GRK1 | Bos taurus (cattle) | IC50 | 243.1750 | 4 | 4 |
| Rhodopsin kinase GRK1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | Ki | 6.8680 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.6595 | 2 | 7 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 1.6153 | 3 | 8 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0430 | 2 | 3 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 20.4600 | 2 | 2 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1.3662 | 51 | 80 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | Ki | 0.6550 | 2 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 24.4063 | 26 | 43 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 5.2786 | 48 | 53 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.6372 | 36 | 48 |
| Sodium-dependent noradrenaline transporter | Mus musculus (house mouse) | Ki | 0.0200 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.9849 | 45 | 57 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.0957 | 48 | 59 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.3194 | 44 | 54 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 1.2240 | 25 | 31 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.4860 | 51 | 63 |
| Sodium-dependent serotonin transporter | Mus musculus (house mouse) | Ki | 0.0004 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.4337 | 22 | 35 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 15.7500 | 2 | 2 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 2.8000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 43.5100 | 3 | 4 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 5.3600 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 18.0000 | 2 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Solute carrier family 22 member 3 | Rattus norvegicus (Norway rat) | IC50 | 68.0000 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Solute carrier family 22 member 4 | Rattus norvegicus (Norway rat) | IC50 | 80.0000 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Sulfotransferase 1A1 | Homo sapiens (human) | Ki | 80.0000 | 1 | 2 |
| Sulfotransferase 2A1 | Homo sapiens (human) | Ki | 80.0000 | 1 | 2 |
| Transcriptional activator protein LuxR | Aliivibrio fischeri | IC50 | 27.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 3.0425 | 19 | 24 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 1.8767 | 19 | 25 |
| Trypanothione reductase | Trypanosoma brucei brucei | IC50 | 3.4000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | IC50 | 13.7500 | 2 | 2 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 6.6250 | 4 | 4 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | Ki | 0.1640 | 2 | 3 |
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | IC50 | 20.0000 | 1 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 15.6667 | 1 | 3 |