idb 1016 profile

ID Source	ID
PubMed CID	6450536
SCHEMBL ID	1649845
MeSH ID	M0185662

Synonym
silipide
idb-106
4h-1-benzopyran-4-one, 2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-, (2r-(2alpha,3beta,6(2r,3r)))-, mixt. with soya phosphatidylcholines
idb 1016
134499-06-2
SCHEMBL1649845
[1-[(4e,9e,12e)-hexadeca-4,9,12-trienoyl]oxy-3-[(6e,10e,12e)-hexadeca-6,10,12-trienoyl]oxypropan-2-yl] 2-(trimethylazaniumyl)ethyl phosphate;(2r,3r)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-

Research Excerpts

Overview

IdB 1016 is a new silybin-phospholipid complex which is more bioavailable than the flavonoid sily bin itself. It displays free radical scavenging and antioxidant properties in liver microsomes.

Excerpt	Reference	Relevance
"IdB 1016 is a new silybin-phospholipid complex which is more bioavailable than the flavonoid silybin itself and displays free radical scavenging and antioxidant properties in liver microsomes. "	( Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016. Albano, E; Carini, R; Comoglio, A; Poli, G, 1992)	1.93
"IdB 1016 is a complex of silybin (the main active component of silymarin) and phosphatidylcholine, which in animal models shows greater oral bioavailability and therefore greater pharmacological activity compared with pure silybin and silymarin. "	( Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. Barzaghi, N; Crema, F; Gatti, G; Perucca, E; Pifferi, G, )	1.87

Treatment

Excerpt	Reference	Relevance
"Treatment with IdB 1016 is associated with reduced body iron stores, especially among patients with advanced fibrosis stage."	( Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C. Bares, JM; Berger, J; Kowdley, KV; Messner, DJ; Nelson, JE; Schildt, S; Standish, LJ, 2008)	0.7

Pharmacokinetics

Excerpt	Reference	Relevance
" In order to assess its pharmacokinetic profile in man, plasma silybin levels were determined after administration of single oral doses of IdB 1016 and silymarin (equivalent to 360 mg silybin) to 9 healthy volunteers."	( Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. Barzaghi, N; Crema, F; Gatti, G; Perucca, E; Pifferi, G, )	0.63
"To develop a new HPLC-UV method of determining silybin in human plasma and to study the pharmacokinetic of silybin-phosphatidylcholine complex (silybinin capsules) in healthy male Chinese volunteers using the new developed method."	( Development of a HPLC-UV assay for silybin-phosphatidylcholine complex (silybinin capsules) and its pharmacokinetic study in healthy male Chinese volunteers. Gao, J; Li, W; Liu, CX; Zhao, HZ, )	0.13

Bioavailability

IdB 1016 is a complex of silybin and phosphatidylcholine. In animal models shows greater oral bioavailability and therefore greater pharmacological activity.

Excerpt	Reference	Relevance
" These data indicate that the bioavailability of silybin is much greater after administration of silipide than after administration of silymarin."	( Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. Gatti, G; Perucca, E; Schandalik, R, 1992)	0.28
" Our results indicate a superior bioavailability of silybin administered orally as IdB 1016."	( Comparative bioavailability of Silipide, a new flavanolignan complex, in rats. Giachetti, C; Magistretti, MJ; Morazzoni, P; Zanolo, G, )	0.36
"IdB 1016 is a complex of silybin (the main active component of silymarin) and phosphatidylcholine, which in animal models shows greater oral bioavailability and therefore greater pharmacological activity compared with pure silybin and silymarin."	( Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. Barzaghi, N; Crema, F; Gatti, G; Perucca, E; Pifferi, G, )	1.87
" However, such an effect is lost when pure silybin in amounts comparable to those present in Silipide is administered instead, due to the low bioavailability of uncomplexed flavonoid."	( Scavenging effect of silipide, a new silybin-phospholipid complex, on ethanol-derived free radicals. Albano, E; Comoglio, A; Malandrino, S; Poli, G; Tomasi, A, 1995)	0.29
" The relative bioavailability of silipide (calculated in the target organ as the ratio between AUCs of cumulative biliary excretion curves) was 10-fold higher than that of silymarin."	( Comparative pharmacokinetics of silipide and silymarin in rats. Malandrino, S; Montalbetti, A; Morazzoni, P; Pifferi, G, )	0.13
" We also aimed to establish the plasma and tumour bioavailability of silybin after repeated administration of IdB 1016."	( Antitumour activity of the silybin-phosphatidylcholine complex, IdB 1016, against human ovarian cancer. Apollonio, P; Bombardelli, E; Ferlini, C; Gallo, D; Giacomelli, S; Morazzoni, P; Prislei, S; Raspaglio, G; Riva, A; Scambia, G, 2003)	0.77
"The aim of the present study was to evaluate the hepatoprotective and the antifibrotic properties of a new silybin-phosphatidylcholine-Vitamin E complex, characterised by elevated oral bioavailability and lipophilicity, on rat hepatic fibrosis induced by dimethylnitrosamine administration and by bile duct ligation."	( Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats. Bendia, E; Benedetti, A; Candelaresi, C; De Minicis, S; Di Sario, A; Marzioni, M; Omenetti, A; Taffetani, S, 2005)	0.33
" The potential for enhanced bioavailability of a phytosome complex containing phosphatidylcholine and silybin, the primary active flavonolignan in silymarin extract, was tested in dogs."	( Bioavailability of a silybin-phosphatidylcholine complex in dogs. Filburn, CR; Griffin, DW; Kettenacker, R, 2007)	0.34

Dosage Studied

Excerpt	Relevance	Reference
"4 hours after dosing and declined thereafter with a half-life of about 2 hours."	( Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. Gatti, G; Perucca, E, 1994)	0.29
" A group of eight beagles (four males, four females) were dosed orally with a silybin-phosphatidylcholine complex (SPC) and a commercially available standardized silymarin extract containing equivalent levels of silybin."	( Bioavailability of a silybin-phosphatidylcholine complex in dogs. Filburn, CR; Griffin, DW; Kettenacker, R, 2007)	0.34

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	9 (47.37)	18.2507
2000's	9 (47.37)	29.6817
2010's	1 (5.26)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (25.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (75.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
1-propanol 1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.	2.89	1	0	propan-1-ols; short-chain primary fatty alcohol	metabolite; protic solvent
acetaminophen Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	2.89	1	0	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	2.89	1	0	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
bromotrichloromethane Bromotrichloromethane: A potent liver poison. In rats, bromotrichloromethane produces about three times the degree of liver microsomal lipid peroxidation as does carbon tetrachloride.	2.89	1	0
cumene hydroperoxide cumene hydroperoxide: RN given refers to parent cpd. cumene hydroperoxide : A peroxol that is cumene in which the alpha-hydrogen is replaced by a hydroperoxy group.	4.06	3	0	peroxol	environmental contaminant; Mycoplasma genitalium metabolite; oxidising agent
allyl alcohol allyl alcohol: structure. allylic alcohol : An alcohol where the hydroxy group is attached to a saturated carbon atom adjacent to a double bond (R groups may be H, organyl, etc.).. allyl alcohol : A propenol in which the C=C bond connects C-2 and C-3. It is has been found in garlic (Allium sativum). Formerly used as a herbicide for the control of various grass and weed seeds.	2.89	1	0	primary allylic alcohol; propenol	antibacterial agent; fungicide; herbicide; insecticide; plant metabolite
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	5.76	3	1	dialdehyde	biomarker
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	2.02	1	0	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
praseodymium Praseodymium: An element of the rare earth family of metals. It has the atomic symbol Pr, atomic number 59, and atomic weight 140.91.	2.89	1	0	f-block element atom; lanthanoid atom
galactosamine 2-amino-2-deoxy-D-galactopyranose : The pyranose form of D-galactosamine.. D-galactosamine : The D-stereoisomer of galactosamine.	2.89	1	0	D-galactosamine; primary amino compound	toxin
transferrin Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.	3.43	1	1
lignin Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.	2.89	1	0
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.89	1	0
nadp [no description available]	3.3	2	0
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	9.31	19	4	1,2-diacyl-sn-glycero-3-phosphocholine
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.89	1	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
silybin Silybin: The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.	5.09	5	2

Condition	Relationship Strength	Studies	Trials
Disease Exacerbation [description not available]	3.48	1	1
Hepatocellular Carcinoma [description not available]	3.48	1	1
Cancer of Liver [description not available]	3.48	1	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	3.48	1	1
Liver Neoplasms Tumors or cancer of the LIVER.	3.48	1	1
Angiogenesis, Pathologic [description not available]	2.42	2	0
Cancer of Ovary [description not available]	2.42	2	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.42	2	0
Cirrhosis, Liver [description not available]	3.82	2	1
Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.	3.82	2	1
Leukemic Infiltration A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site.	2.03	1	0
Carcinoma, Anaplastic [description not available]	2.03	1	0
Cancer of Lung [description not available]	2.03	1	0
Animal Mammary Carcinoma [description not available]	2.44	2	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.03	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.03	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.04	1	0
Adenoma, Basal Cell [description not available]	2.04	1	0
Cancer of Intestines [description not available]	2.04	1	0
Cancer of Prostate [description not available]	2.04	1	0
Adenoma A benign epithelial tumor with a glandular organization.	2.04	1	0
Intestinal Neoplasms Tumors or cancer of the INTESTINES.	2.04	1	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.04	1	0
Chronic Hepatitis C [description not available]	3.43	1	1
Hepatitis C, Chronic INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.	3.43	1	1
Bile Duct Obstruction, Extrahepatic [description not available]	2.9	1	0
Chronic Hepatitis [description not available]	4.28	1	1
Hepatitis, Chronic INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.	4.28	1	1
Experimental Neoplasms [description not available]	2.01	1	0
Acute Liver Injury, Drug-Induced [description not available]	2.89	1	0
Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	2.89	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.89	1	0

idb 1016

Cross-References

Synonyms (7)

Research Excerpts

Overview

Treatment

Pharmacokinetics

Bioavailability

Dosage Studied

Research

Studies (19)

Market Indicators

Research Demand Index: 10.82

Study Types

idb 1016

Cross-References

Synonyms (7)

Research Excerpts

Overview

Treatment

Pharmacokinetics

Bioavailability

Dosage Studied

Research

Studies (19)

Market Indicators

Research Demand Index: 10.82

Study Types

Related Drugs (17)

Related Conditions (32)