Page last updated: 2024-08-05 10:37:32
6-aminopurines
Any compound having 6-aminopurine (adenine) as part of its structure.
ChEBI ID: 20706
Members (22)
Member | Definition | Role |
---|---|---|
2,8-dihydroxyadenine | An oxopurine that is adenine bearing two oxo substituents at positions 2 and 8. | 2,8-dihydroxyadenine; 2,8-dioxoadenine |
2,8-dihydroxyadenine | A member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism. | 2,8-dihydroxyadenine; 2,8-dioxoadenine |
6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile | 6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile | |
6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile | 6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile | |
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile | 6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile | |
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile | 6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile | |
6-n-hydroxylaminopurine | A member of the class of 6-aminopurinnes that is adenine in which one of the exocyclic amino hydrogens is replaced by a hydroxy group. | N(6)-hydroxyadenine |
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine | A member of the class of 6-aminopurines that is 2-fluoroadenine carrying additional 2-chloro-3,4,5-trimethoxybenzyl and pent-4-yn-1-yl substituents at positions 8 and 9 respectively. | 8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine |
8-(Trifluoromethyl)-9H-purin-6-amine | 8-(Trifluoromethyl)-9H-purin-6-amine | |
8-hydroxyadenine | An oxopurine that is adenine bearing a single oxo substituent at position 8. | 8-hydroxyadenine; 8-oxoadenine |
8-hydroxyadenine | A nucleobase analogue that is adenine bearing a single hydroxy substituent at position 8. | 8-hydroxyadenine; 8-oxoadenine |
adefovir | A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. | adefovir |
adefovir dipivoxil | An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection. | adefovir pivoxil |
adenine | The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. | adenine |
angustmycin a | Decoyinine | |
arprinocid | Arprinocid | |
benzylaminopurine | A member of the class of 6-aminopurines that is adenine in which one of the hydrogens of the amino group is replaced by a benzyl group. | N-benzyladenine |
gs-7340 | An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection. | tenofovir alafenamide |
ic 87114 | A member of the class of quinazolines that is quinazolin-4(3H)-one carrying (6-amino-9H-purin-9-yl)methyl, 2-methylphenyl and methyl substituents at positions 2, 3 and 5 respectively. | IC-87114 |
kinetin | A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. | kinetin |
N-[3-[[2-[[4-(dimethylamino)cyclohexyl]amino]-9-propan-2-yl-6-purinyl]amino]phenyl]-2-propenamide | N-[3-[[2-[[4-(dimethylamino)cyclohexyl]amino]-9-propan-2-yl-6-purinyl]amino]phenyl]-2-propenamide | |
nucleocidin | A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness. | nucleocidin |
Research
Studies (21,967)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 5,980 (27.22) | 18.7374 |
1990's | 2,435 (11.08) | 18.2507 |
2000's | 4,780 (21.76) | 29.6817 |
2010's | 6,729 (30.63) | 24.3611 |
2020's | 2,043 (9.30) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 1,498 (5.77%) | 5.53% |
Reviews | 1,655 (6.38%) | 6.00% |
Case Studies | 1,187 (4.58%) | 4.05% |
Observational | 95 (0.37%) | 0.25% |
Other | 21,506 (82.90%) | 84.16% |