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6-aminopurines

Any compound having 6-aminopurine (adenine) as part of its structure.

ChEBI ID: 20706

Members (22)

MemberDefinitionRole
2,8-dihydroxyadenineAn oxopurine that is adenine bearing two oxo substituents at positions 2 and 8.2,8-dihydroxyadenine; 2,8-dioxoadenine
2,8-dihydroxyadenineA member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism.2,8-dihydroxyadenine; 2,8-dioxoadenine
6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile
6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile
6-n-hydroxylaminopurineA member of the class of 6-aminopurinnes that is adenine in which one of the exocyclic amino hydrogens is replaced by a hydroxy group.N(6)-hydroxyadenine
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amineA member of the class of 6-aminopurines that is 2-fluoroadenine carrying additional 2-chloro-3,4,5-trimethoxybenzyl and pent-4-yn-1-yl substituents at positions 8 and 9 respectively.8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine
8-(Trifluoromethyl)-9H-purin-6-amine8-(Trifluoromethyl)-9H-purin-6-amine
8-hydroxyadenineAn oxopurine that is adenine bearing a single oxo substituent at position 8.8-hydroxyadenine; 8-oxoadenine
8-hydroxyadenineA nucleobase analogue that is adenine bearing a single hydroxy substituent at position 8.8-hydroxyadenine; 8-oxoadenine
adefovirA member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.adefovir
adefovir dipivoxilAn organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.adefovir pivoxil
adenineThe parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.adenine
angustmycin aDecoyinine
arprinocidArprinocid
benzylaminopurineA member of the class of 6-aminopurines that is adenine in which one of the hydrogens of the amino group is replaced by a benzyl group.N-benzyladenine
gs-7340An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection.tenofovir alafenamide
ic 87114A member of the class of quinazolines that is quinazolin-4(3H)-one carrying (6-amino-9H-purin-9-yl)methyl, 2-methylphenyl and methyl substituents at positions 2, 3 and 5 respectively.IC-87114
kinetinA member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.kinetin
N-[3-[[2-[[4-(dimethylamino)cyclohexyl]amino]-9-propan-2-yl-6-purinyl]amino]phenyl]-2-propenamideN-[3-[[2-[[4-(dimethylamino)cyclohexyl]amino]-9-propan-2-yl-6-purinyl]amino]phenyl]-2-propenamide
nucleocidinA nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness.nucleocidin

Research

Studies (21,967)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19905,980 (27.22)18.7374
1990's2,435 (11.08)18.2507
2000's4,780 (21.76)29.6817
2010's6,729 (30.63)24.3611
2020's2,043 (9.30)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1,498 (5.77%)5.53%
Reviews1,655 (6.38%)6.00%
Case Studies1,187 (4.58%)4.05%
Observational95 (0.37%)0.25%
Other21,506 (82.90%)84.16%