| Member | Definition | Role |
|---|
| 15-keto-13,14-dihydroprostaglandin f2alpha | A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha. | 13,14-dihydro-15-keto-PGF2alpha |
| 15-ketoprostaglandin f2alpha | A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group of prostaglandin F2alpha. | 15-oxoprostaglandin F2alpha |
| 6-ketoprostaglandin f1 alpha | A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position. | 6-oxoprostaglandin F1alpha |
| dinoprost | A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor. | prostaglandin F2alpha |
| fluprostenol | An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. | fluprostenol |
| latanoprost | A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. | latanoprost |
| phxa 85 | A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension. | latanoprost free acid |
| prostaglandin f1 | | prostaglandin F1alpha |
| prostaglandin f3alpha | A prostaglandin Falpha that is prosta-5,13,17-trien-1-oic acid carrying three hydroxy substituents at positions 9alpha, 11alpha and 15. | prostaglandin F3alpha |
| tafluprost | A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. | tafluprost |
| travoprost | The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol. | travoprost |
| uf 021 | The isopropyl ester of unoprostone. | isopropyl unoprostone |