Page last updated: 2024-08-05 13:15:39
prostaglandins Falpha
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ChEBI ID: 36066
Members (12)
| Member | Definition | Role |
|---|---|---|
| 15-keto-13,14-dihydroprostaglandin f2alpha | A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha. | 13,14-dihydro-15-keto-PGF2alpha |
| 15-ketoprostaglandin f2alpha | A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group of prostaglandin F2alpha. | 15-oxoprostaglandin F2alpha |
| 6-ketoprostaglandin f1 alpha | A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position. | 6-oxoprostaglandin F1alpha |
| dinoprost | A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor. | prostaglandin F2alpha |
| fluprostenol | An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. | fluprostenol |
| latanoprost | A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. | latanoprost |
| phxa 85 | A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension. | latanoprost free acid |
| prostaglandin f1 | prostaglandin F1alpha | |
| prostaglandin f3alpha | A prostaglandin Falpha that is prosta-5,13,17-trien-1-oic acid carrying three hydroxy substituents at positions 9alpha, 11alpha and 15. | prostaglandin F3alpha |
| tafluprost | A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. | tafluprost |
| travoprost | The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol. | travoprost |
| uf 021 | The isopropyl ester of unoprostone. | isopropyl unoprostone |
Research
Studies (17,175)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,317 (30.96) | 18.7374 |
| 1990's | 4,786 (27.87) | 18.2507 |
| 2000's | 3,998 (23.28) | 29.6817 |
| 2010's | 2,572 (14.98) | 24.3611 |
| 2020's | 502 (2.92) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,076 (10.42%) | 5.53% |
| Reviews | 712 (3.58%) | 6.00% |
| Case Studies | 342 (1.72%) | 4.05% |
| Observational | 52 (0.26%) | 0.25% |
| Other | 16,734 (84.02%) | 84.16% |