Page last updated: 2024-09-28

Bulbar Palsy

A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)

Synonyms(8)

Synonym
Bulbar Palsy
Paralysis, Bulbar
Fazio-Londe Disease
Childhood Progressive Bulbar Palsy
Bulbar Palsy, Progressive
Bulbar Palsy, Progressive, Of Childhood
Fazio-Londe Syndrome
Progressive Bulbar Palsy of Childhood

Research Excerpts

Research

Studies (173)

TimeframeStudies, This Condition (%)All Conditions %
pre-199072 (41.62)23.3326
1990's23 (13.29)12.5806
2000's19 (10.98)18.1394
2010's44 (25.43)28.8240
2020's15 (8.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low20
carnitine0low10
histamine0low20
dihydroxyphenylalanine0low90
homovanillic acid0low30
hydroxyindoleacetic acid0low10
amantadine0low20
amitriptyline0medium31
azathioprine0low20
biperiden0low10
chlorpromazine0low10
desipramine0medium11
dibucaine0low10
fluphenazine0low10
fluorouracil0low10
flutamide0low10
apnea0low20
neostigmine0low30
procaine0low10
propranolol0low10
riluzole0medium61
spiperone0low20
trihexyphenidyl0low10
prednisolone0low60
phentolamine0low10
aldosterone0low10
prednisone0low20
penicillin g0low10
aspartic acid0low10
levodopa0medium61
mannitol0low10
cytarabine0low10
fluoxymesterone0low10
trichloroethylene0low10
methylprednisolone0low20
pyrrolidonecarboxylic acid0medium31
pyridostigmine bromide0low20
diethylene glycol0low10
pyrazines0low10
methysergide0low40
barium sulfate0low20
lisuride0low10
carbimazole0low10
bromocriptine0low30
4-methoxyamphetamine0low10
glutamic acid0low30
s-adenosylmethionine0low10
substance p0low10
pergolide0medium21
fomesafen0low60
simvastatin0low10
aripiprazole0low10
fluorodeoxyglucose f180low10
l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide0medium31
4-bromospiperone0low10
atropine0low10
bortezomib0low10
inositol 3-phosphate0low10
strychnine0low10
metrizamide0low10
riboflavin0low380
leuprolide0low10
phenylephrine hydrochloride0low20
ciguatoxins0low10
lead0low10
tetrodotoxin0low10
ganglioside, gd1b0low10
trisialoganglioside gt10low80
tanespimycin0low10
ergoline0medium31
g(m1) ganglioside0medium41
jaw0low10
cytochrome c-t0low20
cholecystokinin0low10
glucagon0low10
oligonucleotides0low10
neurotensin0low10
ganglioside, gd1a0low30
glycolipids0low10
vasoactive intestinal peptide0low10
ascorbic acid0low10
saxitoxin0low20
g(m3) ganglioside0low30
cyclosporine0low10
cyclic gmp0low10
eye0low10
gq1b ganglioside0low50

Protein Targets (891)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0718
5-hydroxytryptamine receptor 2A08210
5-hydroxytryptamine receptor 1A022225
5-hydroxytryptamine receptor 1B021122
5-hydroxytryptamine receptor 1D0516
5-hydroxytryptamine receptor 1F0516
5-hydroxytryptamine receptor 2B0617
5-hydroxytryptamine receptor 60314
Sodium-dependent serotonin transporter013114
Sodium-dependent serotonin transporter0303
5-hydroxytryptamine receptor 7 0628
5-hydroxytryptamine receptor 5A0314
5-hydroxytryptamine receptor 5B0314
5-hydroxytryptamine receptor 3A0314
5-hydroxytryptamine receptor 4 0415
5-hydroxytryptamine receptor 3B0314
AR protein300030
glucocorticoid receptor [Homo sapiens]280028
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 2100010
geminin240024
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0336
Androgen receptor0909
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G2002
acetylcholinesterase130013
thioredoxin reductase240024
RAR-related orphan receptor gamma200020
NFKB1 protein, partial8008
GLI family zinc finger 3200020
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor120012
regulator of G-protein signaling 4160016
EWS/FLI fusion protein130013
estrogen nuclear receptor alpha290029
putative alpha-glucosidase1001
euchromatic histone-lysine N-methyltransferase 2330033
thyroid hormone receptor beta isoform 2220022
heat shock protein beta-17007
peripheral myelin protein 22170017
histone acetyltransferase KAT2A isoform 18008
lamin isoform A-delta10250025
Solute carrier family 22 member 20305
Solute carrier family 22 member 1 0709
Glutamate receptor ionotropic, NMDA 2D0303
Glutamate receptor ionotropic, NMDA 3B0303
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0518
Spike glycoprotein142218
Glutamate receptor ionotropic, NMDA 2A 0518
Glutamate receptor ionotropic, NMDA 2B0518
Glutamate receptor ionotropic, NMDA 2C0518
Glutamate receptor ionotropic, NMDA 10303
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, NMDA 2B0303
Glutamate receptor ionotropic, NMDA 2C0303
Glutamate receptor ionotropic, NMDA 2D0518
Solute carrier family 22 member 10405
Glutamate receptor ionotropic, NMDA 3A0303
Glutamate receptor ionotropic, NMDA 3B0518
Multidrug and toxin extrusion protein 10202
Solute carrier family 22 member 20304
Glutamate receptor ionotropic, NMDA 3A0518
ATP-dependent phosphofructokinase120012
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
USP1 protein, partial150015
GLS protein150015
cytochrome P450 family 3 subfamily A polypeptide 4160016
cytochrome P450 2D6120012
arylsulfatase A180018
cytochrome P450 2D6 isoform 19009
D(1A) dopamine receptor140014
chromobox protein homolog 1180018
atrial natriuretic peptide receptor 2 precursor4004
serine/threonine-protein kinase mTOR isoform 18008
nuclear factor erythroid 2-related factor 2 isoform 1200020
muscarinic acetylcholine receptor M1130013
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
ATP-binding cassette sub-family C member 3018018
Multidrug resistance-associated protein 4018019
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 4022022
Bile salt export pump029029
Albumin0033
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10808
Muscarinic acetylcholine receptor M2013218
Muscarinic acetylcholine receptor M4012115
Muscarinic acetylcholine receptor M10518
Muscarinic acetylcholine receptor M30518
Muscarinic acetylcholine receptor M40518
Muscarinic acetylcholine receptor M50518
Muscarinic acetylcholine receptor M509112
Alpha-2A adrenergic receptor020325
Muscarinic acetylcholine receptor M20519
Muscarinic acetylcholine receptor M1013218
Angiotensin-converting enzyme010010
D(2) dopamine receptor020627
Alpha-2B adrenergic receptor019324
Alpha-2C adrenergic receptor019324
Muscarinic acetylcholine receptor M3014218
D(1A) dopamine receptor017119
D(1B) dopamine receptor0405
UDP-glucuronosyltransferase 1A40002
Sodium-dependent noradrenaline transporter 010111
Histamine H2 receptor09211
Alpha-1D adrenergic receptor019222
5-hydroxytryptamine receptor 2A024428
5-hydroxytryptamine receptor 2C025429
Histamine H1 receptor0415
Histamine H1 receptor015217
D(3) dopamine receptor019121
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 4 subunit alpha0303
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B021122
Alpha-1A adrenergic receptor013316
Histamine H2 receptor82115
D(1A) dopamine receptor5005
5-hydroxytryptamine receptor 6020121
5-hydroxytryptamine receptor 70606
Voltage-dependent N-type calcium channel subunit alpha-1B0202
Sodium channel protein type 7 subunit alpha0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0909
Potassium voltage-gated channel subfamily H member 2015015
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Sodium channel protein type 5 subunit alpha0505
Sodium channel protein type 9 subunit alpha0404
Sigma non-opioid intracellular receptor 10112
Nuclear receptor subfamily 3 group C member 3 010010
Canalicular multispecific organic anion transporter 1017017
Sodium channel protein type 2 subunit alpha0303
Ataxin-2180018
Sigma non-opioid intracellular receptor 1015015
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0303
Sodium channel protein type 8 subunit alpha0303
Histamine H3 receptor0628
Sodium channel protein type 10 subunit alpha0303
ATAD5 protein, partial120012
TDP1 protein250025
Microtubule-associated protein tau9009
estrogen-related nuclear receptor alpha240024
Bloom syndrome protein isoform 18008
neuropeptide S receptor isoform A4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE100010
Chain A, JmjC domain-containing histone demethylation protein 3A4004
5-hydroxytryptamine receptor 3E0101
hypoxia-inducible factor 1 alpha subunit8008
SMAD family member 24004
Fumarate hydratase9009
PPM1D protein6006
SMAD family member 34004
estrogen receptor 2 (ER beta)100010
nuclear receptor subfamily 1, group I, member 3150015
progesterone receptor130013
retinoic acid nuclear receptor alpha variant 1190019
retinoid X nuclear receptor alpha190019
farnesoid X nuclear receptor8008
pregnane X nuclear receptor220022
G100010
polyprotein9009
67.9K protein6006
peroxisome proliferator-activated receptor delta100010
peroxisome proliferator activated receptor gamma140014
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
thyroid stimulating hormone receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)130013
lysosomal alpha-glucosidase preproprotein5005
mu-type opioid receptor isoform MOR-10044
potassium voltage-gated channel subfamily H member 2 isoform d120012
transcriptional regulator ERG isoform 33003
nuclear receptor ROR-gamma isoform 15005
5-hydroxytryptamine receptor 2A0044
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit100010
5-hydroxytryptamine receptor 3B0101
Interferon beta150015
HLA class I histocompatibility antigen, B alpha chain 100010
Cellular tumor antigen p53200020
ATP-dependent translocase ABCB10708
Cytochrome P450 3A40505
5-hydroxytryptamine receptor 1A08412
Neuronal acetylcholine receptor subunit alpha-44004
Neuronal acetylcholine receptor subunit beta-24004
Alpha-1B adrenergic receptor011314
D0606
Glutamate receptor 2112114
D(4) dopamine receptor0719
Alpha-1D adrenergic receptor09313
D(4) dopamine receptor0606
Histamine H1 receptor0437
5-hydroxytryptamine receptor 70415
Alpha-1A adrenergic receptor0539
Alpha-1B adrenergic receptor0427
5-hydroxytryptamine receptor 3A0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
D(2) dopamine receptor08414
Inositol monophosphatase 13003
5-hydroxytryptamine receptor 3D0101
Multidrug and toxin extrusion protein 20101
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 1100010
cytochrome P450 2C9, partial100010
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase3003
IDH1110011
lethal(3)malignant brain tumor-like protein 1 isoform I2002
lethal factor (plasmid)7007
Polyphenol oxidase 20102
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE130013
Chain A, Ferritin light chain5005
phosphopantetheinyl transferase110011
aldehyde dehydrogenase 1 family, member A1110011
cytochrome P450 2C19 precursor4004
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 10206
Carbonic anhydrase 20207
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0004
Carbonic anhydrase 40002
Chain A, 2-oxoglutarate Oxygenase6006
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M40101
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
interleukin 84004
P531001
aryl hydrocarbon receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
activating transcription factor 67007
Histone H2A.x7007
peripheral myelin protein 22 isoform 15005
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a5005
DNA polymerase iota isoform a (long)6006
survival motor neuron protein isoform d7007
cytochrome P450 3A4 isoform 19009
M-phase phosphoprotein 88008
muscleblind-like protein 1 isoform 14004
Gamma-aminobutyric acid receptor subunit pi93214
Bile salt export pump0404
Gamma-aminobutyric acid receptor subunit beta-193214
Gamma-aminobutyric acid receptor subunit delta93214
Gamma-aminobutyric acid receptor subunit gamma-293315
Gamma-aminobutyric acid receptor subunit alpha-593214
Gamma-aminobutyric acid receptor subunit alpha-393214
Gamma-aminobutyric acid receptor subunit gamma-193214
Gamma-aminobutyric acid receptor subunit alpha-293214
Gamma-aminobutyric acid receptor subunit alpha-493214
Gamma-aminobutyric acid receptor subunit gamma-393214
Gamma-aminobutyric acid receptor subunit alpha-693214
Nuclear receptor ROR-gamma4004
Gamma-aminobutyric acid receptor subunit alpha-193315
Gamma-aminobutyric acid receptor subunit beta-393214
Gamma-aminobutyric acid receptor subunit beta-293315
GABA theta subunit93214
ATPase family AAA domain-containing protein 59009
Gamma-aminobutyric acid receptor subunit epsilon93214
Protein-arginine deiminase type-40101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Nitric oxide synthase, brain0101
Luciferase7007
flap endonuclease 15005
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110102
caspase 7, apoptosis-related cysteine protease4004
caspase-34004
nuclear receptor subfamily 1, group I, member 24004
Caspase-73003
caspase-33003
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70102
Histone deacetylase 30303
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120103
Prothrombin0112
Chymotrypsinogen A0202
Carbonic anhydrase 30103
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10103
Carbonic anhydrase 40204
Carbonic anhydrase 60103
Chymase0101
Proteasome subunit alpha type-10102
Proteasome subunit alpha type-20102
Proteasome subunit alpha type-30102
Proteasome subunit alpha type-40102
Proteasome subunit beta type-80102
Proteasome subunit beta type-80101
Proteasome subunit beta type-90102
Proteasome subunit alpha type-50102
Proteasome subunit beta type-40102
Proteasome subunit beta type-60102
Proteasome subunit beta type-50204
Carbonic anhydrase 5A, mitochondrial0103
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100102
Carbonic anhydrase 70103
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30102
Proteasome subunit beta type-20103
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60113
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10303
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90103
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130102
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80102
Histone deacetylase 20303
Proteasome subunit beta type-70102
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150204
Histone deacetylase 80303
Histone deacetylase 60303
Carbonic anhydrase 140103
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0103
Genome polyprotein 0112
dopamine D1 receptor4004
vitamin D3 receptor isoform VDRA7007
peptidyl-prolyl cis-trans isomerase NIMA-interacting 15005
ATP-dependent translocase ABCB10101
Beta-1 adrenergic receptor0617
D(3) dopamine receptor0607
Alpha-2B adrenergic receptor07310
ATP-dependent translocase ABCB10101
Alpha-2C adrenergic receptor07310
Alpha-2A adrenergic receptor07310
D(1B) dopamine receptor0505
Alpha-synuclein2204
Lactoperoxidase0101
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Thrombopoietin4004
Smad37007
NADPH oxidase 10202
Snq2p0002
Adenylate cyclase type 1 0202
Spike glycoprotein0224
Replicase polyprotein 1ab0224
histone deacetylase 9 isoform 33003
mitogen-activated protein kinase 19009
ras-related protein Rab-9A3003
DNA polymerase kappa isoform 14004
Transmembrane protease serine 20224
Transient receptor potential cation channel subfamily V member 10101
Potassium channel subfamily K member 20224
Epidermal growth factor receptor0505
Albumin0033
Major prion protein0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Receptor tyrosine-protein kinase erbB-20303
Major prion protein0011
Integrin beta-34015
Cytochrome P450 1A20213
Tyrosine-protein kinase Fyn0303
Procathepsin L0224
Integrin alpha-IIb4015
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0224
Cytochrome P450 2D60718
Cytochrome P450 2C9 0505
Polyunsaturated fatty acid lipoxygenase ALOX150202
Sphingomyelin phosphodiesterase0101
D(2) dopamine receptor0202
Substance-K receptor0606
Adenylate cyclase type 30202
Sodium-dependent dopamine transporter0505
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Trypanothione reductase0404
Melanocortin receptor 40202
Melanocortin receptor 50404
Pleiotropic ABC efflux transporter of multiple drugs0204
Mu-type opioid receptor0516
Adenylate cyclase type 80202
Delta-type opioid receptor0516
Kappa-type opioid receptor0516
Melanocortin receptor 30202
Cytochrome P450 2J20404
Gastrin/cholecystokinin type B receptor0101
Calmodulin 0112
Aldehyde oxidase 10101
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Aldehyde oxidase0202
Adenylyl cyclase 7 0202
D0202
Angiotensin-converting enzyme 2 0224
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
endonuclease IV7007
glp-1 receptor, partial6006
LMP1 [Human herpesvirus 4]0002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0202
nuclear receptor coactivator 3 isoform a0101
Thymidine kinase 2, mitochondrial0101
Thymidine kinase, cytosolic0101
Thymidine kinase0101
Thymidylate synthase0102
Thymidine kinase0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Thymidine kinase0101
Deoxynucleoside kinase0101
huntingtin isoform 23003
Solute carrier family 22 member 30203
Solute carrier family 22 member 30101
Prostaglandin G/H synthase 10101
Tryptophan 5-hydroxylase 10101
Histamine H3 receptor0101
Solute carrier family 22 member 40101
Transporter0202
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
Chain A, ATP-DEPENDENT DNA HELICASE Q15005
15-lipoxygenase, partial5005
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 11214
Glutamate receptor 31214
Glutamate receptor 41214
Caspase-72002
Chain A, Uracil Phosphoribosyltransferase0101
Skn7p0001
pregnane X receptor4004
nonstructural protein 14004
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
Vpr2002
Solute carrier family 22 member 80103
Amyloid-beta precursor protein1001
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Androgen receptor0617
glucocerebrosidase1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
Adenosine receptor A30314
Beta-3 adrenergic receptor0415
Disintegrin and metalloproteinase domain-containing protein 173003
Chain A, Beta-lactamase6006
alpha-galactosidase4004
cytochrome P450 2C9 precursor3003
Cocaine esterase0102
Arylacetamide deacetylase0001
Arylacetamide deacetylase0001
Arylacetamide deacetylase0001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30012
Hsf1 protein0022
bromodomain adjacent to zinc finger domain 2B6006
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10023
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20012
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40202
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 434004
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90202
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50202
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor2002
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50123
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
apical membrane antigen 1, AMA12002
transforming acidic coiled-coil-containing protein 30001
Plasma kallikrein0002
Macrophage migration inhibitory factor0202
Adenosine receptor A10002
Adenosine receptor A2a0013
Carbonic anhydrase0103
Carbonic anhydrase0003
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0003
Carbonic anhydrase0003
Carbonic anhydrase0003
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
ClpP2002
Solute carrier family 22 member 80103
hypothetical protein, conserved1001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
pyruvate kinase2002
hexokinase-4 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein2002
importin subunit beta-1 isoform 12002
snurportin-12002
DNA polymerase eta isoform 11001
Tyrosine-protein kinase Lck0101
Solute carrier family 15 member 10202
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Monocarboxylate transporter 100001
phosphoglycerate kinase1001
Beta-2 adrenergic receptor0415
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10707
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
DNA polymerase III, partial1001
GTP-binding nuclear protein Ran isoform 11001
Acetylcholinesterase0101
Cholinesterase0202
Acetylcholinesterase0303
Cholinesterase0101
Neurotensin receptor type 10011
Neurotensin receptor type 20113
Myelin basic protein0011
Neurotensin receptor type 10112
Neurotensin receptor type 10225
Neurotensin receptor type 20213
Sortilin0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Solute carrier family 22 member 60101
Beta-lactamase0001
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Beta-lactamase TEM0102
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80101
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Beta-lactamase VIM-1 0001
estrogen receptor beta isoform 10101
Alpha-1A adrenergic receptor0011
Alpha-1A adrenergic receptor0202
Alpha-1B adrenergic receptor0101
Nischarin0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Beta-1 adrenergic receptor0214
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190202
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
NPYLR7B0011
thyrotropin-releasing hormone receptor2002
tumor necrosis factor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor2002
Riboflavin-binding protein0112
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Parkin2002
NPC intracellular cholesterol transporter 1 precursor2002
pyruvate kinase PKM isoform b1001
Dihydrofolate reductase0101
Sodium channel protein type 2 subunit alpha0101
Ornithine decarboxylase1001
UDP-glucuronosyltransferase 1A1 0101
Pteridine reductase 10202
Met repressor 0022
Protein arginine N-methyltransferase 50011
Histone H3K27 methylase0001
Phenylethanolamine N-methyltransferase0012
S-adenosylmethionine decarboxylase proenzyme0102
Protein-L-isoaspartate(D-aspartate) O-methyltransferase0101
Catechol O-methyltransferase0001
Protein arginine N-methyltransferase 10101
Methylosome protein 500011
PINK11001
photoreceptor-specific nuclear receptor0101
serine/threonine-protein kinase PLK11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Solute carrier organic anion transporter family member 1B10101
alternatively spliced Trp40011
5-hydroxytryptamine receptor 1E0101
sphingosine 1-phosphate receptor 30101
Beta-casein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Glycogen phosphorylase, brain form0101
Glycogen phosphorylase, muscle form0101
Endothelin receptor type B0101
Endothelin receptor type B0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
D(4) dopamine receptor0101
D(2) dopamine receptor0101
D0101
Vesicular acetylcholine transporter0101
D(1B) dopamine receptor0101
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0101
Taste receptor type 2 member 460011
Taste receptor type 2 member 100012
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0101
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
Corticotropin releasing hormone receptor 20101
Lysine-specific demethylase 6B0101
Lysine-specific demethylase 4B0101
Tyrosine-protein kinase ABL10101
ATP-dependent molecular chaperone HSP820101
Heat shock protein HSP 90-alpha0325
Heat shock protein HSP 90-beta0226
Breakpoint cluster region protein0101
Cholesteryl ester transfer protein0011
ATP-dependent molecular chaperone HSC820101
Lysine-specific demethylase 5A0101
Endoplasmin0112
DNA-dependent protein kinase catalytic subunit0101
Heat shock protein 75 kDa, mitochondrial0101
Heat-shock protein0101
Putative heat shock protein HSP 90-alpha A40101
Lysine-specific demethylase 4C0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]