Compounds > thiamine hydrochloride
Page last updated: 2024-09-20

thiamine hydrochloride

Description

thiamine hydrochloride : A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6202
CHEMBL ID1200941
CHEBI ID49105
SCHEMBL ID41101

Synonyms (177)

Synonym
thiamine monohydrochloride
berin
vitaneuron
betalin s
thiazolium, monohydrochloride
benerva
eskaphen
thiamol
thiamine hydrochloride
thiadoxine
thiazolium, hydrochloride
hybee
beatine
thiamin chloride
bequin
slowten
vitamin b(sub 1) hydrochloride
bithiamin
trophite
begiolan
bedome
vitamin b hydrochloride
thiaminium chloride hydrochloride
vinothiam
biuno
thiamin hydrochloride
bevitine
vitamin b(sup1)
tiaminal
clotiamina
thiaminium chloride
vetalin s
thiamine, hydrochloride
metabolin
eskapen
usaf cb-20
thiavit
bevitex
vitamin b1 hydrochloride
apate drops
bivita
thiaminal
wln: t6n cnj b1 dz e1- at5k csj d2q e1 &q &g &gh
tiamidon
betabion hydrochloride
thiamine dichloride
thiamine chloride hydrochloride
bethiazine
aneurine hydrochloride
bewon
thiamine, monohydrochloride
nsc-36226
bivatin
lixa-beta
beuion
thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethyl, chloride, monohydrochloride
thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, monohydrochloride
ccris 1906
nsc 36226
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethylthiazolium chloride, monohydrochloride
chloride-hydrochloride salt of thiamine
thiamine hcl
thiamine, chloride, hydrochloride
einecs 200-641-8
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride monohydrochloride
thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride, monohydrochloride
vitamin b1 hydrochloride (van)
fema no. 3322
thiamin dichloride
ai3-18993
PRESTWICK_441
NCGC00017013-01
cas-67-03-8
MLS001332448
MLS001332447
smr000875246
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride
CHEBI:49105 ,
thiamine(2+) dichloride
3-[(4-azaniumyl-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium dichloride
67-03-8
thiamine hydrochloride, meets usp testing specifications
thiamine hydrochloride, >=98%, fcc, fg
thiamine hydrochloride (b1), analytical standard
thiamine hydrochloride, bioreagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
thiamine hydrochloride, reagent grade, >=99% (hplc)
thiamine hydrochloride (usp)
D02094
thiamine chloride hydrochloride (jp17)
thiamine hcl (tn)
NCGC00017013-02
thiamini hydrochloridum
thiaminum hydrochloricum
thiamine chloride, hydrochloride
CHEMBL1200941
thymine hydrochloride
T0181
HMS1569P04
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride hydrochloride
2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl}ethan- 1-ol, chloride, chloride
tox21_110736
dtxcid8020622
dtxsid0040622 ,
S3211
unii-m572600e5p
thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, hydrochloride (1:1:1)
thiamine hydrochloride [usp:jan]
m572600e5p ,
FT-0631293
thiamine hydrochloride [ep impurity]
thiamini hydrochloridum [who-ip latin]
thymine hydrochloride [who-dd]
thiamine hydrochloride [usp monograph]
thiaminum hydrochloricum [hpus]
thiamine hcl [inci]
thiamine hydrochloride [usp-rs]
thiamine hydrochloride [ep monograph]
vitamin b1 [fhfi]
thiamine hydrochloride [vandf]
thiamine hydrochloride [mi]
thiamine hydrochloride [who-dd]
thiamine chloride, hydrochloride [who-ip]
thiamine hydrochloride [fcc]
thiamine hydrochloride [mart.]
thiamine hydrochloride [who-ip]
thiamine chloride hydrochloride [jan]
thiamine hydrochloride [orange book]
AKOS015905506
CCG-220677
SCHEMBL41101
DPJRMOMPQZCRJU-UHFFFAOYSA-M
vitamin bl
3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride
F0001-2415
Q-201928
thiamine hcl (vitamin b1)
thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-
mfcd00012780
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride
F2173-0852
thiamine hydrochloride, 99% (dry wt.), may cont. up to 5% water
thiamine hydrochloride, saj special grade, >=98.5%
thiamine hydrochloride, united states pharmacopeia (usp) reference standard
thiamine hydrochloride, tested according to ph.eur.
thiamine hydrochloride, p.a., 98%
thiamine hydrochloride, pharmaceutical secondary standard; certified reference material
thiamine for system suitability, european pharmacopoeia (ep) reference standard
thiamine hydrochloride, european pharmacopoeia (ep) reference standard
thiamine hydrochloride (vitamin b1)
thiamine hydrochloride (vitamin b1) 1.0 mg/ml in methanol (as free base)
SY010871
thiamine (hydrochloride)
CS-8164
67-03-8 (hcl salt)
vitamin b1 (thiamine hcl)
aneurinehydrochloride
HY-N0680
Q27121486
thiamine hydrochloride 10 microg/ml in acetonitrile
AS-14151
BCP27971
vitamin b1hydrochloride
thiamine chloride hydrochloride;vitamin b1 hydrochloride
FT-0777960
vitamin b1 hydrochloride hydrate
SB57886
thiamine for system suitability
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium hydrochloride chloride
EN300-258109
thiamine hydrochloride (ep impurity)
3-((4-azaniumyl-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium dichloride
thiamine hydrochloride (usp:jan)
thiamine hydrochloride (mart.)
thiamine hydrochloride (usp-rs)
thiamine hydrochloride (usp monograph)
thiamine hydrochloride (ep monograph)
Z1954805523

Roles (1)

RoleDescription
insect repellentAn insecticide that acts as a repellent to insects.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
vitamin B1Any member of the group of 1,3-thiazolium cations that exhibit biological activity against vitamin B1 deficiency in animals. Symptoms of vitamin B1 deficiency include constipation, loss of apetite, fatigue, nausea, delirium, blurry vision and muscle weakness. Severe vitamin B1 deficiency can also lead to a disease known as beriberi. Vitamin B1 consists of the vitamer thiamin and its acid, aldehyde and phosphorylated derivatives (and their corresponding ionized, salt and hydrate forms).
hydrochlorideA salt formally resulting from the reaction of hydrochloric acid with an organic base.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency7.94330.044717.8581100.0000AID485294
USP1 protein, partialHomo sapiens (human)Potency39.81070.031637.5844354.8130AID504865
thioredoxin glutathione reductaseSchistosoma mansoniPotency50.11870.100022.9075100.0000AID485364
pregnane X nuclear receptorHomo sapiens (human)Potency10.00000.005428.02631,258.9301AID1346985
gemininHomo sapiens (human)Potency0.46110.004611.374133.4983AID624296
VprHuman immunodeficiency virus 1Potency28.18381.584919.626463.0957AID651644
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency7.75430.005612.367736.1254AID624032
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency8.91250.251215.843239.8107AID504327
Cellular tumor antigen p53Homo sapiens (human)Potency14.29990.002319.595674.0614AID651631
TAR DNA-binding protein 43Homo sapiens (human)Potency35.48131.778316.208135.4813AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (140)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (39)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (24)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's8 (44.44)24.3611
2020's9 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
rhodamine 6g[no description available]medium10
thiamine[no description available]medium80primary alcohol;
vitamin B1		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
cobalt[no description available]medium10cobalt group element atom;
metal allergen		micronutrient
hydroxide ion[no description available]medium10oxygen hydridemouse metabolite
trehalose[no description available]medium10trehaloseEscherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ascorbic acid[no description available]medium10ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
pyridoxine[no description available]medium10hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cetyltrimethylammonium ion[no description available]medium10quaternary ammonium ion
betadex[no description available]medium10cyclodextrin
pectins[no description available]medium10D-galactopyranuronic acid
n-vinyl-2-pyrrolidinone[no description available]medium10pyrrolidin-2-ones
cuminol[no description available]low00benzyl alcohols;
p-menthane monoterpenoid		fragrance;
insect repellent;
plant metabolite;
volatile oil component;
xenobiotic metabolite
deet[no description available]low00benzamides;
monocarboxylic acid amide		environmental contaminant;
insect repellent;
xenobiotic
piperonal[no description available]low00arenecarbaldehyde;
benzodioxoles		fragrance;
insect repellent;
plant metabolite
terpinolene[no description available]low00p-menthadieneinsect repellent;
plant metabolite;
sedative;
volatile oil component
2-pentylfuran[no description available]low00furansAspergillus metabolite;
bacterial metabolite;
flavouring agent;
human urinary metabolite;
insect repellent;
plant growth stimulator;
volatile oil component
4-anisaldehyde[no description available]low00benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
nootkatone[no description available]low00carbobicyclic compound;
enone;
sesquiterpenoid		fragrance;
insect repellent;
plant metabolite
thiamine[no description available]low00organic chloride salt;
vitamin B1
thiamine pyrophosphate[no description available]low00organic chloride salt;
vitamin B1
thiamine monophosphate[no description available]low00organic chloride salt;
vitamin B1
thiamine triphosphate[no description available]low00ammonium betaine;
thiamine phosphate;
vitamin B1
thiamine pyrophosphate[no description available]low00organophosphate oxoanion;
vitamin B1		human metabolite;
Saccharomyces cerevisiae metabolite
meperidine hydrochloride[no description available]low00hydrochlorideantispasmodic drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic
promazine hydrochloride[no description available]low00hydrochloride
pilocarpine hydrochloride[no description available]low00hydrochloride
mechlorethamine hydrochloride[no description available]low00hydrochlorideantineoplastic agent
promethazine hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
geroprotector;
H1-receptor antagonist;
local anaesthetic;
sedative
pyridoxine hydrochloride[no description available]low00hydrochloride;
vitamin B6
chlorpromazine hydrochloride[no description available]low00hydrochloride;
phenothiazines		anticoronaviral agent;
phenothiazine antipsychotic drug
lidocaine hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug;
local anaesthetic
imipramine hydrochloride[no description available]low00hydrochlorideantidepressant
methapyrilene hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
carcinogenic agent;
H1-receptor antagonist;
sedative
phenazopyridine hydrochloride[no description available]low00hydrochloridecarcinogenic agent;
local anaesthetic;
non-narcotic analgesic
diphenhydramine hydrochloride[no description available]low00hydrochloride;
organoammonium salt		anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative
cycloguanil hydrochloride[no description available]low00hydrochloride;
organic molecular entity
hydralazine hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
vasodilator agent
orphenadrine hydrochloride[no description available]low00hydrochlorideantiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist;
muscle relaxant;
NMDA receptor antagonist;
parasympatholytic
pseudoephedrine hydrochloride[no description available]low00hydrochlorideplant metabolite
procarbazine hydrochloride[no description available]low00hydrochlorideantineoplastic agent
tetrahydrozoline hydrochloride[no description available]low00hydrochloridenasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
pyridoxamine dihydrochloride[no description available]low00hydrochloride;
vitamin B6		Escherichia coli metabolite;
human metabolite;
iron chelator;
mouse metabolite;
nephroprotective agent;
plant metabolite;
Saccharomyces cerevisiae metabolite
neutral red[no description available]low00hydrochlorideacid-base indicator;
dye;
two-colour indicator
cyproheptadine hydrochloride (anhydrous)[no description available]low00hydrochloride
ethambutol hydrochloride[no description available]low00hydrochlorideantitubercular agent
metformin hydrochloride[no description available]low00hydrochlorideenvironmental contaminant;
hypoglycemic agent;
xenobiotic
n-(1-naphthyl)ethylenediamine dihydrochloride[no description available]low00hydrochloride
amiloride hydrochloride, anhydrous[no description available]low00hydrochloridediuretic;
sodium channel blocker
benzophenoneidum[no description available]low00hydrochloridefluorochrome;
histological dye
midodrine hydrochloride[no description available]low00hydrochloridealpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent
quinacrine mustard[no description available]low00hydrochlorideintercalator
mexiletine hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
cyclobenzaprine hydrochloride[no description available]low00hydrochlorideantidepressant;
muscle relaxant
nsc-145,668[no description available]low00hydrochlorideantimetabolite;
antineoplastic agent
selegiline hydrochloride, (r)-isomer[no description available]low00hydrochloride;
terminal acetylenic compound		antiparkinson drug;
dopaminergic agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor
benserazide hydrochloride[no description available]low00hydrochlorideantiparkinson drug;
dopaminergic agent;
EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
minaprine dihydrochloride[no description available]low00hydrochloride
lofepramine hydrochloride[no description available]low00hydrochlorideantidepressant
moricizine hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
buspirone hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist
propafenone hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
carteolol hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
midazolam hydrochloride[no description available]low00hydrochloride;
imidazobenzodiazepine		anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative
cerm-1978[no description available]low00hydrochloride
mitoxantrone hydrochloride[no description available]low00hydrochlorideantineoplastic agent
alo 2145[no description available]low00hydrochloridealpha-adrenergic agonist;
antiglaucoma drug
azelastine hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
anti-asthmatic drug;
bronchodilator agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
H1-receptor antagonist;
platelet aggregation inhibitor
bambuterol hydrochloride[no description available]low00carbamate ester;
hydrochloride;
phenylethanolamines		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
prodrug;
sympathomimetic agent
atomoxetine hydrochloride[no description available]low00hydrochlorideadrenergic uptake inhibitor;
antidepressant
ci 906[no description available]low00hydrochlorideantihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
raloxifene hydrochloride[no description available]low00hydrochloridebone density conservation agent;
estrogen antagonist;
estrogen receptor modulator
nefazodone hydrochloride[no description available]low00hydrochloride
mk 458[no description available]low00hydrochlorideanticonvulsant;
antiparkinson drug;
dopamine agonist
gemcitabine hydrochloride[no description available]low00hydrochloride;
organofluorine compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral drug;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
immunosuppressive agent;
radiosensitizing agent
alosetron hydrochloride[no description available]low00hydrochlorideantiemetic;
serotonergic antagonist
ziprasidone hydrochloride[no description available]low00hydrate;
hydrochloride
naratriptan hydrochloride[no description available]low00hydrochloride
tirofiban hydrochloride[no description available]low00hydrochloride
phenylhydrazine hydrochloride[no description available]low00hydrochloride
fluoxetine hydrochloride[no description available]low00hydrochloride;
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
paroxetine hydrochloride[no description available]low00hydrochlorideantidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor
propranolol hydrochloride[no description available]low00hydrochloride
diltiazem hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
calcium channel blocker;
vasodilator agent
venlafaxine hydrochloride[no description available]low00hydrochloride
trazodone hydrochloride[no description available]low00hydrochlorideadrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor
ciprofloxacin hydrochloride anhydrous[no description available]low00hydrochlorideantibacterial drug;
antiinfective agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
sertraline hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonin uptake inhibitor
tramadol hydrochloride[no description available]low00hydrochlorideadrenergic uptake inhibitor;
antitussive;
capsaicin receptor antagonist;
delta-opioid receptor agonist;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
muscarinic antagonist;
nicotinic antagonist;
NMDA receptor antagonist;
opioid analgesic;
serotonergic antagonist;
serotonin uptake inhibitor
amantadine hydrochloride[no description available]low00hydrochlorideantiviral agent;
dopamine agonist;
NMDA receptor antagonist
amodiaquine hydrochloride[no description available]low00hydrochlorideanticoronaviral agent
doxapram hydrochloride[no description available]low00hydrochloridecentral nervous system stimulant
bupivacaine hydrochloride[no description available]low00hydrochloride;
racemate		adrenergic antagonist;
amphiphile;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor;
local anaesthetic
spectinomycin dihydrochloride[no description available]low00hydrochlorideantibacterial drug;
antimicrobial agent
dobutamine hydrochloride[no description available]low00hydrochloridebeta-adrenergic agonist;
cardiotonic drug;
sympathomimetic agent
desipramine hydrochloride[no description available]low00hydrochloridedrug allergen
mefloquine hydrochloride[no description available]low00hydrochloride
ticlopidine hydrochloride[no description available]low00hydrochloride
thioridazine hydrochloride[no description available]low00hydrochloridefirst generation antipsychotic;
geroprotector
diphenylpyraline hydrochloride[no description available]low00hydrochloridecholinergic antagonist;
H1-receptor antagonist
trifluoperazine hydrochloride[no description available]low00hydrochloride
procainamide hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
siquil[no description available]low00hydrochlorideanticoronaviral agent
mepivacaine hydrochloride[no description available]low00hydrochloride;
piperidinecarboxamide		local anaesthetic
sotalol hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug;
beta-adrenergic antagonist
oxymetazoline hydrochloride[no description available]low00hydrochloridealpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
ay-20694[no description available]low00hydrochloride
alprenolol hydrochloride[no description available]low00hydrochloride
dyclonine hydrochloride[no description available]low00hydrochloridetopical anaesthetic
clomipramine hydrochloride[no description available]low00hydrochlorideanticoronaviral agent;
antidepressant;
serotonergic antagonist;
serotonergic drug
prazosin hydrochloride[no description available]low00hydrochloride
mianserin hydrochloride[no description available]low00hydrochloridegeroprotector
medetomidine hydrochloride[no description available]low00hydrochloride
lomefloxacin hydrochloride[no description available]low00hydrochlorideantimicrobial agent;
antitubercular agent;
photosensitizing agent
methixene hydrochloride[no description available]low00hydrate;
hydrochloride
pirenzepine dihydrochloride[no description available]low00hydrochloride
loperamide hydrochloride[no description available]low00hydrochlorideanticoronaviral agent;
antidiarrhoeal drug;
mu-opioid receptor agonist
talampicillin hydrochloride[no description available]low00hydrochloride
dipivefrin hydrochloride[no description available]low00hydrochlorideadrenergic agonist;
antiglaucoma drug;
sympathomimetic agent
uroxatral[no description available]low00hydrochloride
1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride[no description available]low00hydrochlorideEC 2.7.11.13 (protein kinase C) inhibitor
amperozide hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
dopamine uptake inhibitor;
geroprotector;
second generation antipsychotic;
serotonergic antagonist
eprazinone hydrochloride[no description available]low00hydrochloridemucolytic
irinotecan hydrochloride[no description available]low00hydrochlorideantineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
tiagabine hydrochloride[no description available]low00hydrochlorideanticonvulsant;
GABA reuptake inhibitor
diethylpropion hydrochloride[no description available]low00hydrochlorideappetite depressant
oxybutynin hydrochloride[no description available]low00hydrochloride
nimustine[no description available]low00hydrochlorideantineoplastic agent
cordium[no description available]low00hydrate;
hydrochloride
biperiden hydrochloride[no description available]low00hydrochloride;
piperidines;
tertiary alcohol		antiparkinson drug;
muscarinic antagonist;
parasympatholytic
prilocaine hydrochloride[no description available]low00hydrochloridelocal anaesthetic
moxifloxacin hydrochloride[no description available]low00hydrochlorideantibacterial drug
asl 8052[no description available]low00hydrochlorideanti-arrhythmia drug;
beta-adrenergic antagonist
vanoxerine[no description available]low00hydrochloridedopamine uptake inhibitor
methoctramine[no description available]low00hydrochloridemuscarinic antagonist
betaxolol hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
beta-adrenergic antagonist
fingolimod hydrochloride[no description available]low00hydrochlorideimmunosuppressive agent;
prodrug;
sphingosine-1-phosphate receptor agonist
pivmecillinam hydrochloride[no description available]low00hydrochloride
profenamine hydrochloride[no description available]low00hydrochlorideadrenergic antagonist;
antiparkinson drug;
histamine antagonist;
muscarinic antagonist
aminolevulinic acid hydrochloride[no description available]low00hydrochlorideantineoplastic agent;
dermatologic drug;
photosensitizing agent;
prodrug
1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
serotonergic agonist
ng-nitroarginine methyl ester[no description available]low00hydrochlorideEC 1.14.13.39 (nitric oxide synthase) inhibitor
cinacalcet hydrochloride[no description available]low00hydrochloridecalcimimetic;
P450 inhibitor
epinastine hydrochloride[no description available]low00hydrochloride
methyl 5-aminolevulinate hydrochloride[no description available]low00hydrochlorideantineoplastic agent;
dermatologic drug;
photosensitizing agent;
prodrug
fasudil hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
calcium channel blocker;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
neuroprotective agent;
nootropic agent;
vasodilator agent
ropivacaine[no description available]low00hydrochloridelocal anaesthetic
erlotinib hydrochloride[no description available]low00hydrochloride;
terminal acetylenic compound		antineoplastic agent;
protein kinase inhibitor
memantine hydrochloride[no description available]low00hydrochlorideantidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist
procyclidine hydrochloride[no description available]low00hydrochloride
l 778,123[no description available]low00hydrochlorideantineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor;
radiosensitizing agent
acebutolol hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent
dicyclomine hydrochloride[no description available]low00hydrochlorideantispasmodic drug;
muscarinic antagonist
flavoxate hydrochloride[no description available]low00hydrochlorideantispasmodic drug;
muscarinic antagonist;
parasympatholytic
eflornithine hydrochloride[no description available]low00hydrate;
hydrochloride
bacampicillin hydrochloride[no description available]low00hydrochloride
cocaine hydrochloride[no description available]low00hydrochloridecentral nervous system stimulant;
local anaesthetic
(1R,2S)-tranylcypromine hydrochloride[no description available]low00hydrochloride
ranitidine hydrochloride[no description available]low00hydrochloridedrug allergen
corlanor[no description available]low00hydrochloridecardiotonic drug
emetine dihydrochloride[no description available]low00hydrochlorideanticoronaviral agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
protein synthesis inhibitor
naftifine hydrochloride[no description available]low00allylamine antifungal drug;
hydrochloride
pibutidine hydrochloride[no description available]low00hydrochlorideanti-ulcer drug;
H2-receptor antagonist
terbinafine hydrochloride[no description available]low00allylamine antifungal drug;
hydrochloride		EC 1.14.13.132 (squalene monooxygenase) inhibitor;
P450 inhibitor
cis-flupenthixol dihydrochloride[no description available]low00hydrochloridegeroprotector
levobunolol hydrochloride[no description available]low00hydrochlorideantiglaucoma drug;
beta-adrenergic antagonist
phenylephrine hydrochloride[no description available]low00hydrochloride
nalbuphine hydrochloride[no description available]low00hydrochloride
lotensin[no description available]low00hydrochlorideEC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
tamsulosin hydrochloride[no description available]low00hydrochloridealpha-adrenergic antagonist;
antineoplastic agent
naloxone hydrochloride[no description available]low00hydrochlorideantidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
morphine chloride[no description available]low00hydrochloride
naltrexone hydrochloride[no description available]low00hydrochlorideantidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
triprolidine hydrochloride anhydrous[no description available]low00hydrochlorideH1-receptor antagonist
bromhexine hydrochloride[no description available]low00hydrochloridemucolytic
nab-365[no description available]low00hydrochloridebeta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
cyclizine hydrochloride[no description available]low00hydrochlorideantiemetic;
central nervous system depressant;
cholinergic antagonist;
H1-receptor antagonist
benoxinate hydrochloride[no description available]low00hydrochloridelocal anaesthetic
diphenoxylate hydrochloride[no description available]low00hydrochlorideantidiarrhoeal drug
protriptyline hydrochloride[no description available]low00hydrochlorideantidepressant
l 671152[no description available]low00hydrochloride;
organoammonium salt		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
rs 25259-197[no description available]low00hydrochlorideantiemetic;
serotonergic antagonist
vilazodone hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonergic agonist;
serotonin uptake inhibitor
2-methyl-6-(phenylethynyl)pyridine hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
metabotropic glutamate receptor antagonist
(R)-fluoxetine hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonin uptake inhibitor
(S)-fluoxetine hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonin uptake inhibitor
5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride[no description available]low00hydrochloride;
iminium salt		antineoplastic agent;
EC 2.4.2.4 (thymidine phosphorylase) inhibitor
hmr 1275[no description available]low00hydrochlorideantineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
jte 607[no description available]low00hydrochlorideanti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
cardioprotective agent;
CPSF3 inhibitor;
prodrug
a 77636[no description available]low00hydrochlorideantiparkinson drug;
dopamine agonist
n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride[no description available]low00aromatic ether;
hydrochloride;
methoxybenzenes;
tertiary amino compound		antipsychotic agent;
receptor modulator
u 18666a[no description available]low00hydrochlorideantiviral agent;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
Hedgehog signaling pathway inhibitor;
nicotinic antagonist;
sterol biosynthesis inhibitor
lurasidone hydrochloride[no description available]low00hydrochlorideadrenergic antagonist;
dopaminergic antagonist;
second generation antipsychotic;
serotonergic antagonist
zm 252868[no description available]low00hydrochlorideEC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
epidermal growth factor receptor antagonist
GR 127935 hydrochloride[no description available]low00hydrochlorideserotonergic antagonist
nebivolol hydrochloride[no description available]low00hydrochloride
n,n'-dibenzhydrylethane-1,2-diamine dihydrochloride[no description available]low00hydrochloridegeroprotector;
metabotropic glutamate receptor agonist;
neuroprotective agent
pipamperone dihydrochloride[no description available]low00hydrochloridedopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
brl 15572[no description available]low00hydrochlorideprodrug;
serotonergic antagonist
(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzodioxan hydrochloride[no description available]low00hydrochloridealpha-adrenergic antagonist
(2R,3S)-EHNA hydrochloride[no description available]low00hydrochlorideEC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride[no description available]low00hydrochloridedopamine uptake inhibitor
1-(2-(4-(4-fluoro-benzoyl)-piperidin-1-yl)-ethyl)-3,3-dimethyl-1,2-dihydro-indol-2-one[no description available]low00hydrochloridereceptor modulator;
serotonergic antagonist
glycinexylidide monohydrochloride[no description available]low00hydrochloride
new fuchsin[no description available]low00hydrochloridefluorochrome;
histological dye
3,6-diamino-10-methylacridinium chloride hydrochloride[no description available]low00hydrochlorideantibacterial agent;
antiseptic drug;
carcinogenic agent;
intercalator
GS4012[no description available]low00hydrochloride;
pyridinium salt		VEGF activator
nsc 23766[no description available]low00hydrochlorideantiviral agent;
apoptosis inducer;
EC 3.6.5.2 (small monomeric GTPase) inhibitor;
muscarinic antagonist
rs 39604[no description available]low00hydrochlorideserotonergic antagonist
nnc 55-0396[no description available]low00hydrochlorideangiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker
acridine yellow[no description available]low00aminoacridines;
hydrochloride		fluorochrome
pf-670462[no description available]low00hydrochlorideEC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
sapropterin dihydrochloride[no description available]low00hydrochloridecoenzyme;
diagnostic agent
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Infantile Paralysis0low10
Inflammation0low10
Innate Inflammatory Response0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10

Research Highlights

Bioavailability (2)

ArticleYear
Determination of BET Specific Surface Area of Hydrate-Anhydrate Systems Susceptible to Phase Transformation Using Inverse Gas Chromatography.
AAPS PharmSciTech, Aug-24, Volume: 23, Issue: 7		2022
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]