A macrocyclic lactone with a ring of twelve or more members derived from a polyketide.
| Member | Definition | Role |
|---|
| (7R)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one | | (7R)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one |
| 10-deoxymethynolide | A macrolide that consists of oxacyclododec-9-ene-2,8-dione bearing four methyl substituents at positions 3, 5, 7 and 11 as well as a hydroxy group at position 4 and an ethyl substituent at position 12. The aglycone of the macrolide antibiotic 10-deoxymethymycin. | 10-deoxymethynolide |
| acetylspiramycin | A macrolide antibiotic produced by various Streptomyces species. | spiramycin II |
| aigialomycin d | | (6E,12E)-8,9,16,18-tetrahydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaen-2-one |
| albocycline | | Albocycline |
| alpha-zearalenol | | alpha-Zearalenol |
| archazolid b | | Archazolid B |
| aspergillide a | A macrolide that is 4,15-dioxabicyclo[9.3.1]pentadec-9-en-3-one substituted by a hydroxy group at position 14 and a methyl group at position 5 (the 1R,5S,9E,11R,14S stereoisomer). It is isolated from the marine-derived fungus Aspergillus ostianus and exhibits cytotoxic activity against mouse lymphocytic leukemia cells (L1210). | aspergillide A |
| aspergillide b | A macrolide that is 4,15-dioxabicyclo[9.3.1]pentadec-9-en-3-one substituted by a hydroxy group at position 14 and a methyl group at position 5 (the 1S,5S,9E,11R,14S stereoisomer). It is isolated from the marine-derived fungus Aspergillus ostianus and exhibits cytotoxic activity against mouse lymphocytic leukemia cells (L1210). | aspergillide B |
| beta-zearalenol | | beta-Zearalenol |
| borrelidin | A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties. | borrelidin |
| bromophycolide a | A diterpenoid that is a macrolide isolated from the Fijian red alga Callophycus serratus. It has been found to exhibit moderate cytotoxicity against several human tumour cell lines via specific apotopic cell death. It also displays anti-HIV, antibacterial, antifungal and antimalarial activity. | bromophycolide A |
| ce-108 | | CE-108 |
| cruentaren a | | Cruentaren A |
| dehydrocurvularin | | alpha,beta-Dehydrocurvularin |
| demycarosylturimycin h | A macrolide antibiotic produced by various Streptomyces species that is used to treat toxoplasmosis and various other infections of soft tissues. | spiramycin I |
| doramectin | | Doramectin |
| ecklonialactone a | | Ecklonialactone A |
| ethylene brassylate | | Ethylene brassylate |
| euonine | A sesquiterpene alkaloid that has been isolated from Tripterygium wilfordii and exhibits immunosuppressive and insecticidal properties. It was found to be identical with euonine, previously isolated from Euonymous sieboldiana. | wilformine |
| exaltolide | | Cyclopentadecanolide |
| filipin | A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis. | filipin III |
| fr 148083 | A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB. | 5Z-7-oxozeaenol |
| goniodomin a | | Goniodomin A |
| hexadecanolide | | 16-Hexadecanolide |
| hypothemycin | A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells. | hypothemycin |
| iejimalide b | A macrolide that is isolated from the marine tunicate Eudistoma cf. rigida and exhibits potent in vitro cytotoxic activity. | lejimalide B |
| iriomoteolide-1a | | Iriomoteolide 1a |
| isomigrastatin | | Isomigrastatin |
| kujimycin b | | Lankamycin |
| l 683590 | A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties. | ascomycin |
| lactimidomycin | | Lactimidomycin |
| latrunculin a | A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. | latrunculin A |
| latrunculin b | A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica. | latrunculin B |
| latrunculol a | | latrunculol A |
| laulimalide | A macrolide with formula C30H42O7 that is isolated from the marine sponges, Cacospongia mycofijiensis and Hyattella sp. | laulimalide |
| lienomycin | | Lienomycin |
| LL-Z1640-1 | | LL-Z1640-1 |
| ly-146032 | A polypeptide comprising N-decanoyltryptophan, asparagine, aspartic acid, threonine, glycine, ornithine, aspartic acid, D-alanine, aspartic acid, glycine, D-serine, threo-3-methylglutamic acid and 3-anthraniloylalanine (also known as kynurinine) coupled in sequence and lactonised by condensation of the carboxylic acid group of the 3-anthraniloylalanine with the alcohol group of the threonine residue. | daptomycin |
| methylamphotericin b | The methyl ester of amphotericin B. | amphotericin B methyl ester |
| mirosamicin | | Mycinamicin II |
| musk | | (Z)-7-Hexadecen-1,16-olide |
| mycolactone | | Mycolactone |
| platyphylline | | Platyphylline |
| protylonolide | A 16-membererd macrolide that is the aglycone of the antibiotic 5-O-beta-D-mycaminosyltylactone. | tylactone |
| pyrenophorol | | Pyrenophorol |
| retrorsine | | Retrorsine |
| rimocidin | | Rimocidine |
| roxithromycin | Semisynthetic derivative of erythromycin A. | roxithromycin |
| senkirkine | | Senkirkine |
| soraphen a | A macrolide and an agent highly effective against plant-pathogenic fungi. It was extensively researched for agricultural use until it was discovered to be a teratogen. | soraphen A |
| streptogramin a | A macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus. | pristinamycin IIA |
| taleranol | | beta-Zearalanol |
| umirolimus | | Umirolimus |
| Zearalanone | | Zearalanone |
| zearalenone | A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species. | zearalenone |
| zeranol | | alpha-Zearalanol |
| zk-219477 | | Sagopilone |
| zotarolimus | | zotarolimus |