A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically.
ChEBI ID: 35678
| Member | Definition | Class |
|---|---|---|
| 2-(2-aminoethyl)pyridine | An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2. | 2-pyridylethylamine |
| 2-methylhistamine | An aralkylamino compound that is histamine bearing a methyl substituent at the 2 position on the ring. | 2-methylhistamine |
| 4-methylhistamine | An aralkylamino compound that is histamine bearing a methyl substituent at the 5 position on the ring. | 4-methylhistamine |
| betazole | Pyrazole in which a hydrogen adjacent to one of the nitrogen atoms is substituted by a 2-aminoethyl group. It is a histamine H2-receptor agonist used clinically to test gastric secretory function. | betazole |
| histamine phosphate | A phosphate salt that is the diphosphate salt of histamine. | histamine phosphate |
| mianserin | A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere. | mianserin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 951 (32.99) | 18.7374 |
| 1990's | 573 (19.88) | 18.2507 |
| 2000's | 737 (25.56) | 29.6817 |
| 2010's | 579 (20.08) | 24.3611 |
| 2020's | 43 (1.49) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 561 (17.76%) | 5.53% |
| Reviews | 226 (7.15%) | 6.00% |
| Case Studies | 464 (14.69%) | 4.05% |
| Observational | 5 (0.16%) | 0.25% |
| Other | 1,903 (60.24%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 41.2752 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 37.6505 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 28.1359 | 7 | 7 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.0120 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 23.9341 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 30.9008 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.8692 | 2 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 27.9753 | 6 | 6 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 31.6704 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 34.5344 | 2 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 20.4933 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 37.2212 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 27.3116 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 26.8325 | 3 | 3 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.6403 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0775 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 70.5246 | 3 | 3 |
| polyprotein | Zika virus | Potency | 37.2212 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.1739 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 14.0154 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.3981 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 2.9360 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.7260 | 3 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 2.9360 | 2 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.7195 | 4 | 4 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | IC50 | 0.3802 | 2 | 2 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.8400 | 2 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.8400 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0110 | 3 | 3 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0070 | 11 | 13 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0065 | 5 | 5 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0073 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0046 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0042 | 3 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0043 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0048 | 6 | 8 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0035 | 4 | 4 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | IC50 | 1.4125 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 0.2520 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | IC50 | 1.4125 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | Ki | 0.2520 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0012 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0006 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0475 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 0.1148 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 2.7097 | 3 | 3 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0816 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.1630 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.1610 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 0.4074 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1900 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0750 | 3 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3800 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0750 | 3 | 4 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0830 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3800 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0410 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0750 | 3 | 4 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0213 | 3 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0104 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0620 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0260 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0240 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0620 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.0661 | 4 | 4 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0149 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0620 | 1 | 1 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | Ki | 0.5000 | 1 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 46.8200 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | Ki | 1.4200 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.5430 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.2710 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 7.0795 | 2 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5481 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 2.1970 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.9427 | 2 | 3 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 3.8904 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 2.8410 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 1.5240 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 3.3113 | 2 | 2 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0631 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0631 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | IC50 | 0.1148 | 1 | 1 |
| G-protein coupled receptor | Apis mellifera (honey bee) | IC50 | 73.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.6307 | 3 | 4 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.7554 | 2 | 5 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 2,103,190,000.0006 | 3 | 3 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 6,309,570,000.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.8800 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.0080 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 4.4676 | 2 | 2 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 6.3096 | 1 | 1 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 2.3377 | 2 | 5 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 1.4230 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.3430 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.0780 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.3830 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 1.4050 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.2980 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 2.0660 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2880 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 1.9000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.2300 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.1630 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.1610 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 2.0680 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.0980 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0220 | 1 | 2 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.1010 | 1 | 1 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | Ki | 0.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Kd | 0.3981 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 1.9740 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 1.9740 | 2 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 1.9740 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 1.0958 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 1.0958 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 1.0958 | 2 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | EC50 | 8.3216 | 2 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | EC50 | 3.0232 | 2 | 2 |
| Histamine H3 receptor | Cavia porcellus (domestic guinea pig) | EC50 | 1.5849 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | EC50 | 12.4000 | 1 | 1 |
| Histamine H4 receptor | Homo sapiens (human) | EC50 | 1.0308 | 3 | 4 |
| Histamine H4 receptor | Mus musculus (house mouse) | EC50 | 1.5849 | 1 | 1 |
| Histamine H4 receptor | Rattus norvegicus (Norway rat) | EC50 | 2.5119 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Kb | 0.0300 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | KA | 15.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | KA | 15.0000 | 1 | 2 |
| Carbonic anhydrase | Candida albicans SC5314 | KA | 30.2000 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | KA | 24.0000 | 1 | 1 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ka | 40.0000 | 1 | 1 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ka | 11.2000 | 2 | 2 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | KA | 46.3000 | 1 | 1 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ka | 16.3000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | KA | 13.0000 | 11 | 11 |
| Carbonic anhydrase 12 | Homo sapiens (human) | KA | 0.6900 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | KA | 46.0000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | KA | 6.9000 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | KA | 11.9000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | KA | 15.0000 | 13 | 13 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ka | 1.1000 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | KA | 7.1300 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | KA | 7.6200 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | KA | 0.0940 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ka | 18.0000 | 2 | 2 |
| Carbonic anhydrase 7 | Homo sapiens (human) | KA | 27.8000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | KA | 0.0130 | 1 | 1 |
| Carbonic anhydrase-like protein, putative | Trypanosoma cruzi strain CL Brener | KA | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | KA | 27.8000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | K0.5 | 0.0003 | 1 | 2 |
| Plasma kallikrein | Homo sapiens (human) | KA | 0.0940 | 1 | 1 |