Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").
ChEBI ID: 22676
| Member | Definition | Class |
|---|---|---|
| 4-chloroindole-3-acetic acid | 4-chloroindole-3-acetic acid | |
| indole-3-acetonitrile | A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a 1H-indol-3-yl group. | indole-3-acetonitrile |
| indoleacetic acid | A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group. | indole-3-acetic acid |
| indolebutyric acid | A indol-3-yl carboxylic acid that is butanoic acid carrying a 1H-indol-3-yl substituent at position 1. | indole-3-butyric acid |
| indolepropionic acid | An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3. | 3-(1H-indol-3-yl)propanoic acid |
| phenylacetic acid | A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group. | phenylacetic acid |
| tryptophol | An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2. | tryptophol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 895 (21.74) | 18.7374 |
| 1990's | 425 (10.33) | 18.2507 |
| 2000's | 1,030 (25.02) | 29.6817 |
| 2010's | 1,359 (33.02) | 24.3611 |
| 2020's | 407 (9.89) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 33 (0.74%) | 5.53% |
| Reviews | 148 (3.32%) | 6.00% |
| Case Studies | 26 (0.58%) | 4.05% |
| Observational | 1 (0.02%) | 0.25% |
| Other | 4,250 (95.33%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 4.4668 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 48.9662 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.7082 | 4 | 4 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 23.6666 | 2 | 4 |
| BRCA1 | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.5474 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 42.0923 | 3 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 47.8777 | 3 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.1577 | 3 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 29.8493 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 27.5357 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 27.5357 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 14.9601 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 1.9494 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 96.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 253.0000 | 1 | 3 |
| Beta-lactamase | Klebsiella pneumoniae | IC50 | 480.0000 | 1 | 1 |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | IC50 | 757.0000 | 1 | 1 |
| Kynurenine--oxoglutarate transaminase 1 | Homo sapiens (human) | IC50 | 140.0000 | 2 | 2 |
| Metallo-beta-lactamase type 2 | Klebsiella pneumoniae | IC50 | 1,947.9200 | 1 | 2 |
| Peptide deformylase | Escherichia coli | IC50 | 1,000.0000 | 1 | 1 |
| Peptide deformylase 1A, chloroplastic/mitochondrial | Arabidopsis thaliana (thale cress) | IC50 | 1,000.0000 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 20,000.0000 | 1 | 1 |
| Tryptophan 2,3-dioxygenase | Mus musculus (house mouse) | IC50 | 80.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Beta-lactamase | Klebsiella pneumoniae | Kd | 430.0000 | 1 | 1 |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | Kd | 274.0000 | 1 | 1 |
| Metallo-beta-lactamase type 2 | Klebsiella pneumoniae | Kd | 800.1640 | 1 | 2 |
| Olfactory receptor class A-like protein 1 | Danio rerio (zebrafish) | EC50 | 30.5000 | 1 | 1 |
| Trp operon repressor | Escherichia coli K-12 | Kd | 23.3000 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | Kd | 50,000.0000 | 1 | 1 |