Page last updated: 2024-09-27

Post-Cardiac Arrest Syndrome

A reperfusion syndrome characterized by various pathophysiological processes after CARDIAC ARREST. It may include post-cardiac arrest brain injury (HYPOXIA-ISCHEMIA, BRAIN), cardiocirculatory dysfunction, (e.g., systemic ISCHEMIA), HYPERGLYCEMIA; MULTIPLE ORGAN FAILURE and delayed death.

Synonyms(3)

Synonym
Postresuscitation Disease
Post-Cardiac Arrest Syndrome
Postcardiac Arrest Syndrome

Research

Studies (14)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's4 (28.57)28.8240
2020's10 (71.43)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbon monoxide0low10
hydrogen sulfide0low10
lactic acid0medium21
hydrogen0low10
thyroxine0medium11
glutamine0medium11
tyrosine0low10
argon0low10
helium0low10
xenon0low10
glutamic acid0medium11
fluorodeoxyglucose f180low10
3-nitrotyrosine0low10
resveratrol0low10
iloprost0medium11
atractyloside0low10
sodium lactate0low10
cardiovascular agents0low10
ascorbic acid0medium11
cyclosporine0low10

Protein Targets (392)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
phosphopantetheinyl transferase2002
bromodomain adjacent to zinc finger domain 2B1001
euchromatic histone-lysine N-methyltransferase 26006
pyruvate kinase PKM isoform a1001
geminin3003
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G1001
Tubulin--tyrosine ligase0202
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase2002
RAR-related orphan receptor gamma4004
GLI family zinc finger 32002
AR protein4004
thioredoxin glutathione reductase1001
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha4004
estrogen nuclear receptor alpha7007
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH12002
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 23003
nuclear factor erythroid 2-related factor 2 isoform 13003
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lethal factor (plasmid)1001
lamin isoform A-delta103003
Polyphenol oxidase 20203
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Alpha-2B adrenergic receptor0011
Spike glycoprotein2002
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial2002
thioredoxin reductase4004
GLS protein3003
TDP1 protein3003
regulator of G-protein signaling 42002
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Carbonic anhydrase 10205
Carbonic anhydrase 20306
Integrin beta-32013
Integrin alpha-IIb2013
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 21214
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0214
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0003
Glutamate receptor ionotropic, NMDA 2D0214
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0214
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0214
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial1001
arylsulfatase A2002
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 12002
flap endonuclease 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
ATP-dependent phosphofructokinase2002
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 40304
Carbonic anhydrase 60203
Carbonic anhydrase 5A, mitochondrial0304
Carbonic anhydrase0102
Carbonic anhydrase 70203
Carbonic anhydrase 90304
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0102
Transient receptor potential cation channel subfamily A member 10112
Carbonic anhydrase 130101
Carbonic anhydrase 5B, mitochondrial0203
Prostaglandin E2 receptor EP1 subtype0011
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP2 subtype0011
Prostacyclin receptor0213
Prostacyclin receptor0112
Solute carrier organic anion transporter family member 2A10001
Prostaglandin D2 receptor0011
estrogen receptor 2 (ER beta)2002
cytochrome P450 2D62002
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
cellular tumor antigen p53 isoform a2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Beta-lactamase1001
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Luciferase1001
BRCA11001
ClpP1001
SMAD family member 21001
ATAD5 protein, partial1001
SMAD family member 31001
Microtubule-associated protein tau1001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor1001
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor1001
pregnane X nuclear receptor2002
G2002
67.9K protein1001
Parkin1001
P531001
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
pyruvate kinase1001
caspase-31001
M18 aspartyl aminopeptidase0101
cathepsin L10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
Histone H2A.x1001
lysosomal alpha-glucosidase preproprotein1001
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
thyroid hormone receptor beta isoform a2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
histone deacetylase 9 isoform 31001
glucokinase regulatory protein1001
huntingtin isoform 21001
DNA polymerase beta1001
atrial natriuretic peptide receptor 2 precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 10011
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
FAD-linked sulfhydryl oxidase ALR0001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 11001
DNA polymerase kappa isoform 12002
Vif0101
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Gamma-aminobutyric acid receptor subunit pi1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Acetylcholinesterase0101
Carbonic anhydrase 120102
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Voltage-dependent calcium channel gamma-2 subunit1001
Tyrosine-protein kinase ABL10102
Myc proto-oncogene protein0102
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Transthyretin0113
Estrogen receptor0101
Cellular tumor antigen p532002
Cytochrome P450 1A10101
Amyloid-beta precursor protein0112
Cytochrome P450 1A20101
Prostaglandin G/H synthase 10112
Tyrosine-protein kinase Lck0101
Cholinesterase0101
Cathepsin D0101
Carbonic anhydrase 30102
Aldo-keto reductase family 1 member B10202
ATP-dependent translocase ABCB10102
Luciferin 4-monooxygenase0101
Cytochrome P450 3A40202
Neuronal acetylcholine receptor subunit alpha-40101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0102
Tyrosinase0202
Aromatase0202
Cytochrome P450 2C9 0101
Ornithine decarboxylase0101
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit beta-11001
Ribosyldihydronicotinamide dehydrogenase [quinone]0213
Protein kinase C alpha type0011
Tyrosine-protein phosphatase non-receptor type 10101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
5-hydroxytryptamine receptor 1A0001
Estrogen receptor0011
Nuclear factor NF-kappa-B p105 subunit0101
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Amine oxidase [flavin-containing] A0101
Endothelin receptor type B1001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Sucrase-isomaltase, intestinal0101
Sodium-dependent noradrenaline transporter 0213
Endothelin-1 receptor1001
Amine oxidase [flavin-containing] B0101
Dipeptidyl peptidase 40101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Gamma-aminobutyric acid receptor subunit alpha-61001
Cytochrome P450 2C190101
Prostaglandin G/H synthase 20101
Cannabinoid receptor 10101
Histamine H2 receptor1001
D(1A) dopamine receptor1001
Nuclear receptor ROR-gamma1001
Alpha-glucosidase MAL120101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Prostaglandin G/H synthase 20101
Cholinesterase0101
Inositol monophosphatase 11001
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0001
Bcl-2-like protein 10101
Serine/threonine-protein kinase PAK 10101
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
N1L 0101
NAD(P)H dehydrogenase [quinone] 10002
Tubulin beta-2B chain0101
Lysosomal alpha-glucosidase0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20011
Carbonic anhydrase 130101
Rap guanine nucleotide exchange factor 41001
GABA theta subunit1001
Inositol hexakisphosphate kinase 12002
NAD-dependent protein deacetylase sirtuin-10013
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Carbonic anhydrase 150102
Gamma-aminobutyric acid receptor subunit epsilon1001
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Carbonic anhydrase 140102
Zinc finger protein mex-50011
cytochrome P450 2C9, partial2002
large T antigen0101
Monocarboxylate transporter 40001
Monocarboxylate transporter 20001
Monocarboxylate transporter 10001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
USP1 protein, partial1001
apical membrane antigen 1, AMA11001
EWS/FLI fusion protein1001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]