Compounds > 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone
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2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone

Description

2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135400486
CHEMBL ID390195
SCHEMBL ID800974
MeSH IDM0332305

Synonyms (22)

Synonym
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone
n'-[(e)-(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide
CHEMBL390195 ,
2-hydroxy-1 naphthylaldehydeisonicotinoyl hydrazone
AKOS001279162
n'-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide
EN300-55000
isonicotinic acid, [(2-hydroxy-1-naphthalenyl)methylene]hydrazide
n-[(e)-(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide
S5772
SCHEMBL800974
bdbm50484830
as8351, >=98% (hplc)
n'-[(2-hydroxy-1-naphthyl)methylene]isonicotinohydrazide
(e)-n'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
Z49547268
329183-01-9
HY-100744
CS-7838
n-[(e)-(2-hydroxynaphthalen-1-yl)methylideneamino]pyridine-4-carboxamide
n'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
mfcd00033110
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)100.00000.00011.076810.0000AID649483
Integrase Human immunodeficiency virus 1IC50 (µMol)100.00000.00051.544310.0000AID725310; AID725311
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID725313Inhibition of human Flag-tagged LEDGF interaction to His6-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins measured after 1 hr by AlphaScreen proximity luminescent assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID619952Toxicity in human SK-N-MC cells assessed as cell viability after 3 hrs by trypan blue staining2011Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
AID1317567Selectivity index, ratio of IC50 for rat L8 cells to IC50 for human SK-N-MC cells2016European journal of medicinal chemistry, Sep-14, Volume: 120Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
AID303517Inhibition of cellular iron uptake from 59Fe]transferrin in human SK-N-MC cells at 50 uM relative to control2007Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
AID716228Inhibition to 59Fe uptake from 59Fe-transferrin in human SK-N-MC cells at 25 uM after 3 hrs2012Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
AID292409Inhibition of iron uptake from transferrin in SK-N-MC cells at 50 uM relative to control2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
AID1317563Antiproliferative activity against rat L8 cells after 22 to 72 hrs by MTT assay2016European journal of medicinal chemistry, Sep-14, Volume: 120Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
AID312542Induction of intracellular iron mobilization in human SK-MN-C cells relative to control2008Journal of medicinal chemistry, Jan-24, Volume: 51, Issue:2
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
AID619948Induction of Fe efflux in human SK-N-MC cells assessed as release of intracellular 59Fe up to 25 uM after 3 hrs by gamma-scintillation counting2011Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
AID725311Inhibition of wild type HIV1 integrase 3'-processing activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID1317566Selectivity index, ratio of IC50 for HUVEC to IC50 for human SK-N-MC cells2016European journal of medicinal chemistry, Sep-14, Volume: 120Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
AID649483Inhibition of ribonuclease H activity of HIV1 reverse transcriptase using as poly(dC)-[3H]poly(rG) as substrate2012European journal of medicinal chemistry, Apr, Volume: 50Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.
AID439759Antiproliferative activity against human SK-N-MC cells after 96 hrs by MTT assay2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
AID292406Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
AID312543Inhibition of [59Fe]uptake from human transferrin in SK-MN-C cells relative to control2008Journal of medicinal chemistry, Jan-24, Volume: 51, Issue:2
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
AID312544Antiproliferative activity against human SK-MN-C cells by MTT assay2008Journal of medicinal chemistry, Jan-24, Volume: 51, Issue:2
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
AID303516Effect on iron efflux in human SK-N-MC cells assessed as cellular iron release2007Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
AID677905Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
AID619949Inhibition of 59Fe uptake from transferrin in human SK-N-MC cells at 25 uM after 3 hrs relative to control2011Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
AID716220Antiproliferative activity at human A549 cells after 72 hrs by MTT assay2012Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
AID1317562Antiproliferative activity against human SK-N-MC cells after 22 to 72 hrs by MTT assay2016European journal of medicinal chemistry, Sep-14, Volume: 120Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
AID725310Inhibition of wild type HIV1 integrase strand transfer activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID716219Antiproliferative activity at human MRC5 cells after 72 hrs by MTT assay2012Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
AID1763360Antimalarial activity against Plasmodium falciparum 7G82021Bioorganic & medicinal chemistry, 06-01, Volume: 39A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.
AID716221Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay2012Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
AID1317564Antiproliferative activity against HUVEC after 22 to 72 hrs by MTT assay2016European journal of medicinal chemistry, Sep-14, Volume: 120Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
AID439762Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
AID722575Cytotoxicity against human SK-N-MC cells assessed as growth inhibition after 72 hrs by MTT assay2013Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
AID303514Antiproliferative activity against human SK-N-MC cells by MTT assay2007Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
AID716222Induction of 59Fe mobilization in human SK-N-MC cells at 25 uM after 3 hrs by gamma-scintillation counter2012Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
AID619945Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTS assay2011Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
AID370485Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
AID439761Antiproliferative activity against human SK-N-MC cells2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
AID716225Antiproliferative activity at human SK-N-MC cells after 72 hrs by MTT assay2012Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (8.70)18.2507
2000's11 (47.83)29.6817
2010's9 (39.13)24.3611
2020's1 (4.35)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyridoxal
[no description available]		210hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.3110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
deferiprone
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.		3.55204-pyridonesiron chelator;
protective agent
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		5.22150acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
hydroxyurea
[no description available]		210one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		3.82110carbohydrazideantitubercular agent;
drug allergen
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		2.1310ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
etoposide
[no description available]		2.0710beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		2.0710organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
efavirenz
efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.		2.0710acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.03101,2,3-triazole
deferasirox
Deferasirox: A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.. deferasirox : A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.		2.0310benzoic acids;
monocarboxylic acid;
phenols;
triazoles		iron chelator
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.4220actinomycinmutagen
2-pyridylcarboxaldehyde benzoylhydrazone
2-pyridylcarboxaldehyde benzoylhydrazone: structure in first source		2.0410
1,3,5-triphenylformazan
1,3,5-triphenylformazan: structure in first source		2.0810
2-pyridylcarboxaldehyde isonicotinoylhydrazone
2-pyridylcarboxaldehyde isonicotinoylhydrazone: structure in first source		2.0410
2-acetylpyridine thiosemicarbazone
2-acetylpyridine thiosemicarbazone: RN given refers to parent cpd		3.5520
2-pyridinecarboxaldehyde-1-oxide-3,4-dimethoxybenzene sulfonylhydrazone
2-pyridinecarboxaldehyde-1-oxide-3,4-dimethoxybenzene sulfonylhydrazone: structure given in first source		2.0710
2-acetylpyridine-4-methyl-3-thiosemicarbazone
[no description available]		2.0510
6-(1-(4-fluorophenyl)methyl-1h-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acid ethyl ester
[no description available]		2.0710
3-aminopyridine-2-carboxaldehyde thiosemicarbazone
3-aminopyridine-2-carboxaldehyde thiosemicarbazone: a neuroprotective agent; structure given in first source		4.3960
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone
[no description available]		4.7690
di-2-pyridyl ketone isonicotinoyl hydrazone
di-2-pyridyl ketone isonicotinoyl hydrazone: a chelating agent; structure in first source		2.0410
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0110ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
salinazid
[no description available]		2.1310aromatic carboxylic acid;
pyridinemonocarboxylic acid
salicylaldehyde benzoyl hydrazone
salicylaldehyde benzoyl hydrazone: structure given in first source		2.0310
pyridoxal isonicotinoyl hydrazone
pyridoxal isonicotinoyl hydrazone: acts as iron chelating agent		4.3860
ConditionIndicatedRelationship StrengthStudiesTrials
Iron Overload
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)		02.0410
Benign Neoplasms
[description not available]		02.4920
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.4920
Cancer of Lung
[description not available]		02.0710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0710
Co-infection
[description not available]		02.1310
Koch's Disease
[description not available]		02.1310
HIV Coinfection
[description not available]		02.1310
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.1310
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).		02.1310
Anemias, Iron-Deficiency
[description not available]		02.0310
Anemia, Iron-Deficiency
Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.		02.0310
(pPNET) Peripheral Primitive Neuroectodermal Tumors
[description not available]		0210
Neuroectodermal Tumors, Primitive, Peripheral
A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.		0210