Endocardial Fibroelastosis

A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.

Synonyms(2)

Synonym
Endocardial Fibroelastosis
Endomyocardial Fibroelastosis

Research Excerpts

Overview

Excerpt	Reference
"Endomyocardial fibroelastosis is a rare disorder marked by characteristic morphological changes of the endocardium."	( Mehta, R; Pennell, DJ; Raman, SV; Walker, J, 2005)

Research

Studies (81)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	59 (72.84)	23.3326
1990's	7 (8.64)	12.5806
2000's	8 (9.88)	18.1394
2010's	4 (4.94)	28.8240
2020's	3 (3.70)	9.53

Drug	Relationship Strength	Studies	Trials
carnitine	low	4	0
chlorine	low	1	0
nitrous oxide	low	1	0
hydroxyindoleacetic acid	low	2	0
verapamil	low	1	0
carvedilol	medium	1	1
chlorothiazide	low	2	0
chlorpromazine	low	1	0
diethylcarbamazine	low	1	0
berotek	low	1	0
furosemide	low	1	0
hydralazine	low	1	0
hydrochlorothiazide	low	1	0
indomethacin	low	1	0
losartan	low	1	0
meperidine	low	2	0
potassium chloride	low	1	0
procainamide	low	1	0
promethazine	low	1	0
prednisolone	low	1	0
prednisone	low	8	0
pilocarpine	low	1	0
methylprednisolone	low	1	0
methysergide	low	2	0
betamethasone	low	1	0
streptomycin	low	1	0
technetium	low	1	0
trolamine salicylate	low	3	0
4-methoxyamphetamine	low	2	0
du-21220	low	1	0
angiotensin ii	low	1	0
lanatosides	low	1	0
glycogen	low	4	0
elastin	low	5	0
inositol 3-phosphate	low	1	0
quinidine	low	1	0
digitoxin	low	7	0
digoxin	low	7	0
gadolinium dtpa	low	1	0
enerbol	low	1	0
atrial natriuretic factor	low	2	0
glucagon	low	1	0
sodium pertechnetate tc 99m	low	1	0
sodium ethylxanthate	low	1	0
cardiovascular agents	low	1	0
natriuretic peptide, brain	medium	2	1
ascorbic acid	low	1	0
phenprocoumon	low	1	0
transforming growth factor beta	low	3	0

Protein Targets (611)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	12	1	13
5-hydroxytryptamine receptor 1B	0	11	1	12
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	8	1	9
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
glucocerebrosidase	4	0	0	4
DNA polymerase kappa isoform 1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	4	2	6
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	4	3	9
Type-2 angiotensin II receptor	0	4	0	4
Type-2 angiotensin II receptor	0	3	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	8	0	0	8
RAR-related orphan receptor gamma	11	0	0	11
GLI family zinc finger 3	15	0	0	15
AR protein	17	0	0	17
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
glucocorticoid receptor [Homo sapiens]	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen-related nuclear receptor alpha	15	0	0	15
estrogen nuclear receptor alpha	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
IDH1	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
chromobox protein homolog 1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
thyroid hormone receptor beta isoform 2	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	10	0	0	10
lethal factor (plasmid)	3	0	0	3
lamin isoform A-delta10	13	0	0	13
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	1	9
Spike glycoprotein	11	2	2	15
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
glp-1 receptor, partial	3	0	0	3
thioredoxin reductase	8	0	0	8
GLS protein	7	0	0	7
beta-2 adrenergic receptor	1	0	0	1
Bile salt export pump	0	19	0	19
Beta-2 adrenergic receptor	0	3	2	5
Beta-2 adrenergic receptor	0	1	1	2
ATP-dependent phosphofructokinase	7	0	0	7
pregnane X receptor	2	0	0	2
progesterone receptor	11	0	0	11
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	11	0	0	11
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
thyroid hormone receptor beta isoform a	5	0	0	5
galanin receptor type 3	0	1	0	1
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glutamate receptor 2	7	0	0	7
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Canalicular multispecific organic anion transporter 1	0	13	0	13
ORF73	0	0	2	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
phosphopantetheinyl transferase	4	0	0	4
ATAD5 protein, partial	6	0	0	6
Microtubule-associated protein tau	4	0	0	4
EWS/FLI fusion protein	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
arylsulfatase A	6	0	0	6
lysosomal alpha-glucosidase preproprotein	2	0	0	2
D(1A) dopamine receptor	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
short transient receptor potential channel 6 isoform 1	0	0	1	1
Toll-like receptor 4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 1	0	9	0	11
5-hydroxytryptamine receptor 4	0	10	0	10
Potassium channel subfamily K member 2	0	2	0	2
Amyloid-beta precursor protein	0	1	0	1
Aldo-keto reductase family 1 member B1	0	6	0	6
ATP-dependent translocase ABCB1	0	8	1	20
Beta-1 adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	10	0	10
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Angiotensin-converting enzyme	0	4	0	4
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	8	0	9
Alpha-2C adrenergic receptor	0	6	0	6
D(1A) dopamine receptor	0	8	0	9
UDP-glucuronosyltransferase 1A1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	6	0	6
Alpha-1D adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	10	0	10
5-hydroxytryptamine receptor 2C	0	10	0	10
D(3) dopamine receptor	0	10	0	11
5-hydroxytryptamine receptor 2B	0	10	0	10
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	8	0	8
Potassium channel subfamily K member 10	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Cytochrome P450 1B1	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
Ataxin-2	9	0	0	9
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	5	0	6
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	4	0	0	4
USP1 protein, partial	4	0	0	4
NFKB1 protein, partial	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
regulator of G-protein signaling 4	7	0	0	7
nonstructural protein 1	2	0	0	2
Bloom syndrome protein isoform 1	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
GABA theta subunit	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	2	0	0	2
TDP1 protein	12	0	0	12
Thrombopoietin	2	0	0	2
Smad3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
NADPH oxidase 1	0	1	0	1
retinoid X nuclear receptor alpha	8	0	0	8
G	7	0	0	7
cytochrome P450 2D6	4	0	0	4
polyprotein	2	0	0	2
67.9K protein	5	0	0	5
peroxisome proliferator-activated receptor delta	5	0	0	5
peroxisome proliferator activated receptor gamma	8	0	0	8
Snq2p	0	0	0	2
caspase-3	1	0	0	1
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
Histone H2A.x	3	0	0	3
Caspase-7	2	0	0	2
Spike glycoprotein	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
vitamin D3 receptor isoform VDRA	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	5	0	0	5
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	3	0	0	3
M-phase phosphoprotein 8	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	2	2	4
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Bile salt export pump	0	4	0	4
Epidermal growth factor receptor	0	2	0	2
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Albumin	0	4	3	7
Albumin	0	0	1	1
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	8	0	0	8
Major prion protein	0	0	1	1
Integrin beta-3	3	0	0	3
Cytochrome P450 1A2	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	3	2	5
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M1	0	3	0	4
Muscarinic acetylcholine receptor M3	0	3	0	4
Muscarinic acetylcholine receptor M4	0	3	0	4
Integrin alpha-IIb	3	0	0	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	3	0	4
Muscarinic acetylcholine receptor M5	0	5	0	5
Replicase polyprotein 1a	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Replicase polyprotein 1ab	0	4	2	6
Cytochrome P450 2D6	0	4	1	5
Muscarinic acetylcholine receptor M2	0	3	0	4
Muscarinic acetylcholine receptor M1	0	5	2	7
Cytochrome P450 2C9	0	7	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	0	4
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	3
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Histamine H2 receptor	0	6	0	6
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	2	0	2
Histamine H1 receptor	0	1	1	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	4	0	4
Mu-type opioid receptor	0	3	1	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	3	0	3
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	5	0	0	5
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 7	0	4	0	4
Cytochrome P450 2J2	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	3	0	4
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Angiotensin-converting enzyme 2	0	2	2	4
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	7	0	0	7
Chain A, Cruzipain	5	0	0	5
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
STAT3, partial	0	2	0	2
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
interleukin 8	2	0	0	2
PAX8	0	0	0	2
PPM1D protein	2	0	0	2
alpha-galactosidase	3	0	0	3
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Cytochrome P450 3A4	0	3	0	3
ATP-dependent translocase ABCB1	0	3	0	4
Nuclear receptor ROR-gamma	3	1	1	5
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	5	0	5
Solute carrier organic anion transporter family member 1B1	0	7	0	7
Beta-2 adrenergic receptor	0	1	0	1
Beta-3 adrenergic receptor	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
thyrotropin-releasing hormone receptor	1	0	0	1
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	2	0	3
Carbonic anhydrase 3	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Carbonic anhydrase 6	0	2	0	3
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	4
Carbonic anhydrase 7	0	2	0	3
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	3	0	4
Carbonic anhydrase 13	0	2	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	2	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	1	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Luciferase	3	0	0	3
Parkin	2	0	0	2
pyruvate kinase	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Carbonic anhydrase	0	1	0	1
Hsf1 protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
cytochrome P450 2C9 precursor	4	0	0	4
Delta-type opioid receptor	0	3	0	3
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
endonuclease IV	2	0	0	2
hypothetical protein, conserved	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Adenosine receptor A1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	3	1	5
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Platelet glycoprotein VI	0	1	1	3
Type-1 angiotensin II receptor	0	1	1	2
Liver carboxylesterase 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
dopamine D1 receptor	1	0	0	1
DNA polymerase III, partial	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
flap endonuclease 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	2	0	2
cytochrome P450 2C19 precursor	2	0	0	2
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 1	0	4	0	5
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
huntingtin isoform 2	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Histidine-rich protein PFHRP-II	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Cholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	2	0	2
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Cytochrome P450 2C8	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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