An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of nicotinamidase (EC 3.5.1.19).
ChEBI ID: 84264
| Member | Definition | Class |
|---|---|---|
| niacin | A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group. | nicotinic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 7,110 (66.54) | 18.7374 |
| 1990's | 747 (6.99) | 18.2507 |
| 2000's | 1,172 (10.97) | 29.6817 |
| 2010's | 1,327 (12.42) | 24.3611 |
| 2020's | 329 (3.08) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 462 (3.86%) | 5.53% |
| Reviews | 812 (6.78%) | 6.00% |
| Case Studies | 388 (3.24%) | 4.05% |
| Observational | 6 (0.05%) | 0.25% |
| Other | 10,306 (86.07%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 28.4000 | 2 | 2 |
| Cholesteryl ester transfer protein | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 1,125.0000 | 1 | 1 |
| D-aspartate oxidase | Homo sapiens (human) | IC50 | 2,778.0000 | 1 | 1 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | IC50 | 4.3681 | 16 | 16 |
| Hydroxycarboxylic acid receptor 2 | Mus musculus (house mouse) | IC50 | 0.1400 | 3 | 3 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | Ki | 0.0787 | 3 | 3 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Nicotinamidase | Saccharomyces cerevisiae S288C | Ki | 2,000.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 518.2300 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C9 | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | EC50 | 0.7757 | 27 | 30 |
| Hydroxycarboxylic acid receptor 2 | Mus musculus (house mouse) | EC50 | 0.1093 | 3 | 3 |
| Hydroxycarboxylic acid receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 0.2493 | 3 | 3 |
| Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) | EC50 | 31.9526 | 3 | 3 |