Scleritis

Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.

Synonym
Scleritis

Excerpt	Reference
"Posterior scleritis is an often misdiagnosed disease of the eye."	( Mangouritsas, G; Ulbig, M, 1991)
"Posterior scleritis is a rare disease, the clinical signs of which may vary."	( Robertson, JE; Rosenbaum, JT, 1993)
"Posterior scleritis is an uncommon condition that usually occurs in adults and the diagnosis is often missed."	( Graham, EM; Stanford, MR; Woon, WH, 1995)
"Pseudomonal scleritis is a serious and potentially blinding infection that usually is resistant to medical management."	( Helm, CJ; Holland, GN; Maloney, RK; Mondino, BJ; Webster, RG, 1997)
"Episcleritis is a rare occurrence in childhood, especially in children younger than 5 years of age."	( Read, RW; Sherry, DD; Weiss, AH, 1999)
"Scleritis is a severe ocular inflammation, often associated with ocular complications, and nearly always treated with systemic medications."	( Dunn, JP; Jabs, DA; Marsh, MJ; Mudun, A, 2000)
"Scleritis is often associated with life-threatening systemic diseases and vision-threatening ocular complications."	( Dück, N; Heiligenhaus, A; Hudde, T; Koch, J; Michel, D; Steuhl, KP, 2003)
"Scleritis is a painful inflammation of the sclera that is often difficult to treat."	( Bauer, AM; Becker, MD; Fiehn, C, 2005)
"Aspergillus scleritis is a potentially devastating ocular infection difficult to treat because of poor scleral vascularity."	( Carpenter, J; Howell, A; Hurley, D; Midturi, J; Sierra-Hoffman, M; Winn, R, 2005)
"Posterior scleritis is most often observed in patients with no signs of associated systemic autoimmune disease."	( La Cava, M; Mannino, G; Pecorella, I; Pezzi, PP; Pinca, M, 2006)
"Anterior scleritis is defined as an inflammation of the sclera, located anteriorly to the equator of the eye."	( Besancenot, JF; Bielefeld, P; Bron, A; Muller, G; Vinit, J, 2006)
"Infectious scleritis is a particular risk in cases involving diabetes mellitus, prior scleritis, previous surgery, and immunosuppression."	( Chung, PC; Hsiao, CH; Huang, SC; Hwang, YS; Lin, HC; Ngan, KW; Tsai, YJ, 2007)
"Posterior scleritis is an unusual disease that may cause serious ocular inflammation and potentially blinding consequences."	( Ramirez-Ortiz, MA; Vasquez-Resendis, A, 2007)
"Uveitis and scleritis are the most serious ocular side effects of bisphosphonate therapy."	( French, DD; Margo, CE, 2008)
"Necrotizing scleritis is a rare complication of CA with MMC."	( Akova, YA; Borazan, M; Karalezli, A; Kucukerdonmez, C, 2010)
"Posterior scleritis is an often misdiagnosed eye disease."	( Alpay, A; Ugurbas, SC; Ugurbas, SH, 2012)
"Scleritis is a severe ocular inflammatory disease often associated with ocular complications."	( Los, LI; ten Dam-van Loon, NH; Wieringa, JE; Wieringa, WG, 2013)
"Scleritis is an inflammation of the outer eye coating that manifests with redness and ocular pain, and tends to be more severe when associated with a systemic collagen disease."	( Alrashidi, S; Krema, H; Yousef, YA, 2013)
"Syphilitic scleritis are relatively uncommon."	( Bonnel, S; Fénolland, JR; Froussart-Maille, F; Rambaud, C; Rigal-Sastourné, JC, 2016)
"Immune-mediated scleritis is a rare condition, and the information on the clinical course and complications is scarce."	( Bernauer, W; Brunner, M; Pleisch, B, 2014)
"Nodular anterior scleritis is an uncommon presentation of tuberculosis (TB)."	( Artaraz, J; del Rio, R; Fonollosa, A; Ruiz-Arruza, I; Silva-Ribeiro, AR; Vargas-Kelsh, JG, 2015)
"Episcleritis and scleritis are relatively rare ocular diseases, which are commonly associated with rheumatic diseases including systemic lupus erythematosus (SLE)."	( Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS, 2016)
"Posterior scleritis is an inflammatory disease that may be associated with many autoimmune systemic diseases."	( Bayramoglu, S; Erdogan, M; Sayin, N; Yıldız Ekinci, D, 2018)
"Posterior scleritis is relatively rare but can occur without systemic involvement."	( Biswas, J; Ghose, A; Kumar, A; Majumder, PD, 2018)
"Necrotizing scleritis is a severe complication that can arise after cosmetic eye-whitening conjunctivectomy with MMC."	( Alotaibi, MH; Choi, S; Hwang, DG; Ji, YW; Jung, JW; Park, SY; Seo, KY; Stulting, RD, 2018)
"Necrotizing scleritis is the most common subtype of scleritis in ANCA-positive individuals and even in the absence of systemic involvement."	( Biswas, J; Ganesh, SK; George, AE; Majumder, PD; Sudharshan, S, 2018)
"Posterior scleritis is the least frequent form of scleritis accounting for around 2%-8% of all scleritis cases."	( Amer, R; Levinger, N, 2020)
"Posterior scleritis is an uncommon condition and it is even rarer in the setting of psoriasis."	( Amer, R; Levinger, N, 2020)
"Recurrence of scleritis is common in nodular scleritis and cases with non infectious nodular scleritis often require treatment with immune suppressives."	( Biswas, J; Dutta Majumder, P; Ganesh, SK; George, AE; Patnaik, G; Sudharshan, S, 2020)
"Infectious scleritis is a rare but important cause of scleral inflammation."	( Agarwal, R; Kashyap, S; Sharma, S; Tripathi, M, 2021)
"Episcleritis and scleritis are the most prevalent manifestation of vasculitis."	( Carreño, E; Olivas-Vergara, OM, 2023)
"Acanthamoeba scleritis is a rare complication associated with Acanthamoeba keratitis."	( Davis, A; Heath, M; Riaz, KM, 2023)

Excerpt	Reference
"Posterior scleritis has protean manifestations and can be easily overlooked."	( Attia, S; Bhouri, L; Chaouch, K; Jelliti, B; Jenzri, S; Khairallah, M; Ladjimi, A; Messaoud, R; Zaouali, S, 2003)
"Uveitis and scleritis have been reported in association with a variety of topical, intraocular, periocular, and systemic medications."	( Claes, C; Haverbeke, G; Pertile, G; Zeyen, T, 2003)
"Although scleritis has not been reported as a tubulointerstitial nephritis-associated ocular inflammation, it may be part of the possible spectrum of ocular inflammation occurring as part of the TINU syndrome."	( Daniel, E; Gangaputra, S; Jabs, DA; Kempen, JH, 2006)
"Patients with scleritis have a significantly increased number of rolling and arrested leukocytes in superficial ocular vessels in comparison to patients with mild allergic conjunctivitis and controls."	( Gould, RR; Hoang, L; Lim, LL; Mathers, WD; Planck, SR; Ronick, MB; Rosenbaum, JT; Wong, T, 2006)

Excerpt	Reference
"Despite continuation of OKT3 treatment the scleritis resolved rapidly with increased dosages of prednisone."	( Keown, PA; McCarthy, JM; Rollins, DT; Sullivan, K, 1992)
"To document the clinical course and the treatment of episcleritis associated with brucellosis."	( Bekir, NA; Güngör, K; Namiduru, M, 2001)
"Retrospective study of patients treated for scleritis (n = 87) or episcleritis (n = 18)."	( Dück, N; Heiligenhaus, A; Hudde, T; Koch, J; Michel, D; Steuhl, KP, 2003)
"Deep IMMP is a safe and effective treatment for scleritis."	( Deokule, S; Murray, PI; Saeed, T, 2005)
"One hundred four patients treated for scleritis at the University Medical Centers of Groningen and Utrecht, The Netherlands."	( Los, LI; ten Dam-van Loon, NH; Wieringa, JE; Wieringa, WG, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	22 (4.44)	23.3326
1990's	107 (21.62)	12.5806
2000's	146 (29.49)	18.1394
2010's	155 (31.31)	28.8240
2020's	65 (13.13)	9.53

Drug	Relationship Strength	Studies	Trials
histamine	low	3	0
iodine	low	1	0
methanol	low	1	0
niacin	low	1	0
phosphorylcholine	low	1	0
pyrazinamide	low	2	0
thiamine	low	1	0
n-methyl-3,4-methylenedioxyamphetamine	low	1	0
acetazolamide	low	1	0
albendazole	low	2	0
alendronate	low	6	0
antazoline	low	1	0
aspirin	low	3	0
azathioprine	medium	19	1
bupivacaine	low	1	0
cefuroxime	low	1	0
celecoxib	low	1	0
chloroquine	low	1	0
ciprofloxacin	low	9	0
cyclopentolate	low	1	0
dapsone	low	5	0
diclofenac	low	2	0
pentetic acid	low	1	0
etidronate	low	2	0
brl 42810	low	2	0
fluconazole	low	3	0
flurbiprofen	medium	4	1
gentamicin	low	2	0
miltefosine	low	1	0
hydroxychloroquine	low	1	0
ibuprofen	low	5	0
lidocaine	low	1	0
ifosfamide	low	1	0
indomethacin	low	15	0
isoniazid	low	4	0
2-propanol	low	2	0
ketoconazole	low	2	0
ketoprofen	low	1	0
ketorolac	medium	1	1
leflunomide	low	1	0
mesalamine	low	1	0
metronidazole	low	1	0
naphazoline	low	3	0
ofloxacin	low	1	0
oxyphenbutazone	low	1	0
pamidronate	low	6	0
phenylbutazone	low	1	0
procainamide	low	1	0
risedronic acid	low	2	0
sulfamethoxazole	low	2	0
sulfasalazine	low	1	0
gatifloxacin	low	2	0
thalidomide	low	2	0
thiotepa	low	1	0
trimethoprim	low	2	0
mitomycin	low	11	0
prednisolone	medium	71	1
thyroxine	low	2	0
prednisolone acetate	medium	9	1
prednisone	low	64	0
fluprednisolone	low	2	0
penicillin g	low	5	0
pilocarpine	low	1	0
triiodothyronine	low	1	0
biguanides	low	2	0
chloramphenicol	low	3	0
bromodeoxyuridine	low	1	0
phenylephrine	low	1	0
methicillin	low	1	0
colchicine	low	2	0
fluocinolone acetonide	low	1	0
valine	low	2	0
triamcinolone acetonide	medium	14	1
methylprednisolone	low	28	0
quinoxalines	low	1	0
pyrroles	low	1	0
thiophenes	low	1	0
framycetin	low	2	0
benzathine	low	1	0
fluocortolone	low	3	0
quinazolines	low	1	0
isoxazoles	low	1	0
thiazoles	medium	1	1
betamethasone	low	5	0
fluorometholone	low	3	0
2-aminopurine	low	2	0
fusarium	low	1	0
acetylcysteine	low	1	0
erythromycin	low	3	0
ethambutol	low	3	0
durapatite	low	1	0
vancomycin	low	5	0
fluorescein	low	1	0
methylprednisolone hemisuccinate	low	1	0
vantocil	low	2	0
floxacillin	low	1	0
vidarabine	low	1	0
trolamine salicylate	medium	21	2
phenyl acetate	low	1	0
triamcinolone	low	6	0
cefazolin	low	2	0
amoxicillin	low	1	0
timolol	low	2	0
tobramycin	low	2	0
ribavirin	low	1	0
amikacin	low	6	0
epirubicin	low	1	0
propiconazole	low	6	0
itraconazole	low	5	0
topotecan	low	1	0
ibandronic acid	low	1	0
hexamidine	low	1	0
betamethasone sodium phosphate	low	1	0
histamine phosphate	low	1	0
cephalosporin c	low	1	0
triazoles	low	6	0
zoledronic acid	medium	7	1
voriconazole	low	11	0
imipenem, anhydrous	low	2	0
methotrexate	low	31	0
docetaxel anhydrous	low	1	0
levofloxacin	low	1	0
moxifloxacin	low	2	0
naproxen	low	3	0
2-(2-hydroxy-4-methylphenyl)aminothiazole	medium	1	1
atropine	low	1	0
erlotinib hydrochloride	low	2	0
lenalidomide	low	1	0
cortisone	low	2	0
trimethoprim, sulfamethoxazole drug combination	low	6	0
monensin	low	1	0
difluprednate	low	2	0
loteprednol etabonate	low	1	0
betadex	low	1	0
retinol	low	1	0
tacrolimus	low	3	0
mycophenolic acid	medium	15	2
brivudine	low	1	0
zithromax	low	1	0
melphalan	low	1	0
l 743,872	low	3	0
micafungin	low	1	0
fludarabine	low	1	0
mercaptopurine	low	1	0
terbinafine	low	1	0
amphotericin b	low	7	0
isotretinoin	low	1	0
phenylephrine hydrochloride	low	2	0
dorzolamide	low	1	0
nitrofurantoin	low	1	0
gadolinium dtpa	low	2	0
mocetinostat	low	6	0
tofacitinib	low	2	0
brimonidine tartrate	low	3	0
losartan potassium	low	2	0
indocyanine green	medium	11	1
cellulose	low	1	0
phosphatidylcholines	low	1	0
mesna	low	1	0
ro13-9904	low	3	0
plx4032	low	2	0
triiodothyronine, reverse	low	1	0
piperidines	low	2	0
interleukin-8	low	1	0
dabrafenib	low	1	0
ascorbic acid	low	1	0
tetracycline	low	1	0
minocycline	low	4	0
piroxicam	low	1	0
warfarin	low	1	0
mysteclin f	low	1	0
vitamin b 12	low	2	0
cyclosporine	low	18	0
acyclovir	medium	13	1
folic acid	low	1	0
rifampin	low	5	0
valacyclovir	low	2	0
allopurinol	low	1	0
eye	low	28	0

Protein Targets (1,766)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	20	0	0	20
thioredoxin reductase	36	0	0	36
aldehyde dehydrogenase 1 family, member A1	37	0	0	37
IDH1	25	0	0	25
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	4	0	4
Guanine nucleotide-binding protein G	7	0	0	7
TAR DNA-binding protein 43	17	0	0	17
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	1	3
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	48	0	0	48
GLI family zinc finger 3	53	0	0	53
AR protein	73	0	0	73
retinoic acid nuclear receptor alpha variant 1	48	0	0	48
retinoid X nuclear receptor alpha	45	0	0	45
estrogen nuclear receptor alpha	82	0	0	82
peroxisome proliferator-activated receptor delta	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	38	0	0	38
activating transcription factor 6	18	0	0	18
v-jun sarcoma virus 17 oncogene homolog (avian)	19	0	0	19
Histone H2A.x	19	0	0	19
thyroid hormone receptor beta isoform a	18	0	0	18
heat shock protein beta-1	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	46	0	0	46
lamin isoform A-delta10	52	0	0	52
Voltage-dependent calcium channel gamma-2 subunit	26	0	0	26
Glutamate receptor 2	26	1	0	27
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	18	0	0	18
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	3	0	3
GALC protein	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	34	0	0	34
cytochrome P450 family 3 subfamily A polypeptide 4	41	0	0	41
glucocorticoid receptor [Homo sapiens]	55	0	0	55
estrogen-related nuclear receptor alpha	57	0	0	57
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
arylsulfatase A	19	0	0	19
Carbonic anhydrase	0	3	0	3
euchromatic histone-lysine N-methyltransferase 2	50	0	0	50
Bloom syndrome protein isoform 1	20	0	0	20
geminin	52	0	0	52
peripheral myelin protein 22	22	0	0	22
survival motor neuron protein isoform d	19	0	0	19
muscleblind-like protein 1 isoform 1	16	0	0	16
Gamma-aminobutyric acid receptor subunit pi	27	3	2	32
ATP-binding cassette sub-family C member 3	0	62	0	62
Multidrug resistance-associated protein 4	0	62	0	65
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	11	0	12
Carbonic anhydrase 12	0	5	1	10
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	83	0	83
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	14	1	21
Carbonic anhydrase 2	0	14	3	23
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	6	0	6
Carbonic anhydrase 3	0	4	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	23	0	24
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2D6	0	10	0	11
Cytochrome P450 2A6	0	4	1	5
Cytochrome P450 2C9	0	25	1	27
5-hydroxytryptamine receptor 2A	0	6	0	6
Androgen receptor	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	27	3	2	32
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	27	3	2	32
Gamma-aminobutyric acid receptor subunit gamma-2	27	3	2	32
Gamma-aminobutyric acid receptor subunit alpha-5	27	3	2	32
Gamma-aminobutyric acid receptor subunit alpha-3	27	3	2	32
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	3	1	4
Carbonic anhydrase 4	0	5	1	9
Carbonic anhydrase 6	0	5	1	9
Gamma-aminobutyric acid receptor subunit gamma-1	27	3	2	32
Gamma-aminobutyric acid receptor subunit alpha-2	27	3	2	32
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	6	0	7
Serum paraoxonase/arylesterase 1	0	6	0	6
Dipeptidyl peptidase 4	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	27	3	2	32
Gamma-aminobutyric acid receptor subunit gamma-3	27	3	2	32
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	27	3	2	32
Adenosine receptor A2a	0	5	0	6
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	4	2	6
Delta-type opioid receptor	0	3	0	3
Cytochrome P450 2C19	0	9	0	9
Delta-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	4	1	9
Carbonic anhydrase	0	3	0	4
Kappa-type opioid receptor	0	1	0	4
Carbonic anhydrase 7	0	4	1	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	3	0	5
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	27	5	2	34
Gamma-aminobutyric acid receptor subunit beta-3	27	3	2	32
Gamma-aminobutyric acid receptor subunit beta-2	27	3	2	32
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	3	0	3
Mu-type opioid receptor	0	6	0	6
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	8	1	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	3	0	6
Carbonic anhydrase	0	3	0	6
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	4	0	4
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
Renin	0	1	0	1
Carbonic anhydrase	0	3	0	5
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
GABA theta subunit	27	3	2	32
Canalicular multispecific organic anion transporter 1	0	59	0	59
Carbonic anhydrase 4	0	7	0	8
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	6
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	27	3	2	32
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	5	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	9
Chain A, JmjC domain-containing histone demethylation protein 3A	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	25	0	0	25
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
acetylcholinesterase	15	0	0	15
dopamine D1 receptor	6	0	0	6
15-lipoxygenase, partial	10	0	0	10
pregnane X receptor	10	0	0	10
phosphopantetheinyl transferase	19	0	0	19
USP1 protein, partial	25	0	0	25
NFKB1 protein, partial	8	0	0	8
Microtubule-associated protein tau	19	0	0	19
Thrombopoietin	4	0	0	4
regulator of G-protein signaling 4	11	0	0	11
farnesoid X nuclear receptor	34	0	0	34
vitamin D (1,25- dihydroxyvitamin D3) receptor	37	0	0	37
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform 2	47	0	0	47
flap endonuclease 1	14	0	0	14
muscarinic acetylcholine receptor M1	14	0	0	14
Histone deacetylase 3	0	5	0	5
Histone deacetylase 4	0	4	0	4
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	4	0	4
Ataxin-2	24	0	0	24
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	4	0	4
ATP-dependent phosphofructokinase	14	0	0	14
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	18	0	0	18
Chain B, HADH2 protein	18	0	0	18
Chain A, Ferritin light chain	12	0	0	12
Thymidine kinase	0	3	0	3
GLS protein	19	0	0	19
TDP1 protein	59	0	0	59
Smad3	13	0	0	13
thyroid stimulating hormone receptor	25	0	0	25
EWS/FLI fusion protein	45	0	0	45
hemoglobin subunit beta	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Solute carrier family 22 member 1	0	5	0	10
Bile salt export pump	0	15	0	15
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	2	0	4
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2J2	0	13	0	13
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Purine nucleoside phosphorylase	0	0	4	4
Solute carrier family 22 member 6	0	9	0	12
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	7	0	11
Thymidine kinase	0	2	0	2
Luciferase	21	0	0	21
glp-1 receptor, partial	15	0	0	15
ATAD5 protein, partial	16	0	0	16
Fumarate hydratase	15	0	0	15
caspase 7, apoptosis-related cysteine protease	7	0	0	7
progesterone receptor	35	0	0	35
pregnane X nuclear receptor	47	0	0	47
polyprotein	15	0	0	15
67.9K protein	18	0	0	18
peroxisome proliferator activated receptor gamma	38	0	0	38
caspase-3	7	0	0	7
aryl hydrocarbon receptor	29	0	0	29
nuclear receptor subfamily 1, group I, member 2	17	0	0	17
cellular tumor antigen p53 isoform a	9	0	0	9
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	17	0	0	17
chromobox protein homolog 1	30	0	0	30
nuclear factor erythroid 2-related factor 2 isoform 2	21	0	0	21
transcriptional regulator ERG isoform 3	8	0	0	8
histone deacetylase 9 isoform 3	6	0	0	6
mitogen-activated protein kinase 1	11	0	0	11
urokinase-type plasminogen activator precursor	13	0	0	13
plasminogen precursor	13	0	0	13
urokinase plasminogen activator surface receptor precursor	13	0	0	13
Vif	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
neuropeptide S receptor isoform A	9	0	0	9
Interferon beta	39	0	0	39
Cellular tumor antigen p53	46	0	0	46
Integrin beta-3	4	1	0	5
Integrin alpha-IIb	4	1	0	5
Methionine aminopeptidase	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	20	0	0	20
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	7	0	8
Farnesyl pyrophosphate synthase	0	10	0	10
Acetylcholinesterase	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	6	0	6
Farnesyl pyrophosphate synthase	0	3	0	3
interleukin 8	15	0	0	15
estrogen receptor 2 (ER beta)	22	0	0	22
ras-related protein Rab-9A	7	0	0	7
Polyphenol oxidase 2	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	1	1	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	3
histone acetyltransferase KAT2A isoform 1	15	0	0	15
Aminoglycoside 3'-phosphotransferase	0	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	30	0	0	30
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
apical membrane antigen 1, AMA1	9	0	0	9
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	10	0	0	10
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	25	0	0	25
DNA polymerase kappa isoform 1	14	0	0	14
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 1	0	6	0	7
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Chain A, Cruzipain	12	0	0	12
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	16	0	0	16
Nuclear receptor ROR-gamma	14	0	0	14
Potassium voltage-gated channel subfamily H member 2	0	20	0	22
Aurora kinase B	0	2	4	6
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	7	0	8
cytochrome P450 2D6 isoform 1	7	0	0	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
lethal factor (plasmid)	8	0	0	8
Histamine H1 receptor	0	1	5	6
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	11	0	0	11
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	9	1	10
Spike glycoprotein	22	1	3	26
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	3	3
ras protein, partial	0	0	3	3
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	22	0	0	22
glucocerebrosidase	7	0	0	7
Rac1 protein	0	0	3	3
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	3	3
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	8	0	9
Prostaglandin G/H synthase 2	0	6	0	7
Epidermal growth factor receptor	0	8	4	12
Fatty acid-binding protein, liver	0	6	0	6
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	15	0	16
Seed linoleate 13S-lipoxygenase-1	0	3	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	12	0	13
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	16	3	20
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	3	3
Prostaglandin G/H synthase 2	0	11	0	11
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	4	0	4
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	4	2	6
Sigma non-opioid intracellular receptor 1	0	0	2	2
cystic fibrosis transmembrane conductance regulator	0	2	0	2
DNA polymerase beta	6	0	0	6
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Muscarinic acetylcholine receptor M2	0	9	2	14
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M3	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	8
Muscarinic acetylcholine receptor M5	0	4	1	8
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M2	0	4	1	9
Muscarinic acetylcholine receptor M1	0	5	3	11
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M3	0	4	1	7
Alpha-1D adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	14	0	1	16
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
SMAD family member 2	17	0	0	17
SMAD family member 3	17	0	0	17
G	23	0	0	23
P53	2	0	0	2
thyroid stimulating hormone receptor	13	0	0	13
peripheral myelin protein 22 isoform 1	10	0	0	10
cytochrome P450 3A4 isoform 1	27	0	0	27
M-phase phosphoprotein 8	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	23	0	0	23
Inositol hexakisphosphate kinase 1	23	0	0	23
Protein-arginine deiminase type-4	0	10	0	10
cytochrome P450 2C9, partial	23	0	0	23
Chain A, D-MALTODEXTRIN BINDING PROTEIN	0	0	1	1
Chain A, Limit Dextrinase	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain B, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, Alpha-hemolysin	0	0	1	1
Chain B, Alpha-hemolysin	0	0	1	1
Chain C, Alpha-hemolysin	0	0	1	1
Chain D, Alpha-hemolysin	0	0	1	1
Chain E, Alpha-hemolysin	0	0	1	1
Chain F, Alpha-hemolysin	0	0	1	1
Chain G, Alpha-hemolysin	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	18	2	25
Glycine receptor subunit alpha-1	0	18	0	18
Glycine receptor subunit beta	0	18	0	18
Glycine receptor subunit alpha-2	0	18	0	18
Glycine receptor subunit alpha-3	0	18	0	18
ORF73	0	0	1	1
Thymidine kinase	0	1	0	1
relaxin receptor 1 isoform 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	11	0	0	11
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 8	0	2	0	3
Chain A, Carbonic anhydrase II	0	1	0	1
PPM1D protein	16	0	0	16
thyrotropin-releasing hormone receptor	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	19	0	0	19
Caspase-7	4	0	0	4
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
caspase-3	4	0	0	4
Prostaglandin E synthase	0	2	0	2
3-phosphoinositide-dependent protein kinase 1	0	1	1	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	3	0	3
Procathepsin L	0	3	3	6
Aldo-keto reductase family 1 member B1	0	8	0	8
Neuronal acetylcholine receptor subunit alpha-4	4	2	0	6
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	5	0	5
Neuronal acetylcholine receptor subunit beta-2	4	2	0	6
Beta-3 adrenergic receptor	0	4	1	5
Alpha-1B adrenergic receptor	0	7	0	7
Calpain-2 catalytic subunit	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	2	6
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	10	1	11
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	6	1	7
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	7	0	9
Alpha-1A adrenergic receptor	0	7	0	7
Sodium-dependent dopamine transporter	0	8	1	9
Prostaglandin G/H synthase 2	0	5	0	6
Mitogen-activated protein kinase 14	0	3	4	7
Prostaglandin G/H synthase 1	0	8	0	10
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	2	0	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	3	0	3
streptokinase A precursor	0	0	8	8
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	5	1	6
30S ribosomal protein S7	0	5	1	6
50S ribosomal protein L15	0	5	1	6
50S ribosomal protein L10	0	5	1	6
50S ribosomal protein L11	0	5	1	6
50S ribosomal protein L7/L12	0	5	1	6
50S ribosomal protein L19	0	5	1	6
50S ribosomal protein L1	0	5	1	6
50S ribosomal protein L20	0	5	1	6
50S ribosomal protein L27	0	5	1	6
50S ribosomal protein L28	0	5	1	6
50S ribosomal protein L29	0	5	1	6
50S ribosomal protein L31	0	5	1	6
50S ribosomal protein L31 type B	0	5	1	6
50S ribosomal protein L32	0	5	1	6
50S ribosomal protein L33	0	5	1	6
50S ribosomal protein L34	0	5	1	6
50S ribosomal protein L35	0	5	1	6
50S ribosomal protein L36	0	5	1	6
30S ribosomal protein S10	0	5	1	6
30S ribosomal protein S11	0	5	1	6
30S ribosomal protein S12	0	5	1	6
30S ribosomal protein S13	0	5	1	6
30S ribosomal protein S16	0	5	1	6
30S ribosomal protein S18	0	5	1	6
30S ribosomal protein S19	0	5	1	6
30S ribosomal protein S20	0	5	1	6
30S ribosomal protein S2	0	5	1	6
30S ribosomal protein S3	0	5	1	6
30S ribosomal protein S4	0	5	1	6
30S ribosomal protein S5	0	5	1	6
30S ribosomal protein S8	0	5	1	6
30S ribosomal protein S9	0	5	1	6
50S ribosomal protein L13	0	5	1	6
50S ribosomal protein L14	0	5	1	6
50S ribosomal protein L16	0	5	1	6
50S ribosomal protein L23	0	5	1	6
30S ribosomal protein S15	0	5	1	6
50S ribosomal protein L17	0	5	1	6
50S ribosomal protein L21	0	5	1	6
50S ribosomal protein L30	0	5	1	6
50S ribosomal protein L6	0	5	1	6
30S ribosomal protein S14	0	5	1	6
30S ribosomal protein S17	0	5	1	6
30S ribosomal protein S1	0	5	1	6
50S ribosomal protein L18	0	5	1	6
50S ribosomal protein L2	0	5	1	6
50S ribosomal protein L3	0	5	1	6
50S ribosomal protein L24	0	5	1	6
50S ribosomal protein L4	0	5	1	6
50S ribosomal protein L22	0	5	1	6
50S ribosomal protein L5	0	5	1	6
30S ribosomal protein S21	0	5	1	6
50S ribosomal protein L25	0	5	1	6
50S ribosomal protein L36 2	0	5	1	6
Methionine--tRNA ligase, mitochondrial	0	0	1	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
Spike glycoprotein	0	1	3	4
Replicase polyprotein 1ab	0	2	4	6
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
Transmembrane protease serine 2	0	1	3	4
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	4	0	4
Histidine-rich protein PFHRP-II	0	1	0	2
Alpha-2A adrenergic receptor	0	8	1	9
Replicase polyprotein 1a	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
Replicase polyprotein 1ab	0	3	3	6
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	3	6
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	4	5
Alpha-2C adrenergic receptor	0	4	2	6
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	3	4
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
cytochrome P450 2C9 precursor	10	0	0	10
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	4
DNA gyrase subunit A	0	5	0	9
DNA gyrase subunit B	0	5	0	9
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	3	0	5
DNA topoisomerase 2-alpha	0	2	4	11
DNA gyrase subunit A	0	2	0	4
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	7	0	9
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
endonuclease IV	6	0	0	6
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	8	0	0	8
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	3	2	6
ATP-dependent translocase ABCB1	0	6	0	6
Tubulin beta chain	0	3	2	6
ATP-dependent translocase ABCB1	0	8	1	11
Tubulin alpha-3C chain	0	3	2	6
Serine/threonine-protein kinase pim-1	0	1	4	5
ATP-dependent translocase ABCB1	0	6	0	6
Tubulin alpha-1B chain	0	3	2	6
Tubulin alpha-4A chain	0	3	2	6
Tubulin beta-4B chain	0	3	2	6
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	2	6
Tubulin beta-2A chain	0	3	2	6
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	2	6
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	3	2	6
Tubulin alpha-1A chain	0	3	2	6
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	2	6
Tubulin beta-6 chain	0	3	2	6
Tubulin beta-2B chain	0	3	2	6
Tubulin beta-1 chain	0	3	2	6
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	8	0	8
Bone morphogenetic protein receptor type-1B	0	0	4	4
Membrane-associated progesterone receptor component 1	0	0	3	3
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	4	4
ATP-dependent RNA helicase DDX3X	0	0	4	4
Pirin	0	2	0	2
Pyridoxal kinase	0	0	4	4
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase Chk1	0	1	4	5
Aurora kinase A	0	0	4	4
Cyclin-G-associated kinase	0	0	4	4
Ephrin type-B receptor 6	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 3	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 2	0	1	4	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	4	4
Dynamin-like 120 kDa protein, mitochondrial	0	0	4	4
Tyrosine-protein kinase JAK2	0	3	5	10
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	1	4	5
Serine/threonine-protein kinase ULK1	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	4	4
Nuclear receptor subfamily 1 group I member 2	0	0	7	7
Ribosomal protein S6 kinase alpha-5	0	1	4	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	4	4
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Cyclin-dependent kinase-like 5	0	0	3	3
Serine/threonine-protein kinase 10	0	0	4	4
Serine/threonine-protein kinase D3	0	0	4	4
Structural maintenance of chromosomes protein 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 6	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Tyrosine-protein kinase ABL1	0	0	5	6
GTPase KRas	0	2	0	2
RAF proto-oncogene serine/threonine-protein kinase	0	2	2	6
High affinity nerve growth factor receptor	0	0	4	4
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	4	4
Protein kinase C beta type	0	0	4	4
Insulin receptor	0	1	4	5
Tyrosine-protein kinase Lck	0	1	4	5
Tyrosine-protein kinase Fyn	0	1	4	5
Cyclin-dependent kinase 1	0	1	4	5
Glycogen phosphorylase, liver form	0	0	4	4
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Adenine phosphoribosyltransferase	0	0	3	3
Tyrosine-protein kinase Yes	0	0	4	4
Tyrosine-protein kinase Lyn	0	0	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	4	4
Insulin-like growth factor 1 receptor	0	0	4	4
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	4	4
Hepatocyte growth factor receptor	0	0	4	4
Tyrosine-protein kinase HCK	0	0	4	4
Platelet-derived growth factor receptor beta	0	0	4	4
Tyrosine-protein kinase Fgr	0	0	4	4
Serine/threonine-protein kinase A-Raf	0	2	4	6
Glycogen phosphorylase, brain form	0	0	4	4
Breakpoint cluster region protein	0	0	4	5
Fibroblast growth factor receptor 1	0	0	4	4
Cyclin-dependent kinase 4	0	0	4	4
ADP/ATP translocase 3	0	0	4	4
Inosine-5'-monophosphate dehydrogenase 2	0	2	3	5
Proto-oncogene tyrosine-protein kinase Src	0	0	4	4
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	3	3
Serine/threonine-protein kinase B-raf	0	2	6	10
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Tyrosine-protein kinase Fer	0	0	4	4
Protein kinase C alpha type	0	1	4	5
cAMP-dependent protein kinase catalytic subunit alpha	0	0	4	4
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	4	4
Casein kinase II subunit alpha'	0	0	4	4
Ras-related protein Rab-6A	0	0	4	4
Ephrin type-A receptor 1	0	0	4	4
Multifunctional protein ADE2	0	0	4	4
cAMP-dependent protein kinase catalytic subunit gamma	0	0	2	2
cAMP-dependent protein kinase catalytic subunit beta	0	0	4	4
Ferrochelatase, mitochondrial	0	0	5	5
Ribosomal protein S6 kinase beta-1	0	1	4	5
Tyrosine-protein kinase JAK1	0	3	5	10
Cyclin-dependent kinase 2	0	1	5	6
Beta-adrenergic receptor kinase 1	0	0	4	4
Probable ATP-dependent RNA helicase DDX6	0	0	4	4
Mitogen-activated protein kinase 3	0	0	4	4
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Deoxycytidine kinase	0	0	4	4
Mitogen-activated protein kinase 1	0	2	4	6
Ephrin type-A receptor 2	0	0	4	4
Ephrin type-B receptor 2	0	0	4	4
Non-receptor tyrosine-protein kinase TYK2	0	3	5	10
UMP-CMP kinase	0	0	3	3
Phosphatidylethanolamine-binding protein 1	0	0	3	3
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	4	4
S-adenosylmethionine synthase isoform type-2	0	0	4	4
DnaJ homolog subfamily A member 1	0	0	4	4
RAC-alpha serine/threonine-protein kinase	0	2	4	6
RAC-beta serine/threonine-protein kinase	0	0	4	4
Dual specificity protein kinase TTK	0	0	3	3
DNA replication licensing factor MCM4	0	0	3	3
Myosin-10	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 2	0	2	4	6
Receptor-type tyrosine-protein kinase FLT3	0	0	4	4
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	1	4	5
Serine/threonine-protein kinase receptor R3	0	0	3	3
TGF-beta receptor type-2	0	0	4	4
Electron transfer flavoprotein subunit beta	0	0	3	3
Tyrosine-protein kinase CSK	0	1	4	5
Glycine--tRNA ligase	0	0	4	4
Protein kinase C iota type	0	0	4	4
Exosome RNA helicase MTR4	0	0	4	4
Tyrosine-protein kinase Tec	0	1	4	5
Tyrosine-protein kinase ABL2	0	0	4	4
Tyrosine-protein kinase FRK	0	0	4	4
Tyrosine-protein kinase SYK	0	0	4	4
26S proteasome regulatory subunit 6B	0	0	4	4
Mitogen-activated protein kinase 8	0	1	4	5
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	3	3
Casein kinase I isoform alpha	0	0	4	4
Casein kinase I isoform delta	0	0	4	4
MAP kinase-activated protein kinase 2	0	1	4	5
Elongation factor Tu, mitochondrial	0	0	4	4
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	4	4
Casein kinase I isoform epsilon	0	0	4	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	4	4
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Dual specificity protein kinase CLK3	0	0	3	3
Glycogen synthase kinase-3 alpha	0	0	4	4
Glycogen synthase kinase-3 beta	0	1	4	5
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	3	3
Interleukin-1 receptor-associated kinase 1	0	0	4	4
Ribosomal protein S6 kinase alpha-3	0	1	4	5
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase PLK1	0	0	4	4
LIM domain kinase 1	0	0	4	4
LIM domain kinase 2	0	0	4	4
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-1	0	0	4	4
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	0	4	4
Ephrin type-A receptor 4	0	0	4	4
Adenylate kinase 2, mitochondrial	0	0	4	4
Adenosine kinase	0	0	4	4
Ras-related protein Rab-10	0	0	4	4
Actin-related protein 3	0	0	4	4
Actin-related protein 2	0	0	3	3
GTP-binding nuclear protein Ran	0	0	4	4
Casein kinase I isoform gamma-2	0	0	4	4
Cyclin-dependent kinase 3	0	0	3	3
Cyclin-dependent kinase 6	0	0	4	4
Cyclin-dependent-like kinase 5	0	1	4	5
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
Heat shock factor protein 1	0	2	0	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 1	0	2	4	6
DNA topoisomerase 2-beta	0	1	4	5
Protein kinase C theta type	0	0	4	4
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	0	4	4
Focal adhesion kinase 1	0	0	4	4
Protein kinase C zeta type	0	0	2	2
Protein kinase C delta type	0	0	4	4
Tyrosine-protein kinase BTK	0	1	4	5
Activated CDC42 kinase 1	0	0	4	4
Epithelial discoidin domain-containing receptor 1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	4	4
Tyrosine-protein kinase Mer	0	0	4	4
Serine/threonine-protein kinase 4	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	4	4
Integrin-linked protein kinase	0	0	4	4
Rho-associated protein kinase 1	0	0	4	4
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 1	0	1	1	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	4	4
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	0	4	4
cGMP-dependent protein kinase 1	0	0	4	4
Cyclin-dependent kinase 13	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	3	3
Chromodomain-helicase-DNA-binding protein 4	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Cyclin-dependent kinase 10	0	0	2	2
Ephrin type-A receptor 7	0	0	2	2
Delta(24)-sterol reductase	0	0	3	3
Ribosomal protein S6 kinase alpha-1	0	0	4	4
Dual specificity testis-specific protein kinase 1	0	0	3	3
Myosin light chain kinase, smooth muscle	0	0	4	4
Mitogen-activated protein kinase 11	0	1	4	5
Serine/threonine-protein kinase STK11	0	0	4	4
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
MAP kinase-activated protein kinase 3	0	0	1	1
Discoidin domain-containing receptor 2	0	0	4	4
AP2-associated protein kinase 1	0	0	4	4
Myosin light chain kinase 3	0	0	4	4
Uncharacterized aarF domain-containing protein kinase 5	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	4	4
Rab-like protein 3	0	0	3	3
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Serine/threonine-protein kinase MRCK gamma	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase N3	0	0	3	3
Serine/threonine-protein kinase ULK3	0	0	4	4
Dual serine/threonine and tyrosine protein kinase	0	1	1	2
Uncharacterized protein FLJ45252	0	0	4	4
Acyl-CoA dehydrogenase family member 11	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	4	4
Serine/threonine-protein kinase MARK2	0	0	4	4
ATP-dependent RNA helicase DHX30	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	4	4
STE20-related kinase adapter protein alpha	0	0	4	4
Myosin-14	0	0	4	4
AarF domain-containing protein kinase 1	0	0	4	4
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
MAP kinase-activated protein kinase 5	0	1	4	5
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Misshapen-like kinase 1	0	0	3	3
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	4	4
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
ATP-dependent RNA helicase DDX1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
PAS domain-containing serine/threonine-protein kinase	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	4	4
EKC/KEOPS complex subunit TP53RK	0	0	4	4
Dual specificity testis-specific protein kinase 2	0	0	4	4
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase kinase kinase 3	0	0	4	4
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	4	4
Nucleolar GTP-binding protein 1	0	0	4	4
Serine/threonine-protein kinase D2	0	0	4	4
NUAK family SNF1-like kinase 2	0	0	3	3
RNA cytidine acetyltransferase	0	0	4	4
Serine/threonine-protein kinase SIK2	0	0	4	4
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	4	4
dCTP pyrophosphatase 1	0	0	4	4
Dual specificity protein kinase CLK4	0	0	4	4
Casein kinase I isoform gamma-1	0	0	4	4
Serine/threonine-protein kinase PAK 6	0	0	2	2
Phenylalanine--tRNA ligase beta subunit	0	0	4	4
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
BMP-2-inducible protein kinase	0	0	4	4
Obg-like ATPase 1	0	0	3	3
Midasin	0	0	4	4
Interleukin-1 receptor-associated kinase 4	0	0	4	4
Mitogen-activated protein kinase kinase kinase 20	0	1	4	5
Cyclin-dependent kinase 12	0	0	4	4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	3	3
Serine/threonine-protein kinase pim-2	0	0	3	3
Serine/threonine-protein kinase 26	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-2	0	0	4	4
Serine/threonine-protein kinase TBK1	0	1	4	5
Septin-9	0	0	4	4
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO2	0	0	4	4
Serine/threonine-protein kinase ICK	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase SIK3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 2	0	0	4	4
Thyroid hormone receptor-associated protein 3	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	1	4	5
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Serine/threonine-protein kinase 24	0	0	3	3
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Dihydrofolate reductase	0	6	0	7
5-hydroxytryptamine receptor 6	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	7	0	8
Transthyretin	0	1	1	6
Albumin	0	6	9	15
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	5	1	6
Aldo-keto reductase family 1 member B1	0	4	0	4
UDP-glucuronosyltransferase 2B7	0	1	0	7
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	4	0	5
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	17	0	0	17
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Androgen receptor	0	4	1	5
Genome polyprotein	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
Serine/threonine-protein kinase B-raf	0	2	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	4	0	0	4
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	6	0	0	6
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	4	0	4
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	4	0	4
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	4	0	4
Lanosterol 14-alpha demethylase	0	6	2	8
60 kDa chaperonin	0	5	0	5
10 kDa chaperonin	0	5	0	5
Pantothenate synthetase	0	2	0	2
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
bcl-2-like protein 11 isoform 1	0	0	1	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	2	0	2
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	2	2
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	0	0	2
lysosomal alpha-glucosidase preproprotein	5	0	0	5
huntingtin isoform 2	2	0	0	2
nuclear receptor ROR-gamma isoform 1	12	0	0	12
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Acid-sensing ion channel 3	0	2	0	2
Aldo-keto reductase family 1 member C4	0	3	0	3
Aldo-keto reductase family 1 member C3	0	5	0	5
Aldo-keto reductase family 1 member C2	0	3	0	3
Acid-sensing ion channel 1	0	2	0	2
Aldo-keto reductase family 1 member C1	0	3	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	3	0	0	3
Thymidylate synthase	0	5	0	5
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	4	3	7
Alpha-synuclein	4	3	0	7
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	3	0	6
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	2	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Protein arginine N-methyltransferase 5	0	1	0	1
Prothrombin	0	1	1	2
Urokinase-type plasminogen activator	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	2	0	3
Macrophage migration inhibitory factor	0	3	0	3
Histamine H2 receptor	0	3	2	5
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	2	1	3
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Solute carrier family 22 member 1	0	4	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Histamine H3 receptor	0	1	2	3
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
nonstructural protein 1	7	0	0	7
Solute carrier organic anion transporter family member 1A4	0	3	0	5
Albumin	0	0	2	2
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	5	0	9
Caspase-1	0	6	0	7
Caspase-3	0	4	0	4
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Caspase-4	0	4	0	4
Caspase-5	0	4	0	4
Caspase-9	0	4	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase TEM	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	6	0	7
Phospholipase A2, major isoenzyme	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	1	2
Thromboxane-A synthase	0	3	0	3
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	6	6
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	1	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	6	0	10
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	8	0	12
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Cellular retinoic acid-binding protein 1	0	0	1	1
Olfactory receptor 51E2	0	1	0	1
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	1
Substance-K receptor	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	1	2
matrix metalloproteinase 1, partial	0	0	1	1
pyruvate kinase	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	1	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	1	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
DNA primase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	3	0	3
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Caspase-7	3	0	0	3
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Platelet-activating factor receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Stromelysin-1	0	2	0	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Zinc finger protein mex-5	0	0	0	1
Trace amine-associated receptor 1	0	0	1	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
Alpha-1A adrenergic receptor	0	1	2	3
Alpha-1B adrenergic receptor	0	1	2	3
Nischarin	0	1	0	1
Hormone-sensitive lipase	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
caspase recruitment domain family, member 15	0	1	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
tyrosine-protein kinase Yes	3	0	0	3
Vascular endothelial growth factor receptor 2	0	1	1	2
G protein-coupled receptor kinase 6	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Serine/threonine-protein kinase ATR	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	3	3
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	2	2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
NS5	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	3	0	3
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	3
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	2	3
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
H	0	2	0	2
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Cyclin-dependent kinase 18	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Protease	0	2	1	3
Chain A, Glutathione S-transferase	0	1	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Cytochrome P450 2B1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	1	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	1	1	2
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Protein kinase C eta type	0	0	1	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	1	1	2
Tyrosine-protein kinase ZAP-70	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	1	1	2
Cytoplasmic tyrosine-protein kinase BMX	0	1	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	3	2	8
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	1	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	1	1	2
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
NPYLR7B	0	0	1	1
DNA topoisomerase 1	0	1	2	4
DNA topoisomerase 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Endothelial PAS domain-containing protein 1	0	0	1	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
twin arginine protein translocation system - TatA protein	0	0	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (495)

Protein Targets (1,766)

Scleritis

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (495)

Drugs Studied (194)

Protein Targets (1,766)