A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
| Member | Definition | Role |
|---|
| 1-amino-1-phenylmethyl phosphonic acid | A member of the class of phosphonic acids that is phosphonic acid having a amino(phenyl)methyl group attached to the phosphorus. | 1-amino-1-phenylmethyl phosphonic acid |
| 1,2-diamino-4-nitrobenzene | The primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. | 4-nitro-1,2-phenylenediamine |
| 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish. | PhIP |
| 2-amino-5-chlorophenol | Phenol carrying amino and chloro substituents at positions 2 and 5 respectively. It is part of the degradation pathway of 4-chloronitrobenzene, CHEBI:34399. | 2-amino-5-chlorophenol |
| 2-aminoethoxydiphenyl borate | An organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group. | 2-aminoethoxydiphenylborane |
| 2-aminopropanol | An amino alcohol that is alanine in which the carboxy group has been reduced to the corresponding alcohol. | 2-aminopropan-1-ol |
| 2-aminothiazole | A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. | 1,3-thiazol-2-amine |
| 2-aminothiazoline | A 1,3-thiazole that is 4,5-dihydro-1,3-thiazole substituted by an amino group at position 2. | 4,5-dihydro-1,3-thiazol-2-amine |
| 2-anisidine | A substituted aniline that is aniline in which the hydrogen ortho to the amino group has been replaced by a methoxy group. It is used as a chemical intermediate in the synthesis of azo pigments and dyes. | o-anisidine |
| 2-nitro-4-phenylenediamine | A primary amino compound that is p-phenylenediamine in which one of the hydrogens attached to the benzene ring is replaced by a nitro group. It is a cosmetic hair dye intermediate that is used in permanent hair colouring products (diluted 1:1 with an oxidising agent prior to application). | 2-nitro-p-phenylenediamine |
| 2,6-diaminopurine | A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups. | 9H-purine-2,6-diamine |
| 2,6-diaminotoluene | A diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups. | 2,6-diaminotoluene |
| 3-aminopropylphosphonic acid | A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 3-aminopropyl group. It is a partial agonist of GABAB receptors. | (3-aminopropyl)phosphonic acid zwitterion; (3-aminopropyl)phosphonic acid |
| 3-hydroxy-4-methoxyphenethylamine | A monomethoxybenzene that is dopamine in which the hydroxy group at position 4 is replaced by a methoxy group. | 4-methoxytyramine |
| 3-methoxytyramine | A monomethoxybenzene that is dopamine in which the hydroxy group at position 3 is replaced by a methoxy group. It is a metabolite of the neurotransmitter dopamine and considered a potential biomarker of pheochromocytomas and paragangliomas. | 3-methoxytyramine |
| 3-methylthiopropylamine | A derivative of propylamine having a methylmercapto group at the 3-position. | 3-methylthiopropylamine |
| 3-morpholinopropylamine | A member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group a the N atom. | 3-morpholinopropylamine |
| 3-phenylpropylamine | A phenylalkylamine that is benzene in which one of the hydrogens is substituted by a 3-aminopropyl group. | 3-phenylpropylamine |
| 3-tyramine | A primary amino compound that is 2-phenylethanamine substituted by a hydroxy group at position 3. | m-tyramine |
| 4-amino-1,2-oxazolidin-3-one | A member of the class of oxazolidines that is isoxazoldin-3-one which is substituted at position 4 by an amino group. | 4-amino-1,2-oxazolidin-3-one |
| 4-aminobutyric acid methyl ester | A methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol. | methyl 4-aminobutanoate |
| 4-anisidine | A substituted aniline that is aniline in which the hydrogen para to the amino group has been replaced by a methoxy group. It is used as a reagent for the detection of oxidation products such as aldehydes and ketones in fats and oils. | p-anisidine |
| 4-methoxybenzylamine | An aralkylamino compound that is benzylamine substituted by a methoxy group at the para position. | 1-(4-methoxyphenyl)methanamine |
| 4-phenylbutylamine | A phenylalkylamine that is benzene in which one of the hydrogens is substituted by a 4-aminobutyl group. | 4-phenylbutylamine |
| 5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | A member of the class of thiadiazoles that is 1,3,4-thiadiazol-2-amine which is substituted by a (5-nitro-1,3-thiazol-2-yl)sulfanediyl group at position 5. It is a c-Jun N-terminal kinase inhibitor (IC50 = 0.7uM) and exhibits antibacterial properties. | halicin |
| 5-(nonyloxy)tryptamine | A tryptamine derivative that consists of serotonin bearing an additional O-nonyl substituent. 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). | 5-nonyloxytryptamine |
| 5-aminofluorescein | A primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. | 5-aminofluorescein |
| 5-hydroxykynuramine | A hydroxykynurenamine where the hydroxy group is located at the 5-position. | 5-hydroxykynurenamine |
| 5-methoxytryptamine | A member of the class of tryptamines that is the methyl ether derivative of serotonin. | 5-methoxytryptamine |
| 6-aminonicotinamide | A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. | 6-aminonicotinamide |
| 7-aminocholesterol | A 3beta-sterol that is cholesterol substituted at position 7 by an amino group. | 7-aminocholesterol |
| 8-amino-8-demethylriboflavin | A benzopteridine that is riboflavin in which the methyl group at position 8 has been replaced by an amino group. | 8-amino-8-demethylriboflavin |
| a 77636 | An isochromene that is 3,4-dihydroisochromene-5,6-diol bearing additional aminomethyl and 1-adamantyl substituents at positions 1 and 3 respectively (the 1R,3S-diastereomer). Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. | (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol |
| aclonifen | A primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops. | aclonifen |
| agmatine | | agmatine |
| alendronate | A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups. | alendronic acid |
| alogliptin | A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of type 2 diabetes. | alogliptin |
| alpha-acetyllysine methyl ester | An alpha-amino acid ester obtained by formal condensation of the carboxy group of N(alpha)-acetyl-L-lysine with the hydroxy group of methanol. | N(alpha)-acetyl-L-lysine methyl ester |
| amfenac | An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery. | amfenac |
| aminacrine | An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections. | 9-aminoacridine |
| aminoethylphosphonic acid | A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 2-aminoethyl group. | (2-aminoethyl)phosphonic acid zwitterion; (2-aminoethyl)phosphonic acid |
| amlodipine | A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina. | amlodipine |
| ampyrone | A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. | 4-aminoantipyrine |
| amrubicin | A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol. | amrubicin |
| as 1842856 | A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. | AS1842856 |
| aspartimide | A pyrrolidinone that is succinimide substituted by an amino group at position 3. | 3-aminosuccinimide |
| asulam | A carbamate ester that is methyl carbamate substituted by a (4-aminophenyl)sulfonyl group at the nitrogen atom. A dihydropteroate synthase inhibitor, it is used (normally as the corresponding sodium salt, asulam-sodium) as a herbicide, mainly for killing bracken. | asulam |
| b 43 | A member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively). | RK-24466 |
| baclofen | A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant. | baclofen zwitterion; baclofen |
| benserazide | A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone. | benserazide |
| betazole | Pyrazole in which a hydrogen adjacent to one of the nitrogen atoms is substituted by a 2-aminoethyl group. It is a histamine H2-receptor agonist used clinically to test gastric secretory function. | betazole |
| butamben | An amino acid ester resulting from the formal condensation of the carboxy group of 4-aminobenzoic acid with the hydroxy group of butan-1-ol. Its local anaesthetic properties have been used for surface anaesthesia of the skin and mucous membranes, and for relief of pain and itching associated with some anorectal disorders. | butamben |
| caldopentamine | A polyazaalkane that is the 1,5,9,13,17-pentaaza derivative of heptodecane. | caldopentamine |
| cathestatin b | A carboxamide obtained by the formal condensation of the carboxylic group of oxirane-2,3-dicarboxylic acid with the amino group of N-(4-aminobutyl)-L-tyrosinamide (the 2S,3S stereoisomer). An antibiotic isolated from the fermentation broth of Penicillium citrinum, it acts as a potent inhibitor of cysteine protease. | cathestatin B |
| cgs 15943 | A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors. | 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; CGS 15943 |
| chrysobactin | A catechol-type siderophore with a structure of D-lysyl-L-serine substituted on N(2) of the lysyl residue by a 2,3-dihydroxybenzoyl group. It is produced by the Gram-negative bacillus Dickeya dadantii (previously known as Erwinia chrysanthem). Only the catecholate hydroxyl groups participate in metal coordination, so chrysobactin cannot provide full 1:1 coordination of Fe(III); at neutral pH and concentrations of about 0.1 mM, ferric chrysobactin exists as a mixture of bis and tris complexes. | chrysobactin |
| cki 7 | A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I. | N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide |
| crambescidin 800 | An organic heteropentacyclic guanidine alkaloid isolated from the marine sponge Crambe crambe and Batzella. It exhibits anti-HIV-1 and anti-HSV-1 activity. | crambescidin 800 |
| cystamine | An organic disulfide obtgained by oxidative dimerisation of cysteamine. | cystamine |
| dezocine | (7S,8S)-7-Amino-8-methyl-5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogen at position 8 and one of the hydrogens at position 6 are substituted by each end of a tetramethylene bridge. A synthetic opioid analgesic, it has mixed opiod agonist and antagonist properties. Although it is used for pain management, it can produce opioid withdrawal syndrome in patients already dependent on other opioids, and its clinical application is limited by side effects such as dizziness. | dezocine |
| didesethylflurazepam | A primary amino compound resulting from the dealkylation of both ethyl groups of the anti-insomnia drug flurazepam. It is the major metabolite of flurazepam. | didesethylflurazepam |
| dopamine 3-o-sulfate | An aryl sulfate that is dopamine in which the phenolic hydrogen at position 3 has been replaced by a sulfo group. | dopamine 3-O-sulfate zwitterion; dopamine 3-O-sulfate |
| dopamine 4-o-sulfate | An aryl sulfate that is dopamine in which the phenolic hydrogen at position 4 has been replaced by a sulfo group. | dopamine 4-O-sulfate zwitterion; dopamine 4-O-sulfate |
| dopamine quinone | A member of the class of 1,2-benzoquinones that is 1,2-benzoquinone in which a hydrogen at para to one of the oxo groups has been replaced by a 2-aminoethyl group. | dopaminoquinone |
| entinostat | A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3). | entinostat |
| er-086526 | A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage | eribulin |
| fingolimod | An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate. | fingolimod |
| fipronil | A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively. | 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile |
| fortimicin a | An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms. | astromicin |
| fty 720p | A primary amino compound that is fingolimod in which one on the hydroxy groups has been converted into its dihydrogen phosphate derivative. It is the active metabolite of fingolimod. | fingolimod phosphate |
| fumonisin b1 | A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. | fumonisin B1 |
| fumonisin b2 | A fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case). | fumonisin B2 |
| fumonisin b4 | A fumonisin that is fumonisin B2 that is lacking hydroxy group located gamma- to the amino substituent. | fumonisin B4 |
| galactosamine | The pyranose form of D-galactosamine. | 2-amino-2-deoxy-D-galactopyranose |
| gamma-glutamyltyrosine | A dipeptide composed of L-glutamic acid and L-tyrosine joined by a peptide linkage. | gamma-Glu-Tyr |
| gs 4071 | A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). An antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza. | oseltamivir acid |
| gsk690693 | A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively. | GSK690693 |
| huperzine a | A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease. | huperzine A |
| iFSP1 | A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1. | iFSP1 |
| kynuramine | A member of the class of kynurenamines that is aniline substituted at position 2 by a 3-aminopropanoyl group. | kynuramine |
| l 779976 | A member of the class of indoles that is (betaS)-beta-methyl-D-tryptophan in which the primary amino group undergoes formal condensation with the carboxy group of 4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1-carboxylic acid and the carboxy group undegoes formal condensation with the amino group of (1R,3S)-cyclohexane-1,3-diyldimethanamine. It is a selective nonpeptidic agonist of the somatostatin subtype-2 (SST2) receptor with Ki of 0.05 nM. | L-779976 |
| lucitanib | A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine. | E-3810 free base |
| mecysteine | An L-cysteinyl ester resulting from the formal condensation of the carboxylic acid group of L-cysteine with methanol. It is used (as the hydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough. | methyl L-cysteinate |
| mescaline | A phenethylamine alkaloid that is phenethylamine substituted at positions 3, 4 and 5 by methoxy groups. | mescaline |
| mexiletine | An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol. | mexiletine |
| ML240 | A member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). | ML240 |
| monoacetylcadaverine | An N-substituted cadaverine that is cadaverine in which one of the amino groups has been converted to the corresponding acetamide. | N-acetylcadaverine |
| monodansylcadaverine | A sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. | monodansylcadaverine |
| muscimol | A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita. | muscimol |
| n-(3-(aminomethyl)benzyl)acetamidine | An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase. | N-[3-(aminomethyl)benzyl]acetamidine |
| n-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide | A sulfonamide that is 5-chloronaphthalene-2-sulfonamide in which one of the hydrogens of the nitrogen atom is substituted by a 4-aminobutyl group. | N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide |
| n(1)-guanyl-1,7-diaminoheptane | A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038). | 2-(7-aminoheptyl)guanidine |
| n(beta)-alanyldopamine | | 3-amino-N-[2-(3,4-dihydroxyphenyl)ethyl]propanamide |
| nepicastat | A member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. | nepicastat |
| neutral red base | A member of the class of phenazines carrying methyl, amino and dimethylamino substituents at positions 2, 3 and 7 respectively. The free base of neutral red, which acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0. | neutral red base |
| nsc 23766 | An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1). | NSC 23766 |
| o 129 | A member of the class of pteridines that is pteridine in which the hydrogens at positions 2 and 4 are replaced by amino groups, whilst those at positions 6 and 7 are replaced by isopropyl groups. | 2,4-diamino-6,7-diisopropylpteridine |
| o-methyltyramine | A primary amino compound consisting of ethylamine having a 4-methoxyphenyl substituent at the 2-position. | 4-methoxyphenylethylamine |
| oseltamivir | A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza. | oseltamivir |
| oxidopamine | A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease). | oxidopamine |
| paromamine | An aminoglycoside that is 4alpha,6alpha-diaminocyclohexane-1beta,2alpha,3beta-triol in which the pro-R hydroxy group has been converted into its 2-amino-alpha-D-glucoside derivative. | paromamine |
| pateamine a | A marine macrodiolide that is isolated from the sponge Mycale hentscheli and exhibits anticancer and antiviral properties | pateamine |
| phenetidine | An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin. | 4-ethoxyaniline |
| phenylalaninol | An amino alcohol resulting from the formal reduction of the carboxy group of L-phenylalanine to the corresponding alcohol. | L-phenylalaninol |
| phosphorylethanolamine | The ethanolamine mono-ester of phosphoric acid, and a metabolite of phospholipid metabolism. This phosphomonoester shows strong structural similarity to the inhibitory neurotransmitter GABA, and is decreased in post-mortem Alzheimer's disease brain. | O-phosphoethanolamine |
| pibutidine | An aromtic ether that is 4-(piperidin-1-ylmethyl)pyridin-2-ol in which the hydroxy group has been substituted by a {(2Z)-4-[(2-amino-3,4-dioxocyclobut-1-en-1-yl)amino]but-2-en-1-yl}oxy group. It is a H2 receptor antagonist which was developed for the treatment of peptic ulcers and duodenal ulcers. | pibutidine |
| pp242 | A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties. | torkinib |
| pyrazon | A pyridazinone that is pyridazin-3(2H)-one substituted by an amino group at position 5, a chloro group at position 4 and a phenyl group at position 2. | chloridazon |
| ro 60-0175 | A member of the class of indoles that is 6-chloro-5-fluoroindole in which the hydrogen attached to the nitrogen has been replaced by a 2-aminopropyl group. | 1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine |
| s-adenosyl-3-thiopropylamine | A thioadenosine that is adenosine in which the hydroxy group at C-5' is replaced by a 3-aminopropyl group. | S-adenosyl-3-thiopropylamine |
| SL-327 | A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2. | SL-327 |
| st 1059 | An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states. | deglymidodrine |
| sulfaphenazole | A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent. | sulfaphenazole |
| tafenoquine | An aminoquinoline that is 8-aminoquinoline which is substituted by methoxy groups at positions 2 and 6, a methyl group at position 4, and a m-(trifluoromethyl)phenoxy group at position 5, and in which the amino substituent at position 8 is itself substituted by a 5-aminopentan-2-yl group. | N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine |
| tele-methylhistamine | A primary amino compound that is the N(tele)-methyl derivative of histamine. | N(tele)-methylhistamine |
| terazosin | | terazosin |
| thiobenzyl benzyloxycarbonyl-l-lysinate | An L-lysine derivative that is L-lysine in which the amino group is replaced by a [(benzyloxy)carbonyl]amino group and the carboxy group is replaced by a (benzylsulfanyl)carbonyl group. It is a substrate for a sensitive colorimetric assay for trypsin-like enzymes. | thiobenzyl benzyloxycarbonyl-L-lysinate |
| tipifarnib | A quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). | tipifarnib |
| torin 2 | A member of the class of pyridoquinolines that is benzo[h][1,6]naphthyridin-2-one carrying additional 3-(trifluoromethyl)phenyl and 6-aminopyridin-3-yl substituents at positions 1 and 9 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties. | torin 2 |
| tosufloxacin | A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 3-aminopyrrolidin-1-yl substituents at positions 1, 6 and 7 respectively. | 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid |
| tromethamine | A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC. | tris |
| tyramine | A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine. | tyramine |
| tyramine o-sulfate | An aryl sulfate that is tyramine in which the phenolic hydrogen at position 4 has been replaced by a sulfo group. | sulfuric acid [4-(2-aminoethyl)phenyl] ester; tyramine sulfate zwitterion; tyramine sulfate |