A drug used for the treatment of hyperplasia (increaced cell production within an organ or tissue).
ChEBI ID: 59844
| Member | Definition | Class |
|---|---|---|
| doxazosin | A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure. | doxazosin |
| dutasteride | An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland. | dutasteride |
| finasteride | An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia. | finasteride |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 134 (3.37) | 18.7374 |
| 1990's | 898 (22.56) | 18.2507 |
| 2000's | 1,356 (34.07) | 29.6817 |
| 2010's | 1,259 (31.63) | 24.3611 |
| 2020's | 333 (8.37) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,032 (22.37%) | 5.53% |
| Reviews | 706 (15.30%) | 6.00% |
| Case Studies | 181 (3.92%) | 4.05% |
| Observational | 17 (0.37%) | 0.25% |
| Other | 2,678 (58.04%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.2481 | 7 | 13 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.0999 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 18.8336 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 10.8267 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 26.1216 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.7829 | 8 | 13 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 42.2416 | 6 | 17 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 21.1987 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 30.3396 | 2 | 4 |
| G | Vesicular stomatitis virus | Potency | 0.8709 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 14.1837 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 4.5003 | 2 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 17.4159 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 60.4474 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 0.8709 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 48.0193 | 2 | 4 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 51.7026 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 8.6171 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 58.1904 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 51.9621 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 51.4296 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 44.4311 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 21.7284 | 1 | 3 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.8949 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 45.2716 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 45.2716 | 2 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.6540 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 29.2857 | 3 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 31.4891 | 3 | 6 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 6.8448 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 60.4474 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | Mycobacterium tuberculosis H37Rv | IC50 | 231.0000 | 1 | 2 |
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Homo sapiens (human) | IC50 | 2.3915 | 22 | 25 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Homo sapiens (human) | Ki | 0.2580 | 2 | 2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Rattus norvegicus (Norway rat) | IC50 | 180.0078 | 5 | 7 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0595 | 3 | 4 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Homo sapiens (human) | IC50 | 23.3455 | 23 | 27 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.3286 | 5 | 7 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Rattus norvegicus (Norway rat) | Ki | 0.0770 | 2 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.3680 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.2340 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5440 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2850 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5440 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.2850 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.7290 | 1 | 4 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0015 | 5 | 5 |
| Alpha-1A adrenergic receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.0032 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 3 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0008 | 5 | 5 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 3 | 5 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0034 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0015 | 6 | 6 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 3 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.7290 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0012 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0012 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0012 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 2.2155 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 1.8151 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 2.7480 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 1.8890 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 28.6000 | 3 | 4 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 5.7490 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 92.0000 | 1 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 2.2155 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 1.8151 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 1.4022 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 1.8151 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.1880 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.1490 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 2.6880 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.4280 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0020 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 0.3300 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC40 | 0.0323 | 1 | 3 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | EC40 | 0.0323 | 1 | 3 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | EC40 | 0.0323 | 1 | 3 |