A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
| Member | Definition | Class |
|---|
| acitretin | | all-trans-acitretin |
| agn 190299 | A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene. | tazarotenic acid |
| alitretinoin | A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry. | 9-cis-retinoic acid |
| dibenzothiophene | A mancude organic heterotricyclic parent that consists of a thiophene ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions. | dibenzothiophene |
| etretinate | | etretinate |
| glycolic acid | A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated. | glycolic acid |
| isotretinoin | A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases. | isotretinoin |
| podophyllotoxin | An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. | podophyllotoxin |
| salicylic acid | A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. | salicylic acid |
| tazarotene | The ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin. | tazarotene |
| tetrahydroxy-1,4-quinone | A hydroxybenzoquinone in which all four protons of the benzoquinone structure are substituted by hydroxy groups. A systemic keratolytic, it is normally supplied as its hydrate (CHEBI:137471). | tetrahydroxy-1,4-benzoquinone |
| tretinoin | A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. | all-trans-retinoic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 29.9033 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 14.7901 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 46.6243 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 27.6165 | 2 | 7 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 32.5347 | 1 | 12 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 16.6627 | 9 | 48 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 25.6316 | 2 | 9 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 16.3607 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 13.7145 | 1 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 33.8078 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 15.5802 | 2 | 6 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 30.4647 | 2 | 5 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 68.6594 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 68.6594 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 39.5093 | 2 | 15 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 22.9856 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 7.6110 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 37.7637 | 1 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 37.4340 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 3.7092 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.5594 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 69.9054 | 2 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.2837 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 20.9030 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.4506 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 14.3577 | 1 | 6 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 67.7406 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 6.1711 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 24.7076 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 6.5591 | 11 | 78 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 28.6886 | 2 | 10 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 13.6148 | 10 | 42 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 26.3710 | 1 | 11 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0095 | 1 | 2 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 21.3349 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 26.3463 | 5 | 19 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 12.2837 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 20.9030 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 12.5504 | 3 | 16 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 12.4424 | 3 | 17 |
| GLS protein | Homo sapiens (human) | Potency | 10.1019 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 20.7340 | 3 | 9 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.7770 | 1 | 8 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 44.4648 | 2 | 11 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 22.5873 | 1 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 74.9545 | 1 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.2837 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 43.6709 | 2 | 10 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.1335 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 0.2060 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.2837 | 1 | 6 |
| Interferon beta | Homo sapiens (human) | Potency | 6.1535 | 2 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0299 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.7943 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 42.1752 | 2 | 10 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 27.6221 | 2 | 13 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.0795 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.5012 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.1267 | 4 | 20 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.5801 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 41.1599 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 6.7786 | 1 | 4 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 5.0500 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 21.9338 | 3 | 21 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 12.1294 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 2.3754 | 2 | 7 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 2.3934 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 13.6764 | 4 | 21 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 24.9921 | 4 | 16 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 53.8083 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 13.4451 | 1 | 4 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.0234 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 32.4344 | 3 | 14 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 37.6188 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 20.0341 | 2 | 6 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 44.7164 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 7.0731 | 2 | 19 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.3282 | 1 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 6.1440 | 3 | 23 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 5.0529 | 3 | 21 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 4.6451 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 28.3072 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 24.1809 | 3 | 5 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 24.1809 | 3 | 5 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 6.3096 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 9.9712 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 11.5079 | 2 | 30 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 35.4813 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 32.8438 | 3 | 8 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.3738 | 3 | 28 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 16.8579 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 28.0472 | 3 | 9 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 37.9117 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 41.4632 | 2 | 8 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 11.0781 | 2 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 25.7050 | 3 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 48.9224 | 1 | 8 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.7770 | 1 | 8 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 13.8500 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.6030 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.3840 | 1 | 2 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 13.8500 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 346.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 4.7220 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.6695 | 1 | 2 |
| Albumin | Homo sapiens (human) | Ki | 5,888,440,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.7220 | 1 | 2 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0004 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.0680 | 2 | 5 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.7220 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.0680 | 2 | 5 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 3 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 6.6120 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 3.0190 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.1800 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 266.1364 | 4 | 11 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 509.8500 | 1 | 2 |
| Calcium-activated potassium channel subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.5600 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 324.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 560.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 170.9424 | 5 | 17 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 161.7929 | 2 | 14 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 165.9500 | 2 | 14 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 164.7214 | 2 | 14 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 7.2000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 680.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 177.5071 | 5 | 17 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 224.3786 | 2 | 14 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 161.9571 | 2 | 14 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 209.5929 | 2 | 14 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 186.5214 | 2 | 14 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 305.8800 | 3 | 15 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 167.0286 | 2 | 14 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 160.9133 | 3 | 15 |
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | IC50 | 2.2283 | 4 | 6 |
| Chain A, Nuclear Receptor ROR-beta | Rattus norvegicus (Norway rat) | Ki | 0.2800 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 0.5830 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 301.3000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | IC50 | 28.7000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.5190 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 2.5290 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 116.2000 | 1 | 5 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | IC50 | 0.1995 | 1 | 1 |
| Nuclear receptor ROR-beta | Homo sapiens (human) | IC50 | 12.6224 | 2 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | IC50 | 0.1995 | 1 | 1 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 2.1450 | 1 | 1 |
| Olfactory receptor 51E2 | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | IC50 | 0.8200 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 2,300.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 270.0000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 18.0000 | 2 | 3 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 18.0000 | 2 | 3 |
| Retinoic acid receptor alpha | Homo sapiens (human) | IC50 | 1.8047 | 4 | 5 |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | IC50 | 0.2096 | 3 | 5 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Ki | 0.0571 | 3 | 4 |
| retinoic acid receptor alpha isoform 1 | Homo sapiens (human) | IC50 | 0.0084 | 1 | 1 |
| Retinoic acid receptor beta | Homo sapiens (human) | IC50 | 0.6044 | 4 | 5 |
| Retinoic acid receptor beta | Mus musculus (house mouse) | IC50 | 0.3367 | 2 | 3 |
| Retinoic acid receptor beta | Homo sapiens (human) | Ki | 0.0098 | 3 | 4 |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | IC50 | 0.3360 | 2 | 3 |
| Retinoic acid receptor gamma | Homo sapiens (human) | IC50 | 0.0090 | 3 | 4 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Ki | 0.0072 | 4 | 6 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | IC50 | 0.3537 | 2 | 3 |
| Retinoic acid receptor RXR-alpha | Mus musculus (house mouse) | IC50 | 20.8164 | 3 | 5 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Ki | 0.2212 | 7 | 8 |
| retinoic acid receptor RXR-alpha isoform a | Homo sapiens (human) | IC50 | 0.0189 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | IC50 | 0.5060 | 1 | 2 |
| Retinoic acid receptor RXR-beta | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 2 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | Ki | 0.1593 | 4 | 6 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | IC50 | 0.1770 | 1 | 2 |
| Retinoic acid receptor RXR-gamma | Mus musculus (house mouse) | IC50 | 50.0000 | 2 | 2 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | Ki | 0.0746 | 4 | 6 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 0.8442 | 10 | 19 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 43.8258 | 1 | 2 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 280.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 144.7720 | 1 | 2 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 670.5000 | 2 | 2 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 1,020.0000 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.5380 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 91.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 0.6733 | 12 | 12 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Ki | 2.1800 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 | 0.6220 | 10 | 10 |
| Tubulin beta chain | Sus scrofa (pig) | Ki | 2.1800 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 0.8685 | 13 | 13 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 67.1914 | 7 | 7 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 19,400.0000 | 1 | 1 |
| Tyrosine-protein phosphatase YopH | Yersinia pseudotuberculosis IP 32953 | Ki | 1,000.0000 | 1 | 1 |
| Ubiquitin-like domain-containing CTD phosphatase 1 | Homo sapiens (human) | IC50 | 66,000.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Ki | 100,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | ID50 | 1.0000 | 1 | 1 |
| Estrogen receptor | Mus musculus (house mouse) | Kis | 19,400.0000 | 1 | 4 |
| Estrogen receptor beta | Mus musculus (house mouse) | Kis | 19,400.0000 | 1 | 4 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | INH | 1,000.0000 | 1 | 1 |
| Ornithine decarboxylase | Mus musculus (house mouse) | Activity | 0.6000 | 1 | 1 |
| Ornithine decarboxylase | Mus musculus (house mouse) | ID50 | 0.0001 | 1 | 1 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | ID50 | 0.0000 | 1 | 1 |
| PAX8 | Homo sapiens (human) | AC50 | 0.2600 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | ID50 | 3,900.0000 | 1 | 1 |
| Retinoic acid receptor alpha | Homo sapiens (human) | AC50 | 0.0190 | 1 | 1 |
| Retinoic acid receptor alpha | Homo sapiens (human) | EC30 | 0.0010 | 2 | 2 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Relative EC30 | 0.0022 | 2 | 2 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Relative IC50 | 0.0009 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | AC50 | 0.0020 | 1 | 1 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC30 | 0.0008 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | Relative EC30 | 0.0016 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | Relative IC50 | 0.0007 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | AC50 | 0.0030 | 1 | 1 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC30 | 0.0002 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Relative EC30 | 0.0006 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Relative IC50 | 0.0007 | 2 | 2 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | AC50 | 0.0070 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Activity | 3.4500 | 1 | 1 |
| Solute carrier family 22 member 7 | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | Activity | 23.5000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Activity | 19,400.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Kis | 19,400.0000 | 1 | 1 |