| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1064571 | Induction of superoxide radical generation in bovine NADH-respiring submitochondrial particles assessed as oxidation of CPH after 2 mins by ESR spectroscopy relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1064556 | Drug degradation in mouse N18TG2 cells assessed as alpha-TOH formation at 10 nmol after 24 hrs by HPLC analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1416210 | Inhibition of PTP1B (1 to 298 residues) (unknown origin) using DifMUP as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID448013 | Inhibition of human SK-BR-3 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID448010 | Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1326576 | Cytotoxicity against hamster AG17-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1064569 | Induction of superoxide radical generation in bovine NADH-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy in presence of superoxide dismutase relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1416217 | Reversible inhibition of PTP1B (1 to 298 residues) (unknown origin) using 10 fold excess DifMUP as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID1064561 | Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy in presence of rotenone | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID448640 | Effect on actin cytoskeletal structure in mouse 4T1 cells assessed as rapid loss of F-actin fiber-associated detachment from neighbouring cells at 10 uM after 4 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1064560 | Induction of superoxide radical generation in mouse N18TG2 cells assessed as CMH oxidation at 200 uM after 2 hrs by ESR spectroscopy relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1326580 | Cytotoxicity against human CEM13 cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID448616 | Inhibition of mouse 4T1 cells adhesion to fibronectin at 5 to 100 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID448618 | Inhibition of mouse 4T1 cells adhesion to vitronectin at 5 to 100 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1064572 | Inhibition of oxygen consumption in bovine succinate-respiring submitochondrial particles involving complexes 2,3,4 after 3 mins relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1416213 | Intrinsic redox activity of compound after 60 mins in presence of resazurin/DTT | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID1326566 | Antioxidant activity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as inhibition of t-BuO2H-dependant mutant formation at 0.3 uM preincubated with compound followed by t-BuO2H addition after 48 hrs by Ames test | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID448611 | Inhibition of human SK-BR-3 cells adhesion to gelatinous matrix protein-coated surface at 100 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1326572 | Cytotoxicity against human CEM13 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID448624 | Inhibition of mouse 4T1 cells metastasis at 50 uM after 30 mins by Boyden chamber assay | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1064565 | Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1064576 | Inhibition of bovine mitochondrial electron transport protein complex 1 NADH:dUQ oxidoreductase activity by spectrophotometry | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1064566 | Induction of superoxide radical generation in bovine NADH-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1326568 | Antioxidant activity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as inhibition of t-BuO2H-dependant mutant formation at 30 uM preincubated with compound followed by t-BuO2H addition after 48 hrs by Ames test | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1064558 | Drug degradation in denaturated rat liver homogenates assessed as compound recovery at 500 nmol after 4 hrs by HPLC analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1064578 | Cytotoxicity against human HeLa cells at 100 to 200 uM by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1416216 | Competitive inhibition of PTP1B (1 to 298 residues) (unknown origin) using 60 uM DifMUP as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID1064575 | Inhibition of bovine mitochondrial electron transport protein complex 2 succinate:DCPIP oxidoreductase activity by spectrophotometry | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1326564 | Genotoxicity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as frequency of reversion from histidine auxotrophy to prototrophy at 30 mM after 48 hrs by Ames test (Rvb = 209 +/- 10 No _unit) | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1326571 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1326567 | Antioxidant activity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as inhibition of t-BuO2H-dependant mutant formation at 3 uM preincubated with compound followed by t-BuO2H addition after 48 hrs by Ames test | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1064557 | Drug degradation in rat liver homogenates assessed as alpha-TOH formation at 500 nmol after 4 hrs by HPLC analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID448011 | Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface at 10 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1416215 | Competitive inhibition of PTP1B (1 to 298 residues) (unknown origin) using 30 uM DifMUP as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID448012 | Inhibition of human MCF7 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID448638 | Induction of FAK degradation in mouse 4T1 cells at 5 uM after 1 hr by Western blotting | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID448610 | Inhibition of human MCF7 cells adhesion to gelatinous matrix protein-coated surface at 100 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1064577 | Cytotoxicity against mouse N18TG2 cells at 6.25 to 100 uM by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1064573 | Inhibition of oxygen consumption in bovine NADH-respiring submitochondrial particles involving complexes 1,3,4 after 3 mins relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1326574 | Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1416214 | Competitive inhibition of PTP1B (1 to 298 residues) (unknown origin) using 15 uM DifMUP as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID448617 | Inhibition of mouse 4T1 cells adhesion to laminin at 5 to 100 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1064559 | Drug degradation in rat liver homogenates at 500 nmol after 4 hrs by HPLC analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1384567 | Inhibition of human GSTO1-1 by MMA (V) reductase assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. |
| AID103204 | Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells. |
| AID1326570 | Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1064574 | Inhibition of bovine mitochondrial electron transport protein complex 3 dUQH2:cytochrome c oxidoreductase activity by spectrophotometry | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1416211 | Effect on fluorescence read out during PTP1B enzymatic reaction compound treated post enzyme-substrate reaction and susequent H2O2-mediated enzyme deactivation | 2017 | MedChemComm, Jun-01, Volume: 8, Issue:6
| PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. |
| AID1064568 | Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy in presence of superoxide dismutase relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1326561 | Genotoxicity in Escherichia coli PQ37 expressing lacZ gene assessed as ratio of inducible beta-galactosidase activity to alkaline phosphatase activity at 30 mM after 2 hrs by SOS-chromotest relative to control | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID448615 | Inhibition of mouse 4T1 cells adhesion to collagen 4 at 5 to 100 uM after 60 mins by ELISA | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID448633 | Effect on actin cytoskeletal structure in mouse 4T1 cells assessed as rapid dissolution of actin stress fibers at 50 uM after 4 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Sep-24, Volume: 52, Issue:18
| alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. |
| AID1064570 | Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH after 2 mins by ESR spectroscopy relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. |
| AID1326575 | Cytotoxicity against mouse LMTK cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1326573 | Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1326569 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
| Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |