Roles > lachrymator
Page last updated: 2024-08-05 15:17:47

lachrymator

Any substance that stimulates the corneal nerves in the eves to cause tears.

ChEBI ID: 74136

Members (5)

MemberDefinitionClass
allyl isothiocyanateAn isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.allyl isothiocyanate
benzyl bromideA member of the class of benzyl bromides that is toluene substituted on the alpha-carbon with bromine.benzyl bromide
bromoacetoneAn alpha-bromoketone that is acetone in which one of the hydrogens is replaced by a bromine atom. A poweful lachrymator, it was formerly used as a chemical weapon.bromoacetone
methyl isothiocyanateAn isothiocyanate having a methyl group attached to the nitrogen. It is also the active nematicide of the pronematicide metam-sodium.methyl isothiocyanate
nonivamideA capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.nonivamide

Research

Studies (707)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199047 (6.65)18.7374
1990's48 (6.79)18.2507
2000's177 (25.04)29.6817
2010's332 (46.96)24.3611
2020's103 (14.57)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials13 (1.75%)5.53%
Reviews14 (1.88%)6.00%
Case Studies5 (0.67%)4.05%
Observational1 (0.13%)0.25%
Other711 (95.56%)84.16%

Protein Targets (79)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency22.387211
15-lipoxygenase, partialHomo sapiens (human)Potency25.118911
acetylcholinesteraseHomo sapiens (human)Potency36.388311
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency33.470313
AR proteinHomo sapiens (human)Potency39.753357
aryl hydrocarbon receptorHomo sapiens (human)Potency52.949113
Bloom syndrome protein isoform 1Homo sapiens (human)Potency50.118722
Cellular tumor antigen p53Homo sapiens (human)Potency10.870711
Chain A, Ferritin light chainEquus caballus (horse)Potency28.183811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.007111
cytochrome P450 2C19 precursorHomo sapiens (human)Potency7.943311
cytochrome P450 2C9 precursorHomo sapiens (human)Potency3.162311
cytochrome P450 2C9, partialHomo sapiens (human)Potency0.691811
cytochrome P450 2D6Homo sapiens (human)Potency13.802911
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency25.118911
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency22.970226
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency0.870911
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency59.117812
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency112.202011
endonuclease IVEscherichia coliPotency0.707911
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.113478
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency23.496223
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency35.601824
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency57.122012
farnesoid X nuclear receptorHomo sapiens (human)Potency14.550022
GVesicular stomatitis virusPotency0.691811
GABA theta subunitRattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency22.970213
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency22.970213
GLI family zinc finger 3Homo sapiens (human)Potency38.646424
GLS proteinHomo sapiens (human)Potency10.000011
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency30.106511
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency76.958811
heat shock protein beta-1Homo sapiens (human)Potency55.438822
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency3.162313
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency0.691811
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency0.691812
Interferon betaHomo sapiens (human)Potency0.691811
interleukin 8Homo sapiens (human)Potency70.901112
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency1.584911
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency30.619923
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency8.492111
pregnane X nuclear receptorHomo sapiens (human)Potency28.482514
progesterone receptorHomo sapiens (human)Potency34.359713
RAR-related orphan receptor gammaMus musculus (house mouse)Potency45.967025
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency25.134337
retinoid X nuclear receptor alphaHomo sapiens (human)Potency3.498011
TDP1 proteinHomo sapiens (human)Potency28.606622
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency46.543525
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.001611
thyroid stimulating hormone receptorHomo sapiens (human)Potency19.910324
transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Potency0.086622
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency55.881822
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency76.958811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Macrophage migration inhibitory factorHomo sapiens (human)IC500.675022
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)IC5085.900011
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)Ki1.223011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)EC508.120012
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)EC507.63241416
Transient receptor potential cation channel subfamily A member 1Mus musculus (house mouse)EC5022.000011
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)EC503.437733
Transient receptor potential cation channel subfamily M member 8Mus musculus (house mouse)EC500.500011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)EC50160.000011
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)EC500.441033
Transient receptor potential cation channel subfamily V member 2Rattus norvegicus (Norway rat)EC500.550022
Transient receptor potential cation channel subfamily V member 4Rattus norvegicus (Norway rat)EC500.550022
Tyrosine-protein kinase JAK1Homo sapiens (human)EC508.120012

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)Activity10.000011