Roles > nitric oxide donor
Page last updated: 2024-08-05 14:52:35

nitric oxide donor

An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide.

ChEBI ID: 50566

Members (10)

MemberDefinitionClass
4-phenyl-3-furoxancarbonitrileA 1,2,5-oxadiazole substituted by an oxido, cyano and phenyl groups at positions 2, 3 and 4, respectively. It is a vasodilator and inhibitor of platelet aggregation.4-phenyl-3-furoxancarbonitrile
hydroxylamineThe simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria.hydroxylamine
isosorbide dinitrateisosorbide dinitrate
isosorbide-5-mononitrateisosorbide mononitrate
molsidomineA member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate; molsidomine
molsidomineA member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate; molsidomine
naproxen-n-butyl nitrateA carboxylic ester obtained by formal condensation of the carboxy group of naproxen with the hydroxy group of 4-(nitrooxy)butanol. A cyclooxygenase-inhibiting nitric oxide donator that is metabolised to naproxen and a nitric oxide donating moiety, effective in treatment of osteoarthritis.naproxcinod
nitroglycerinA nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.nitroglycerin
s-nitroso-n-acetylpenicillamineA nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.S-nitroso-N-acetyl-D-penicillamine
s-nitrosoglutathioneA glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group.S-nitrosoglutathione

Research

Studies (20,362)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19907,032 (34.53)18.7374
1990's5,515 (27.08)18.2507
2000's4,683 (23.00)29.6817
2010's2,570 (12.62)24.3611
2020's562 (2.76)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials3,872 (16.42%)5.53%
Reviews1,391 (5.90%)6.00%
Case Studies1,114 (4.72%)4.05%
Observational25 (0.11%)0.25%
Other17,185 (72.86%)84.16%

Protein Targets (84)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency12.589311
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency22.411312
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency1.778311
AR proteinHomo sapiens (human)Potency0.002111
arylsulfatase AHomo sapiens (human)Potency29.632212
ATAD5 protein, partialHomo sapiens (human)Potency29.081011
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency9.511822
Bloom syndrome protein isoform 1Homo sapiens (human)Potency9.976724
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency44.668411
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency17.494523
Chain A, Beta-lactamaseEscherichia coli K-12Potency20.940523
Chain A, Ferritin light chainEquus caballus (horse)Potency44.668411
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency8.912511
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.158511
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency7.996012
chromobox protein homolog 1Homo sapiens (human)Potency40.797723
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency39.810711
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency6.924124
endonuclease IVEscherichia coliPotency8.154812
estrogen nuclear receptor alphaHomo sapiens (human)Potency12.744811
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency5.308011
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency4.121513
flap endonuclease 1Homo sapiens (human)Potency8.436811
GABA theta subunitRattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency6.924112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency6.924112
gemininHomo sapiens (human)Potency9.916933
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency1.032311
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency0.316222
IDH1Homo sapiens (human)Potency14.581011
importin subunit beta-1 isoform 1Homo sapiens (human)Potency1.032311
Integrin alpha-IIbHomo sapiens (human)Potency31.622811
Integrin beta-3Homo sapiens (human)Potency31.622811
lamin isoform A-delta10Homo sapiens (human)Potency12.950523
lethal factor (plasmid)Bacillus anthracis str. A2012Potency7.943311
Microtubule-associated protein tauHomo sapiens (human)Potency25.139725
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency2.648924
neuropeptide S receptor isoform AHomo sapiens (human)Potency22.535812
NFKB1 protein, partialHomo sapiens (human)Potency12.924424
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency25.115111
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency100.000011
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency30.131311
plasminogen precursorMus musculus (house mouse)Potency7.943311
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency5.011911
RAR-related orphan receptor gammaMus musculus (house mouse)Potency2.660311
regulator of G-protein signaling 4Homo sapiens (human)Potency50.118711
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency26.603222
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency21.192311
Single-stranded DNA cytosine deaminaseHomo sapiens (human)Potency49.221524
Smad3Homo sapiens (human)Potency2.818411
snurportin-1Homo sapiens (human)Potency1.032311
survival motor neuron protein isoform dHomo sapiens (human)Potency31.622811
thioredoxin reductaseRattus norvegicus (Norway rat)Potency12.313313
ThrombopoietinHomo sapiens (human)Potency6.990624
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.012611
thyroid stimulating hormone receptorHomo sapiens (human)Potency15.848911
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency7.943311
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency7.943311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine transporter 1Trypanosoma bruceiKi1,000.000011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC50133.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Cannabinoid receptor 1Rattus norvegicus (Norway rat)IC5050.000011
Estrogen receptor 1Homo sapiens (human)IC5024.673911
Glutathione reductase, mitochondrialHomo sapiens (human)IC5050.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Thioredoxin glutathione reductase Schistosoma mansoniIC505.650022
Thioredoxin reductase 1, cytoplasmicRattus norvegicus (Norway rat)IC50400.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-dependent translocase ABCB1Homo sapiens (human)EC50100.000011
Multidrug resistance-associated protein 1 Homo sapiens (human)EC5042.000011
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