Tetrachloroisophthalonitrile (TCIP) is a white crystalline solid with a melting point of 185-187 °C. It is used as a monomer in the synthesis of high-performance polymers. TCIP has been reported to be synthesized via a multi-step process involving the chlorination of isophthalonitrile. It is a highly reactive compound and can undergo various reactions, such as polymerization, cycloaddition, and nucleophilic substitution. TCIP has also been studied for its potential applications in electronic devices and as a flame retardant. Its high thermal stability, good dielectric properties, and excellent chemical resistance make it suitable for various applications. TCIP is a potential candidate for the preparation of novel materials with unique properties. It is also a key intermediate for the synthesis of other important compounds, such as pharmaceuticals, agrochemicals, and dyes. TCIP is a versatile building block for organic synthesis and has been extensively studied for its potential applications in different fields.'
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tetrachloroisophthalonitrile: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
chlorothalonil : A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 15910 |
| CHEMBL ID | 468167 |
| CHEBI ID | 3639 |
| SCHEMBL ID | 21254 |
| MeSH ID | M0047579 |
| Synonym |
|---|
| BIDD:ER0402 |
| chlorothalonil (tpn) |
| tetrachlorisoftalonitril |
| clorthalonil |
| unii-j718m71a7a |
| chlorthalonil |
| j718m71a7a , |
| tetrachlorobenzene-1,3-dicarbonitrile |
| EN300-42790 |
| DIVK1C_006920 |
| CHEBI:3639 , |
| meta-tcpn |
| m-tetrachlorophthalonitrile |
| m-tcpn |
| meta-tetrachlorophthalodinitrile |
| 2,4,5,6-tetrachloro-3-cyanobenzonitrile |
| 2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile |
| 1,3-dicyanotetrachlorobenzene |
| SPECTRUM_001557 |
| SPECTRUM5_001845 |
| QTL1_000080 |
| BSPBIO_003432 |
| inchi=1/c8cl4n2/c9-5-3(1-13)6(10)8(12)7(11)4(5)2-1 |
| 2,4,5,6-tetrachloroisophthalonitrile |
| 1,3-benzenedicarbonitrile, 2,4,5,6-tetrachloro- |
| daconil 2787 flowable fungicide |
| daconil 2787 w75 |
| 2,4,5,6-tetrachloro-1,3-dicyanobenzene |
| bravo 6f |
| chloroalonil |
| dacosoil |
| 1,3-dicyano-2,4,5,6-tetrachlorobenzene |
| chlorthalonil [german] |
| ai3-28721 |
| nopcocide n40d & n96 |
| forturf |
| dac 2787 |
| tetrachlorisoftalonitril [czech] |
| clorthalonil [german] |
| terraclactyl |
| nopcocide n-96 |
| dac-2787 |
| caswell no. 215b |
| hsdb 1546 |
| tetrachloro-1,3-dicyanobenzene |
| 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile |
| faber |
| isophthalonitrile, tetrachloro- |
| nci-c00102 |
| epa pesticide chemical code 081901 |
| daconil 2787 w-75 fungicide |
| nopcocide |
| exotherm termil |
| daconil 2787 |
| daconil m |
| exotherm |
| einecs 217-588-1 |
| ccris 150 |
| sweep |
| repulse |
| clortocaf ramato |
| bravo 500 |
| clortosip |
| brn 1978326 |
| vanox |
| chlorothalonil [ansi:bsi:iso] |
| daconil flowable |
| termil |
| bravo-w-75 |
| tpn (pesticide) |
| isophthalonitrile, 2,4,5,6-tetrachloro- |
| bravo |
| chlorothalonil |
| 1897-45-6 |
| daconil |
| tetrachloroisophthalonitrile |
| chlorothalonil, analytical standard |
| NCGC00094560-02 |
| NCGC00094560-03 |
| NCGC00094560-01 |
| KBIOSS_002037 |
| KBIOGR_000388 |
| KBIO1_001864 |
| KBIO2_007173 |
| KBIO3_002935 |
| KBIO2_002037 |
| KBIO2_004605 |
| SPECTRUM2_001649 |
| SPBIO_001777 |
| SPECTRUM3_001896 |
| SPECPLUS_000824 |
| SPECTRUM4_000094 |
| NCGC00094560-04 |
| NCGC00094560-05 |
| AC-10332 |
| T0895 |
| perchloroisophthalonitrile |
| CHEMBL468167 |
| NCGC00094560-07 |
| NCGC00094560-06 |
| NCGC00094560-08 |
| AKOS009158423 |
| 2,4-dicyanotetrachlorobenzene |
| dtxcid20319 |
| dtxsid0020319 , |
| tox21_300862 |
| NCGC00259236-01 |
| cas-1897-45-6 |
| NCGC00254766-01 |
| tox21_201687 |
| A813350 |
| 2,4,5,6-tetrakis(chloranyl)benzene-1,3-dicarbonitrile |
| CCG-39077 |
| tetrachloroisophthalodinitrile |
| FT-0602408 |
| chlorothalonil [mi] |
| chlorothalonil [hsdb] |
| chlorothalonil [iarc] |
| m-tetrachlorophthalodinitrile |
| chlorothalonil [iso] |
| SCHEMBL21254 |
| W-107745 |
| siclor |
| tripart faber |
| sipcam uk rover 500 (salt/mix) |
| bravo ultrex |
| daconil 1000 |
| thalonil |
| 2,4,5,6-tetrachloro-1,3-isophthalonitrile |
| tetrachloro-m-phthalodinitrile |
| benzenedicarbonitrile, 2,4,5,6-tetrachloro- |
| hortyl |
| nuocide (salt/mix) |
| bravo 720 |
| tripart ultrafaber |
| nopcocide n 96 |
| dakoflo |
| taloberg (salt/mix) |
| tuffcide (salt/mix) |
| mfcd00045594 |
| chlorothalonil, pestanal(r), analytical standard |
| chlorothalonil 10 microg/ml in cyclohexane |
| chlorothalonil 100 microg/ml in cyclohexane |
| tcpn |
| Q418320 |
| AMY22437 |
| CS-0034415 |
| HY-N6625 |
| BS-42280 |
| Z431554228 |
Tetrachloroisophthalonitrile is an agricultural and horticultural fungicide used in many parts of the world.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Tetrachloroisophthalonitrile (TCPN) is an agricultural and horticultural fungicide used in many parts of the world. " | ( Fungicide-induced contact dermatitis. Buhagen, M; Johnsson, M; Leira, HL; Solvang, S, 1983) | 1.71 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Laboratory bioassays and field treatments of a pond system were undertaken to determine the toxic effects of chlorothalonil on aquatic fauna." | ( The toxicity of chlorothalonil to aquatic fauna and the impact of its operational use on a pond ecosystem. Doe, K; Ernst, W; Hennigar, P; Jonah, P; Julien, G; Young, J, 1991) | 0.28 |
| " The EC10 and EC50 for chlorothalonil ranged from 2 to 108 and from 25 to 159 nM; for Sea-Nine 211 values were 6-204 and 38-372 nM; for dichlofluanid effective concentrations were 95-830 and 244-4311 nM; tolylfluanid yielded values between 99-631 and 213-2839 nM; and Irgarol 1051 was the least toxic compound showing values from 3145 to >25600 and from 6076 to >25600 nM." | ( Comparative toxicity of alternative antifouling biocides on embryos and larvae of marine invertebrates. Bellas, J, 2006) | 0.33 |
| " Mixture toxicities were studied using the concentration addition model (isobolograms and toxic unit summation), and the mixture toxicity index (MTI)." | ( Toxicity of four antifouling biocides and their mixtures on the brine shrimp Artemia salina. Aoyama, I; Koutsaftis, A, 2007) | 0.34 |
| " Irgarol 1051 was not toxic at concentrations below 40x10(3)nM." | ( Comparative toxicity of single and combined mixtures of selected pollutants among larval stages of the native freshwater mussels (Unio elongatulus) and the invasive zebra mussel (Dreissena polymorpha). Barata, C; Faria, M; Fernández-Sanjuan, M; Lacorte, S; López, MA, 2010) | 0.36 |
| " Both pesticides, however, were considerably more toxic under realistic ambient temperature regimes than in a climate-controlled laboratory." | ( Interactive effects of pesticide mixtures, predators, and environmental regimes on the toxicity of two pesticides to red-eyed tree frog larvae. Johnson, LA; Welch, B; Whitfield, SM, 2013) | 0.39 |
| " The eggs may be exposed to pesticides, the toxic effect of which may appear as embryo lethality and development anomalies." | ( Toxicity of chlorothalonil containing formulation and Cu-sulphate to chicken. Budai, P; Kormos, E; Lehel, J; Somody, G; Szabó, R; Takács, A; Tatai, A, 2012) | 0.38 |
| " At typical field application rates, the chemical regime associated with potato production does not appear to have any detrimental impacts on turtle egg development, except for the use of the soil fumigant metam sodium, which is highly toxic to turtle eggs at the lowest recommended application rate." | ( Toxicity of pesticides associated with potato production, including soil fumigants, to snapping turtle eggs (Chelydra serpentina). de Solla, SR; Martin, PA; Palonen, KE, 2014) | 0.4 |
| " In the present study, the accumulation of the fungicide chlorothalonil (CT) and its toxic metabolite hydroxy-chlorothalonil (HCT) in soil as well as their related soil genotoxicity under greenhouse conditions was investigated." | ( Soil genotoxicity induced by successive applications of chlorothalonil under greenhouse conditions. Cui, N; Jin, X; Khorram, MS; Wang, D; Yu, Y; Zhou, W, 2014) | 0.4 |
| " The present study assesses toxic effects on amphibians of 10 commonly used commercial pesticides in tropical agriculture using 2 approaches." | ( Acute toxicity tests and meta-analysis identify gaps in tropical ecotoxicology for amphibians. Donnelly, MA; Ghose, SL; Kerby, J; Whitfield, SM, 2014) | 0.4 |
| " Tier II evaluation by spray of pesticides at their field recommended doses on potted mustard plants showed monocrotophos as the highly toxic insecticide with 100% mortality even with 1h of exposure followed by thiamethoxam, dichlorvos, profenofos and chlorpyriphos which are not to be recommended for use in pollinator attractive flowering plants." | ( Evaluation of pesticide toxicity at their field recommended doses to honeybees, Apis cerana and A. mellifera through laboratory, semi-field and field studies. Bhatt, JC; Jain, SK; Sah, K; Stanley, J; Sushil, SN, 2015) | 0.42 |
| " According to the maximum residue limits (MRLs) and acceptable daily intakes (ADIs), the final residues of beta-cypermethrin, pyriproxyfen, avermectin, diflubenzuron, and chlorothalonil were safe for human consumption after these pesticides were applied by spraying 2 times at the dosages of 900, 750, 540, 562." | ( Evaluation of the safe use and dietary risk of beta-cypermethrin, pyriproxyfen, avermectin, diflubenzuron and chlorothalonil in button mushroom. Dong, F; Du, P; He, H; Liu, X; Wu, X; Xu, J; Zhang, Y; Zheng, Y, 2017) | 0.46 |
| "Chlorothalonil is a fungicide which is highly toxic to aquatic organisms." | ( A pulsed-dose study evaluating chronic toxicity of chlorothalonil to fish: A case study for environmental risk assessment. Hamer, M; Maynard, SK; Schneider, S, 2019) | 0.51 |
| " A primary intermediate product of degradation, 4-hydroxychlorothalonil (4-OH-CHT) has demonstrated toxic effects on aquatic organisms." | ( Potential toxic effects of 4-OH-chlorothalonil and photodegradation product on human skin health. Armbrust, KL; Vebrosky, EN; Xu, W, 2020) | 0.56 |
| "5x more toxic than chlorothalonil; estimated LC50 values ranged from 5-18 µg/L for pyraclostrobin and 15-50 µg/L for chlorothalonil." | ( Acute aquatic toxicity of two commonly used fungicides to midwestern amphibian larvae. Hopkins, AP; Hoverman, JT, 2023) | 0.91 |
| "During the study period, approximately 1,651 reports were identified with 2391 cases associated with a device failure, and 254 reporting a patient-related adverse event." | ( Patient adverse events and technical failures with the bravo capsule pH system: insights from the MAUDE database. Adler, DG; Bhandari, P; Chandan, S; Facciorusso, A; Gkolfakis, P; Kewalramani, A; Mozell, D; Ramai, D; Swaminath, A, 2023) | 0.91 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The purpose of this study was to examine plasma-activated buffer solution (PABS) and plasma-activated water (PAW) combined with ultrasonication (U) treatment on the reduction of chlorothalonil fungicide and the quality of tomato fruits during storage." | ( Effect of plasma-activated water and buffer solution combined with ultrasound on fungicide degradation and quality of cherry tomato during storage. Aadil, RM; Ali, M; Cheng, JH; Esua, OJ; Goksen, G; Lorenzo, JM; Manzoor, MF; Tazeddinova, D; Zeng, XA, 2023) | 0.91 |
| "In this study, two prediction models were developed using visible/near-infrared (Vis/NIR) spectroscopy combined with partial least squares discriminant analysis (PLS-DA) and least squares support vector machine (LS-SVM) for the detection of pesticide residues of avermectin, dichlorvos, and chlorothalonil at different concentration levels on the surface of cauliflowers." | ( Non-destructive detection and recognition of pesticide residue levels on cauliflowers using visible/near-infrared spectroscopy combined with chemometrics. Li, Y; Li, Z; Liu, Y; Wang, K; Xue, J; Yin, J; Zhang, M, 2023) | 0.91 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Although bioavailability of any compound is reduced when soil complexes are formed, further research is needed to evaluate accumulation and availability of CTN soil-bound residues over long-term applications, and the consequent detrimental effects on the environment and on soil quality and fertility." | ( Transformation pathways of 14c-chlorothalonil in tropical soils. Lavorenti, A; Pacovsky, RS; Regitano, JB; Tornisielo, VL, 2001) | 0.31 |
| "Cyclodextrins (CDs) can improve the apparent solubility and bioavailability of a variety of organic compounds through the formation of inclusion complexes; accordingly, they are suitable for application in innovative remediation technologies of contaminated soils." | ( Influence of selected cyclodextrins in sorption-desorption of chlorpyrifos, chlorothalonil, diazinon, and their main degradation products on different soils. Báez, ME; Espinoza, J; Fuentes, E; Silva, R, 2017) | 0.46 |
| " High-intensity sonication treatments also significantly increased the bioavailability of phenolic, chlorophyll, and anthocyanins and the antioxidant activity of spinach juice." | ( High-intensity ultrasonication impact on the chlorothalonil fungicide and its reduction pathway in spinach juice. Aadil, RM; Ali, M; Goksen, G; Iqbal, MW; Lorenzo, JM; Manzoor, MF; Zeng, XA, 2023) | 0.91 |
| " Surfactants can promote the bioavailability of organic compounds for enhanced microbial degradation, but the performance depends on soil and surfactant properties, sorption-desorption equilibria of contaminants and surfactants, and possible adverse effects of surfactants on microorganisms." | ( Effect of surfactants on the sorption-desorption, degradation, and transport of chlorothalonil and hydroxy-chlorothalonil in agricultural soils. Báez, ME; Espinoza, J; Fuentes, E; Peña, A; Sarkar, B; Vidal, J, 2023) | 0.91 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the bile of rats dosed with chlorthalonil (0." | ( Biotransformation of the fungicide chlorthalonil by glutathione conjugation. Dekant, W; Klos, C; Rosner, E, 1996) | 0.29 |
| " Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring." | ( Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. Heloísa Chiorato, S; Lúcia Scherholz de Castro, V, 2007) | 0.34 |
| " anguillarum in our study may reflect a dose-response range that did not elicit an effect on those immune responses responsible for control and clearance of this particular pathogen." | ( Immunotoxicological effects of a sub-chronic exposure to selected current-use pesticides in rainbow trout (Oncorhynchus mykiss). Balfry, SK; Kennedy, CJ; Ross, PS; Shelley, LK, 2009) | 0.35 |
| " Increasing of applied ozone dosage was not significantly effect on the removal percentages of pesticides whereas increasing of ozonation temperature caused a negative effect on the removal percentages of pesticides." | ( Removal of chloropyrifos ethyl, tetradifon and chlorothalonil pesticide residues from citrus by using ozone. Ceyhan, M; Kusvuran, E; Mavruk, F; Yildirim, D, 2012) | 0.38 |
| " The results indicated that both CT and HCT accumulated in soil with repeated applications of CT, and the accumulation level was strongly correlated to application dosage and its frequency." | ( Soil genotoxicity induced by successive applications of chlorothalonil under greenhouse conditions. Cui, N; Jin, X; Khorram, MS; Wang, D; Yu, Y; Zhou, W, 2014) | 0.4 |
| Role | Description |
|---|---|
| antifungal agrochemical | Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| dinitrile | A dinitrile is a compound containing two nitrile groups. |
| tetrachlorobenzene | Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions. |
| aromatic fungicide | An organic aromatic compound that has been used as a fungicide. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 15.8489 | 5.6234 | 17.2929 | 31.6228 | AID485281 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 0.0020 | 14.6779 | 39.8107 | AID1476 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 10.0227 | 0.0025 | 41.7960 | 15,848.9004 | AID1347395; AID1347398 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.2818 | 0.1000 | 20.8793 | 79.4328 | AID588453 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 0.0251 | 27.9203 | 501.1870 | AID651751 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 4.9081 | 3.1890 | 29.8841 | 59.4836 | AID1224846; AID1224894 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 1.4169 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 22.4841 | 0.1737 | 34.3047 | 61.8120 | AID1346859; AID1346924 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 10.0000 | 0.0316 | 37.5844 | 354.8130 | AID504865 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 22.4841 | 0.1737 | 34.3047 | 61.8120 | AID1346859; AID1346924 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.3429 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.6989 | 0.0007 | 14.5928 | 83.7951 | AID1259368; AID1259369; AID1259392 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 2.0085 | 0.1800 | 13.5574 | 39.8107 | AID1460; AID1468 |
| AR protein | Homo sapiens (human) | Potency | 5.6627 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID588515; AID588516; AID743035; AID743036; AID743042; AID743053; AID743054; AID743063 |
| Smad3 | Homo sapiens (human) | Potency | 0.2512 | 0.0052 | 7.8098 | 29.0929 | AID588855 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 44.6684 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 7.3808 | 0.0006 | 57.9133 | 22,387.1992 | AID1259377; AID1259378 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 8.0897 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| progesterone receptor | Homo sapiens (human) | Potency | 19.7965 | 0.0004 | 17.9460 | 75.1148 | AID1346784; AID1346795 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 17.9178 | 0.0002 | 14.3764 | 60.0339 | AID588532; AID588533; AID720691; AID720692; AID720719 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 2.3256 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.9231 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531; AID588544; AID588546 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 4.3671 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.8613 | 0.3758 | 27.4851 | 61.6524 | AID588526; AID588527; AID743217; AID743220 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 8.4235 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982; AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.0711 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID1259248; AID1259383; AID588513; AID588514; AID743069; AID743075; AID743077; AID743078; AID743079; AID743080; AID743091 |
| 67.9K protein | Vaccinia virus | Potency | 21.1546 | 0.0001 | 8.4406 | 100.0000 | AID720579; AID720580 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 8.9536 | 0.0010 | 24.5048 | 61.6448 | AID588534; AID588535; AID743212; AID743215; AID743227 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 3.2704 | 0.0010 | 19.4141 | 70.9645 | AID588537; AID743094; AID743140; AID743191 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 18.9723 | 0.0237 | 23.2282 | 63.5986 | AID588541; AID588543; AID743222; AID743223 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 3.9811 | 0.0165 | 25.3078 | 41.3999 | AID602332 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 12.5893 | 0.0007 | 23.0674 | 1,258.9301 | AID651777 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 1.2374 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 3.3728 | 0.0016 | 28.0151 | 77.1139 | AID1224843; AID1224895 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 23.1606 | 0.1434 | 27.6121 | 59.8106 | AID1159516; AID1159519 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 5.5753 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 1.5433 | 0.0578 | 21.1097 | 61.2679 | AID1159526; AID1159528 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 57.1182 | 0.0391 | 47.5451 | 146.8240 | AID1224845; AID1224896 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 0.4395 | 0.0067 | 23.4960 | 68.5896 | AID1346980 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 5.1453 | 0.3162 | 12.4435 | 31.6228 | AID902; AID924 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 0.0018 | 15.6638 | 39.8107 | AID894 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 0.7943 | 0.3548 | 28.0659 | 89.1251 | AID504847 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 2.5119 | 0.0100 | 39.5371 | 1,122.0200 | AID588547 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 0.4395 | 0.0067 | 23.4960 | 68.5896 | AID1346980 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.4621 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743066; AID743067 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 6.1513 | 0.0420 | 27.3789 | 61.6448 | AID743210; AID743228 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 2.7384 | 0.0398 | 16.7842 | 39.8107 | AID1454; AID1724; AID995 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 4.4668 | 24.8329 | 44.6684 | AID651749 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.9320 | 0.0006 | 27.2152 | 1,122.0200 | AID651741; AID743202 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 1.5849 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 2.1451 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 5.0119 | 0.1259 | 12.2344 | 35.4813 | AID1458 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 0.0580 | 10.6949 | 26.6086 | AID602310 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 0.3162 | 12.7657 | 31.6228 | AID881 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 11.0410 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 23.0509 | 0.0023 | 19.5956 | 74.0614 | AID651631; AID651743; AID720552 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 3.9811 | 0.3162 | 11.4157 | 31.6228 | AID924 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 3.9811 | 0.3162 | 11.4157 | 31.6228 | AID924 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 11.0410 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 1.4125 | 0.5623 | 9.3985 | 25.1189 | AID652106 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 0.0063 | 8.2350 | 39.8107 | AID881 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1.0000 | 10.4756 | 28.1838 | AID1457 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.7569 | 0.0119 | 17.9420 | 71.5630 | AID651632; AID720516 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.6440 | 0.0119 | 12.2221 | 68.7989 | AID651632 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1102300 | Fungicidal activity against Rhizoctonia solani infected in third leaf stage of rice plant at 50 mg/l applied as spray after 5 days under green house conditions relative to control | 2003 | Journal of agricultural and food chemistry, Mar-12, Volume: 51, Issue:6 | Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. |
| AID426460 | Antifungal activity against Corynespora cassiicola at 500 ug/ml relative to control | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides. |
| AID1882205 | Antifungal activity against Alternaria solani relative to control | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Natural and synthetic β-carboline as a privileged antifungal scaffolds. |
| AID1091342 | Genotoxicity in Cucumis sativus (cucumber) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untrea | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1105342 | Antifungal activity against Puccinia asparagi assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1511401 | Antifungal activity against Penicillium citrinum assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1112270 | Fungicidal activity against Neofusicoccum australe Mel-2 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1112264 | Fungicidal activity against Diplodia mutila Iso-2 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1081278 | Antifungal activity against Rhizoctonia solani Kuhn by mycelium growth rate test | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis, fungicidal activity, and structure-activity relationship of spiro-compounds containing macrolactam (macrolactone) and thiadiazoline rings. |
| AID1091367 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1083140 | Fungicidal activity against Corynespora cassiicola infected in drug-pretreated cucumber two seeded leaves assessed as decrease in disease index at 75% WP formulation (acetone Rvb = 5.23 +/-0.88%) | 2012 | Journal of agricultural and food chemistry, Nov-28, Volume: 60, Issue:47 | Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives. |
| AID1091352 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to u | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID744033 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1091386 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HNE-dG adducts measured per 10'9 nucleotides using [32P]labeling based autoradiography (Rvb = 2 no unit) | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1112255 | Fungicidal activity against Diplodia mutila F (12)2 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID632677 | Antifungal activity against Corynespora cassiicola assessed as growth inhibition at 500 ug/mL by potted plant test | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23 | Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: notable effects of the sugar moiety. |
| AID1091356 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091362 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1102628 | Antifungal activity against Colletotrichum orbiculare infested cucumber plant grown under greenhouse condition assessed as reduction in lesion formation on second leaves at 10 to 500 ug/ml sprayed at two-leaf stage 1 day prior inoculation measured after 6 | 2004 | Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4 | Antifungal activity of beta-asarone from rhizomes of Acorus gramineus. |
| AID1081393 | Fungicidal activity Botryotinia fuckeliana assessed as inhibition of mycelium growth at 50 mg/L at 24 degC measured after 2 days | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and fungicidal activity of aryl carbamic acid-5-aryl-2-furanmethyl ester. |
| AID1112263 | Fungicidal activity against Diplodia mutila Q assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091355 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091341 | Genotoxicity in Cucumis sativus (cucumber) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untrea | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1511404 | Antifungal activity against Aspergillus niger assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1081277 | Antifungal activity against Magnaporthe oryzae by mycelium growth rate test | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis, fungicidal activity, and structure-activity relationship of spiro-compounds containing macrolactam (macrolactone) and thiadiazoline rings. |
| AID1091388 | Genotoxicity in Vitis vinifera exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091351 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to u | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID775478 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1112271 | Fungicidal activity against Neofusicoccum australe Kat-1 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1592367 | Antifungal activity against Physalospora pyricola assessed as reduction in growth at 50 mg/l by mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1112258 | Fungicidal activity against Neofusicoccum luteum M (13)8 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID775482 | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID701473 | Antifungal activity against Aspergillus niger | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | The biology and chemistry of antifungal agents: a review. |
| AID1103390 | In vitro antifungal activity against Colletotrichum orbiculare on two-leaf stage cucumber plant assessed as inhibition of anthracnose development at 500 ug/mL | 2005 | Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20 | Isolation and antifungal activity of 4-phenyl-3-butenoic acid from Streptomyces koyangensis strain VK-A60. |
| AID1112261 | Fungicidal activity against Neofusicoccum australe Mel-2 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091353 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1592370 | Antifungal activity against Rhizoctonia cerealis assessed as reduction in growth mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1511402 | Antifungal activity against Fusarium oxysporum assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1112246 | Fungicidal activity against Neofusicoccum luteum infected Pinot noir grapevine assessed as dieback lesion length at 210 g AI /100 L applied 24 hr prior inoculation to pruning wound measured after 3 months | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091343 | Genotoxicity in Cucumis sativus (cucumber) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untrea | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1112259 | Fungicidal activity against Neofusicoccum luteum G(s)-1 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1105339 | Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID775475 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1091347 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to u | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091380 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID775484 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1091370 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1592365 | Antifungal activity against Sclerotinia sclerotiorum assessed as reduction in growth at 50 mg/l by mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1112265 | Fungicidal activity against Diplodia mutila F (12)2 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID701466 | Antifungal activity against Macrophomina phaseolina | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | The biology and chemistry of antifungal agents: a review. |
| AID1091354 | GenoToxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID775483 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1091378 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091373 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreate | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1511403 | Antifungal activity against Colletotrichum orbiculare assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1102295 | Fungicidal activity against Botryotinia fuckeliana infected first-leaf stage of cucumber plant at 50 mg/l applied as spray after 4 to 5 days under green house conditions relative to control | 2003 | Journal of agricultural and food chemistry, Mar-12, Volume: 51, Issue:6 | Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. |
| AID1112268 | Fungicidal activity against Neofusicoccum luteum G(s)-1 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1112256 | Fungicidal activity against Diplodia mutila Iso-2 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091364 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1102280 | Fungicidal activity against Blumeria graminis infected first-leaf stage of barley plant at 50 mg/l applied as spray under green house conditions relative to control | 2003 | Journal of agricultural and food chemistry, Mar-12, Volume: 51, Issue:6 | Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. |
| AID744031 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 24 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID775479 | Bactericidal activity against Staphylococcus aureus ATCC 6538 after 18 to 24 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1592366 | Antifungal activity against Phytophthora capsici assessed as reduction in growth at 50 mg/l by mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1091990 | Antifungal activity against Puccinia triticina inoculated on 100 ug/mL compound pre-treated wheat plants with 3 to 5 leaves assessed as growth inhibition | 2009 | Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10 | Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance. |
| AID1091339 | Genotoxicity in Vitis vinifera exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091374 | Genotoxicity inCucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091371 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HNE-dG adducts using [32P]labeling based autoradiography (Rvb = 34 cpm) | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091365 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091344 | Genotoxicity in Cucumis sativus (cucumber) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID744035 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1112254 | Fungicidal activity against Diplodia mutila Q assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1081276 | Antifungal activity against Phomopsis asparagi by mycelium growth rate test | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis, fungicidal activity, and structure-activity relationship of spiro-compounds containing macrolactam (macrolactone) and thiadiazoline rings. |
| AID1091338 | Genotoxicity in Vitis vinifera exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1511397 | Antifungal activity against Verticillium dahliae assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1592369 | Antifungal activity against Gibberella fujikuroi assessed as reduction in growth at 50 mg/l by mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1091375 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreate | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1511398 | Antifungal activity against Fusarium oxysporum sp. vasinfectum assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1112257 | Fungicidal activity against Neofusicoccum luteum N(12)2 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1592345 | Antifungal activity against Rhizoctonia cerealis assessed as reduction in growth at 50 mg/l by mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1091385 | Genotoxicity in Vitis vinifera exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1105343 | Antifungal activity against Rhizoctonia solani assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1091376 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreate | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID775480 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1091345 | Genotoxicity in Cucumis sativus (cucumber) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1105340 | Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID775472 | Fungicidal activity against Candida albicans ATCC 10231 after 18 to 24 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID744032 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition after 24 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1091384 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1102285 | Fungicidal activity against Puccinia recondita infected first leaf stage of wheat plant at 50 mg/l applied as spray after 10 days under green house conditions relative to control | 2003 | Journal of agricultural and food chemistry, Mar-12, Volume: 51, Issue:6 | Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. |
| AID1592368 | Antifungal activity against Colletotrichum (W. anthracnose) assessed as reduction in growth at 50 mg/l by mycelium growth rate method relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. |
| AID1882206 | Antifungal activity against Bipolaris maydis relative to control | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Natural and synthetic β-carboline as a privileged antifungal scaffolds. |
| AID1091350 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to u | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1511399 | Antifungal activity against Cytospora juglandis assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID775474 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1112269 | Fungicidal activity against Neofusicoccum australe J-3 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1081279 | Antifungal activity against Sclerotinia sclerotiorum by mycelium growth rate test | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis, fungicidal activity, and structure-activity relationship of spiro-compounds containing macrolactam (macrolactone) and thiadiazoline rings. |
| AID1102290 | Fungicidal activity against Phytophthora infestans infected second leaf-stage of tomato plant at 50 mg/l applied as spray after 4 days under green house conditions relative to control | 2003 | Journal of agricultural and food chemistry, Mar-12, Volume: 51, Issue:6 | Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. |
| AID382909 | Antifungal activity against Sclerotinia sclerotiorum | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides. |
| AID1091346 | Genotoxicity in Cucumis sativus (cucumber) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091382 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID744038 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1081280 | Antifungal activity against Botryotinia fuckeliana by mycelium growth rate test | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis, fungicidal activity, and structure-activity relationship of spiro-compounds containing macrolactam (macrolactone) and thiadiazoline rings. |
| AID1091369 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1105344 | Antifungal activity against Valsa mali assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1511405 | Antifungal activity against Curvularia lunata assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1102305 | Fungicidal activity against Magnaporthe grisea infected second leaf stage of rice plant at 50 mg/l applied as spray after 5 days under green house conditions relative to control | 2003 | Journal of agricultural and food chemistry, Mar-12, Volume: 51, Issue:6 | Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. |
| AID1080691 | Antifungal activity against Phytophthora infestans infected compound pre-treated tomato plant seedlings assessed as tomato late blight disease control efficacy at 100 ug/mL measured after 2 days under greenhouse conditions | 2009 | Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13 | Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi. |
| AID1091359 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1112262 | Fungicidal activity against Neofusicoccum australe Kat-1 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091387 | Genotoxicity in Vitis vinifera exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID775477 | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1112235 | Fungicidal activity against Neofusicoccum luteum infected Pinot noir grapevine assessed as pathogen incidence at 210 g AI /100 L applied 24 hr prior inoculation to pruning wound measured after 3 months | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1112260 | Fungicidal activity against Neofusicoccum australe J-3 assessed as conidial germination inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID775476 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID376577 | Antifungal activity against Colletotrichum fragariae assessed as zone of inhibition | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. |
| AID1091357 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091379 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091340 | Genotoxicity in Vitis vinifera exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091363 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID744034 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1000 ug/mL after 72 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1091349 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to u | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091361 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091366 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091368 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID701439 | Antifungal activity against Fusarium oxysporum | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | The biology and chemistry of antifungal agents: a review. |
| AID1091381 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID775473 | Bactericidal activity against Bacillus cereus ATCC 14579 after 18 to 24 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1091358 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1112266 | Fungicidal activity against Neofusicoccum luteum M (13)8 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091377 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreate | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1082825 | Antifungal activity against Colletotrichum lagenaria assessed as inhibition of spore germination at 24 +/- 1 degC for 8 hr (plant disease: on leaf and fruit) | 2012 | Journal of agricultural and food chemistry, Apr-18, Volume: 60, Issue:15 | Synthesis and antifungal activities of carabrol ester derivatives. |
| AID1080690 | Antifungal activity against Phytophthora infestans infected compound pre-treated tomato plant seedlings assessed as tomato late blight disease control efficacy at 50 ug/mL measured after 2 days under greenhouse conditions | 2009 | Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13 | Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi. |
| AID744037 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1091348 | Genotoxicity in Phaseolus vulgaris (bush beans) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to u | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1091372 | Genotoxicity in Cucurbita pepo (pumpkin) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreate | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID1112267 | Fungicidal activity against Neofusicoccum luteum N(12)2 assessed as mycelial growth inhibition after 48 hr | 2012 | Pest management science, May, Volume: 68, Issue:5 | Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. |
| AID1091360 | Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants. |
| AID775481 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID744036 | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1511400 | Antifungal activity against Aspergillus flavus assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1105341 | Antifungal activity against Phytophthora parasitica assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 22 (4.99) | 18.7374 |
| 1990's | 38 (8.62) | 18.2507 |
| 2000's | 103 (23.36) | 29.6817 |
| 2010's | 174 (39.46) | 24.3611 |
| 2020's | 104 (23.58) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (37.17) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 10 (2.19%) | 5.53% |
| Reviews | 9 (1.97%) | 6.00% |
| Case Studies | 11 (2.41%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 427 (93.44%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||