Page last updated: 2024-08-05 11:29:24

C21-steroid

A steroid that has a structure based on a 21-carbon (pregnane) skeleton. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure.

ChEBI ID: 61313

Members (11)

MemberDefinitionRole
20 beta-dihydroprogesteroneA C21-steroid that is pregnane which contains a double bond between positions 4 and 5 and is substituted by an oxo group at position 3 and a hydroxy group at position 20.20-hydroxypregn-4-en-3-one
3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-oneA 17alpha-hydroxy steroid that is 3alpha-hydroxy-5beta-pregnan-20-one carrying an additional hydroxy group at position 17alpha.3alpha,17alpha-dihydroxy-5beta-pregnan-20-one
5beta-pregnane-3,20-dioneA C21-steroid that is 5beta-pregnane with oxo groups at positions 3 and 20.5beta-pregnane-3,20-dione
6 beta-hydroxycortisolA C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.6beta-hydroxycortisol
algestoneA C21-steroid that is pregn-4-ene substituted by oxo groups at position 3 and 20 and hydroxy groups at positions 16 and 17.algestone
corticosteroneA 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.corticosterone
cortisoneA C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.cortisone
fludrocortisonefludrocortisone
prednisoloneA glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.prednisolone
prednisoneA synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.prednisone
pregnenoloneA 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.pregnenolone

Research

Studies (115,877)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199054,137 (46.72)18.7374
1990's17,007 (14.68)18.2507
2000's19,360 (16.71)29.6817
2010's20,174 (17.41)24.3611
2020's5,199 (4.49)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials9,096 (7.06%)5.53%
Reviews6,622 (5.14%)6.00%
Case Studies26,235 (20.35%)4.05%
Observational286 (0.22%)0.25%
Other86,686 (67.24%)84.16%