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C21-steroid
A steroid that has a structure based on a 21-carbon (pregnane) skeleton. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure.
ChEBI ID: 61313
Members (11)
| Member | Definition | Role |
|---|---|---|
| 20 beta-dihydroprogesterone | A C21-steroid that is pregnane which contains a double bond between positions 4 and 5 and is substituted by an oxo group at position 3 and a hydroxy group at position 20. | 20-hydroxypregn-4-en-3-one |
| 3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one | A 17alpha-hydroxy steroid that is 3alpha-hydroxy-5beta-pregnan-20-one carrying an additional hydroxy group at position 17alpha. | 3alpha,17alpha-dihydroxy-5beta-pregnan-20-one |
| 5beta-pregnane-3,20-dione | A C21-steroid that is 5beta-pregnane with oxo groups at positions 3 and 20. | 5beta-pregnane-3,20-dione |
| 6 beta-hydroxycortisol | A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. | 6beta-hydroxycortisol |
| algestone | A C21-steroid that is pregn-4-ene substituted by oxo groups at position 3 and 20 and hydroxy groups at positions 16 and 17. | algestone |
| corticosterone | A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. | corticosterone |
| cortisone | A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20. | cortisone |
| fludrocortisone | fludrocortisone | |
| prednisolone | A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. | prednisolone |
| prednisone | A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. | prednisone |
| pregnenolone | A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20. | pregnenolone |
Research
Studies (115,877)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 54,137 (46.72) | 18.7374 |
| 1990's | 17,007 (14.68) | 18.2507 |
| 2000's | 19,360 (16.71) | 29.6817 |
| 2010's | 20,174 (17.41) | 24.3611 |
| 2020's | 5,199 (4.49) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 9,096 (7.06%) | 5.53% |
| Reviews | 6,622 (5.14%) | 6.00% |
| Case Studies | 26,235 (20.35%) | 4.05% |
| Observational | 286 (0.22%) | 0.25% |
| Other | 86,686 (67.24%) | 84.16% |