Crush Syndrome

Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.

Synonym
Crush Syndrome

Excerpt	Reference
"Crush syndrome is a form of traumatic rhabdomyolysis characterized by systemic involvement, in which acute renal failure is potentially life-threatening."	( Hiraide, A; Ishikawa, K; Iwai, A; Kishi, M; Mizushima, Y; Morimoto, F; Nakata, Y; Shimazu, T; Takaoka, M; Tanaka, H; Yoshioka, T, 1997)
"Crush syndrome is defined as traumatic rhabdomyolysis with systemic and local complications."	( Dönmez, O; Durmaz, O; Meral, A; Yavuz, M, 2001)
"The pathogenesis of crush syndrome is severe traumatic damage to the organism accompanied by shock and stress, acute toxemia, etc."	( Arakelyan, L; Kevorkian, G; Knaryan, V; Marouchyan, G, 2002)
"Crush syndrome is systemic manifestations caused by rhabdomyolysis; the most important component of crush syndrome is acute kidney injury."	( Sever, MS, 2007)
"Crush syndrome is a devastating condition leading to multiple organ failure."	( Imamura, Y; Jin, T; Matsumoto, H; Matsumoto, N; Nakagawa, J; Nakane, Y; Ogura, H; Shimazaki, J; Shimazu, T; Yamada, T; Yamakawa, K, 2016)
"Crush syndrome is characterized by ischemia/reperfusion injury (IRI)."	( Kobayashi, J; Murata, I, 2018)

Excerpt	Reference
"Crush syndrome has been described as extensive muscle damage, leading to acute renal failure."	( Arinsoy, T; Bali, M; Buyan, N; Derici, U; Erbas, D; Hasanoglu, E; Ozkaya, O; Sindel, S; Soylemezoglu, O, 2002)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	58 (38.41)	23.3326
1990's	24 (15.89)	12.5806
2000's	24 (15.89)	18.1394
2010's	39 (25.83)	28.8240
2020's	6 (3.97)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
carbon monoxide	low	2	0
methane	low	1	0
chlorine	low	1	0
hydrogen sulfide	low	1	0
creatine	low	2	0
lactic acid	low	2	0
glycine	low	1	0
glycerol	low	3	0
hydrogen carbonate	low	4	0
dalteparin	low	2	0
histamine	low	1	0
niacinamide	low	1	0
niacin	low	1	0
nitrates	low	2	0
nitrites	low	3	0
pyruvic acid	low	1	0
taurine	low	1	0
uric acid	low	1	0
acetaminophen	low	1	0
amantadine	low	1	0
aspirin	low	1	0
bupivacaine	low	1	0
chlorpromazine	low	1	0
amphetamine	low	1	0
dipyridamole	low	1	0
furosemide	low	1	0
glafenine	low	1	0
halothane	low	1	0
isoniazid	low	1	0
practolol	low	1	0
succinylcholine	low	1	0
sulfobromophthalein	low	1	0
n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine	low	1	0
thymidine	low	1	0
thyroxine	low	2	0
triiodothyronine	low	2	0
carbon tetrachloride	low	1	0
cyanides	low	1	0
bromodeoxyuridine	low	1	0
mannitol	low	9	0
nitromethane	low	1	0
butobarbital	low	1	0
tromethamine	low	1	0
isoprene	low	1	0
pyrazolanthrone	low	1	0
catechin	low	1	0
hexacosanoic acid	low	1	0
malondialdehyde	low	2	0
acetylcysteine	low	1	0
d-alpha tocopherol	low	2	0
paraquat	low	1	0
sulfur hexafluoride	low	2	0
acetylglucosamine	low	1	0
phosphoric acid, trisodium salt	low	1	0
sodium bisulfide	low	1	0
glutamic acid	low	2	0
atorvastatin	low	1	0
3-iodobenzylguanidine	low	1	0
adenosine	low	1	0
epigallocatechin gallate	low	1	0
glutathione disulfide	low	1	0
sivelestat	low	1	0
perftoran	low	1	0
proline	low	1	0
fibrin	low	2	0
raffinose	low	1	0
cocaine	low	1	0
enkephalin, leucine	low	2	0
sodium bicarbonate	medium	2	1
dinoprostone	low	2	0
vitamin k semiquinone radical	low	1	0
alprostadil	low	1	0
amphotericin b	low	1	0
phenylephrine hydrochloride	low	1	0
tin	low	1	0
phosphorus	low	2	0
heroin	low	1	0
pregabalin	low	1	0
beta-escin	low	1	0
enkephalin, leucine-2-alanine	low	2	0
enkephalin-leu, ala(2)-arg(6)-	low	2	0
mocetinostat	low	5	0
losartan potassium	low	1	0
cytochrome c-t	low	1	0
atrial natriuretic factor	low	1	0
endothelin-1	low	2	0
ubiquinone	low	1	0
sodium nitrite	low	1	0
heme	low	1	0
ascorbic acid	low	2	0
transforming growth factor beta	low	1	0
glutaminase	low	1	0
flavin mononucleotide	low	1	0
muramidase	low	1	0
inosine diphosphate	low	1	0
allopurinol	low	1	0

Protein Targets (1,114)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	16	0	0	16
GLS protein	11	0	0	11
Thrombopoietin	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
histone acetyltransferase KAT2A isoform 1	10	0	0	10
lethal factor (plasmid)	11	0	0	11
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	11	1	1	13
ATP-dependent phosphofructokinase	8	0	0	8
5-hydroxytryptamine receptor 2C	0	5	2	7
5-hydroxytryptamine receptor 2A	0	5	2	7
5-hydroxytryptamine receptor 1A	0	5	3	8
5-hydroxytryptamine receptor 1B	0	5	2	7
5-hydroxytryptamine receptor 1D	0	3	2	5
5-hydroxytryptamine receptor 1F	0	3	2	5
5-hydroxytryptamine receptor 2B	0	5	2	7
5-hydroxytryptamine receptor 6	0	1	2	3
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	3	2	5
5-hydroxytryptamine receptor 5A	0	1	2	3
5-hydroxytryptamine receptor 5B	0	1	2	3
5-hydroxytryptamine receptor 3A	0	1	2	3
5-hydroxytryptamine receptor 4	0	1	2	3
5-hydroxytryptamine receptor 3B	0	1	2	3
RAR-related orphan receptor gamma	20	0	0	20
ATAD5 protein, partial	6	0	0	6
Microtubule-associated protein tau	13	0	0	13
Smad3	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
thyroid stimulating hormone receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	9	0	0	9
EWS/FLI fusion protein	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	15	0	0	15
estrogen-related nuclear receptor alpha	23	0	0	23
estrogen nuclear receptor alpha	39	0	0	39
peroxisome proliferator activated receptor gamma	12	0	0	12
aryl hydrocarbon receptor	12	0	0	12
chromobox protein homolog 1	11	0	0	11
thyroid hormone receptor beta isoform 2	22	0	0	22
peripheral myelin protein 22	17	0	0	17
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	2	2	13
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	14
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	2	0	4
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	7	0	7
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	21	0	21
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	15	0	18
Carbonic anhydrase 2	0	15	0	19
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	2	1	4
Prostaglandin G/H synthase 1	0	2	1	3
Carbonic anhydrase 3	0	2	0	3
Cytochrome P450 3A4	0	5	1	6
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2C9	0	5	1	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	9	2	2	13
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	9	2	2	13
Gamma-aminobutyric acid receptor subunit gamma-2	9	2	3	14
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	9	2	2	13
Gamma-aminobutyric acid receptor subunit alpha-3	9	2	2	13
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	12	0	14
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 6	0	4	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	9	2	2	13
Gamma-aminobutyric acid receptor subunit alpha-2	9	2	2	13
Gamma-aminobutyric acid receptor subunit alpha-4	9	2	2	13
Gamma-aminobutyric acid receptor subunit gamma-3	9	2	2	13
Gamma-aminobutyric acid receptor subunit alpha-6	9	2	2	13
Carbonic anhydrase 5A, mitochondrial	0	6	0	8
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	3	0	5
Nuclear receptor ROR-gamma	7	0	0	7
Cytochrome P450 2J2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	9	3	3	15
Gamma-aminobutyric acid receptor subunit beta-3	9	2	2	13
Gamma-aminobutyric acid receptor subunit beta-2	9	2	3	14
Carbonic anhydrase 9	0	5	0	7
GABA theta subunit	9	2	2	13
Canalicular multispecific organic anion transporter 1	0	12	0	12
Carbonic anhydrase 15	0	6	0	7
Carbonic anhydrase 13	0	3	0	5
Gamma-aminobutyric acid receptor subunit epsilon	9	2	2	13
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	5	0	7
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	8	0	0	8
15-lipoxygenase, partial	4	0	0	4
pregnane X receptor	5	0	0	5
phosphopantetheinyl transferase	8	0	0	8
USP1 protein, partial	12	0	0	12
NFKB1 protein, partial	5	0	0	5
AR protein	35	0	0	35
regulator of G-protein signaling 4	11	0	0	11
glucocorticoid receptor [Homo sapiens]	24	0	0	24
farnesoid X nuclear receptor	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	5	0	0	5
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	8	0	0	8
flap endonuclease 1	5	0	0	5
geminin	20	0	0	20
survival motor neuron protein isoform d	9	0	0	9
muscarinic acetylcholine receptor M1	6	0	0	6
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
Ataxin-2	5	0	0	5
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	3	0	3
Putative glycosyltransferase WbgO	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
NPYLR7B	0	0	3	3
IDH1	11	0	0	11
Histone H2A.x	7	0	0	7
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	8	0	0	8
nuclear receptor ROR-gamma isoform 1	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	6	0	0	6
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	1	3	1	6
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	3	5
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	2	7
Adenosine receptor A2a	0	3	1	5
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
interleukin 8	6	0	0	6
TDP1 protein	18	0	0	18
estrogen receptor 2 (ER beta)	9	0	0	9
transcriptional regulator ERG isoform 3	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	24	0	0	24
lamin isoform A-delta10	21	0	0	21
Polyphenol oxidase 2	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	20	0	0	20
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	4	0	4
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
GLI family zinc finger 3	19	0	0	19
putative alpha-glucosidase	1	0	0	1
Solute carrier family 22 member 2	0	3	0	6
Solute carrier family 22 member 1	0	4	0	7
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	8	2	11
Glutamate receptor ionotropic, NMDA 2A	0	7	2	10
Glutamate receptor ionotropic, NMDA 2B	0	7	2	10
Glutamate receptor ionotropic, NMDA 2C	0	7	2	10
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	7	2	10
Solute carrier family 22 member 1	0	5	0	6
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	7	2	10
Multidrug and toxin extrusion protein 1	0	4	0	4
Solute carrier family 22 member 2	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	7	2	10
Solute carrier family 22 member 3	0	2	0	2
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Substance-P receptor	0	2	0	2
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	2	1	3
Beta-2 adrenergic receptor	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	1	1	2
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, Cruzipain	6	0	0	6
peroxisome proliferator-activated receptor delta	12	0	0	12
tumor necrosis factor	2	0	0	2
vitamin D3 receptor isoform VDRA	8	0	0	8
Cytochrome P450 2C19	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	5
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	4
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	8	0	0	8
DNA polymerase kappa isoform 1	8	0	0	8
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	3	1	1	5
Myeloperoxidase	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	1	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	6	1	7
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	4	0	0	4
pregnane X nuclear receptor	13	0	0	13
caspase-3	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
ATP-dependent translocase ABCB1	0	6	0	7
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	2
Solute carrier organic anion transporter family member 1B1	0	1	0	4
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Dihydroorotate dehydrogenase	0	2	0	2
Protease	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Cytochrome P450 2E1	0	1	0	1
peripheral myelin protein 22 isoform 1	4	0	0	4
DNA polymerase beta	4	0	0	4
DNA polymerase eta isoform 1	4	0	0	4
neuropeptide S receptor isoform A	5	0	0	5
Arginase	0	2	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
Prothrombin	0	2	3	5
Aldo-keto reductase family 1 member B1	0	3	0	3
Sucrase-isomaltase, intestinal	0	1	0	1
Mu-type opioid receptor	0	6	3	10
Delta-type opioid receptor	0	4	3	8
Kappa-type opioid receptor	0	3	2	6
Melatonin receptor type 1A	0	0	1	1
Melatonin receptor type 1B	0	0	1	1
Death-associated protein kinase 1	0	1	0	1
Beta-secretase 1	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	9	0	10
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	2	0	0	2
NADPH oxidase 1	0	1	0	1
G	6	0	0	6
polyprotein	2	0	0	2
67.9K protein	4	0	0	4
Snq2p	0	0	0	1
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
histone deacetylase 9 isoform 3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Transmembrane protease serine 2	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Albumin	0	2	1	3
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	3
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	3
Alpha-1B adrenergic receptor	0	2	0	2
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	3
D	0	3	0	3
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	0	3
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	6	1	7
Histamine H2 receptor	0	3	2	5
Alpha-1D adrenergic receptor	0	2	0	3
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	1	0	2
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 2C	0	2	0	2
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Histamine H1 receptor	0	2	2	4
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	4	2	6
D(3) dopamine receptor	0	2	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	4	0	1	5
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	3	0	4
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Aldehyde oxidase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	2	4
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	0	3	0	3
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Liver carboxylesterase 1	0	0	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	2	0	2
GALC protein	4	0	0	4
nonstructural protein 1	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
Solute carrier family 22 member 3	0	2	0	3
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Androgen receptor	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	5	0	5
activating transcription factor 6	11	0	0	11
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Beta-lactamase	4	0	0	4
Chain A, Ferritin light chain	4	0	0	4
acid sphingomyelinase	2	0	0	2
RGS12	2	0	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
cytochrome P450 2C9 precursor	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
tumor susceptibility gene 101 protein	1	0	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	4	0	0	4
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Inositol monophosphatase 1	3	0	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	3	1	5
Delta-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	6	1	7
Kappa-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	2	1	3
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Mu-type opioid receptor	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	0	1	1
Chain A, POLYMERASE PA	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Genome polyprotein	0	1	0	1
Luciferase	6	0	0	6
galactokinase	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
POsterior Segregation	0	0	1	1
Prostaglandin E synthase	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
Polycomb protein EED	0	0	1	1
NAD kinase	0	2	1	3
Dihydrofolate reductase	0	0	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	1	0	1
Transthyretin	0	1	1	4
Polymerase acidic protein	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Heme oxygenase 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Neutrophil elastase	0	3	0	3
72 kDa type IV collagenase	0	1	0	1
Hepatocyte growth factor receptor	0	2	0	2
Matrilysin	0	1	0	1
60 kDa chaperonin	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Apoptosis regulator Bcl-2	0	2	0	2
Microtubule-associated protein tau	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Fatty acid synthase	0	1	0	1
CPG DNA methylase	0	1	0	1
Lethal factor	0	1	0	1
Phosphoglycerate mutase 1	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Signal transducer and activator of transcription 1-alpha/beta	0	0	1	1
DNA repair protein RAD52 homolog	0	1	0	1
Fatty acid synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
BH3-interacting domain death agonist	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Lactoperoxidase	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Bcl-2-related protein A1	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
10 kDa chaperonin	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] reductase	0	1	0	1
MAP kinase-activated protein kinase 5	0	1	0	1
CREB-binding protein	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Bcl-2-like protein 10	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	5	0	0	5
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Glutathione reductase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	3	0	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	2	1	3
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
PPM1D protein	2	0	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Photosystem I iron-sulfur center	0	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Renin	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	0	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
Beta-2 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	0	0	1
Alpha-1B adrenergic receptor	0	0	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Mitogen-activated protein kinase 10	0	1	0	1
Chain A, Mitogen-activated protein kinase 10	0	1	0	1
Chain A, Mitogen-activated protein kinase 10	0	1	0	1
endonuclease IV	2	0	0	2
Parkin	1	0	0	1
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	1	0	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Renin	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Dual specificity protein kinase TTK	0	1	1	2
Mitogen-activated protein kinase 8	0	1	1	2
Mitogen-activated protein kinase 9	0	1	1	2
Casein kinase I isoform epsilon	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	0	1
Mitogen-activated protein kinase 12	0	0	1	1
Mitogen-activated protein kinase 10	0	1	1	2
Cyclin-dependent kinase 16	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Aurora kinase C	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Pyridoxal kinase	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
hemoglobin subunit beta	1	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
Riboflavin-binding protein	0	1	1	2
Chymotrypsin-like elastase family member 1	0	1	0	1
Kallikrein-1	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Cathepsin G	0	1	0	1
Chymotrypsin-like elastase family member 2A	0	1	0	1
Myeloblastin	0	1	0	1
Trypsin-3	0	1	0	1
Neutrophil elastase	0	1	0	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Androgen receptor	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (151)

Protein Targets (1,114)

Crush Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (151)

Drugs Studied (121)

Protein Targets (1,114)