An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88).
ChEBI ID: 77763
| Member | Definition | Class |
|---|---|---|
| 2-piperidone | A delta-lactam that is piperidine which is substituted by an oxo group at position 2. | piperidin-2-one |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 292 (23.14) | 18.7374 |
| 1990's | 97 (7.69) | 18.2507 |
| 2000's | 245 (19.41) | 29.6817 |
| 2010's | 499 (39.54) | 24.3611 |
| 2020's | 129 (10.22) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 65 (4.98%) | 5.53% |
| Reviews | 34 (2.61%) | 6.00% |
| Case Studies | 16 (1.23%) | 4.05% |
| Observational | 3 (0.23%) | 0.25% |
| Other | 1,187 (90.96%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 13,000.0000 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 13,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Peptidyl-prolyl cis-trans isomerase FKBP5 | Homo sapiens (human) | Kd | 2,800.0000 | 1 | 1 |