ascorbic-acid and Hepatitis

Topics: Amantadine; Antiviral Agents; Ascorbic Acid; Dosage Forms; Drug Evaluation; Encephalitis; Hepatitis; Herpes Simplex; Herpes Zoster; Humans; Idoxuridine; Influenza, Human; Inosine Pranobex; Interferons; Levamisole; Rimantadine; Subacute Sclerosing Panencephalitis; Trifluridine; Virus Diseases

In vitro data suggest that vitamin C alters numerous parameters of immune function and might have potential as an agent which prevents infection. When an uncontrolled Japanese trial claimed efficacy of vitamin C in preventing posttransfusion hepatitis, a randomized double-blind controlled trial was initiated to determine if this claim of vitamin C efficacy could be confirmed. For 2 days before surgery and 2 wk after operation, cardiac surgery patients received orally either a lactose placebo or 800 mg of vitamin C four times daily. One hundred seventy-five patients completed the study. Highly significant elevations of plasma vitamin C were seen in the vitamin C treatment group as compared to the placebo group (p < 0.0005), but no significant difference in the incidence of posttransfusion hepatitis (p < 0.50) or the clinical course of hepatitis was seen between the two treatment groups.

Topics: Alanine Transaminase; Ascorbic Acid; Aspartate Aminotransferases; Cardiovascular Diseases; Double-Blind Method; Female; Hepatitis; Hepatitis B Surface Antigens; Humans; Male; Middle Aged; Placebos; Transfusion Reaction

Topics: Adult; Aged; Ascorbic Acid; Blood Proteins; Clinical Trials as Topic; Folic Acid; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Middle Aged; Nicotinic Acids; Vitamin B 12

l-ascorbic acid (vitamin C) insufficiency is considered one of the major risk factors for the development of liver disease. However, its specific effects and related mechanisms in vivo are largely unknown. The objective of this study was to investigate the in vivo protective role of vitamin C and its related mechanisms in liver injury with Gulo(-/-) mice that cannot synthesize vitamin C like humans due to the lack of l-gulonolactone-γ-oxidase (Gulo), an essential enzyme for vitamin C synthesis.. When liver injury was induced in Gulo(-/-) mice by injection of concanavalin A (Con A), there was greater extensive liver damage accompanied by an increased number of apoptotic hepatocytes in vitamin C-insufficient Gulo(-/-) mice. Additionally, the plasma and hepatic levels of the proinflammatory cytokines, such as TNF-α and IFN-γ, were much higher in the vitamin C-insufficient Gulo(-/-) mice than in the control mice. Moreover, increased numbers of liver-infiltrating T-cells in the vitamin C-insufficient Gulo(-/-) mice were related to the increased hepatic levels of IFN-inducible factor (IP-10). Although the vitamin C-insufficient Gulo(-/-) mice had higher amounts of interleukin-22 (IL-22), a hepatoprotective cytokine, a defect in IL-22Rα expression and its downstream STAT3 activation in hepatocytes were found.. We first demonstrate the novel in vivo action mechanisms of vitamin C on the prevention of disease development in the liver, through the regulation of excessive immune activation and maintenance of the IL-22Rα signaling pathways.. These results suggest that severe liver damage induced by inflammation could be prevented by sufficient supplementation with vitamin C.

Topics: Animals; Antioxidants; Ascorbic Acid; Ascorbic Acid Deficiency; Chemical and Drug Induced Liver Injury; Cytokines; Enzyme Activation; Hepatitis; Inflammation Mediators; L-Gulonolactone Oxidase; Male; Mice; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; STAT3 Transcription Factor; T-Lymphocytes

To investigate the effects of antihistamine treatment on immune function in rats with experimental hepatitis.. Thirty Wistar rats were randomly allocated into three groups:experimental hepatitis group (EH group), antihistamine treatment group (AH group) and normal control group (NC group). Rats in the EH group received the subcutaneous injection of 40% carbon tetrachloride oil solution and were fed on diet with low-protein, low-choline, high-fat and high-alcohol,while rats in the AH group received antihistamine treatment(ketotifen + vitamin C) additionally.They were sacrificed after 4 weeks, and the levels of serum alanine aminotransferase(ALT), total bilirubin (TBil), histamine(HA), IFNgamma, IL-12, IL-4 and IL-10 were determined. The levels of IL-12 mRNA and IFN-gamma mRNA in liver tissue were determined via real-time reverse transcriptional polymerase chain reaction(RT-PCR).. (1) Compared to the NC group, in the EH group, the levels of ALT, TBil, and circulating and intrahepatic HA were significantly increased(P less than 0.05); intrahepatic HA were significantly decreased(P less than 0.05) after antihistamine treatment. (2) Compared to the NC group, in the EH group, the levels of IL-4, IL-10 were significantly increased((0.504+/-0.202)ng/ml and (29.025+/-1.478) pg/ml vs (0.811+/-0.244)ng/ml and (33.72+/-4.293)pg/ml respectively, P less than 0.05), and the levels of IL-12 were decreased ((6.515+/-2.893)pg/ml vs (3.519+/-1.113)pg/ml, P less than 0.05); and after antihistamine treatment the levels of IL-4 and IL-10 were significantly decreased (were (0.423+/-0.168)ng/ml and (30.412+/-3.275)pg/ml, P less than 0.05), the levels of IL-12 were significantly increased (P less than 0.05), but the level of IFNgamma had no significance (P more than 0.05). The levels of intrahepatic IL-12 mRNA and IFNgamma mRNA had similar results.. Antihistamine treatment may improve liver function and correct Th1/Th2 unbalance.

Topics: Animals; Ascorbic Acid; Disease Models, Animal; Hepatitis; Histamine Antagonists; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-4; Ketotifen; Liver; Male; Rats; Rats, Wistar; Th1-Th2 Balance; Tumor Necrosis Factor-alpha

Topics: Ascorbic Acid; Biopsy; Fatty Liver; Hepatitis; Humans; Liver; Transaminases; Ursodeoxycholic Acid; Vitamin E

Topics: Antioxidants; Ascorbic Acid; Fatty Liver; Female; Hepatitis; Humans; Male; Prognosis; Risk Assessment; Treatment Outcome; Vitamin E

To assess the degree of oxidative stress, we measured plasma ubiquinone-10 percentage (%CoQ-10) in total amounts of ubiquinone-10 in patients with chronic active hepatitis, liver cirrhosis, and hepatocellular carcinoma, and in age-matched control subjects, %CoQ-10 values were 12.9 +/- 10.3 (n = 28), 10.6 +/- 6.8 (n = 28), 18.9 +/- 11.1 (n = 20), and 6.4 +/- 3.3 (n = 16), respectively, showing a significant increase in oxidative stress in patient groups as compared to control subjects. There were no differences in total amounts of ubiquinone-10 and ubiquinol-10 among the four groups. We next measured %CoQ-10 in plasmas obtained from nine patients treated with percutaneous transluminal coronary angioplasty (PTCA). Plasmas were collected when hospitalized, and at the time (0, 4, 8, 12, 16, and 20 hr, and 1, 2, 3, 4, and 7 days) after the PTCA. %CoQ-10 values before and right after PTCA were 9.9 +/- 2.8 and 11.4 +/- 2.0, respectively, reached a maximum (20-45) at 1 or 2 days later, and decreased to 7.9 +/- 2.7 at 7 days after PTCA, indicating an increase in oxidative stress in patients during coronary reperfusion.

Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Ascorbic Acid; beta Carotene; Bilirubin; Biomarkers; Carcinoma, Hepatocellular; Carotenoids; Female; Hepatitis; Humans; Liver Cirrhosis; Liver Neoplasms; Lycopene; Male; Middle Aged; Oxidative Stress; Reference Values; Ubiquinone; Uric Acid; Vitamin E

Topics: Adult; Amino Acids; Ascorbic Acid; Bile; Bile Acids and Salts; Chronic Disease; Electrolytes; Hepatitis; Humans; Lipids; Middle Aged; Proteins

Topics: Adult; Ascorbic Acid; Female; Hepatitis; Humans; Male; Middle Aged; Pancreatitis; Peptic Ulcer; Thiamine

Topics: Ascorbic Acid; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Vitamin E

Topics: Adolescent; Adult; Alkaline Phosphatase; Ascorbic Acid; Aspartate Aminotransferases; Bilirubin; Carotenoids; Cholesterol; Drainage; Female; Folic Acid; Glucose Tolerance Test; Hepatitis; Humans; Ileum; Intestinal Absorption; Intestinal Obstruction; Intestine, Small; Jejunum; Lipids; Male; Middle Aged; Necrosis; Obesity; Postoperative Complications; Surgical Wound Infection; Thrombophlebitis; Triglycerides; Uric Acid; Vitamin A; Vitamin B 12; Vitamin E; Xylose

Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Amino Acids; Anemia; Ascorbic Acid; Diagnosis, Differential; Hepatitis; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Male; Rickets; Tyrosine

Topics: Adult; Aged; Ascorbic Acid; Avitaminosis; Cholecystitis; Chronic Disease; Citrates; Female; Hepatitis; Humans; Male; Methods; Middle Aged; Niacinamide; Pyruvates; Sorbitol; Thiamine

Topics: Adult; Aged; Animals; Ascorbic Acid; Diagnosis, Differential; Female; Haptoglobins; Hepatitis; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methionine; Middle Aged; Rabbits; Rats; Vitamin K

Topics: Ascorbic Acid; Drug Therapy; Folic Acid; Hepatitis; Hepatitis A; Humans; Niacinamide; Vitamin B 12; Vitamin B Complex; Vitamin K; Vitamins

Topics: Ascorbic Acid; Child, Preschool; Hepatitis; Humans; Hyperbilirubinemia; In Vitro Techniques; Indicators and Reagents; Infant; Infant, Newborn; Jaundice; Spectrophotometry; Urine

Topics: Ammonium Compounds; Ascorbic Acid; Communicable Diseases; Glucuronates; Hepatitis; Hepatitis A; Humans; Lipotropic Agents; Niacin; Niacinamide; Quaternary Ammonium Compounds

Topics: Ascorbic Acid; Bilirubin; Blood; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Viral Vaccines

Topics: Adolescent; Ascorbic Acid; Cortisone; gamma-Globulins; Hepatic Encephalopathy; Hepatitis; Hepatitis A; Humans; Infusions, Parenteral; Niacin; Niacinamide; Pyridoxine; Riboflavin; Vitamin B 12; Vitamin E

Topics: Alanine Transaminase; Ascorbic Acid; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; D-Alanine Transaminase; Hepatitis; Liver Diseases; Rats; Research; Toxicology; Transaminases

Topics: Ascorbic Acid; Balneology; Child; Chlamydia Infections; Hepatitis; Hepatitis A; Humans; Hyperbilirubinemia; Liver Function Tests; Vitamin A; Vitamin B Complex; Vitamin D

Topics: Ascorbic Acid; Child; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Infant; Vitamins

Topics: Acute Disease; Ascorbic Acid; Hepatitis; Hepatitis A; Vitamins

Topics: Ascorbic Acid; Hepatitis; Hepatitis A; Humans; Neostigmine; Vitamins

Topics: Ascorbic Acid; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Vitamins

Topics: Ascorbic Acid; Child; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Infant; Vitamins

Topics: Ascorbic Acid; Child; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Infant; Vitamins

Topics: Ascorbic Acid; Child; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Infant; Vitamins

Topics: Ascorbic Acid; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Vitamins

Topics: Ascorbic Acid; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Vitamins

Topics: Ascorbic Acid; Hepatitis; Hepatitis A; Humans; Infections; Vitamins