Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
| Member | Definition | Class |
|---|
| (R)-ketamine | The R- (less active) enantiomer of ketamine. | (R)-ketamine |
| 1-(1-phenylcyclohexyl)pyrrolidine | Pyrrolidine in which the hydrogen attached to the nitrogen is substituted by a 1-phenylcyclohex-1-yl group. | rolicyclidine |
| 2-amino-5-phosphonovalerate | The 5-phosphono derivative of 2-aminopentanoic acid; acts as an N-methyl-D-aspartate receptor antagonist. | 2-amino-5-phosphonopentanoic acid |
| 7-chlorokynurenic acid | A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid. | 7-chlorokynurenic acid |
| amantadine | A member of the class of adamantanes that is used as an antiviral and antiparkinson drug. | amantadine |
| amantadine hydrochloride | A hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts. | amantadine hydrochloride |
| dextromethadone | A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. | dextromethadone |
| dextromethorphan | A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough. | dextromethorphan |
| dizocilpine | An organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. | dizocilpine |
| dizocilpine maleate | A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. | dizocilpine maleate |
| esketamine | The S- (more active) enantiomer of ketamine. | esketamine |
| ginsenoside rb3 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-xylopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Rb3 |
| isoliquiritigenin | A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. | isoliquiritigenin |
| ketamine | A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group. | ketamine |
| kynurenic acid | A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4. | kynurenic acid |
| levomethadone | A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine. | levomethadone |
| memantine | A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. | memantine |
| memantine hydrochloride | A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. | memantine hydrochloride |
| nitrous oxide | A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream. | dinitrogen oxide |
| noribogaine | An organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a hydroxy group. It is the primary (and long-lived) metabolite of ibogaine, the psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe iboga. | noribogaine |
| nortilidine | An ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate that is ent-dextilidine in which one of the methyl groups attached to the nitrogen is replaced by hydrogen. ent-Dextilidine is metabolised to (1R,2S)-nortilidine by the liver. | (1R,2S)-nortilidine |
| orphenadrine | A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol. | orphenadrine |
| orphenadrine citrate | A citrate salt which comprises equimolar amounts of orphenadrine and citric acid. | orphenadrine citrate |
| orphenadrine hydrochloride | A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride. | orphenadrine hydrochloride |
| pentamidine | A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. | pentamidine |
| phencyclidine | A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects. | phencyclidine |
| ro 25-6981 | A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor. | Ro 25-6981 |
| sdz eaa 494 | A member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). | midafotel |
| tenocyclidine | A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and thiophen-2-yl groups attached at position 1. A dissociative anaesthetic drug with halluccinogenic and stimulant effects. Its effects are similar to those of phencyclidine (PCP, an analogue with the thienyl group replaced by phenyl), but it is rather more potent. | tenocyclidine |
| tramadol | A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol |
| tramadol hydrochloride | A hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.5301 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 37.9330 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 16.8037 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 32.6427 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 33.5204 | 5 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 26.6032 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.9845 | 4 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.1405 | 2 | 6 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 42.6207 | 2 | 10 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 22.1042 | 2 | 6 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.2368 | 1 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 31.6894 | 1 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 20.3596 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 58.6544 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 24.9426 | 1 | 10 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 20.3596 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 49.0670 | 2 | 6 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 11.9669 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 19.7830 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 9.7717 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 13.7372 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.4621 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.4216 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 6.9764 | 3 | 5 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 56.1992 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 44.5670 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 0.6310 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 19.1391 | 4 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 11.7340 | 1 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 23.9094 | 1 | 17 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.4079 | 4 | 8 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 1.7377 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 13.7372 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 15.2854 | 4 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.9924 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 17.2467 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 5.2143 | 1 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 11.2637 | 6 | 9 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 37.0314 | 2 | 4 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.7996 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 13.3322 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 19.0301 | 2 | 10 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 16.2210 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 66.2026 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 1.7377 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 29.1485 | 2 | 7 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.2471 | 1 | 11 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5893 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 10.6910 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 9.7121 | 1 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 10.5549 | 1 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 7.5660 | 2 | 5 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.2182 | 1 | 3 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 6.4092 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.8961 | 1 | 2 |
| Nrf2 | Homo sapiens (human) | Potency | 16.5928 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 34.3762 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.5941 | 2 | 6 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 22.9778 | 2 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 49.6681 | 1 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 20.9608 | 1 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 50.0249 | 2 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 17.9008 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 11.7192 | 1 | 6 |
| PPM1D protein | Homo sapiens (human) | Potency | 33.7170 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 17.8686 | 3 | 5 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 28.1838 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.5706 | 2 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 44.9840 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 39.5724 | 2 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 29.1945 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 19.6015 | 1 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 10.0324 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 66.2026 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 4.2871 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.1155 | 2 | 15 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 89.1251 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 12.8082 | 3 | 10 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.5503 | 2 | 17 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.7969 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.3840 | 4 | 8 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 47.8889 | 1 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 25.1705 | 2 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 75.0865 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 175.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 2.8300 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 0.3600 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 1.0375 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.2965 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 3.3910 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 2.1580 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 1.9060 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.9985 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.9060 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.9985 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 1.1210 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.5210 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 19.9000 | 1 | 4 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 175.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 10.0000 | 1 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.0049 | 1 | 1 |
| Acrosin | Sus scrofa (pig) | Ki | 2.3000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.4400 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.4195 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.7655 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.6625 | 1 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.8950 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.8650 | 1 | 1 |
| Amiloride-sensitive amine oxidase [copper-containing] | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 0.7930 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 15.6000 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 19.7000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 15.7215 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 12.8802 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 3.8000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 42.2500 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 505.1429 | 3 | 7 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 10.0000 | 1 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| Cholinesterase | Mus musculus (house mouse) | Ki | 0.5224 | 2 | 2 |
| Coagulation factor X | Homo sapiens (human) | IC50 | 10.4000 | 1 | 1 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 56.3172 | 4 | 4 |
| Cytochrome P450 2B6 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 55.2752 | 5 | 5 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 264.0000 | 1 | 1 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 1 | 1 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 18.6000 | 1 | 1 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 136.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 7.1153 | 10 | 10 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 56.3172 | 4 | 4 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 3.9980 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.3580 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.0060 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Diamine acetyltransferase 1 | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 1.8700 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 39.0000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | Ki | 137.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 70.4335 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 127.0000 | 1 | 2 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 127.0000 | 1 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 127.0000 | 1 | 2 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 127.0000 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 4 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 4 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 4 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 4 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 4 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 3.0344 | 20 | 27 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | Ki | 1.2235 | 11 | 19 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 45.2489 | 38 | 59 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 0.4887 | 29 | 37 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 5.4275 | 14 | 19 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | Ki | 1.3081 | 9 | 17 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 49.5724 | 33 | 53 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 0.3571 | 27 | 35 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | IC50 | 3.0576 | 13 | 15 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 46.0777 | 36 | 55 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | Ki | 1.2232 | 11 | 19 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.3571 | 27 | 35 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | IC50 | 5.0040 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 52.7492 | 30 | 48 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | Ki | 1.3786 | 8 | 16 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 0.3687 | 28 | 37 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | IC50 | 5.0040 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 52.7492 | 30 | 48 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | Ki | 1.3786 | 8 | 16 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 0.3624 | 26 | 34 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | IC50 | 5.0040 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 52.7492 | 30 | 48 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | Ki | 1.3786 | 8 | 16 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 0.3624 | 26 | 34 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | IC50 | 5.0040 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 52.7492 | 30 | 48 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | Ki | 1.3786 | 8 | 16 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 0.3624 | 26 | 34 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 49.4823 | 2 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.1440 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 6.9610 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 6.8450 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 250.0000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | IC50 | 0.0388 | 1 | 3 |
| Matrilysin | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Matrix protein 2 | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 153.9250 | 4 | 4 |
| Matrix protein 2 | Influenza A virus (A/udorn/1972(H3N2)) | IC50 | 109.8600 | 5 | 5 |
| Mitogen-activated protein kinase 11 | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| Mitogen-activated protein kinase 12 | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| Mitogen-activated protein kinase 13 | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 21.5820 | 4 | 5 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 37.7000 | 3 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.1480 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.9005 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.3205 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 55.0000 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.1750 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0370 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.8525 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1185 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.9717 | 2 | 3 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 1.0465 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 5.8200 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 8.5250 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 8.5250 | 2 | 2 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 15.7215 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 12.8802 | 1 | 1 |
| Plasminogen | Homo sapiens (human) | IC50 | 28.4000 | 3 | 5 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 35.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 12.8145 | 5 | 5 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 12.8802 | 1 | 1 |
| Prolyl endopeptidase | Sus scrofa (pig) | IC50 | 0.0060 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 4.8800 | 1 | 1 |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | IC50 | 81.0000 | 2 | 2 |
| Protein arginine N-methyltransferase 5 | Homo sapiens (human) | IC50 | 582.0000 | 1 | 1 |
| Protein disulfide-isomerase | Homo sapiens (human) | Ki | 36.1000 | 1 | 1 |
| Protein S100-B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 1 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 2 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 3 | Homo sapiens (human) | IC50 | 35.8333 | 3 | 3 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 0.1236 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.8233 | 1 | 3 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0365 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 29.9430 | 3 | 4 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 21.7757 | 3 | 3 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 1,550.0000 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 3.1590 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.5100 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.4400 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.4195 | 1 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.2304 | 1 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.1222 | 1 | 2 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 1.0900 | 1 | 4 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 285.4333 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 39.4443 | 5 | 7 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 8.9000 | 3 | 3 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 256.9667 | 3 | 3 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 9.5000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 0.0810 | 1 | 1 |
| Suppressor of tumorigenicity 14 protein | Homo sapiens (human) | Ki | 1.1600 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 55.0000 | 2 | 2 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| Vesicular glutamate transporter 3 | Rattus norvegicus (Norway rat) | Ki | 945.0000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 47.3000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Aryl hydrocarbon receptor | Homo sapiens (human) | EC50 | 0.3000 | 1 | 1 |
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Chain A, Immunoglobulin | Mus musculus (house mouse) | Kd | 0.0020 | 1 | 1 |
| Chain B, Immunoglobulin | Mus musculus (house mouse) | Kd | 0.0020 | 1 | 1 |
| G protein-coupled receptor GPR35 | Rattus norvegicus (Norway rat) | EC50 | 66.0000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 199.8000 | 9 | 9 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Kd | 0.0372 | 1 | 1 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | EC50 | 500.0000 | 1 | 1 |
| Matrix protein 2 | Influenza A virus (A/udorn/1972(H3N2)) | EC50 | 0.6600 | 2 | 2 |
| Matrix protein 2 | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 0.3200 | 1 | 1 |
| Matrix protein 2 | Influenza A virus (A/udorn/1972(H3N2)) | Kd | 58.2925 | 4 | 4 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Mus musculus (house mouse) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Mus musculus (house mouse) | Kd | 9.1000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Kd | 9.1000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | EC50 | 11.6000 | 1 | 1 |
| Protein S100-B | Homo sapiens (human) | Kd | 1.0000 | 1 | 1 |
| Protein S100-B | Rattus norvegicus (Norway rat) | Kd | 47.0000 | 2 | 2 |
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a | Homo sapiens (human) | EC50 | 91.1400 | 1 | 1 |
| Taste receptor type 2 member 46 | Homo sapiens (human) | EC50 | 31.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | Km | 1.4000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | K0.5 | 26.0000 | 1 | 2 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Kb | 86.0000 | 2 | 4 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Kb | 86.0000 | 2 | 4 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Kb | 86.0000 | 2 | 4 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Kb | 86.0000 | 2 | 4 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | Kb | 69.5000 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Kb | 69.5000 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | Kb | 69.5000 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | Kb | 69.5000 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | Kb | 69.5000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | K0.5 | 0.2500 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Kb | 53.7311 | 4 | 9 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | K0.5 | 26.0000 | 1 | 2 |
| Mu-type opioid receptor | Mus musculus (house mouse) | K0.5 | 26.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | K0.5 | 30.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Mus musculus (house mouse) | K0.5 | 30.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | K0.5 | 30.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | K0.5 | 30.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Mus musculus (house mouse) | K0.5 | 30.0000 | 1 | 2 |
| Quinone oxidoreductase | Mus musculus (house mouse) | Activity | 4.6433 | 3 | 3 |
| Quinone oxidoreductase | Mus musculus (house mouse) | CD | 6.2333 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Activity | 18.4000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Km | 30.5000 | 1 | 2 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | CD | 11.0000 | 1 | 1 |