A organic heteromonocyclic compound that consists of a cylcopentane ring in which two carbon atoms are replaced by a sulfur and nitrogen atom respectively.
ChEBI ID: 48865
| Member | Definition | Role |
|---|---|---|
| 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. | TDZD-8 |
| np 031112 | A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. | tideglusib |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 36 (19.35) | 29.6817 |
| 2010's | 96 (51.61) | 24.3611 |
| 2020's | 54 (29.03) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (3.03%) | 5.53% |
| Reviews | 16 (8.08%) | 6.00% |
| Case Studies | 1 (0.51%) | 4.05% |
| Observational | 1 (0.51%) | 0.25% |
| Other | 174 (87.88%) | 84.16% |