Any substance that inhibits the polymerisation of the protein actin.
ChEBI ID: 70728
| Member | Definition | Class |
|---|---|---|
| ck-0944666 | A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. | CK-666 |
| cytochalasin b | An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments. | cytochalasin B |
| latrunculin a | A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. | latrunculin A |
| latrunculin b | A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica. | latrunculin B |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,861 (47.51) | 18.7374 |
| 1990's | 1,316 (21.85) | 18.2507 |
| 2000's | 1,165 (19.35) | 29.6817 |
| 2010's | 618 (10.26) | 24.3611 |
| 2020's | 62 (1.03) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4 (0.06%) | 5.53% |
| Reviews | 98 (1.58%) | 6.00% |
| Case Studies | 5 (0.08%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6,115 (98.28%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 5.0119 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 21.3174 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 5.2079 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 1.2995 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 21.3174 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 4.5530 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.0000 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.9448 | 2 | 4 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 63.0957 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 60.4566 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.0000 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Actin | Saccharomyces cerevisiae S288C | IC50 | 0.0733 | 1 | 3 |
| Actin, alpha skeletal muscle | Oryctolagus cuniculus (rabbit) | IC50 | 8.4700 | 1 | 1 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 | 15.8500 | 2 | 2 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 15.8500 | 2 | 2 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 4.1000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 3 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 4 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |