Glycosuria, Renal

An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.

Synonym
Glycosuria, Renal
Renal Glucosuria
Renal Glycosuria

Excerpt	Reference
"Primary renal glucosuria is an inherited defect of tubular glucose reabsorption and usually classified in type A and type B."	( Brodehl, J; Byrd, DJ; Oemar, BS, 1987)
"Renal glycosuria is an inherited disorder of renal tubule function in which significant amounts of glucose are excreted in the urine in the simultaneous presence of normal blood glucose levels."	( Basile, A; Cecchin, E; De Marchi, S; De Paoli, P; Donadon, W; Jengo, A; Jus, A; Proto, G; Schinella, D; Villalta, D, 1984)
"Primary renal glucosuria is a benign condition in which serum glucose level is normal."	( Kavukçu, S; Türkmen, M; Uzuner, N, 1996)
"Primary renal glucosuria is classified as types A, B, or O based on the characteristics of the transport defect."	( Cooper, C; Heilig, CW; Sankarasubbaiyan, S, 2001)
"Renal glycosuria is defined as the excretion of glucose in urine in a normoglycemic state."	( Limsuwat, C; Prabhakar, SS, 2012)
"Familial renal glycosuria is an inherited disorder resulting in glucose excretion in the urine despite normal blood glucose concentrations."	( Forsén, B; Groop, L; Groop, PH; Gullström, M; Ottosson-Laakso, E; Tuomi, T; Vikman, P, 2016)
"Renal glucosuria is a renal tubular disorder caused by genetic conditions, drugs, and poisons."	( Chen, M; Gu, X; Wang, Y; Xu, Y, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	112 (76.19)	23.3326
1990's	12 (8.16)	12.5806
2000's	10 (6.80)	18.1394
2010's	12 (8.16)	28.8240
2020's	1 (0.68)	9.53

Drug	Relationship Strength	Studies
acetone	low	2
ammonium hydroxide	low	2
chlorine	low	1
hydrogen sulfide	low	1
creatine	low	1
glycine	low	3
glycolic acid	low	1
hydrogen carbonate	low	2
homogentisic acid	low	1
taurine	low	1
uric acid	low	9
urea	low	2
p-aminohippuric acid	low	2
buformin	low	1
camostat	low	1
chlorpropamide	low	2
erythrosine	low	1
gabexate	low	1
gentamicin	low	1
hydroxychloroquine	low	1
potassium chloride	low	1
propranolol	low	1
tolbutamide	low	3
prednisolone	low	1
phentolamine	low	1
alloxan	low	1
hydroxyproline	low	1
prednisone	low	2
alanine	low	3
desoxycorticosterone acetate	low	1
glutamine	low	1
sucrose	low	1
galactose	low	3
edetic acid	low	1
phlorhizin	low	6
methionine	low	1
desoxycorticosterone	low	1
histidine	low	3
methandrostenolone	low	1
arginine	low	3
fluoxymesterone	low	1
thiophenes	low	1
fructosamine	low	1
osmium	low	1
thulium	low	1
cadmium	low	1
tricalcium phosphate	low	1
deuterium	low	1
galactose	low	4
ammonium chloride	low	1
osmium tetroxide	low	1
fludrocortisone	low	1
transferrin	low	1
captopril	low	1
glucose, (beta-d)-isomer	low	4
panipenem	low	1
melanotan-ii	low	1
imipenem, anhydrous	low	1
carbapenems	low	1
xylose	low	1
proline	low	1
naproxen	low	1
cortisone	low	2
glycogen	low	3
arabinose	low	1
carnosine	low	1
maleic acid	low	1
riboflavin	low	2
glycosides	low	1
n-benzoylalanine	low	1
D-fructopyranose	low	1
lithium	low	1
cystine	low	1
bilirubin	low	1
vitamin d 2	low	1
xylulose	low	1
lisinopril	low	1
enalapril	low	1
phosphorus	low	7
dizocilpine maleate	low	1
dapagliflozin	low	2
ipragliflozin	low	1
acebutolol	low	1
empagliflozin	low	1
pituitrin	low	3
dihydrotachysterol	low	1
glucagon	low	4
bucladesine	low	1
ro13-9904	low	1
canagliflozin	low	1
ascorbic acid	low	1
tetracycline	low	4
cyclosporine	low	1
guanosine triphosphate	low	1

Protein Targets (681)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
TDP1 protein	19	0	0	19
glucocorticoid receptor [Homo sapiens]	17	0	0	17
estrogen-related nuclear receptor alpha	12	0	0	12
thyroid hormone receptor beta isoform 2	9	0	0	9
lamin isoform A-delta10	15	0	0	15
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Carbonic anhydrase 1	0	4	0	9
Carbonic anhydrase 2	0	5	1	11
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Proton-coupled amino acid transporter 1	0	6	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Xcogt	0	0	1	1
Chain A, Xcogt	0	0	1	1
Chain A, Xcogt	0	0	1	1
phosphopantetheinyl transferase	8	0	0	8
USP1 protein, partial	5	0	0	5
Microtubule-associated protein tau	7	0	0	7
Bloom syndrome protein isoform 1	4	0	0	4
vitamin D3 receptor isoform VDRA	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	5	0	0	5
NFKB1 protein, partial	2	0	0	2
GLS protein	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	9	0	0	9
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	5	0	0	5
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	7	0	0	7
Cytochrome P450 3A4	0	1	0	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	4	0	0	4
RAR-related orphan receptor gamma	11	0	0	11
GLI family zinc finger 3	16	0	0	16
AR protein	20	0	0	20
thioredoxin glutathione reductase	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
estrogen nuclear receptor alpha	20	0	0	20
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
IDH1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
geminin	10	0	0	10
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	3	3	8
Spike glycoprotein	6	0	2	8
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, Cruzipain	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
DNA polymerase kappa isoform 1	5	0	0	5
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
glp-1 receptor, partial	2	0	0	2
ATAD5 protein, partial	4	0	0	4
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
urokinase plasminogen activator surface receptor precursor	3	0	0	3
relaxin receptor 1 isoform 1	2	0	0	2
relaxin receptor 2 isoform 1	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
cytochrome P450 2D6	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	5	0	0	5
Solute carrier family 22 member 1	0	1	0	2
EWS/FLI fusion protein	6	0	0	6
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Solute carrier family 22 member 2	0	2	0	2
Transmembrane protease serine 2	0	2	2	4
Prothrombin	0	3	0	3
Serine protease hepsin	0	3	0	3
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Procathepsin L	0	2	2	4
Furin	0	2	0	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Liver carboxylesterase 1	0	0	0	1
Trypsin-3	0	1	0	1
Hepatocyte growth factor activator	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Transmembrane protease serine 6	0	2	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
Angiotensin-converting enzyme 2	0	2	2	4
Sodium/glucose cotransporter 1	0	5	5	10
Sodium/glucose cotransporter 2	0	6	5	11
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
15-lipoxygenase, partial	3	0	0	3
Thrombopoietin	1	0	0	1
Metallo-beta-lactamase type 2	0	1	1	3
peripheral myelin protein 22 isoform 1	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
Bile salt export pump	0	14	0	14
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	7	1	8
Angiotensin-converting enzyme	0	7	0	8
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	3	0	3
Angiotensin-converting enzyme	0	4	0	4
Solute carrier family 15 member 1	0	3	0	3
Beta-lactamase TEM	0	1	0	2
Mu-type opioid receptor	0	0	1	1
TAR DNA-binding protein 43	3	0	0	3
Beta-lactamase	0	3	0	5
Canalicular multispecific organic anion transporter 1	0	9	0	10
Beta-lactamase	0	3	0	3
Beta-lactamase class B VIM-2	0	1	1	3
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Carbonic anhydrase 4	0	4	0	6
Histamine H2 receptor	3	0	0	3
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 15	0	2	0	3
Chain A, Ferritin light chain	1	0	0	1
retinoid X nuclear receptor alpha	9	0	0	9
G	4	0	0	4
arylsulfatase A	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
thyroid hormone receptor beta isoform a	3	0	0	3
transcriptional regulator ERG isoform 3	3	0	0	3
survival motor neuron protein isoform d	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	1	1	6
Solute carrier family 22 member 6	0	3	0	4
Bile salt export pump	0	3	0	3
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Albumin	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit delta	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-3	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-2	4	1	1	6
Lanosterol 14-alpha demethylase	0	2	0	2
GABA theta subunit	4	1	1	6
Inositol hexakisphosphate kinase 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit epsilon	4	1	1	6
cytochrome P450 2C9, partial	4	0	0	4
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
pregnane X receptor	4	0	0	4
progesterone receptor	11	0	0	11
regulator of G-protein signaling 4	3	0	0	3
pregnane X nuclear receptor	12	0	0	12
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	2	0	0	2
Glucocorticoid receptor	0	6	2	13
Sex hormone-binding globulin	0	0	2	2
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Cholinesterase	0	0	1	1
Sodium/glucose cotransporter 2	0	1	1	2
Sodium/myo-inositol cotransporter 2	0	1	0	1
Solute carrier family 5 member 4	0	2	0	2
SMAD family member 2	5	0	0	5
GALC protein	3	0	0	3
SMAD family member 3	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Histone H2A.x	5	0	0	5
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Cellular tumor antigen p53	8	0	0	8
Amyloid-beta precursor protein	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	2
Beta-lactamase VIM-1	0	1	0	2
farnesoid X nuclear receptor	3	0	0	3
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Type-2 angiotensin II receptor	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Chain A, Beta-lactamase	3	0	0	3
Genome polyprotein	0	2	1	3
Luciferase	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Fumarate hydratase	1	0	0	1
hypothetical protein, conserved	1	0	0	1
polyprotein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	4	0	0	4
thyrotropin-releasing hormone receptor	2	0	0	2
eyes absent homolog 2 isoform a	2	0	0	2
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Smad3	1	0	0	1
Androgen receptor	0	4	1	5
Nuclear receptor ROR-gamma	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	2	0	2
Coagulation factor XII	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	3	0	3
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
67.9K protein	1	0	0	1
2-dehydropantoate 2-reductase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	1	0	2
Adenosine receptor A2a	0	1	1	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	1	5
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Muscarinic acetylcholine receptor M2	0	4	1	5
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	4	3	9
Muscarinic acetylcholine receptor M1	0	2	1	3
Alpha-2C adrenergic receptor	0	4	3	9
Muscarinic acetylcholine receptor M3	0	2	1	3
Alpha-1D adrenergic receptor	0	4	2	7
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Chain B, Aspartate Aminotransferase	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Chain B, Aspartate Aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain B, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain B, Aspartate aminotransferase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Melanocortin receptor 4	0	2	1	3
Melanocortin receptor 5	0	1	1	2
Melanocortin receptor 3	0	0	1	1
Melanocortin receptor 5	0	0	1	1
Melanocortin receptor 3	0	2	1	3
Urotensin-2 receptor	0	0	1	1
Melanocortin receptor 4	0	0	1	1
Melanocyte-stimulating hormone receptor	0	2	1	3
Melanocyte-stimulating hormone receptor	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cytochrome P450 2C9	0	5	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	3
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Caspase-1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
Caspase-5	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Caspase-9	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Solute carrier family 22 member 6	0	3	0	5
Prostaglandin G/H synthase 1	0	1	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 8	0	1	0	2
ClpP	1	0	0	1
Hsf1 protein	0	0	2	2
D(1A) dopamine receptor	2	0	0	2
estrogen receptor beta isoform 1	0	2	0	2
Alpha-1A adrenergic receptor	0	0	1	1
5-hydroxytryptamine receptor 4	0	4	0	4
Cytochrome P450 2D6	0	2	0	2
Alpha-1B adrenergic receptor	0	4	3	7
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	3	5
Alpha-2C adrenergic receptor	0	2	3	5
Alpha-2A adrenergic receptor	0	2	3	5
Alpha-1D adrenergic receptor	0	4	3	8
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	1	5
Alpha-1A adrenergic receptor	0	3	3	7
Histamine H1 receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	2	2	5
5-hydroxytryptamine receptor 2B	0	4	1	5
Alpha-1A adrenergic receptor	0	4	3	7
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Ataxin-2	3	0	0	3
Nischarin	0	1	0	1
PPM1D protein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
Sodium/nucleoside cotransporter 1	0	1	0	1
Sodium/nucleoside cotransporter 2	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Sodium/glucose cotransporter 1	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
Solute carrier family 28 member 3	0	1	0	1
Prostaglandin D2 receptor 2	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Glutamate 5-kinase	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Solute carrier family 22 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
ATP-dependent translocase ABCB1	0	2	0	2
Beta-1 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Adenosine receptor A3	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	4
D(1A) dopamine receptor	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
tumor necrosis factor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
glucocerebrosidase	1	0	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-synuclein	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Potassium channel subfamily K member 2	0	0	1	1
Albumin	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Vitamin D3 receptor	0	0	0	1
Aldo-keto reductase family 1 member B1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Research

Studies (147)

Protein Targets (681)

Glycosuria, Renal

Synonyms(3)

Research Excerpts

Overview

Research

Studies (147)

Drugs Studied (116)

Protein Targets (681)