An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of quinine 3-monooxygenase (EC 1.14.13.67).
ChEBI ID: 77783
| Member | Definition | Class |
|---|---|---|
| sulfaphenazole | A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent. | sulfaphenazole |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 105 (29.75) | 18.7374 |
| 1990's | 46 (13.03) | 18.2507 |
| 2000's | 85 (24.08) | 29.6817 |
| 2010's | 84 (23.80) | 24.3611 |
| 2020's | 33 (9.35) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 8 (2.19%) | 5.53% |
| Reviews | 4 (1.10%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 353 (96.71%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| arylsulfatase A | Homo sapiens (human) | Potency | 0.3793 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 50.1187 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 84.2790 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.2241 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 1.1988 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.7438 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.9877 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 14.5750 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0200 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 1.1988 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.7438 | 1 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 0.2241 | 1 | 6 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 1.1988 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 1.1988 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 1.1988 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0224 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.0795 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.3535 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 100.0000 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 9.3049 | 2 | 3 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C18 | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 13.7564 | 31 | 31 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 0.3500 | 2 | 2 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 6 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 6 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 6 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 6 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 6 |