A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group.
ChEBI ID: 33707
| Member | Definition | Role |
|---|---|---|
| 2,4-diaminobutyric acid | A diamino acid that is butyric acid in which a hydrogen at position 2 and a hydrogen at position 4 are replaced by amino groups. | 2,4-diaminobutyric acid |
| 4-amino-3-hydroxybutyric acid | A gamma-amino acid comprising 4-aminobutyric acid having a 2-hydroxy substituent. | gamma-amino-beta-hydroxybutyric acid zwitterion; gamma-amino-beta-hydroxybutyric acid |
| baclofen | A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant. | baclofen zwitterion; baclofen |
| gabaculine | An alpha,beta-unsaturated monocarboxylic acid that is cyclohexa-1,3-diene-1-carboxylic acid carrying an amino group at position 5. | 5-aminocyclohexa-1,3-diene-1-carboxylic acid |
| gabapentin | A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome. | gabapentin |
| gamma-aminobutyric acid | A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. | gamma-aminobutyric acid zwitterion; gamma-aminobutyric acid |
| glutamate-1-semialdehyde | A 5-oxo monocarboxylic acid that is 5-oxopentanoic acid substituted by an amino group at position 4 (the 4S-stereoisomer). | (S)-4-amino-5-oxopentanoic acid zwitterion; (S)-4-amino-5-oxopentanoic acid |
| pregabalin | A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. | pregabalin |
| vigabatrin | A gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase | vigabatrin |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 10,344 (22.66) | 18.7374 |
| 1990's | 9,299 (20.37) | 18.2507 |
| 2000's | 11,550 (25.30) | 29.6817 |
| 2010's | 10,855 (23.78) | 24.3611 |
| 2020's | 3,605 (7.90) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,319 (6.01%) | 5.53% |
| Reviews | 6,305 (11.42%) | 6.00% |
| Case Studies | 3,207 (5.81%) | 4.05% |
| Observational | 123 (0.22%) | 0.25% |
| Other | 42,262 (76.54%) | 84.16% |