Compounds > 1,2-didodecanoylglycerol
Page last updated: 2024-12-06

1,2-didodecanoylglycerol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,2-Didodecanoylglycerol (1,2-DDG) is a synthetic diacylglycerol (DAG) that is known for its effects on the endocannabinoid system and its potential therapeutic applications. It is synthesized through various chemical methods, often involving the reaction of glycerol with dodecanoic acid (lauric acid) under specific conditions. 1,2-DDG has been shown to activate peroxisome proliferator-activated receptor alpha (PPARĪ±) and cannabinoid receptors (CB1 and CB2), which are involved in various physiological processes. Due to its effects on these receptors, 1,2-DDG has been studied for its potential therapeutic benefits in conditions such as obesity, inflammation, and pain. It is also explored for its potential to improve metabolic health and reduce insulin resistance.'
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1,2-didodecanoylglycerol: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID33979
SCHEMBL ID2701820
MeSH IDM0084714

Synonyms (36)

Synonym
dilaurin
D-4260
(2-dodecanoyloxy-3-hydroxypropyl) dodecanoate
dg 12:0_12:0
lauric acid, diester with glycerol
unii-mfl3zie8sk
einecs 248-586-9
glyceryl dilaurate
mfl3zie8sk ,
1,2-dilaurin
rac-1,2-didodecanoylglycerol
dodecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester
1,2-didodecanoylglycerol
unii-9s1016g3a2
9s1016g3a2 ,
17598-94-6
2,3-dilauroyl-d-glycerol
didansylhistamine
glyceryl 1,2-dilaurate
glycerol 1,2-dilaurate
laurin, 1,2-di-
1,2-dilauroyl-rac-glycerol
glycerol 1,2-didodecanoate
1,2-o-dilauroylglycerol
SCHEMBL2701820
2-(dodecanoyloxy)-1-(hydroxymethyl)ethyl laurate #
J-016832
d-alpha,beta-dilaurin
1,2-dilauroylglycerol
FT-0772288
DTXSID30880897
Q27273003
CS-0185627
PD120074
3-hydroxypropane-1,2-diyl didodecanoate
HY-W127391

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" However, the high toxicity and low bioavailability of current antimalarials and emerging drug resistance necessitates drug-delivery research."( Parasite impairment by targeting Plasmodium-infected RBCs using glyceryl-dilaurate nanostructured lipid carriers.
Basu, H; Jain, SA; Joshi, MD; Mathur, D; Pathak, S; Patravale, VB; Prabhu, PS; Sharma, S; Soni, U, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (3 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care3

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Earth Science A-D-E Creamy Cleanser -- 8 fl ozEarth ScienceBeauty & Personal Careglyceryl dilaurate, allantoin, ascorbic acid, tocopherol, tocopherol, glyceryl stearate, glycerin, lactic acid, phenoxyethanol, PEG-8 stearate, retinyl palmitate, ergocalciferol2024-11-29 10:47:42
Every Man Jack Beard Butter - Sandalwood -- 4 ozEvery Man JackBeauty & Personal Careglyceryl dilaurate, cetyl alcohol, dehydroacetic acid, panthenol, glycerin, linalool, stearyl alcohol2024-11-29 10:47:42
Every Man Jack Beard Butter - Sea Salt -- 4 ozEvery Man JackBeauty & Personal Careglyceryl dilaurate, benzyl alcohol, benzyl salicylate, cetyl alcohol, citronellol, dehydroacetic acid, glycerin, limonene, linalool, stearyl alcohol2024-11-29 10:47:42

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (42.86)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.17 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.110alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		1.9510aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
artemether
Artemether: An artemisinin derivative that is used in the treatment of MALARIA.. artemether : An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.1310artemisinin derivative;
cyclic acetal;
organic peroxide;
semisynthetic derivative;
sesquiterpenoid		antimalarial
1-palmitoylphosphatidylethanolamine
[no description available]		1.97101-acyl-sn-glycero-3-phosphoethanolamine
1,2-dilauroylphosphatidylethanolamine
[no description available]		1.9710
clindamycin
Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.		2.1310
lysophosphatidylethanolamine
lysophosphatidylethanolamine : A glycerophosphoethanolamine resulting from partial hydrolysis of a phosphatidylethanolamine, which removes one of the fatty acid groups. The structure is depicted in the image where R(1) = acyl, R(2) = H or where R(1) = H, R(2) = acyl.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		02.5220
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.5220
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.1310
Gastric Fistula
Abnormal passage communicating with the STOMACH.		01.9610
Cholecystoduodenal Fistula
[description not available]		01.9610
Duodenal Diseases
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).		01.9610