A state of increased vulnerability to stressors, following declines in function and reserves across multiple physiologic systems, characterized by MUSCLE WEAKNESS; FATIGUE; slowed motor performance; low physical activity; and unintentional weight loss.
| Excerpt | Reference |
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| "Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems." | ( Badrasawi, M; Nor Fadilah, R; Shahar, S; Singh, DK; Zahara, AM, 2016) |
| "Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality." | ( Chang, CC; Chang, TY; Chen, JW; Chen, LK; Hsu, CY; Huang, PH; Lin, SJ; Liu, LK, 2016) |
| "Frailty is associated with a functional decline of multiple physiological systems, of which they may be a cause or consequence." | ( Bertoli, A; Cianfarani, MA; Federici, M; Gasbarra, E; Tarantino, U; Valentini, A, 2017) |
| "Frailty is a multidimensional syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalization, and death in the elderly." | ( Fuchs, D; Gostner, JM; Laffon, B; Lorenzo-López, L; Marcos-Pérez, D; Maseda, A; Millán-Calenti, JC; Pásaro, E; Sánchez-Flores, M; Strasser, B; Valdiglesias, V, 2017) |
| "Frailty is a multifactorial geriatric syndrome characterized by progressive decline in health and associated with decreased muscle mass, strength, and functional capacity." | ( de Capitani, MD; de Santana, DA; Fernandes, AL; Gualano, B; Hayashi, AP; Jambassi-Filho, JC; Roschel, H, 2017) |
| "Frailty is as an independent predictor of nonresponse to CRT." | ( Anselme, F; Bertaina, G; Buiciuc, O; Diouf, M; Guédon-Moreau, L; Hermida, JS; Klug, D; Kubala, M; Savouré, A; Traullé, S, 2017) |
| "Frailty is a progressive physiologic decline in multiple body systems, characterized by loss of function, loss of physiologic reserve, and increased vulnerability to disease and death." | ( Bonassi, S; Fuchs, D; Gostner, JM; Lorenzi, M; Marcos-Pérez, D; Onder, G; Strasser, B; Valdiglesias, V, 2018) |
| "Frailty is reported among one in every eleven older adults in this study." | ( Abdul Razak, I; Ahmad, NS; Ahmad, SN; Bulgiba, A; Choo, WY; Hairi, F; Hairi, NN; Ismail, N; Kamaruzzaman, SB; Kandiben, S; Mohd Ali, Z; Othman, S; Peramalah, D; Said, MA, 2018) |
| "Frailty is an important challenge because the loss of physiological reserve means that even minor stressors can lead to disability and death in those who are frail." | ( Banga, S; Heinze-Milne, SD; Howlett, SE, 2019) |
| "Frailty is a syndrome of vulnerability and physical decline with aging that increases risk for disability, hospitalizations, and death." | ( Espinoza, SE; Jiwani, R; Wang, CP; Wang, J, 2019) |
| "Frailty is a geriatric syndrome that leads to poor health outcomes with aging." | ( Bair-Kelps, D; Conde, A; Espinoza, SE; Ganapathy, V; Jergensen, TE; Jiwani, R; Kelly, LC; Li, Y; Michalek, J; Moris, M; Musi, N; Orsak, B; Powers, B; Romo, T; Wang, CP, 2020) |
| "Frailty is one such measure that is tightly correlated with human aging." | ( Bernier, M; de Cabo, R; Di Germanio, C; Moats, JM; Palliyaguru, DL, 2019) |
| "Frailty is associated with less intraoperative blood pressure variation, and the relationship of frailty with 30-day mortality is partially mediated by episodes of absolute change >15% in fractional MAP." | ( Deiner, SG; James, LA; Levin, MA; Lin, HM, 2019) |
| "Frailty is a clinical condition associated with loss of muscle mass and strength (sarcopenia)." | ( Chevalier, S; Jacob, KJ; Lamarche, M; Morais, JA, 2019) |
| "Frailty is a state characterised by diminished physiological reserve that leaves an individual vulnerable to external stressors and delays recovery." | ( Leopold-George, NTN; Nethathe, GD, 2019) |
| "Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to negative health outcomes." | ( Laffon, B; Lorenzo-López, L; Marcos-Pérez, D; Maseda, A; Millán-Calenti, JC; Pásaro, E; Sánchez-Flores, M; Valdiglesias, V, 2019) |
| "Frailty is a common occurrence among HIV-infected patients under ART, with depression as an independent predictive factor." | ( Ophinni, Y; Shatri, H; Wahyudi, ER; Wulunggono, W; Yunihastuti, E, 2019) |
| "Physical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion." | ( Bandeen-Roche, K; Cappola, AR; Fried, LP; Gabr, RE; Huang, J; Kalyani, RR; Russ, DW; Varadhan, R; Xue, QL, 2019) |
| "Frailty is highly prevalent among Malaysian institutionalised older adults." | ( Mohamd Izhar, IA; Mohd Rasdi, HF; Murukesu, RR; Ponvel, P; Singh, DKA; Subramaniam, P; Tan, XV, 2019) |
| "In general, frailty is defined as a syndrome of physiological degeneration in the elderly." | ( Álvarez, S; Brañas, F; López-Bernaldo de Quirós, JC; Moreno, S; Muñoz-Fernández, MÁ; Sánchez-Conde, M, 2020) |
| "The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine." | ( Cai, JP; Du, MH; Li, YY; Liang, YD; Liu, JP; Liu, Q; Liu, Z; Luo, Y; Sun, N; Wan, YH; Wang, H; Yang, JF; Yao, SM; Zheng, PP, 2020) |
| "Frailty is broadly characterized by vulnerability and decline in physical, mental and social activities and is more common in elderly patients with type 2 diabetes mellitus (T2DM)." | ( Aida, E; Asakawa, H; Eda, T; Fujihara, Y; Harada, M; Honda, M; Ito, T; Iwaya, C; Kayashima, Y; Kitajima, Y; Muta, K; Nawata, H; Tajima, M; Teruya, Y; Yamaguchi, N; Yanagita, I; Yanase, T; Yoshimoto, M; Yoshimoto, S, 2020) |
| "Frailty is described as reversible, so early detection offers the potential of returning the subject to a robust status." | ( Boulanger, É; Dauchet, L; Guilbaud, A; Mailliez, A; Puisieux, F, 2020) |
| "Frailty is a syndrome characterized by the loss of physiological reserves and an increase in vulnerability, and it serves as a marker of declining health." | ( Achenbach, SJ; Atkinson, EJ; Bancos, I; LeBrasseur, N; Singh, S, 2020) |
| "Frailty is a multidimensional syndrome, which is a worldwide concern within the field of geriatrics due to the aggravating effect on the physical and mental functions of the elderly." | ( Adznam, SN; Jamaluddin, R; Norazman, CW, 2020) |
| "Frailty is now seen as a significant factor in older people with diabetes, whose mortality and disability increased." | ( Ren, CX; Wang, YY; Xu, J; Zhang, XY; Zhang, Y; Zhu, YX, 2020) |
| "Frailty is a common geriatric condition due to aging and defined as a decline in strength and a decrease in the physiologic ability to maintain the homeostasis." | ( Soh, Y; Won, CW, 2020) |
| "Frailty is an expression that reconciles and condenses loss of autonomy, both physical and cognitive decline and a wide spectrum of adverse outcomes due to aging." | ( Bertino, G; Bonfiglio, C; Catania, VE; Malaguarnera, G; Malaguarnera, M; Vicari, E, 2020) |
| "Frailty is common in patients with chronic heart failure (CHF) and is associated with poor outcomes." | ( Clark, AL; Pellicori, P; Squire, IB; Sze, S; Weston, J; Zhang, J, 2021) |
| "Frailty is a geriatric syndrome of decreased physiologic reserve and resistance to stressors that results in increased vulnerability to adverse health outcomes with aging." | ( Bray, GA; Crandall, JP; Florez, H; Golden, SH; Hazuda, HP; Kriska, AM; Luchsinger, JA; Pan, Q; Venditti, EM, 2021) |
| "Frailty is a major challenge for healthcare systems in ageing societies." | ( Banerjee, J; Chakrawarty, A; Chatterjee, P; De, K; Dey, AB; Khan, MA; Rajan, SP; Singh, V, 2021) |
| "The degree of frailty is related to survival across the different illness trajectories despite the differing survival patterns among trajectories." | ( Amblàs-Novellas, J; Espaulella, J; Gómez-Batiste, X; Latorre-Vallbona, N; Martori, JC; Moine, S; Murray, SA; Oller, R; Santaeugènia, SJ; Torné, A, 2021) |
| "Background Frailty is a multifactorial physiological syndrome most often associated with age but which has received increasing recognition as a component of chronic illnesses such as heart failure." | ( Fujiki, S; Kashimura, T; Minamino, T; Mitsuma, W; Obata, H; Ozaki, K; Sakai, K; Shimizu, I; Suda, M; Tomii, A; Uehara, A; Watanabe, H, 2021) |
| "Frailty is a condition of global impairment due to depletion of physiological reserves." | ( Abbasciano, R; Murphy, GJ; Pathak, S; Tomkova, K; Wozniak, M, 2021) |
| "Frailty is a state of heightened vulnerability and susceptibility to physiologic stressors that increases with age." | ( Beilin, LJ; Ekram, ARMS; Ernst, ME; Espinoza, S; Fitzgerald, S; McNeil, JJ; Murray, AM; Newman, AB; Orchard, SG; Ryan, J; Shah, RC; Ward, SA; Williamson, JD; Wolfe, R; Woods, RL, 2022) |
| "Frailty syndrome is an age-related condition involving a loss of resilience, susceptibility to adverse health outcomes, and poor quality of life." | ( Balducci, C; Brunelli, L; Cereda, C; Davin, A; De Simone, G; Forloni, G; Guaita, A; Mimmi, MC; Pansarasa, O; Pastorelli, R; Sestito, G, 2021) |
| "Frailty is an important contributor to morbidity and mortality in chronic liver disease." | ( Long, MT; Louissaint, J; Mehta, M; Parikh, NS; Tapper, EB, 2021) |
| "Frailty is a multifactorial syndrome, with a high prevalence in those over 70 years of age, in which, in addition to Fried's criteria of frailty, aspects of health, functional, cognitive-affective and social status must be analyzed." | ( Izaguirre-Riesgo, A; Menéndez-González, L; Montero-Rodríguez, Á; Orts-Cortés, MI; Tranche-Iparraguirre, S, 2021) |
| "Frailty is a major age-associated syndrome leading to disability." | ( Arc-Chagnaud, C; Brioche, T; Chopard, A; Correas, AG; Fernandez-Marcos, PJ; Garcia-Dominguez, E; Gomez-Cabrera, MC; Muñoz-Cánoves, P; Olaso-Gonzalez, G; Salvador-Pascual, A; Sebastiá, V; Serna, E; Serrano, AL; Serrano, M; Viña, J, 2021) |
| "Frailty is associated with chronic inflammation, which may be modified by aspirin." | ( Chan, A; Ekram, ARMS; Ernst, ME; Espinoza, SE; Fitzgerald, SM; Lockery, JE; McNeil, JJ; Murray, AM; Nelson, MR; Newman, AB; Orchard, SG; Polekhina, G; Reid, CM; Ryan, J; Shah, RC; Stocks, NP; Storey, E; Trevaks, R; Ward, SA; Wolfe, R; Woods, RL, 2022) |
| "Frailty is an age-related state of increased risk for health-related adverse outcomes that reflects multisystem physiological changes and likely influences the clinical expression and disease progression of neurodegenerative disorders." | ( Belvisi, D; Berardelli, A; Borraccino, A; Bruno, G; Canevelli, M; Costanzo, M; Fabbrini, A; Fabbrini, G; Giangrosso, M, 2022) |
| "Frailty is a significant risk factor for poor outcomes among older patients with diffuse large B-cell lymphoma (DLBCL)." | ( Chan, H; Disperati, P; Elinder-Camburn, A; Leitch, S; Merriman, E; Zhang, J, 2022) |
| "Frailty is a significant public health and clinical issue among the elder population." | ( Chang, CY; Chu, NF; Kuo, CC; Lin, MH; Lu, CH; Tsai, MK; Wu, DM, 2022) |
| "Frailty syndrome is associated with poor outcomes, morbidity and premature mortality." | ( Avellán-Castillo, O; Cauli, O; García-Sánchez, J; Mafla-España, MA; Tejedor-Cabrera, C; Torregrosa, MD, 2022) |
| "Frailty is a geriatric syndrome that combines physiological decline, disruptions of homeostatic mechanisms across multiple physiologic systems and thus, strong vulnerability to further pathological stress." | ( Cestac, P; Delcourt, N; Guillotin, S; Lorthois, S; Schmidt, E; Vallet, A, 2022) |
| "Frailty is a complicated syndrome that occurs at various ages, with highest incidence in aged populations, suggesting associations between the pathogenesis of frailty and age-related changes." | ( Chen, SY; Rong, XY; Sun, XY; Wang, HJ; Zhao, C; Zou, YR, 2022) |
| "Frailty is a prevalent complication predicting morbidity and mortality in cirrhosis." | ( Fan, X; Guo, G; Hui, Y; Li, C; Li, Y; Sun, C; Sun, M; Wang, B; Wang, X; Yang, W; Yu, Z; Zhang, J; Zhao, C, 2022) |
| "Frailty is common in patients with atrial fibrillation (AF), with possible impact on therapies and outcomes." | ( Bakhai, A; De Caterina, R; Diemberger, I; Fumagalli, S; Gordillo de Souza, JA; Kirchhof, P; Manu, MC; Mazzone, AM; Pecen, L; Reimitz, PE, 2022) |
| "Frailty is highly prevalent in heart failure populations and a major risk factor for adverse drug reactions (ADRs) and adverse drug events (ADEs)." | ( Duong, MH; Gnjidic, D; Goyal, P; Hilmer, SN; McLachlan, AJ; Sakiris, MA, 2022) |
| "Frailty is increasing in prevalence." | ( Bachus, E; Belohlávek, J; Butt, JH; Chiang, CE; Claggett, BL; de Boer, RA; Desai, AS; Drożdż, J; Hernandez, AF; Inzucchi, SE; Jhund, PS; Katova, T; Kitakaze, M; Kosiborod, MN; Lam, CSP; Lindholm, D; Maria Langkilde, A; Martinez, F; McMurray, JJV; Merkely, B; Petersson, M; Saraiva, JFK; Shah, SJ; Solomon, SD; Vaduganathan, M; Vardeny, O; Wilderäng, U, 2022) |
| "Prefrailty is the intermediate stage between frailty and robust condition." | ( Bertino, G; Bonfiglio, C; Castorina, M; Catania, VE; Cauli, O; Chisari, LM; Malaguarnera, G; Malaguarnera, M, 2022) |
| "Frailty is an increasingly common problem, and frail patients are less likely to receive new pharmacologic therapies because the risk-benefit profile is perceived to be less favorable than in nonfrail patients." | ( Anand, IS; Atar, D; Butt, JH; Desai, AS; Dewan, P; Echeverria, LE; Ge, J; Gong, J; Jhund, PS; Køber, L; Lam, CSP; Lefkowitz, MP; Maggioni, AP; Martinez, F; McMurray, JJV; Packer, M; Rizkala, AR; Rouleau, JL; Sim, D; Solomon, SD; Van Veldhuisen, DJ; Vrtovec, B; Zannad, F; Zile, MR, 2022) |
| "Frailty is a geriatric syndrome associated with disability and negative health outcome." | ( Boyer, S; Cardinaud, N; Druet-Cabanac, M; Dumoitier, N; Gayot, C; Laroche, ML; Laubarie-Mouret, C; Rebiere, M; Rudelle, K; Tchalla, A, 2022) |
| "Physical frailty is an aging-related clinical syndrome involving decreases in body weight, mobility, activity, and walking speed that occurs in individuals with sarcopenia and is accelerated by increased oxidative stress." | ( Fukumaru, K; Kikuchi, K; Maruyama, I; Matsubara, Y; Matsuoka, T; Matsuzaki, R; Mizuno, K; Norimatsu, K; Omiya, Y; Otsuka, S; Sakakima, H; Takada, S; Tani, A, 2022) |
| "Sarcopenia and frailty are common in patients with heart failure (HF) and are strongly associated with prognosis." | ( da Fonseca, GWP; Sato, R; Vatic, M; von Haehling, S, 2022) |
| "Malnutrition and frailty are strongly associated with AKI after CABG." | ( Aykut, A; Salman, N, 2022) |
| "Frailty is common in patients with heart failure (HF) and is associated with adverse outcome, but it is uncertain how frailty should best be measured." | ( Clark, AL; Pellicori, P; Sze, S; Weston, J; Zhang, J, 2023) |
| "Frailty is strongly associated with adverse outcomes in ambulatory patients with HF." | ( Clark, AL; Pellicori, P; Sze, S; Weston, J; Zhang, J, 2023) |
| "Frailty is common in patients with heart failure (HF) and is associated with adverse outcome, but it is uncertain how frailty should best be measured." | ( Clark, AL; Pellicori, P; Sze, S; Weston, J; Zhang, J, 2023) |
| "Frailty is strongly associated with adverse outcomes in ambulatory patients with HF." | ( Clark, AL; Pellicori, P; Sze, S; Weston, J; Zhang, J, 2023) |
| "Frailty is common in patients with heart failure (HF) and is associated with adverse outcome, but it is uncertain how frailty should best be measured." | ( Clark, AL; Pellicori, P; Sze, S; Weston, J; Zhang, J, 2023) |
| "Frailty is strongly associated with adverse outcomes in ambulatory patients with HF." | ( Clark, AL; Pellicori, P; Sze, S; Weston, J; Zhang, J, 2023) |
| "Frailty, is a geriatric syndrome that reduces the resistance to stress situations caused by activities of daily living and increases morbidity and mortality." | ( Candemir, B; Göker, B; Gülbahar, Ö; İleri, İ; Sel, AT; Yalçın, MM; Yetkin, İ, 2023) |
| "Frailty is the third most common complication of diabetes after macrovascular and microvascular complications." | ( Bu, F; Cheng, H; Deng, XH; Lyu, QY; Tang, L; Wang, ZL; Zhan, NN; Zhao, Y, 2023) |
| "Oral frailty is defined as an age-related gradual loss of oral functions, accompanied by a decline in cognitive and physical functions." | ( Ekawa, K; Kato, N; Kusunoki, H; Motone, M; Shimizu, H; Shinmura, K; Yamasaki, K; Yoshihara, F, 2023) |
| "Frailty is the intermediate condition between being healthy and disabled, and can lead to negative health outcomes." | ( Asai, S; Funahashi, K; Imagama, S; Inoue, H; Ishikawa, H; Kihira, D; Kishimoto, K; Koshima, H; Maeda, M; Ohashi, Y; Okui, N; Sato, R; Sobue, Y; Suzuki, M; Terabe, K, 2023) |
| "Because frailty is a significant factor contributing to MTX discontinuation due to AEs, the latter should be carefully monitored in frail RA patients who use MTX." | ( Asai, S; Funahashi, K; Imagama, S; Inoue, H; Ishikawa, H; Kihira, D; Kishimoto, K; Koshima, H; Maeda, M; Ohashi, Y; Okui, N; Sato, R; Sobue, Y; Suzuki, M; Terabe, K, 2023) |
| "Frailty is a complex geriatric syndrome caused by degenerative changes in the body or various chronic diseases." | ( Guo, X; Hu, W; Meng, J; Meng, M; Qu, G; Su, W; Sun, Y; Wang, X; Wu, B; Zhao, D, 2023) |
| "Frailty is associated with the aging process, gradual loss of multiple body functions, and poor health outcomes." | ( Balun, A; Özbek, K, 2023) |
| "Frailty is an independent predictor of major bleeding in patients undergoing PCI for acute coronary syndrome." | ( Balun, A; Özbek, K, 2023) |
| "Frailty is an age-related syndrome characterized by reduced recovery from stressors and increased risks of morbidity and mortality." | ( Evans, MK; Ezike, N; Kaushal, S; Mode, NA; Noren Hooten, N; Smith, JT; Zonderman, AB, 2023) |
| "Frailty is associated with dysregulation in the physiological systems and several biomarkers were linked to this fact in our study." | ( Calderón, JM; Carratalá, A; Pozo, A; Rodríguez, E; Sanchis, J, 2023) |
| "Frailty is common in Parkinson's disease (PD) and increases vulnerability to adverse outcomes." | ( Guan, Q; Hong, R; Jin, L; Li, S; Peng, K; Wang, X; Wu, Z; Xie, L; Yue, L; Zhang, J, 2023) |
| "Frailty is common among hemodialysis patients and is associated with mortality and fractures." | ( Hori, M; Maruyama, S; Morozumi, K; Takahashi, H; Yasuda, K, 2023) |
| "Frailty is an age-related geriatric syndrome that leads to a series of clinically negative events." | ( Chen, S; Huang, F; Huang, X; Lin, C; Lin, S; Yuan, Y; Zhu, P, 2023) |
| "Frailty is a significant problem for older persons since it is linked to a number of unfavorable consequences." | ( Cai, S; Huang, S; Xiao, H; Yang, W; Zhang, W, 2023) |
| "Frailty is associated with impaired sleep quality and sleep duration." | ( Antonio, L; Bartfai, G; Casanueva, FF; Cook, MJ; Gielen, E; Huhtaniemi, IT; Maggi, M; O'Neill, TW; Punab, M; Rastrelli, G; Sharma, SD; Slowikowska-Hilczer, J; Tournoy, J; Vanderschueren, D; Wu, FC, 2023) |
| Excerpt | Reference |
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| "Despite the high prevalence of frailty among patients receiving hemodialysis, few preventable or treatable contributing causes have been identified." | ( Chertow, GM; Chiang, JM; Delgado, C; Johansen, KL; Kaysen, GA; Segal, M, 2019) |
| "Exclusion criteria are baseline frailty (Fried criteria), diabetes, dementia, untreated depression, active malignancy, or severe cardiovascular, pulmonary, and neurologic diseases." | ( Bair-Kelps, D; Conde, A; Espinoza, SE; Ganapathy, V; Jergensen, TE; Jiwani, R; Kelly, LC; Li, Y; Michalek, J; Moris, M; Musi, N; Orsak, B; Powers, B; Romo, T; Wang, CP, 2020) |
| "To identify the prevalence of frailty and analyze its associated factors, among HIV-1 infected adults under antiretroviral therapy in Indonesia." | ( Ophinni, Y; Shatri, H; Wahyudi, ER; Wulunggono, W; Yunihastuti, E, 2019) |
| "As aging increases the likelihood of frailty, which encompasses metabolic, musculoskeletal, and cognitive deficits, there is a need for effective anti-aging treatments." | ( Bithi, N; Brown, JM; Henderson, YO; Hine, C; Link, C; Llarena, N; Schugar, R; Yang, J, 2021) |
| "The Fried's frailty phenotype was also administered on the same 107 older adults and scores of both were co-related." | ( Banerjee, J; Chakrawarty, A; Chatterjee, P; De, K; Dey, AB; Khan, MA; Rajan, SP; Singh, V, 2021) |
| "In elderly HCV patients, poor frailty status strongly predicted new LTCI certification after DAA therapy." | ( Hasuike, S; Iwakiri, H; Kuroki, K; Kusumoto, K; Matsuura, Y; Mukuda, T; Nagata, K; Nakamura, K; Ochiai, T; Ozono, Y; Shimoda, K; Tsuchimochi, M, 2021) |
| "We aimed to construct a simplified frailty score and examine survival and treatment-related mortality (TRM) according to frailty status and treatment intensity in an older real-world population with DLBCL." | ( Barzenje, DA; Brodtkorb, M; Holte, H; Isaksen, KT; Jerm, MB; Liestøl, K; Mastroianni, MA; Ramslien, LF; Rinde, M; Rostoft, S; Rusten, LS; Slaaen, M; Smeland, EB, 2021) |
| "In multivariable frailty regression, better performance status, gross-total versus not gross-total resection, MGMT hypermethylation, IDH mutation, smaller planning target volume and salvage therapy were significantly associated with longer OS (all p < 0." | ( Ehret, F; Grosu, AL; Kaul, D; Klement, RJ; Lewitzki, V; Polat, B; Popp, I; Sweeney, RA, 2022) |
| "Even mice treated later in life, after frailty was already established, showed some improvement." | ( Alimohammadiha, G; Fielder, E; Griffin, B; Ishaq, A; Jurk, D; Kelly, G; Korolchuk, VI; Low, E; Miwa, S; Parker, C; von Zglinicki, T; Wan, T; Weigand, BM, 2022) |
| "Regardless of frailty status, among Japanese patients with AF aged 80 years or older who were ineligible for standard OACs, once-daily 15-mg edoxaban was associated with reduced incidence of stroke or systemic embolism and may be a suitable treatment option for these patients." | ( Akao, M; Akashi, S; Akishita, M; Hayashi, T; Ikeno, E; Manita, M; Oguri, M; Okumura, K; Taura, J; Watanabe, S; Yamashita, T, 2022) |
| "Patients with higher comorbidity and frailty burdens were less likely to be treated with trimodal therapy." | ( Edwards, JK; Gaber, CE; Lund, JL; Nichols, HB; Sandler, RS; Sanoff, HK; Shaheen, NJ, 2022) |
| "Because patients with frailty are often perceived to have a less favorable risk/benefit profile, they may be less likely to receive new pharmacologic treatments." | ( Bachus, E; Belohlávek, J; Butt, JH; Chiang, CE; Claggett, BL; de Boer, RA; Desai, AS; Drożdż, J; Hernandez, AF; Inzucchi, SE; Jhund, PS; Katova, T; Kitakaze, M; Kosiborod, MN; Lam, CSP; Lindholm, D; Maria Langkilde, A; Martinez, F; McMurray, JJV; Merkely, B; Petersson, M; Saraiva, JFK; Shah, SJ; Solomon, SD; Vaduganathan, M; Vardeny, O; Wilderäng, U, 2022) |
| "Change in frailty score from baseline to year 5, according to randomization, using an intention-to-treat protocol, was assessed using repeated measures." | ( Buring, JE; Cook, NR; Copeland, T; Djousse, L; Dushkes, R; LeBoff, MS; Lee, IM; Manson, JE; Okereke, OI; Orkaby, AR; Ward, R, 2022) |
| "Time to death was analysed by a Cox frailty model with replicate as frailty term and source of mosquito (wild versus laboratory), treatment type (ivermectin vs control) and their interaction as categorical fixed effects." | ( Asefa, L; Degefa, T; Duchateau, L; Eba, K; Habtewold, T; Yewhalaw, D, 2023) |
| "Using a novel frailty index (FI) and two common frailty screening tools, we examined quality of life (QoL) and physical function (PF) in frail versus non-frail men receiving treatment for mCRPC." | ( Alibhai, SMH; Breunis, H; Emmenegger, U; Gregg, R; Hansen, AR; Kim, VS; Timilshina, N; Tomlinson, G; Yang, H, 2023) |