Restless Legs Syndrome

A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.

Synonym
Restless Legs Syndrome

Excerpt	Reference
"Restless legs syndrome is a common complaint in pregnancy affecting up to one in every three women."	( McParland, P; Pearce, JM, 1990)
"Restless legs syndrome is a common and sometimes incapacitating disorder in chronic uraemic patients."	( Ausserwinkler, M; Schmidt, P, 1989)
"The restless legs syndrome is a sensory and motor disorder of evening, repose, and sleep."	( Côté, L; Fahn, S; Hening, W; Walters, A, 1986)
"Restless legs syndrome is a common finding in patients with ESRD and is associated with substantial morbidity."	( Chertow, GM; Lazarus, JM; Winkelman, JW, 1996)
"Restless legs syndrome is a frequent dyssomnia with well-known clinical features but uncertain origin and treatment."	( Huidobro, A; Sanz-Fuentenebro, FJ; Tejadas-Rivas, A, 1996)
"Restless legs syndrome is one of the most common neurological disorders, with a prevalence of 2% to 9% in the elderly population."	( Clarenbach, P; Stiasny, K; Trenkwalder, C; Wetter, TC, 2001)
"Restless legs syndrome is a distinctive clinical syndrome with a prevalence of about 5% in the general population."	( Walther, BW, 2002)
"Restless legs syndrome is a common and not fully appreciated disorder."	( Kinge, E; Lossius, MI, 2004)
"Restless legs syndrome is a chronic condition defined as an irresistible desire to move one's limbs, usually associated with paraesthesia/dysaesthesia and motor restlessness."	( Kinge, E; Lossius, MI, 2004)
"Restless legs syndrome is a common neurological condition with 2-10% prevalence in the general population."	( Mühlau, G, 2004)
"The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole."	( Kakar, RS; Kushida, CA, 2005)
"The diagnosis of restless legs syndrome is made on the basis of the clinical symptoms and, if applicable, complemented with a polysomnography."	( Bachmann, CG; Trenkwalder, C, 2005)
"Restless legs syndrome is a very common and still under-diagnosed neurologic condition that can cause severe morbidity."	( Ondo, WG, 2005)
"Restless legs syndrome is characterized by an urge to move the legs, uncomfortable sensations in the legs and worsening of these symptoms during rest with at least temporary relief brought on by activity."	( Fornadi, K; Molnar, MZ; Shapiro, CM, 2006)
"Restless legs syndrome is a neurological disorder characterized by a desire to move limbs, which is usually only present or worsens during rest or at night."	( Allis, JC; Pondé, MP; Spolador, T, 2006)
"The restless legs syndrome is a disorder belonging to the family of movement disorders during sleep, often remains unrecognized, although it is the second most common cause of chronic sleep deficiency and daytime sleepiness."	( Szakács, Z; Vida, Z, 2007)
"Restless legs syndrome is a common condition that results in difficulties falling and staying asleep and perception of poor sleep quality."	( Kuzniar, TJ; Silber, MH, 2007)
"Restless legs syndrome is a common sensorimotor disorder occurring in approximately 10% of the general population."	( Mavroudakis, N, 2007)
"Restless legs syndrome is now widely recognized and is usually successfully treated with medication."	( Narus, MS; Nutt, JG; Ross, DA, 2008)
"Restless legs syndrome is a neurological disorder that can be treated with ropinirole."	( Boey, S; Hermida, JS; Szymanski, C, 2008)
"Late-onset restless legs syndrome is associated with low iron content of the basal ganglia and increased activity of the dorsolateral prefrontal cortex."	( Argyropoulou, MI; Astrakas, LG; Konitsiotis, S; Margariti, P; Tsouli, S; Tzarouhi, L, 2008)
"Restless legs syndrome is a neurological disorder characterized by unpleasant sensations and pain, predominantly in the lower extremities while at rest, accompanied by an uncontrollable urge for movement for relief."	( Kasubick, R; Shecterle, L; St Cyr, J, 2008)
"Restless legs syndrome is divided into primary and secondary forms."	( Killick, R; Wong, K; Yee, B, 2009)
"Although, restless legs syndrome is frequently characterized as a sleep disorder, it does not only influence sleep but also the daytime functioning of the patients."	( Lindner, A; Molnár, MZ; Novák, M, 2011)
"Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest."	( Allen, RP; Connor, JR; Earley, CJ; Patton, SM; Ponnuru, P; Wang, XS, 2011)
"Restless Legs Syndrome is a very common disorder in hemodialysis patients."	( Giannaki, CD; Hadjigeorgiou, GM; Karatzaferi, C; Koukoulis, GN; Koutedakis, Y; Lavdas, E; Liakopoulos, V; Sakkas, GK; Stefanidis, I; Tsianas, N, 2011)
"Restless Legs Syndrome is a common problem that is under-diagnosed."	( Goel, D; Gupta, R; Lahan, V, 2012)
"Restless legs syndrome is a curious neurological disorder of unknown aetiology."	( Duntley, SP; Shaw, PJ, 2012)
"Restless legs syndrome is associated with increased prevalence of mood disturbances, sleep disturbances, and an impaired quality of life."	( Mehta, SH; Sethi, KD, 2012)
"Restless legs syndrome is a very rare ADR that was more frequently reported in association with antidepressants, neuroleptics, or tramadol."	( Bondon-Guitton, E; Montastruc, AJ; Perez-Lloret, S; Rascol, O; Rey, MV, 2012)
"Pathophysiology of restless legs syndrome is poorly understood."	( Lodi, R; Malucelli, E; Manners, D; Marconi, S; Montagna, P; Pizza, F; Plazzi, G; Provini, F; Rizzo, G; Testa, C; Tonon, C; Vetrugno, R, 2012)
"Restless legs syndrome is a disorder associated with the imperative need to move the legs, starting at different times of day and it gets worse at night, relieved by activity, affecting the quality of life and sleep who sufferers it."	( Castaño-Cárcamo, M; Escobar-Cordoba, F; Rey de Castro, J, 2014)
"Restless legs syndrome is an underdiagnosed sensori-motor disorder and psychotropic drugs are one of the main secondary causes of the illness."	( Celebi, F; Soyata, AZ; Yargc, LI, 2016)
"Restless legs syndrome is a common neurological condition affecting a substantial portion of the population."	( Faulkner, MA, 2018)
"The prevalence of restless legs syndrome is low among women of child-bearing age in the Nigerian population and may be lower in pregnancy."	( Adedeji, TA; Fawale, MB; Ijarotimi, OA; Ismaila, IA; Komolafe, MA; Kullima, AA; Olowookere, SA; Oluyombo, R, 2018)
"Restless legs syndrome is a movement sleep disorder that may be linked to dopaminergic dysfunction and in which vitamin D may play a role."	( Abaalkhail, B; Alhejaili, F; Pandi-Perumal, SR; Wali, SO, 2019)
"Restless legs syndrome is a chronic disorder that is characterized by an urge to move the legs and unpleasant sensations in the lower extremities."	( Sieminski, M; Zemojtel, L, 2019)
"Restless legs syndrome is a common sensorimotor movement disorder affecting an estimated 15-20% of the general adult population in the United Sates."	( Goswami, U; Pusalavidyasagar, S, 2020)

Excerpt	Reference
"Most patients with restless legs syndrome have periodic movements of sleep, but most patients with the nocturnal disorder do not have restless legs when awake."	( Krueger, BR, 1990)
"The "restless legs syndrome" has been described in persons who consume a lot of caffeine(2,3), in patients with iron deficiency anemia(4), and in patients with chronic renal failure(5)."	( Missak, SS, 1987)
"Restless legs syndrome has attracted increasing interest as a clinically significant, common and treatable disorder."	( Reading, P, 2010)
"Restless legs syndrome has high prevalence, as it occurs in 5-10 % of the general population."	( Lindner, A; Molnár, MZ; Novák, M, 2011)
"Restless legs syndrome has a multi-factorial etiology that ranges from a genetic and hereditary, which are called primary restless legs syndrome, to its association with multiple pathologies, known as secondary restless legs syndrome."	( Castaño-Cárcamo, M; Escobar-Cordoba, F; Rey de Castro, J, 2014)

Excerpt	Reference
"Since the treatment of restless legs syndrome (RLS) with levodopa or classical opioids is problematic, new treatment possibilities would be valuable."	( Lauerma, H; Markkula, J, 1999)
"The history, clinical aspects, and treatment of restless legs syndrome (RLS), a heterogeneous distressing sensorimotor disorder, and periodic limb movements (PLMs) that are the typical motor accompaniment of the syndrome, are described."	( Montagna, P; Provini, F; Vetrugno, R, 2006)
"Algorithms for treatment of restless legs syndrome (RLS) include both nonpharmacologic and pharmacologic therapy."	( Hening, WA, 2007)
"Studies involving intravenous magnesium treatment for restless legs syndrome have not included pregnant women."	( Bartell, S; Zallek, S, 2006)
"Dopaminergic agents are the first-line treatment of restless legs syndrome (RLS), and have been used for the treatment of this disorder since the 1980s."	( García-Borreguero, D; Williams, AM, 2010)
"Pramipexole is an effective treatment for restless legs syndrome (RLS), but no controlled studies have lasted >12 weeks."	( Albrecht, S; Allen, RP; Brenner, SS; Busse, M; Ferini-Strambi, L; Fraessdorf, M; Garcia-Borreguero, D; Hening, W; Högl, B; Poewe, W; Trenkwalder, C, 2011)
"Dopaminergic drugs are the mainstay of treatment for restless legs syndrome (RLS)."	( Baumann, CR; Eisele, G; Gantenbein, AR; Schreglmann, SR, 2012)
"Gabapentin enacarbil is a new treatment for restless legs syndrome (RLS)."	( Burke, RA; Faulkner, MA, 2011)
"Dopaminergic drugs are commonly used to treat restless legs syndrome."	( Cheng, YH; Chew, KT; Hsieh, KC; Lai, YY; Nguyen, D; Ramanathan, L; Siegel, JM, 2017)
"Low dosage DA, as given when treating restless legs syndrome (RLS), has been thought only to have mild side effects."	( Ibsen, JD; Lindström, ES; Skovbølling, SL, 2022)
"There are several well-known treatments for Restless Legs Syndrome (RLS), including dopamine agonists (pramipexole, ropinirole, rotigotine), anticonvulsants (gabapentin and its analogs, pregabalin), oral or intravenous iron, opioids and benzodiazepines."	( DelRosso, LM; Spruyt, K; Walters, AS; Yeh, PG, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	126 (8.36)	23.3326
1990's	134 (8.89)	12.5806
2000's	506 (33.55)	18.1394
2010's	571 (37.86)	28.8240
2020's	171 (11.34)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	101	32
ammonium hydroxide	low	1	0
betaine	low	1	0
carbamates	medium	35	15
chlorine	low	1	0
hydrogen sulfide	low	1	0
3,4-dihydroxyphenylacetic acid	low	1	0
creatine	low	2	0
glycerol	medium	1	1
histamine	low	5	0
dihydroxyphenylalanine	low	5	0
inositol	low	1	0
melatonin	medium	15	2
niacin	low	1	0
uric acid	low	1	0
urea	low	2	0
3-methoxytyrosine	low	1	0
homovanillic acid	low	4	0
hydroxyindoleacetic acid	low	4	0
acetaminophen	low	2	0
acetyl-dl-leucine	low	1	0
alprazolam	medium	2	1
amantadine	low	2	0
dan 2163	low	1	0
amitriptyline	medium	2	1
amlodipine	medium	1	1
aspirin	low	3	0
atenolol	low	1	0
baclofen	low	4	0
bamethan	low	1	0
biperiden	low	1	0
bupivacaine	medium	4	1
buspirone	low	1	0
caffeine	low	8	0
verapamil	low	1	0
carbamazepine	medium	13	4
carisoprodol	low	1	0
chloral hydrate	low	1	0
chlorpromazine	low	1	0
cilostazol	low	1	0
citalopram	low	4	0
clebopride	low	1	0
clomipramine	low	1	0
clonazepam	medium	46	11
clonidine	medium	10	2
cyproheptadine	low	2	0
deferoxamine	low	1	0
diazepam	low	2	0
dipyridamole	medium	2	2
disopyramide	low	1	0
valproic acid	medium	5	1
domperidone	medium	4	1
droperidol	low	2	0
fentanyl	low	3	0
fluoxetine	medium	4	1
flurazepam	low	1	0
guanethidine	low	1	0
haloperidol	low	3	0
hydroxyzine	low	2	0
lidocaine	low	1	0
imipramine	low	1	0
avapro	low	1	0
ketamine	low	2	0
lamotrigine	low	2	0
lorazepam	low	1	0
mepivacaine	medium	2	1
metformin	low	1	0
methylphenidate	low	2	0
metoclopramide	medium	2	1
mianserin	medium	11	1
mirtazapine	medium	11	1
modafinil	low	1	0
apnea	low	4	0
nefazodone	low	2	0
neostigmine	low	1	0
nifedipine	medium	1	1
orphenadrine	low	2	0
oxazepam	low	1	0
oxidopamine	low	4	0
oxybutynin	medium	20	8
perphenazine	low	1	0
phenacetin	low	1	0
phenobarbital	low	1	0
pindolol	low	1	0
piracetam	low	3	0
pirenzepine	low	3	0
piribedil	medium	2	2
prazosin	low	1	0
primidone	low	1	0
propiomazine	medium	1	1
propofol	medium	2	1
propranolol	low	3	0
risperidone	low	2	0
saccharin	medium	2	2
sodium fluoride	low	1	0
talipexole	low	3	0
temazepam	medium	2	1
thalidomide	low	1	0
thioridazine	low	1	0
tinidazole	low	1	0
tolazoline	low	1	0
trazodone	low	2	0
triazolam	medium	4	1
trihexyphenidyl	low	1	0
trimeprazine	low	1	0
zolpidem	low	3	0
zonisamide	low	2	0
zopiclone	medium	1	1
corticosterone	low	1	0
prednisolone	low	1	0
thyroxine	low	1	0
dextroamphetamine	low	1	0
aldosterone	low	1	0
prednisone	low	2	0
penicillin g	low	1	0
alanine	low	2	0
aspartic acid	low	2	0
glutamine	low	4	0
physostigmine	low	2	0
sucrose	medium	2	1
apomorphine	medium	7	3
tetrabenazine	low	1	0
carbostyril	low	7	0
tyrosine	low	1	0
leucine	low	1	0
lactose	medium	1	1
colchicine	low	1	0
histidine	low	1	0
tryptophan	low	4	0
arginine	low	1	0
quinoxalines	low	1	0
phenothiazine	low	1	0
cyclamic acid	medium	2	2
4-bromophenyl phenyl ether	low	1	0
cyclohexanol	low	2	0
pyrroles	low	2	0
thiophenes	medium	80	24
isoxazoles	low	2	0
thiazoles	medium	24	9
hydrazine	low	1	0
metofenazate	low	1	0
dextropropoxyphene	medium	4	1
methoxyhydroxyphenylglycol	low	1	0
malondialdehyde	low	2	0
lithium carbonate	low	1	0
d-alpha tocopherol	medium	6	1
s,n,n'-tripropylthiocarbamate	low	5	0
pimozide	medium	4	1
manganese	low	2	0
mercury	low	1	0
palladium	low	1	0
rhenium	low	1	0
zirconium	low	1	0
magnesium sulfate	low	1	0
ferrous sulfate	medium	9	4
trolamine salicylate	low	2	0
selegiline	low	2	0
phytanic acid	low	1	0
bromocriptine	medium	6	3
phenyl acetate	medium	12	7
cetylpyridinium chloride anhydrous	low	1	0
transferrin	medium	20	2
glutamic acid	low	10	0
glucaric acid	medium	8	4
amoxicillin	low	1	0
tramadol	medium	10	1
methyldopa	low	2	0
enkephalin, methionine	low	1	0
paroxetine	low	3	0
pergolide	medium	32	12
fomesafen	low	6	0
quinpirole	low	1	0
fluorodopa f 18	low	3	0
aripiprazole	low	8	0
atorvastatin	low	2	0
duloxetine hydrochloride	low	2	0
adenosine	medium	7	1
venlafaxine hydrochloride	low	2	0
glucose, (beta-d)-isomer	low	1	0
n-acetylaspartic acid	low	2	0
6-sulfatoxymelatonin	medium	2	1
triazoles	low	2	0
fluorodeoxyglucose f18	low	2	0
sertraline	low	1	0
s20098	low	1	0
clarithromycin	low	1	0
nicotine	low	2	0
fibrinogen	low	2	0
tandospirone	low	1	0
homocysteine	low	2	0
carbidopa, levodopa drug combination	medium	9	1
vitamin b 6	medium	2	1
fingolimod hydrochloride	low	1	0
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide	medium	4	2
hydroquinidine	medium	1	1
saccharolactone	low	1	0
ro 8-0576	medium	1	1
reboxetine	low	1	0
safinamide	low	2	0
perrhenate	low	1	0
proline	low	1	0
asenapine	low	1	0
varenicline	low	1	0
benzofurans	low	1	0
oxytocin	low	1	0
quinidine	medium	1	1
diprenorphine	low	1	0
dironyl	medium	1	1
tacrolimus	low	1	0
cocaine	low	3	0
mycophenolic acid	low	1	0
clindamycin	low	1	0
enkephalin, leucine	low	1	0
cannabidiol	low	1	0
buprenorphine	low	2	0
ferlixit	low	1	0
eszopiclone	low	2	0
capsaicin	low	1	0
D-fructopyranose	low	3	0
pica	medium	9	2
lithium	low	2	0
raclopride	medium	3	1
quinine	low	4	0
dinoprostone	low	1	0
cholecalciferol	low	1	0
rutin	medium	2	1
entacapone	low	2	0
humulene	low	2	0
diosmin	medium	1	1
codeine	low	5	0
topiramate	low	4	0
istradefylline	low	1	0
fluvoxamine	low	1	0
aluminum	low	1	0
bismuth	low	1	0
naltrexone	medium	1	1
troxerutin	low	1	0
selenium	low	3	0
dihydroergotoxine	low	1	0
ferrous fumarate	low	1	0
n-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane	low	1	0
ergoline	medium	22	11
enkephalin, leucine-2-alanine	low	1	0
rebaudioside a	low	1	0
hypericum	medium	1	1
taxane	low	1	0
stalevo	medium	1	1
perampanel	medium	1	1
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	2	0
tasimelteon	low	1	0
alpha-synuclein	low	5	0
ribose	low	1	0
acebutolol	medium	11	5
lactulose	low	1	0
lurasidone hydrochloride	low	1	0
losartan potassium	medium	4	1
technetium tc 99m exametazime	low	1	0
ferryl iron	low	1	0
indocyanine green	low	1	0
rifamycins	low	2	0
ent-dextilidine	low	3	0
mdv 3100	low	2	0
beta-endorphin	low	1	0
sodium oxybate	low	3	0
sodium tetradecyl sulfate	medium	1	1
quetiapine fumarate	low	11	0
neurotensin	low	2	0
mme	low	1	0
ascorbic acid	medium	7	1
tetracycline	low	1	0
piroxicam	low	1	0
mobiflex	low	1	0
warfarin	low	1	0
ferric oxide, saccharated	medium	8	4
vitamin b 12	low	9	0
lactoferrin	low	1	0
deoxyguanosine	low	1	0
sapropterin	low	2	0
folic acid	low	12	0
neopterin	low	1	0
clozapine	low	6	0
olanzapine	low	10	0
allopurinol	low	1	0
tegaserod	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
eye	low	1	0
ferric carboxymaltose	medium	14	6
carbidopa	medium	21	5
leptin	low	1	0

Protein Targets (1,670)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	41	0	0	41
Chain A, HADH2 protein	27	0	0	27
Chain B, HADH2 protein	27	0	0	27
RAR-related orphan receptor gamma	58	0	0	58
GLI family zinc finger 3	78	0	0	78
AR protein	95	0	0	95
aldehyde dehydrogenase 1 family, member A1	41	0	0	41
thyroid stimulating hormone receptor	40	0	0	40
estrogen receptor 2 (ER beta)	32	0	0	32
nuclear receptor subfamily 1, group I, member 3	64	0	0	64
progesterone receptor	43	0	0	43
glucocorticoid receptor [Homo sapiens]	71	0	0	71
retinoic acid nuclear receptor alpha variant 1	66	0	0	66
estrogen-related nuclear receptor alpha	79	0	0	79
pregnane X nuclear receptor	69	0	0	69
estrogen nuclear receptor alpha	112	0	0	112
aryl hydrocarbon receptor	38	0	0	38
thyroid stimulating hormone receptor	32	0	0	32
activating transcription factor 6	26	0	0	26
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	29	0	0	29
v-jun sarcoma virus 17 oncogene homolog (avian)	38	0	0	38
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	20	0	0	20
thyroid hormone receptor beta isoform 2	69	0	0	69
nuclear factor erythroid 2-related factor 2 isoform 1	62	0	0	62
cytochrome P450 3A4 isoform 1	42	0	0	42
Gamma-aminobutyric acid receptor subunit pi	42	14	4	60
Voltage-dependent calcium channel gamma-2 subunit	35	0	0	35
Gamma-aminobutyric acid receptor subunit beta-1	42	14	4	60
Gamma-aminobutyric acid receptor subunit delta	42	14	4	60
Gamma-aminobutyric acid receptor subunit gamma-2	42	14	6	62
Glutamate receptor 2	37	3	1	41
Gamma-aminobutyric acid receptor subunit alpha-5	42	14	4	60
Gamma-aminobutyric acid receptor subunit alpha-3	42	14	4	60
Gamma-aminobutyric acid receptor subunit gamma-1	42	14	4	60
Gamma-aminobutyric acid receptor subunit alpha-2	42	14	4	60
Gamma-aminobutyric acid receptor subunit alpha-4	42	14	4	60
Gamma-aminobutyric acid receptor subunit gamma-3	42	14	4	60
Gamma-aminobutyric acid receptor subunit alpha-6	42	14	4	60
Gamma-aminobutyric acid receptor subunit alpha-1	42	15	6	63
Gamma-aminobutyric acid receptor subunit beta-3	42	14	4	60
Gamma-aminobutyric acid receptor subunit beta-2	42	14	6	62
Kelch-like ECH-associated protein 1	0	0	1	1
GABA theta subunit	42	14	4	60
Gamma-aminobutyric acid receptor subunit epsilon	42	14	4	60
Histone acetyltransferase KAT8	0	1	0	1
Sodium-dependent dopamine transporter	0	40	5	45
D(2) dopamine receptor	0	66	15	90
D(4) dopamine receptor	0	30	6	43
D(3) dopamine receptor	0	60	8	77
D(2) dopamine receptor	0	59	9	72
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	31	0	0	31
Chain A, JmjC domain-containing histone demethylation protein 3A	21	0	0	21
Chain A, 2-oxoglutarate Oxygenase	29	0	0	29
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	23	0	0	23
endonuclease IV	10	0	0	10
thioredoxin reductase	54	0	0	54
RGS12	2	0	0	2
phosphopantetheinyl transferase	31	0	0	31
NFKB1 protein, partial	20	0	0	20
GLS protein	49	0	0	49
TDP1 protein	85	0	0	85
Microtubule-associated protein tau	32	0	0	32
Thrombopoietin	12	0	0	12
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	9	0	0	9
apical membrane antigen 1, AMA1	12	0	0	12
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	16	0	0	16
hypothetical protein, conserved	5	0	0	5
regulator of G-protein signaling 4	45	0	0	45
euchromatic histone-lysine N-methyltransferase 2	96	0	0	96
Bloom syndrome protein isoform 1	31	0	0	31
lysosomal alpha-glucosidase preproprotein	14	0	0	14
peripheral myelin protein 22 isoform 1	18	0	0	18
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	51	0	0	51
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	2	0	0	2
DNA polymerase beta	12	0	0	12
flap endonuclease 1	20	0	0	20
DNA polymerase iota isoform a (long)	27	0	0	27
geminin	74	0	0	74
M-phase phosphoprotein 8	22	0	0	22
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	2	2
muscarinic acetylcholine receptor M1	39	0	0	39
lamin isoform A-delta10	78	0	0	78
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	53	6	59
Zinc finger protein mex-5	0	0	1	1
ATP-dependent phosphofructokinase	49	0	0	49
hypoxia-inducible factor 1 alpha subunit	24	0	0	24
retinoid X nuclear receptor alpha	47	0	0	47
peroxisome proliferator activated receptor gamma	43	0	0	43
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	41	0	0	41
Histone H2A.x	24	0	0	24
thyroid hormone receptor beta isoform a	23	0	0	23
heat shock protein beta-1	18	0	0	18
Cellular tumor antigen p53	55	0	0	55
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
cytochrome P450 2D6 isoform 1	32	0	0	32
lethal factor (plasmid)	25	0	0	25
Bile salt export pump	0	115	0	115
Major prion protein	0	0	5	5
Trypanothione reductase	0	7	0	7
ATAD5 protein, partial	33	0	0	33
Smad3	20	0	0	20
EWS/FLI fusion protein	40	0	0	40
peripheral myelin protein 22	44	0	0	44
ATP-binding cassette sub-family C member 3	0	83	0	83
Multidrug resistance-associated protein 4	0	83	0	85
Solute carrier family 22 member 6	0	7	0	7
Carbonic anhydrase 12	0	7	0	15
UDP-glucuronosyltransferase 1A9	0	1	0	7
Bile salt export pump	0	15	0	15
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	17	0	31
Carbonic anhydrase 2	0	18	3	36
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	2	1	4
Cytochrome P450 1A2	0	10	1	14
Prostaglandin G/H synthase 1	0	6	0	6
Carbonic anhydrase 3	0	7	0	13
Cytochrome P450 3A4	0	29	3	36
Cytochrome P450 2D6	0	31	1	34
Cytochrome P450 2C9	0	29	1	31
Polyunsaturated fatty acid lipoxygenase ALOX15	0	9	0	9
Sulfotransferase 1A1	0	0	0	1
UDP-glucuronosyltransferase 1-6	0	4	0	6
Arachidonate 5-lipoxygenase-activating protein	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	5	0	8
Carbonic anhydrase 4	0	8	0	16
Prostaglandin G/H synthase 1	0	9	0	9
Carbonic anhydrase 6	0	8	0	16
Carbonic anhydrase 5A, mitochondrial	0	8	2	18
Prostaglandin G/H synthase 2	0	6	0	7
Carbonic anhydrase 7	0	8	0	16
Nuclear receptor ROR-gamma	12	0	0	12
Cytochrome P450 2J2	0	21	0	22
Carbonic anhydrase 9	0	9	1	19
Canalicular multispecific organic anion transporter 1	0	79	0	79
Carbonic anhydrase 15	0	5	0	10
Carbonic anhydrase 13	0	3	0	10
Carbonic anhydrase 14	0	6	0	14
Carbonic anhydrase 5B, mitochondrial	0	8	0	16
toxin B	0	0	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
NPYLR7B	0	0	3	3
arylsulfatase A	37	0	0	37
IDH1	25	0	0	25
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	32	0	0	32
nuclear receptor ROR-gamma isoform 1	28	0	0	28
survival motor neuron protein isoform d	22	0	0	22
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	10	0	0	10
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	7	0	7
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	9	3	13
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	3	0	3
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	10	1	16
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	8	7	17
Adenosine receptor A2b	0	2	1	5
Adenosine receptor A2b	0	3	2	6
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	7	3	13
Adenosine receptor A2a	0	8	2	16
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	5	0	9
Glutamate receptor ionotropic, NMDA 1	0	12	1	18
Proton-coupled amino acid transporter 1	0	6	0	7
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	3	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	21	0	0	22
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	3	4	7
Androgen receptor	0	9	0	10
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	3	0	4
Guanine nucleotide-binding protein G	5	0	0	5
interleukin 8	9	0	0	9
transcriptional regulator ERG isoform 3	6	0	0	6
ras-related protein Rab-9A	14	0	0	14
Polyphenol oxidase 2	0	4	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	4	0	4
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	14	0	0	14
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	2
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	14	7	21
Gamma-aminobutyric acid receptor subunit gamma-2	0	14	4	18
Cholecystokinin receptor type A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	13	7	20
Gamma-aminobutyric acid receptor subunit alpha-3	0	13	5	18
Gamma-aminobutyric acid receptor subunit alpha-2	0	13	5	18
Gamma-aminobutyric acid receptor subunit beta-2	0	12	4	16
Cholecystokinin receptor type A	0	4	0	4
ATPase family AAA domain-containing protein 5	27	0	0	27
Ataxin-2	43	0	0	43
acetylcholinesterase	42	0	0	42
putative alpha-glucosidase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	27	0	0	27
Solute carrier family 22 member 2	0	16	0	21
Solute carrier family 22 member 1	0	33	0	40
Glutamate receptor ionotropic, NMDA 2D	0	5	0	5
Glutamate receptor ionotropic, NMDA 3B	0	5	0	5
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	53	1	3	57
Glutamate receptor ionotropic, NMDA 2A	0	10	1	16
Glutamate receptor ionotropic, NMDA 2B	0	11	1	17
Glutamate receptor ionotropic, NMDA 2C	0	10	1	16
Glutamate receptor ionotropic, NMDA 1	0	6	0	6
Glutamate receptor ionotropic, NMDA 2A	0	6	0	6
Glutamate receptor ionotropic, NMDA 2B	0	6	0	6
Glutamate receptor ionotropic, NMDA 2C	0	5	0	5
Glutamate receptor ionotropic, NMDA 2D	0	10	1	16
Solute carrier family 22 member 1	0	15	0	20
Glutamate receptor ionotropic, NMDA 3A	0	5	0	5
Glutamate receptor ionotropic, NMDA 3B	0	10	1	16
Multidrug and toxin extrusion protein 1	0	19	0	19
Solute carrier family 22 member 2	0	13	0	15
Glutamate receptor ionotropic, NMDA 3A	0	10	1	16
USP1 protein, partial	37	0	0	37
cytochrome P450 family 3 subfamily A polypeptide 4	65	0	0	65
cytochrome P450 2D6	58	0	0	58
D(1A) dopamine receptor	38	0	0	38
atrial natriuretic peptide receptor 2 precursor	15	0	0	15
serine/threonine-protein kinase mTOR isoform 1	20	0	0	20
Polyunsaturated fatty acid lipoxygenase ALOX15B	16	0	0	16
Voltage-dependent L-type calcium channel subunit alpha-1F	0	18	0	18
5-hydroxytryptamine receptor 4	0	53	1	54
Albumin	0	0	12	12
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	36	0	36
Muscarinic acetylcholine receptor M2	0	33	3	38
Muscarinic acetylcholine receptor M4	0	33	1	35
Muscarinic acetylcholine receptor M1	0	15	0	15
Muscarinic acetylcholine receptor M3	0	14	0	14
Muscarinic acetylcholine receptor M4	0	15	0	15
5-hydroxytryptamine receptor 2C	0	35	1	36
Muscarinic acetylcholine receptor M5	0	15	0	15
Muscarinic acetylcholine receptor M5	0	35	0	36
Alpha-2A adrenergic receptor	0	56	4	63
Muscarinic acetylcholine receptor M2	0	15	0	15
Muscarinic acetylcholine receptor M1	0	35	4	42
Angiotensin-converting enzyme	0	28	0	28
5-hydroxytryptamine receptor 2A	0	39	2	41
Alpha-2B adrenergic receptor	0	47	3	53
Alpha-2C adrenergic receptor	0	47	3	53
5-hydroxytryptamine receptor 1A	0	54	4	59
Muscarinic acetylcholine receptor M3	0	35	2	38
D(1A) dopamine receptor	0	36	6	47
D(1B) dopamine receptor	0	10	1	15
UDP-glucuronosyltransferase 1A4	0	4	0	12
Histamine H2 receptor	0	28	4	32
Alpha-1D adrenergic receptor	0	44	3	51
5-hydroxytryptamine receptor 2A	0	58	6	66
5-hydroxytryptamine receptor 2C	0	61	5	66
5-hydroxytryptamine receptor 1B	0	43	1	44
5-hydroxytryptamine receptor 1D	0	17	1	18
5-hydroxytryptamine receptor 1F	0	17	1	18
5-hydroxytryptamine receptor 2B	0	32	2	34
5-hydroxytryptamine receptor 6	0	8	1	9
Histamine H1 receptor	0	11	1	12
Sodium-dependent serotonin transporter	0	55	7	62
5-hydroxytryptamine receptor 7	0	17	1	18
5-hydroxytryptamine receptor 5A	0	8	1	9
5-hydroxytryptamine receptor 5B	0	8	1	9
Histamine H1 receptor	0	42	7	51
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	10	0	12
UDP-glucuronosyltransferase 1A3	0	0	0	4
5-hydroxytryptamine receptor 3A	0	14	1	15
5-hydroxytryptamine receptor 2B	0	56	3	59
Alpha-1A adrenergic receptor	0	42	7	49
Histamine H2 receptor	28	6	2	40
D(1A) dopamine receptor	13	2	0	15
5-hydroxytryptamine receptor 6	0	38	1	41
5-hydroxytryptamine receptor 7	0	17	0	17
Voltage-dependent N-type calcium channel subunit alpha-1B	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	18	0	18
Potassium voltage-gated channel subfamily H member 2	0	62	0	62
Voltage-dependent L-type calcium channel subunit alpha-1S	0	18	0	18
Voltage-dependent L-type calcium channel subunit alpha-1C	0	22	0	23
Sodium channel protein type 5 subunit alpha	0	15	0	15
Sodium channel protein type 9 subunit alpha	0	11	0	11
Sigma non-opioid intracellular receptor 1	0	8	1	9
5-hydroxytryptamine receptor 4	0	9	1	11
Nuclear receptor subfamily 3 group C member 3	0	27	0	27
Sodium channel protein type 2 subunit alpha	0	8	0	8
Sigma non-opioid intracellular receptor 1	0	41	1	42
5-hydroxytryptamine receptor 3B	0	14	1	15
Sodium channel protein type 3 subunit alpha	0	9	0	9
Sodium channel protein type 11 subunit alpha	0	6	0	6
Sodium channel protein type 8 subunit alpha	0	6	0	6
Histamine H3 receptor	0	10	2	12
Sodium channel protein type 10 subunit alpha	0	7	0	7
Chain A, Ferritin light chain	15	0	0	15
acid sphingomyelinase	4	0	0	4
G	32	0	0	32
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Potassium channel subfamily K member 2	0	7	5	12
Interferon beta	48	0	0	48
HLA class I histocompatibility antigen, B alpha chain	32	0	0	32
ATP-dependent translocase ABCB1	0	31	1	49
Alpha-2B adrenergic receptor	0	27	6	33
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Alpha-2C adrenergic receptor	0	27	6	33
Alpha-2A adrenergic receptor	0	27	6	33
Alpha-1A adrenergic receptor	0	18	4	28
Alpha-1B adrenergic receptor	0	11	3	18
Potassium channel subfamily K member 2	0	2	0	2
Inositol hexakisphosphate kinase 1	32	0	0	32
cytochrome P450 2C9, partial	32	0	0	32
Chain A, Beta-lactamase	20	0	0	20
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	16	0	0	16
DNA polymerase eta isoform 1	6	0	0	6
urokinase-type plasminogen activator precursor	11	0	0	11
plasminogen precursor	11	0	0	11
urokinase plasminogen activator surface receptor precursor	11	0	0	11
DNA polymerase kappa isoform 1	22	0	0	22
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	14	2	19
Solute carrier family 15 member 1	0	4	0	4
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
neuropeptide S receptor isoform A	10	0	0	10
Chain A, Putative fructose-1,6-bisphosphate aldolase	14	0	0	14
farnesoid X nuclear receptor	33	0	0	33
peroxisome proliferator-activated receptor delta	32	0	0	32
cellular tumor antigen p53 isoform a	10	0	0	10
cytochrome P450 2C19 precursor	21	0	0	21
cytochrome P450 2C9 precursor	18	0	0	18
vitamin D3 receptor isoform VDRA	28	0	0	28
potassium voltage-gated channel subfamily H member 2 isoform d	43	0	0	43
Integrin beta-3	6	1	1	8
Integrin alpha-IIb	6	1	1	8
5-hydroxytryptamine receptor 1A	0	27	16	43
Tryptophan 5-hydroxylase 1	0	5	0	5
Alpha-1B adrenergic receptor	0	39	6	45
D	0	31	0	33
D(3) dopamine receptor	0	29	2	33
D(2) dopamine receptor	0	13	0	13
Alpha-1D adrenergic receptor	0	35	6	41
D(1B) dopamine receptor	0	19	0	19
D(4) dopamine receptor	0	21	1	22
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	2	0	2
D	0	12	0	12
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	7	0	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	1	2
Nitric oxide synthase, brain	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	4
Cationic amino acid transporter 3	0	1	0	1
5-hydroxytryptamine receptor 3E	0	6	1	7
SMAD family member 2	14	0	0	14
Fumarate hydratase	23	0	0	23
PPM1D protein	12	0	0	12
SMAD family member 3	14	0	0	14
polyprotein	23	0	0	23
67.9K protein	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	41	0	0	41
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	7	0	0	7
mu-type opioid receptor isoform MOR-1	0	0	5	5
5-hydroxytryptamine receptor 2A	0	0	5	5
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 3B	0	6	1	7
Neuronal acetylcholine receptor subunit alpha-4	5	6	3	15
Neuronal acetylcholine receptor subunit beta-2	5	6	3	15
Histamine H1 receptor	0	6	4	10
5-hydroxytryptamine receptor 7	0	20	1	21
5-hydroxytryptamine receptor 3A	0	11	1	12
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
Inositol monophosphatase 1	15	0	0	15
5-hydroxytryptamine receptor 3D	0	6	1	7
Multidrug and toxin extrusion protein 2	0	11	0	11
5-hydroxytryptamine receptor 3C	0	6	1	7
Chain A, Hyaluronidase, phage associated	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glucocerebrosidase	9	0	0	9
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein, liver	0	6	0	6
Myeloperoxidase	0	6	0	6
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	12	2	14
Beta-1 adrenergic receptor	0	2	3	6
Beta-2 adrenergic receptor	0	10	3	13
Beta-1 adrenergic receptor	0	10	3	13
Beta-3 adrenergic receptor	0	5	3	8
Beta-2 adrenergic receptor	0	4	2	8
glp-1 receptor, partial	19	0	0	19
Chain A, Cruzipain	5	0	0	5
caspase 7, apoptosis-related cysteine protease	17	0	0	17
caspase-3	17	0	0	17
Caspase-7	6	0	0	6
caspase-3	6	0	0	6
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Histone deacetylase 1	0	4	0	4
Histone deacetylase 2	0	4	0	4
Solute carrier organic anion transporter family member 1B3	0	1	0	2
Histone deacetylase 6	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	9	1	11
Solute carrier organic anion transporter family member 1B1	0	5	0	7
Thromboxane A2 receptor	0	0	0	1
Endothelin-1 receptor	0	3	1	4
Type-1B angiotensin II receptor	0	3	0	3
Type-1 angiotensin II receptor	0	3	1	5
Type-2 angiotensin II receptor	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
Leukotriene B4 receptor 2	0	1	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Zinc finger protein mex-5	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	5	3	8
Hexokinase-2	0	1	0	1
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Genome polyprotein	0	2	1	3
dopamine D1 receptor	6	0	0	6
ATP-dependent translocase ABCB1	0	8	0	8
ATP-dependent translocase ABCB1	0	8	0	9
Alpha-synuclein	4	6	0	10
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
Kappa-type opioid receptor	0	24	9	38
Acetylcholine receptor subunit alpha	0	5	2	7
Acetylcholine receptor subunit gamma	0	5	2	7
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	5	2	7
UDP-glucuronosyltransferase 2B7	0	6	0	11
Neuronal acetylcholine receptor subunit beta-2	0	5	2	8
Cytochrome P450 2B6	0	2	1	5
Sodium-dependent dopamine transporter	0	26	3	29
Neuronal acetylcholine receptor subunit beta-4	0	5	2	8
Neuronal acetylcholine receptor subunit alpha-3	0	5	2	7
Cytochrome P450 2C19	0	11	0	14
UDP-glucuronosyltransferase 2B10	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	6
Neuronal acetylcholine receptor subunit alpha-4	0	5	2	8
Acetylcholine receptor subunit delta	0	5	2	7
Beta-2 adrenergic receptor	0	7	0	9
Angiotensin-converting enzyme	0	2	0	2
Beta-1 adrenergic receptor	0	6	1	9
Beta-3 adrenergic receptor	0	5	0	5
Alpha-2A adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	6	0	0	6
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	1	0	1
Cholinesterase	0	12	0	12
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	3	5
Amine oxidase [flavin-containing] A	0	11	0	11
Acetylcholinesterase	0	14	0	15
Amine oxidase [flavin-containing] B	0	14	3	17
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	6	0	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	2	1	4
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	2	0	2
Acetylcholinesterase	0	8	0	9
L-lactate dehydrogenase A chain	0	2	0	2
Cytochrome P450 2C11	0	2	0	2
Cytochrome P450 2A6	0	4	1	5
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
Cannabinoid receptor 1	0	4	0	5
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	0	1	1
Cannabinoid receptor 2	0	2	1	4
Mu-type opioid receptor	0	28	13	45
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Delta-type opioid receptor	0	21	9	34
Cholinesterase	0	6	0	7
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Transient receptor potential cation channel subfamily V member 1	0	3	2	6
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	2	4
Transient receptor potential cation channel subfamily V member 2	0	2	2	4
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
15-lipoxygenase, partial	14	0	0	14
transient receptor potential cation channel subfamily V member 1	4	0	0	4
Transient receptor potential cation channel subfamily V member 1	0	4	1	5
Lysine-specific histone demethylase 1A	0	3	0	3
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	2	0	2
Corticotropin-releasing factor receptor 2	0	1	0	1
Vpr	3	0	0	3
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 2 subunit alpha	0	6	0	6
Sodium channel protein type 3 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	3	0	3
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 13	0	4	0	6
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
Caspase-2	0	0	1	1
Carbonic anhydrase	0	5	0	10
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	3	0	3
Snq2p	0	0	0	5
Adenylate cyclase type 1	0	4	0	4
Spike glycoprotein	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
histone deacetylase 9 isoform 3	3	0	0	3
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	1	3	4
Albumin	0	1	8	10
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	4	0	4
Procathepsin L	0	1	3	4
Replicase polyprotein 1a	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
Adenylate cyclase type 3	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	5	0	10
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	3	4
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Aldehyde oxidase	0	4	0	6
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	3	4
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	3	3
Vitamin D3 receptor	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	18	0	0	18
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	4	0	4
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	6	1	7
Potassium-transporting ATPase alpha chain 1	0	2	0	2
Potassium-transporting ATPase subunit beta	0	2	0	2
Solute carrier family 22 member 6	0	4	0	6
Solute carrier family 22 member 8	0	5	0	8
Histamine H4 receptor	0	6	4	10
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	3	0	5
NPC intracellular cholesterol transporter 1 precursor	7	0	0	7
Sodium-dependent noradrenaline transporter	0	5	0	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	21	2	24
Sigma intracellular receptor 2	0	7	0	7
Sodium-dependent serotonin transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	6	0	6
Transporter	0	23	1	25
importin subunit beta-1 isoform 1	12	0	0	12
snurportin-1	12	0	0	12
GTP-binding nuclear protein Ran isoform 1	6	0	0	6
streptokinase A precursor	0	0	2	2
Protein-arginine deiminase type-4	0	2	0	2
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	4	4
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	9	0	9
Gamma-aminobutyric acid receptor subunit delta	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	10	2	12
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	12	3	15
Translocator protein	0	2	0	2
Translocator protein	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	11	2	13
Gamma-aminobutyric acid receptor subunit epsilon	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	0	12	2	14
Gamma-aminobutyric acid receptor subunit gamma-1	0	9	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	0	9	0	9
Gamma-aminobutyric acid receptor subunit theta	0	9	0	9
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	7	0	8
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	1	0	2
Delta-type opioid receptor	0	20	3	27
Mu-type opioid receptor	0	17	4	22
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Nischarin	0	2	0	2
Nischarin	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Endothelin receptor type B	0	3	0	3
5-hydroxytryptamine receptor 3A	0	5	0	5
Endothelin receptor type B	0	3	0	3
5-hydroxytryptamine receptor 2C	0	5	0	5
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	3	1	4
Transporter	0	6	0	6
5-hydroxytryptamine receptor 1A	0	3	0	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	0	4	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Liver carboxylesterase 1	0	1	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	5	0	5
Leukotriene B4 receptor 1	0	1	0	2
Cytochrome P450 2D1	0	3	0	3
Cytochrome P450 2D26	0	3	0	3
Cytochrome P450 2D3	0	3	0	3
Kappa-type opioid receptor	0	8	3	13
Mu-type opioid receptor	0	9	3	16
Cytochrome P450 2D4	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	4	4
PAX8	0	0	0	1
pregnane X receptor	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	11	0	0	11
caspase-1 isoform alpha precursor	3	0	0	3
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	6
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
GALC protein	12	0	0	12
nonstructural protein 1	13	0	0	13
Solute carrier family 22 member 3	0	1	0	1
C-8 sterol isomerase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
huntingtin isoform 2	7	0	0	7
chaperonin GroEL	1	0	0	1
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	2	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	9	0	10
Amine oxidase [flavin-containing] B	0	4	0	4
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	1	1	2
Gamma-aminobutyric acid	0	1	1	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Translocator protein	0	4	2	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	6	3	10
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
serine-protein kinase ATM isoform a	2	0	0	2
fatty acid synthase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Glutamate receptor 1	2	3	1	6
Glutamate receptor 3	2	3	1	6
Glutamate receptor 4	2	3	1	6
Caspase-7	3	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	12	0	0	12
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Aurora kinase B	0	1	0	1
Delta-type opioid receptor	0	20	5	27
Kappa-type opioid receptor	0	9	6	16
Chain A, limonene-1,2-epoxide hydrolase	0	1	0	1
Chain A, Epoxide hydrolase	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	13	0	0	13
serine/threonine-protein kinase PLK1	4	0	0	4
eyes absent homolog 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	2	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	2	0	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	2	0	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	2	0	2
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	10	0	0	10
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	2	0	2
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
D(3) dopamine receptor isoform e	1	0	0	1
Retinoic acid receptor RXR-alpha	0	0	3	3
N-acetyltransferase Eis	0	3	0	3
Opioid receptor, delta 1b	0	2	0	2
Opioid receptor homologue	0	2	0	2
Proenkephalin-B	0	0	1	1
Mu-type opioid receptor	0	23	6	32
Mu-type opioid receptor	0	2	0	2
Substance-P receptor	0	1	0	1
Catechol O-methyltransferase	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
UDP-glucuronosyltransferase 2B15	0	0	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Sphingosine 1-phosphate receptor 1	0	0	1	1
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Cytochrome P450 2C8	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1A2	0	2	0	4
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	3	1	4
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Cocaine esterase	0	2	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	1	3
AP-2 complex subunit sigma	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	3	0	3
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase	0	4	0	10
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase	0	3	0	9
Carbonic anhydrase	0	2	0	8
Carbonic anhydrase	0	4	0	10
Carbonic anhydrase	0	3	0	9
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carboxylic ester hydrolase	0	1	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
ClpP	3	0	0	3
Carbonic anhydrase	0	5	0	5
Carbonic anhydrase	0	5	0	5
Carbonic anhydrase, alpha family	0	5	0	5
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Tyrosine-protein kinase Lck	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	2	0	0	2
Potassium voltage-gated channel subfamily A member 5	0	3	0	3
Potassium voltage-gated channel subfamily D member 2	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-2 angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Prostate-specific antigen	0	1	0	1
Androgen receptor	0	5	2	7
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	0	3
Acetylcholinesterase	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	4	2	6
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	2	2	4
Melatonin receptor type 1B	0	4	2	6
Melatonin receptor type 1C	0	2	2	4
Melatonin receptor type 1B	0	2	2	4
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Dipeptidyl peptidase 4	0	2	1	3
Aldehyde oxidase 1	0	2	0	2
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
estrogen receptor beta isoform 1	0	2	0	2
Cystathionine gamma-lyase	0	1	0	1
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	3	0	3
Angiotensin-converting enzyme	0	3	0	3
G-protein coupled receptor	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	3	3
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	4
Nociceptin receptor	0	1	0	1
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-3	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	2	2
Muscarinic acetylcholine receptor M4	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Parkin	4	0	0	4
tumor necrosis factor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	2	0	2
DNA repair protein RAD52 homolog	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
XBP1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
DNA damage-inducible transcript 3 protein	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
5-hydroxytryptamine receptor 1B	0	6	1	7
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
interferon gamma precursor	0	0	0	2
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Histidine-rich protein PFHRP-II	0	2	0	2
Multidrug resistance protein 1a	0	0	0	1
Dipeptidyl peptidase 4	0	0	1	1
Amine oxidase [flavin-containing] A	0	6	0	7
Amine oxidase [flavin-containing] B	0	1	0	2
hemoglobin subunit beta	1	0	0	1
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	4	1	5
Synaptic vesicular amine transporter	0	3	1	4
Synaptic vesicular amine transporter	0	2	0	2
Neuraminidase	0	2	0	2
Chymotrypsinogen A	0	1	0	1
Neuraminidase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	2	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Carbonic anhydrase	0	5	0	5
Carbonic anhydrase	0	4	0	4
Taste receptor type 2 member 31	0	0	1	1
Beta-carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Carbonic anhydrase	0	4	0	4
Delta carbonic anhydrase	0	4	0	4
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Renin	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Transcriptional activator protein LuxR	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Glycoprotein	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Chloroquine resistance transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,508)

Protein Targets (1,670)

Restless Legs Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,508)

Drugs Studied (340)

Protein Targets (1,670)