Any pathway inhibitor that inhibits the synthesis of fatty acids.
ChEBI ID: 50185
| Member | Definition | Class |
|---|---|---|
| 2,2-dimethylmalonate | A dicarboxylic acid that is malonic acid in which both methylene hydrogens have been replaced by methyl groups. | dimethylmalonic acid |
| cerulenin | An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function. | cerulenin |
| ethionamide | A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide. | ethionamide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,090 (62.39) | 18.7374 |
| 1990's | 135 (7.73) | 18.2507 |
| 2000's | 219 (12.54) | 29.6817 |
| 2010's | 247 (14.14) | 24.3611 |
| 2020's | 56 (3.21) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 53 (2.78%) | 5.53% |
| Reviews | 84 (4.41%) | 6.00% |
| Case Studies | 53 (2.78%) | 4.05% |
| Observational | 5 (0.26%) | 0.25% |
| Other | 1,710 (89.76%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 5.9282 | 5 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 44.2846 | 5 | 9 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 20.9310 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 24.3365 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 18.5569 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.7028 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 34.1683 | 2 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.0977 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 1.1883 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 24.3282 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Fatty acid synthase | Gallus gallus (chicken) | IC50 | 13.0000 | 1 | 1 |
| Fatty acid synthase | Homo sapiens (human) | IC50 | 13.5533 | 3 | 3 |
| Genome polyprotein | Human rhinovirus sp. | IC50 | 2,500.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 4.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 2.5000 | 1 | 1 |
| Serine racemase | Mus musculus (house mouse) | IC50 | 5,630.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | Kic | 1.9000 | 1 | 1 |