Roles > ATP synthase inhibitor
Page last updated: 2024-08-05 15:20:06

ATP synthase inhibitor

A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase.

ChEBI ID: 20854

Members (3)

MemberDefinitionClass
bedaquilineA quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria.bedaquiline
carbonyl cyanide p-trifluoromethoxyphenylhydrazoneA hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.carbonyl cyanide p-trifluoromethoxyphenylhydrazone
dicyclohexylcarbodiimideA carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.1,3-dicyclohexylcarbodiimide

Research

Studies (3,538)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,419 (40.11)18.7374
1990's676 (19.11)18.2507
2000's498 (14.08)29.6817
2010's656 (18.54)24.3611
2020's289 (8.17)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials42 (1.13%)5.53%
Reviews150 (4.04%)6.00%
Case Studies47 (1.27%)4.05%
Observational20 (0.54%)0.25%
Other3,451 (93.02%)84.16%

Protein Targets (95)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency31.622811
activating transcription factor 6Homo sapiens (human)Potency29.689612
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency6.409212
AR proteinHomo sapiens (human)Potency15.1173710
Bloom syndrome protein isoform 1Homo sapiens (human)Potency7.079511
Cellular tumor antigen p53Homo sapiens (human)Potency24.332735
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency15.848911
Chain A, CruzipainTrypanosoma cruziPotency15.848911
Chain A, Ferritin light chainEquus caballus (horse)Potency31.622811
Chain A, HADH2 proteinHomo sapiens (human)Potency39.810711
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency23.119413
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency36.004112
Chain B, HADH2 proteinHomo sapiens (human)Potency39.810711
cytochrome P450 2C9, partialHomo sapiens (human)Potency3.790811
cytochrome P450 2D6Homo sapiens (human)Potency7.563711
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency5.011922
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency18.999111
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency2.861312
DNA polymerase kappa isoform 1Homo sapiens (human)Potency8.912511
estrogen nuclear receptor alphaHomo sapiens (human)Potency16.2806914
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency14.562212
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency9.3592612
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency10.000011
farnesoid X nuclear receptorHomo sapiens (human)Potency33.552022
GVesicular stomatitis virusPotency3.790811
GABA theta subunitRattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency5.011911
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency5.011911
GLI family zinc finger 3Homo sapiens (human)Potency57.828224
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency20.324612
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency35.374912
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency15.848912
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency19.952611
Histone H2A.xCricetulus griseus (Chinese hamster)Potency113.004011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency3.790811
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency34.421412
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency79.432811
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency3.790812
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency3.981111
Integrin alpha-IIbHomo sapiens (human)Potency15.848911
Integrin beta-3Homo sapiens (human)Potency15.848911
Interferon betaHomo sapiens (human)Potency3.790811
interleukin 8Homo sapiens (human)Potency53.080411
lethal factor (plasmid)Bacillus anthracis str. A2012Potency2.241212
LuciferasePhotinus pyralis (common eastern firefly)Potency14.162311
Microtubule-associated protein tauHomo sapiens (human)Potency7.714923
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency8.433136
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency43.646511
Nuclear receptor ROR-gammaHomo sapiens (human)Potency18.833611
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency1.619626
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency17.832935
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency12.882458
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency26.823222
phosphopantetheinyl transferaseBacillus subtilisPotency89.125111
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency15.848911
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency70.794611
pregnane X nuclear receptorHomo sapiens (human)Potency57.993212
progesterone receptorHomo sapiens (human)Potency12.197211
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.479835
retinoid X nuclear receptor alphaHomo sapiens (human)Potency13.000947
SMAD family member 2Homo sapiens (human)Potency55.477212
SMAD family member 3Homo sapiens (human)Potency55.477212
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.810711
survival motor neuron protein isoform dHomo sapiens (human)Potency4.659112
TDP1 proteinHomo sapiens (human)Potency1.122022
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency10.175123
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.631022
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency42.239522
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency1.443312
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency35.374912

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP synthase subunit c Mycolicibacterium smegmatisIC500.011934
Cytochrome P450 1A2Homo sapiens (human)IC5010.000011
Cytochrome P450 2C19Homo sapiens (human)IC505.800022
Cytochrome P450 2C9 Homo sapiens (human)IC5010.000011
Cytochrome P450 2D6Homo sapiens (human)IC5010.000011
Cytochrome P450 3A4Homo sapiens (human)IC5035.000044
Endothelial PAS domain-containing protein 1Homo sapiens (human)IC500.410022
Hypoxia-inducible factor 1-alphaHomo sapiens (human)IC500.410022
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC504.842588
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC504.360011
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)IC501.600011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP synthase subunit cBacillus sp. PS3Kd0.500011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)EC5015.000011