Roles > mitochondrial NADH:ubiquinone reductase inhibitor
Page last updated: 2024-08-05 15:17:41

mitochondrial NADH:ubiquinone reductase inhibitor

null

ChEBI ID: 38498

Members (9)

MemberDefinitionClass
4-chloro-n-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1h-pyrazole-5-carboxamidetebufenpyrad
deguelinA rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.deguelin
dequaliniumA quinolinium ion comprising decane in which one methyl hydrogen at each end of the molecule has been replaced by a 4-amino-2-methylquinolin-1-yl group.dequalinium
dequalinium chlorideAn organic chloride salt that is the dichloride salt of dequalinium.dequalinium chloride
fenazaquinfenazaquin
fenpyroximatefenpyroximate
pyridabenpyridaben
rotenoneA member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).rotenone
tolfenpyradAn aromatic amide obtained by formal condensation of the carboxy group of 4-chloro-3-ethyl-1-methylpyrazole-5-carboxylic acid with the amino group of 1-[4-(4-methylphenoxy)phenyl]methylamine.tolfenpyrad

Research

Studies (5,514)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,396 (25.32)18.7374
1990's495 (8.98)18.2507
2000's1,167 (21.16)29.6817
2010's1,759 (31.90)24.3611
2020's697 (12.64)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials31 (0.52%)5.53%
Reviews165 (2.75%)6.00%
Case Studies51 (0.85%)4.05%
Observational2 (0.03%)0.25%
Other5,743 (95.84%)84.16%

Protein Targets (165)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency29.881612
67.9K proteinVaccinia virusPotency6.037412
activating transcription factor 6Homo sapiens (human)Potency61.644822
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency37.646012
Alpha-synucleinHomo sapiens (human)Potency23.109311
Amyloid-beta precursor proteinHomo sapiens (human)Potency16.360111
AR proteinHomo sapiens (human)Potency1.4242844
aryl hydrocarbon receptorHomo sapiens (human)Potency44.668411
arylsulfatase AHomo sapiens (human)Potency5.358211
ATAD5 protein, partialHomo sapiens (human)Potency10.265334
Ataxin-2Homo sapiens (human)Potency6.122223
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency5.188812
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency2.266411
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency0.134611
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency0.082611
Bloom syndrome protein isoform 1Homo sapiens (human)Potency15.864323
Cellular tumor antigen p53Homo sapiens (human)Potency10.2948313
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency19.295023
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency37.646014
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency14.670834
Chain A, CruzipainTrypanosoma cruziPotency26.635725
Chain A, Ferritin light chainEquus caballus (horse)Potency11.220211
Chain A, HADH2 proteinHomo sapiens (human)Potency26.808814
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency26.280023
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency16.942114
Chain B, HADH2 proteinHomo sapiens (human)Potency26.808814
chromobox protein homolog 1Homo sapiens (human)Potency47.748523
cytochrome P450 2C19 precursorHomo sapiens (human)Potency3.006012
cytochrome P450 2C9 precursorHomo sapiens (human)Potency31.622811
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.760112
cytochrome P450 2D6Homo sapiens (human)Potency10.223212
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency14.383714
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency9.1378213
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency4.912713
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency40.911017
D(1A) dopamine receptorHomo sapiens (human)Potency12.589311
D(1A) dopamine receptorSus scrofa (pig)Potency9.269612
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency33.498311
DNA polymerase betaHomo sapiens (human)Potency35.716812
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency30.036512
DNA polymerase kappa isoform 1Homo sapiens (human)Potency12.723613
endonuclease IVEscherichia coliPotency14.125411
estrogen nuclear receptor alphaHomo sapiens (human)Potency7.94211159
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency25.468927
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.1846940
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency22.637515
EWS/FLI fusion proteinHomo sapiens (human)Potency11.336048
farnesoid X nuclear receptorHomo sapiens (human)Potency38.642027
flap endonuclease 1Homo sapiens (human)Potency21.192322
Fumarate hydrataseHomo sapiens (human)Potency17.252913
GVesicular stomatitis virusPotency5.760112
GABA theta subunitRattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency8.598317
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency8.598317
gemininHomo sapiens (human)Potency6.415046
GLI family zinc finger 3Homo sapiens (human)Potency0.5803211
GLS proteinHomo sapiens (human)Potency11.220211
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency30.6532513
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.034016
Glycoprotein hormones alpha chainHomo sapiens (human)Potency1.122011
Guanine nucleotide-binding protein GHomo sapiens (human)Potency11.220211
heat shock protein beta-1Homo sapiens (human)Potency50.684925
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency11.6463211
Histone H2A.xCricetulus griseus (Chinese hamster)Potency113.004011
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency44.668411
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.760112
huntingtin isoform 2Homo sapiens (human)Potency7.943311
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency42.615024
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency5.997624
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.760114
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency17.680714
Integrin alpha-IIbHomo sapiens (human)Potency25.787712
Integrin beta-3Homo sapiens (human)Potency25.787712
Interferon betaHomo sapiens (human)Potency5.057036
lamin isoform A-delta10Homo sapiens (human)Potency2.003425
lethal factor (plasmid)Bacillus anthracis str. A2012Potency13.131112
M-phase phosphoprotein 8Homo sapiens (human)Potency31.595414
Microtubule-associated protein tauHomo sapiens (human)Potency14.957214
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency2.008522
neuropeptide S receptor isoform AHomo sapiens (human)Potency12.589312
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency22.138712
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency158.194013
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency7.6971315
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency0.145811
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency56.824614
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency118.9301210
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency6.112827
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency1.200123
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency16.927812
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency26.7414413
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency39.810711
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency20.6579411
phosphopantetheinyl transferaseBacillus subtilisPotency37.630712
plasminogen precursorMus musculus (house mouse)Potency0.158511
polyproteinZika virusPotency17.252913
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency4.155214
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency25.118911
PPM1D proteinHomo sapiens (human)Potency1.855712
pregnane X nuclear receptorHomo sapiens (human)Potency19.169525
pregnane X receptorRattus norvegicus (Norway rat)Potency0.667813
progesterone receptorHomo sapiens (human)Potency29.388928
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.2652212
ras-related protein Rab-9AHomo sapiens (human)Potency77.522313
regulator of G-protein signaling 4Homo sapiens (human)Potency22.485212
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency17.678039
retinoid X nuclear receptor alphaHomo sapiens (human)Potency15.8171415
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency6.490024
Single-stranded DNA cytosine deaminaseHomo sapiens (human)Potency89.125124
SMAD family member 2Homo sapiens (human)Potency0.173415
SMAD family member 3Homo sapiens (human)Potency0.173415
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency0.034111
survival motor neuron protein isoform dHomo sapiens (human)Potency9.442615
TDP1 proteinHomo sapiens (human)Potency2.0048214
thioredoxin reductaseRattus norvegicus (Norway rat)Potency7.658323
ThrombopoietinHomo sapiens (human)Potency5.011922
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency26.4561214
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency12.721823
thyroid stimulating hormone receptorHomo sapiens (human)Potency22.1126621
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency0.158511
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency0.158511
USP1 protein, partialHomo sapiens (human)Potency53.401515
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency35.488624
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency22.421056
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.034016

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 6Homo sapiens (human)IC500.870011
5-hydroxytryptamine receptor 6Homo sapiens (human)Ki0.404011
AcetylcholinesteraseHomo sapiens (human)IC50126.700011
Acyl carrier protein, mitochondrialBos taurus (cattle)IC500.005111
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC508.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
COUP transcription factor 2 isoform aHomo sapiens (human)IC500.050522
Cytochrome P450 2C19Homo sapiens (human)IC503.648611
Dihydroorotate dehydrogenase Plasmodium falciparum (malaria parasite P. falciparum)IC5010.000011
Dihydroorotate dehydrogenase (fumarate)Saccharomyces cerevisiae S288CIC5010.000011
galanin receptor type 3Homo sapiens (human)IC500.014622
Heat shock protein HSP 90-alphaHomo sapiens (human)IC501.630011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialBos taurus (cattle)IC500.005111
NADH-ubiquinone oxidoreductase chain 1Bos taurus (cattle)IC500.016123
Pancreatic triacylglycerol lipaseSus scrofa (pig)IC50500.000011
Small conductance calcium-activated potassium channel protein 1Rattus norvegicus (Norway rat)IC500.880033
Small conductance calcium-activated potassium channel protein 1Rattus norvegicus (Norway rat)Ki0.221011
Small conductance calcium-activated potassium channel protein 2Rattus norvegicus (Norway rat)IC500.880033
Small conductance calcium-activated potassium channel protein 2Rattus norvegicus (Norway rat)Ki0.221011
Small conductance calcium-activated potassium channel protein 3Homo sapiens (human)IC501.650022
Small conductance calcium-activated potassium channel protein 3Rattus norvegicus (Norway rat)IC500.880033
Small conductance calcium-activated potassium channel protein 3Rattus norvegicus (Norway rat)Ki0.180522
transactivating tegument protein VP16 [Human herpesvirus 1]Human alphaherpesvirus 1 (Herpes simplex virus type 1)IC5085.401022

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Amine oxidase [flavin-containing] A Rattus norvegicus (Norway rat)Kd0.180011
calcineurin A1, putativeCandida dubliniensis CD36EC50180.000011
Estrogen receptorRattus norvegicus (Norway rat)EC5020.765012
Estrogen receptor betaRattus norvegicus (Norway rat)EC5020.765012
heat shock protein 90Candida albicansEC50106.774733
Small conductance calcium-activated potassium channel protein 3Rattus norvegicus (Norway rat)Kd0.180011
streptokinase A precursorStreptococcus pyogenes M1 GASEC5012.875522