An antagonist that binds to and activates aryl hydrocarbon receptors (AhRs).
ChEBI ID: 76998
Member | Definition | Class |
---|---|---|
alpha-naphthoflavone | An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14). | alpha-naphthoflavone |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 160 (25.08) | 18.7374 |
1990's | 162 (25.39) | 18.2507 |
2000's | 160 (25.08) | 29.6817 |
2010's | 119 (18.65) | 24.3611 |
2020's | 37 (5.80) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 1 (0.15%) | 5.53% |
Reviews | 10 (1.50%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 654 (98.35%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
alpha-galactosidase | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
Chain A, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
Chain B, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 3 |
lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
Microtubule-associated protein tau | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
phosphopantetheinyl transferase | Bacillus subtilis | Potency | 44.6684 | 1 | 1 |
TDP1 protein | Homo sapiens (human) | Potency | 8.4144 | 1 | 1 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Adenosine receptor A1 | Homo sapiens (human) | IC50 | 1.1325 | 1 | 1 |
Adenosine receptor A1 | Homo sapiens (human) | Ki | 0.6606 | 1 | 1 |
Aromatase | Homo sapiens (human) | IC50 | 1.0350 | 2 | 2 |
Aromatase | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
Aryl hydrocarbon receptor | Mus musculus (house mouse) | IC50 | 0.0250 | 1 | 1 |
ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 24.6000 | 1 | 1 |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 1.3550 | 2 | 2 |
Carboxylic ester hydrolase | Sus scrofa (pig) | IC50 | 0.0478 | 1 | 1 |
cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 2.3034 | 1 | 1 |
Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 2.4555 | 26 | 26 |
Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.0450 | 1 | 1 |
Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 2.1195 | 38 | 38 |
Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 10.8787 | 34 | 34 |
Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
Cytochrome P450 2B6 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 15.0000 | 4 | 4 |
Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 15.0000 | 4 | 4 |
Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 13.3333 | 6 | 6 |
Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 13.3333 | 6 | 6 |
Cytochrome P450 3A6 | Oryctolagus cuniculus (rabbit) | Ki | 80.1000 | 1 | 1 |
DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 4.9800 | 1 | 1 |
Histamine H3 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 20.0000 | 1 | 1 |
Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0500 | 1 | 1 |
Substance-K receptor | Homo sapiens (human) | IC50 | 5.8471 | 1 | 1 |
Substance-K receptor | Homo sapiens (human) | Ki | 1.9490 | 1 | 1 |
Thromboxane-A synthase | Homo sapiens (human) | IC50 | 6.7608 | 1 | 1 |
UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 115.4000 | 1 | 5 |
UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 115.4000 | 1 | 5 |
UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 115.4000 | 1 | 5 |
UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 115.4000 | 1 | 5 |
UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 115.4000 | 1 | 5 |
Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 20.0000 | 1 | 1 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Cytochrome P450 1A1 | Homo sapiens (human) | EC50 | 2.5000 | 2 | 2 |
Cytochrome P450 1B1 | Homo sapiens (human) | EC50 | 26.7000 | 3 | 3 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Cytochrome P450 1B1 | Homo sapiens (human) | Ks | 0.7000 | 1 | 1 |