Page last updated: 2024-08-05 15:32:59

aryl hydrocarbon receptor antagonist

An antagonist that binds to and activates aryl hydrocarbon receptors (AhRs).

ChEBI ID: 76998

Members (1)

MemberDefinitionClass
alpha-naphthoflavoneAn extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).alpha-naphthoflavone

Research

Studies (638)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990160 (25.08)18.7374
1990's162 (25.39)18.2507
2000's160 (25.08)29.6817
2010's119 (18.65)24.3611
2020's37 (5.80)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1 (0.15%)5.53%
Reviews10 (1.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other654 (98.35%)84.16%

Protein Targets (66)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency14.125411
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.622811
alpha-galactosidaseHomo sapiens (human)Potency7.079511
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency31.622811
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.481311
Chain A, CruzipainTrypanosoma cruziPotency39.810711
Chain A, HADH2 proteinHomo sapiens (human)Potency35.716822
Chain B, HADH2 proteinHomo sapiens (human)Potency35.716822
cytochrome P450 2C19 precursorHomo sapiens (human)Potency1.995311
cytochrome P450 2C9 precursorHomo sapiens (human)Potency7.943311
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency12.589311
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency12.589322
GABA theta subunitRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency12.589311
glucocerebrosidaseHomo sapiens (human)Potency31.622811
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency7.943313
lethal factor (plasmid)Bacillus anthracis str. A2012Potency25.118911
Microtubule-associated protein tauHomo sapiens (human)Potency17.782811
mitogen-activated protein kinase 1Homo sapiens (human)Potency31.622811
phosphopantetheinyl transferaseBacillus subtilisPotency44.668411
TDP1 proteinHomo sapiens (human)Potency8.414411
thyroid stimulating hormone receptorHomo sapiens (human)Potency31.622822

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A1Homo sapiens (human)IC501.132511
Adenosine receptor A1Homo sapiens (human)Ki0.660611
AromataseHomo sapiens (human)IC501.035022
AromataseHomo sapiens (human)Ki0.020011
Aryl hydrocarbon receptorMus musculus (house mouse)IC500.025011
ATP-dependent translocase ABCB1Homo sapiens (human)IC5024.600011
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC501.355022
Carboxylic ester hydrolase Sus scrofa (pig)IC500.047811
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC502.303411
Cytochrome P450 1A1Homo sapiens (human)IC502.45552626
Cytochrome P450 1A1Homo sapiens (human)Ki0.045011
Cytochrome P450 1A2Homo sapiens (human)IC502.11953838
Cytochrome P450 1A2Homo sapiens (human)Ki0.020011
Cytochrome P450 1B1Homo sapiens (human)IC5010.87873434
Cytochrome P450 1B1Homo sapiens (human)Ki0.016011
Cytochrome P450 2A6Homo sapiens (human)IC5025.000011
Cytochrome P450 2B6Homo sapiens (human)IC5013.000011
Cytochrome P450 2C19Homo sapiens (human)IC5015.000044
Cytochrome P450 2C9 Homo sapiens (human)IC5015.000044
Cytochrome P450 2D6Homo sapiens (human)IC5013.333366
Cytochrome P450 3A4Homo sapiens (human)IC5013.333366
Cytochrome P450 3A6Oryctolagus cuniculus (rabbit)Ki80.100011
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)IC504.980011
Histamine H3 receptorCavia porcellus (domestic guinea pig)IC5020.000011
Multidrug resistance-associated protein 1 Homo sapiens (human)IC5011.300011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)IC500.010011
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)IC500.050011
Substance-K receptorHomo sapiens (human)IC505.847111
Substance-K receptorHomo sapiens (human)Ki1.949011
Thromboxane-A synthase Homo sapiens (human)IC506.760811
UDP-glucuronosyltransferase 1-6Homo sapiens (human)IC50115.400015
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)IC50115.400015
UDP-glucuronosyltransferase 1A4Homo sapiens (human)IC50115.400015
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)IC50115.400015
UDP-glucuronosyltransferase 2B7Homo sapiens (human)IC50115.400015
Xanthine dehydrogenase/oxidaseBos taurus (cattle)IC5020.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cytochrome P450 1A1Homo sapiens (human)EC502.500022
Cytochrome P450 1B1Homo sapiens (human)EC5026.700033

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cytochrome P450 1B1Homo sapiens (human)Ks0.700011