1-Deoxynojirimycin (DNJ) is a naturally occurring iminosugar that inhibits the activity of α-glucosidase, an enzyme involved in the breakdown of carbohydrates. DNJ has been shown to have potential therapeutic effects in the treatment of diabetes, obesity, and other metabolic disorders. DNJ is found in a variety of plants, including mulberry, moringa, and lychee. It can be synthesized chemically or extracted from natural sources. The mechanism of action of DNJ involves its binding to the active site of α-glucosidase, preventing the enzyme from hydrolyzing carbohydrates. This leads to a reduction in blood glucose levels, which can be beneficial for individuals with diabetes. DNJ has also been shown to have anti-inflammatory and antioxidant properties. Research into DNJ is ongoing, with a focus on its potential use in the treatment of a range of diseases.'
1-deoxy-nojirimycin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 29435 |
| CHEMBL ID | 307429 |
| CHEBI ID | 44369 |
| SCHEMBL ID | 2969 |
| MeSH ID | M0026526 |
| Synonym |
|---|
| AC-1386 |
| 1,5-dideoxy-1,5-imino- |
| moranoline |
| nojirimycin, 1-deoxy- |
| chebi:44369 , |
| HMS3267J09 |
| BIO1_000415 |
| BIO1_001393 |
| BIO1_000904 |
| SMP2_000333 |
| BSPBIO_000993 |
| c6h13no4 |
| 3,4,5-piperidinetriol, 2-(hydroxymethyl)-, (2r-(2alpha,3beta,4alpha,5beta))- |
| 1,5-deoxy-1,5-imino-d-mannitol |
| (2r,3r,4r,5s)-2-(hydroxymethyl)piperidine-3,4,5-triol |
| 1-deoxynojirimycin , |
| 19130-96-2 |
| DNM , |
| 1,5-dideoxy-1,5-imino-d-glucitol |
| (2r,3r,4r,5s)-2-hydroxymethyl-piperidine-3,4,5-triol |
| DNJ , |
| noj , |
| 1-deoxy-nojirimycin |
| d-1-deoxynojirimycin |
| (+)-1-deoxynojirimycin |
| 5-amino-1,5-dideoxy-d-glucopyranose |
| deoxynojirimycin |
| DB03206 |
| 1OIM , |
| 1 deoxynojirimycin |
| 2J77 |
| duvoglustat |
| NCGC00025085-02 |
| NCGC00025085-03 |
| 1-deoxynojirimycin (dnj) |
| (2r,3r,4r,5s)-2-(hydroxymethyl)piperidine-3,4,5-triol, 10 |
| chembl307429 , |
| bdbm18351 |
| moranolin |
| HMS1990A15 |
| bay-h-5595 |
| HMS1792A15 |
| AKOS006275143 |
| D09605 |
| duvoglustat (usan/inn) |
| duvoglustat [usan:inn] |
| ec 606-239-2 |
| unii-fz56898fle |
| fz56898fle , |
| bay-h 5595 |
| S3839 |
| (2r,3r,4r,5s)-2-(hydroxymethyl)-3,4,5-piperidinetriol |
| s-gi |
| gtpl4642 |
| SCHEMBL2969 |
| 1-deoxynojirimycin [mi] |
| duvoglustat [usan] |
| 3,4,5-piperidinetriol, 2-(hydroxymethyl)-, (2r,3r,4r,5s)- |
| glucopyranose, 5-amino-1,5-dideoxy-, d- |
| 3,4,5-piperidinetriol, 2-(hydroxymethyl)-, (2r-(2.alpha.,3.beta.,4.alpha.,5.beta.))- |
| duvoglustat [inn] |
| LXBIFEVIBLOUGU-JGWLITMVSA-N |
| 1,5-didesoxy-1,5-imino-d-glucitol |
| 1, 5-dideoxy-1,5-imino-d-glucitol |
| W-201703 |
| Q-100789 |
| HMS3403A15 |
| mfcd00063474 |
| DTXSID70172647 |
| CS-5594 |
| HY-14860 |
| sr-01000597392 |
| SR-01000597392-1 |
| 1-deoxynojirimycin, analytical standard |
| antibiotic s-gi |
| HB4599 |
| BS-15755 |
| 1-deoxynojirimycin (hydrochloride) |
| Q15274561 |
| duvoglustat (hydrochloride) |
| A14383 |
| AMY37043 |
| CCG-266301 |
| A854588 |
| D5612 |
| EN300-7411893 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-six non-insulin-dependent diabetes mellitus (NIDDM) subjects were studied in a double-blind randomized study comparing treatment with a single dosage of 100 mg miglitol or placebo and a single-blind crossover comparison of three test meals in which the carbohydrate contained either 30, 50, or 70% starch, and quantities of fat and protein were kept constant." | ( alpha-Glucosidase inhibition by miglitol in NIDDM patients. Kingma, PJ; Menheere, PP; Nieuwenhuijzen Kruseman, AC; Sels, JP, 1992) | 0.28 |
| " The single-channel conductance was not altered by any of the three inhibitors, and the slopes of log-log dose-response curves at low concentrations and desensitization did not appear to be affected." | ( Inhibitors of asparagine-linked oligosaccharide processing alter the kinetics of the nicotinic acetylcholine receptor. Covarrubias, M; Kopta, C; Steinbach, JH, 1989) | 0.28 |
| "01) reduced by miglitol although no reduction in fasting blood glucose, HbA1, plasma lipids, insulin dosage or weight was observed." | ( Effect of alpha-glucosidase inhibition on glucose profiles in insulin dependent diabetes. Gray, RS; Hillman, RJ; Scott, M, 1989) | 0.28 |
| " Aggregation rates of both older and younger cells were unaffected, as measured by disapperance of single cells, though older cells formed somewhat smaller aggregates at the highest dosage used." | ( Response of aggregating chick corneal cells to modifiers of N-linked oligosaccharides, endoglycosidase H and deoxymannojirimycin. Overton, J, 1988) | 0.27 |
| " Nondiabetic mice of the same strain were dosed for 3 and 7 days." | ( Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice. Bezerra, J; Bustamante, S; Flores, C; Goda, T; Koldovský, O; Lee, SM, 1987) | 0.27 |
| " Thus, with the dosage schedule employed, Bay-m-1099, but not Bay-o-1248, significantly reduced postprandial increments in plasma insulin." | ( The effect of two new alpha-glucosidase inhibitors on metabolic responses to a mixed meal in normal volunteers. Gerich, JE; Heiling, V; Kennedy, FP; Miles, JM, 1987) | 0.27 |
| " This might be due to the short duration of the treatment periods or the low dosage of the drug." | ( Smoothing effect of a new alpha-glucosidase inhibitor BAY m 1099 on blood glucose profiles of sulfonylurea-treated type II diabetic patients. Arends, J; Willms, BH, 1986) | 0.27 |
| " Further studies should concentrate on the critical dosage which may strike a satisfactory balance between effects and side effects." | ( The effect of two new glucosidase inhibitors on blood glucose in healthy volunteers and in type II diabetics. Federlin, KF; Hillebrand, I; Laube, H; Mehlburger, L, ) | 0.13 |
| " Dosing was begun at 8 mg/kg/day and subsequent doses were 16, 32, 48, and 64 mg/kg/day." | ( The tolerability and pharmacokinetics of N-butyl-deoxynojirimycin in patients with advanced HIV disease (ACTG 100). The AIDS Clinical Trials Group (ACTG) of the National Institute of Allergy and Infectious Diseases. Fischl, M; Karim, A; Kessler, H; Merigan, T; Pottage, J; Powderly, W; Richman, D; Sherman, J; Smith, S; Tierney, M, 1995) | 0.29 |
| " These symptoms are usually dose dependent, mild to moderate in severity, occur at the onset of treatment, decline with time and resolve promptly on discontinuation of the drug or with dosage adjustment." | ( Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus. Scott, LJ; Spencer, CM, 2000) | 0.31 |
| "To evaluate miglitol, a new oral alpha-glucosidase inhibitor, and discuss its pharmacology, therapeutics, pharmacokinetics, dosing guidelines, adverse effects, drug interactions, and clinical efficacy." | ( Miglitol: assessment of its role in the treatment of patients with diabetes mellitus. Baker, DE; Campbell, LK; Campbell, RK, 2000) | 0.31 |
| " During the extension, dosage was increased to 100 mg TID in patients in one center to improve the response." | ( Low-dose N-butyldeoxynojirimycin (OGT 918) for type I Gaucher disease. Aerts, J; Elstein, D; Heitner, R; Weely, Sv; Zimran, A, ) | 0.13 |
| " A second drug, N-butyldeoxyglactonojirimycin, looks very promising for treating storage diseases with neurological involvement as high systemic dosing is achievable without any side-effects." | ( Substrate reduction therapy in mouse models of the glycosphingolipidoses. Andersson, U; Butters, TD; Dwek, RA; Heare, T; Jeyakumar, M; Platt, FM, 2003) | 0.32 |
| " Globotriaosylceramide storage was remarkably reduced in kidney of mice after a 4-week treatment at a dosage of approximately 3 mg/kg body weight/day." | ( Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. Chang, HH; Fan, JQ; Higuchi, Y; Ishii, S; Mannen, K; Shimada, T; Taguchi, A; Yoshioka, H, 2009) | 0.35 |
| " The aims of this study were (i) to design a controlled release (CR) mucoadhesive (in the intestine) formulation of miglitol which would inhibit the alpha-glucosidase enzyme for a longer duration of time (in comparison to the non-controlled release (IR) formulation) thus reducing the dosing frequency, and also controlling the postprandial glucose levels more effectively over a longer period of time; (ii) to assess the effect of different formulation parameters on the release of miglitol in vitro from the CR pellets; (iii) to evaluate the mucoadhesion of pellets in the intestine ex vivo; (iv) to study the effect of formulation parameters on plasma GLP-1 levels; and (v) to find out the effect of formulations on postprandial glucose levels." | ( Design and evaluation of oral bioadhesive controlled release formulations of miglitol, intended for prolonged inhibition of intestinal alpha-glucosidases and enhancement of plasma glucagon like peptide-1 levels. Babu, RK; Deshpande, MC; Trivedi, RK; Venkateswarlu, V, 2009) | 0.35 |
| " There is uncertainty as to whether an increase in the dosage of ERT has a beneficial effect." | ( Gaucher disease: a systematic review and meta-analysis of bone complications and their response to treatment. Amato, D; Piran, S, 2010) | 0.36 |
| " These data suggest that the KD-R and NB-DNJ may be a potential combinatorial therapy for Sandhoff disease by enhancing NB-DNJ delivery to the brain and may allow lower dosing to achieve the same degree of efficacy as high dose monotherapy." | ( Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. Baek, RC; Bronson, RT; Butters, TD; Denny, CA; Heinecke, KA; Kim, YP; Loh, KS; Platt, FM; Seyfried, TN, 2010) | 0.36 |
| " We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions." | ( Reduced expression of β2 integrin genes in rat peripheral leukocytes by inhibiting postprandial hyperglycemia. Fukaya, N; Goda, T; Mochizuki, K; Shimada, M; Tanaka, Y, 2010) | 0.36 |
| " Although the daily insulin dosage and the glucose level before meals did not differ between the two groups, the 1-h postprandial glucose level after each meal, 2-h glucose level after lunch and dinner, mean and standard deviation of glucose, and amplitude of glucose excursion were significantly lower or smaller in the MDI plus miglitol group than in the MDI group." | ( Effect of the α-glucosidase inhibitor miglitol on the glucose profile in Japanese type 2 diabetic patients receiving multiple daily insulin injections. Fukuda, H; Fuse, J; Ishii, S; Katabami, T; Kato, H; Kobayashi, H; Kobayashi, S; Kondo, A; Nagai, Y; Ohmori, S; Ohta, A; Sada, Y; Tanaka, Y, 2012) | 0.38 |
| " The area under curve (AUC) of rats with DNJ-MS was significantly increased, compared to animals dosed with mulberry powder (control)." | ( A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect. Higuchi, O; Kimura, F; Miyazawa, T; Nakagawa, K; Sookwong, P; Vichasilp, C, 2012) | 0.62 |
| " Data from the migalastat HCl clinical program will guide dosing and intervals for patients with Fabry disease with renal impairment." | ( An open-label study to determine the pharmacokinetics and safety of migalastat HCl in subjects with impaired renal function and healthy subjects with normal renal function. Barlow, C; Boudes, P; DiMino, T; France, N; Johnson, FK; Mudd, PN; Sitaraman, S; Vosk, J, 2015) | 0.42 |
| " Hence, dosage adjustment is not warranted in the use of AGIs in T2DM patients in situations of comorbidity." | ( Reappraisal and perspectives of clinical drug-drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus. Babu, RJ; Dash, RP; Srinivas, NR, 2018) | 0.48 |
| " He had received enzyme replacement therapy from the age of 18 months, and concomitant miglustat treatment was commenced, with dosing according to body surface area uptitrated over 1 month with dietary modifications when he reached the age of 30 months." | ( Combination therapy in a patient with chronic neuronopathic Gaucher disease: a case report. Ceravolo, F; Concolino, D; Falvo, F; Grisolia, M; Moricca, MT; Sestito, S, 2017) | 0.46 |
| " Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has recently been brought back into use for treatment of infections in newborns; however, it is still used off-label in neonatal clinical practice due to the lack of an evidence-based dosing regimen." | ( Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants. Chen, XK; Dong, Q; Guo, YJ; Jin, F; Kou, C; Luo, XJ; Qi, H; Qi, X; Qi, YJ; Shen, AD; Shen, YH; Shi, HY; Tang, BH; Wang, YC; Wu, YE; Zhao, W; Zheng, Y, 2019) | 0.51 |
| " Simulation indicated that the current dosing regimen (30 mg/kg q12h) is adequate with an MIC of 1 mg/L." | ( Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants. Chen, XK; Dong, Q; Guo, YJ; Jin, F; Kou, C; Luo, XJ; Qi, H; Qi, X; Qi, YJ; Shen, AD; Shen, YH; Shi, HY; Tang, BH; Wang, YC; Wu, YE; Zhao, W; Zheng, Y, 2019) | 0.51 |
| "Based on the developmental PK-PD analysis of latamoxef, a rational dosing regimen of 30 mg/kg q12h or q8h was required in newborns, depending on the pathogen." | ( Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants. Chen, XK; Dong, Q; Guo, YJ; Jin, F; Kou, C; Luo, XJ; Qi, H; Qi, X; Qi, YJ; Shen, AD; Shen, YH; Shi, HY; Tang, BH; Wang, YC; Wu, YE; Zhao, W; Zheng, Y, 2019) | 0.51 |
| "Migalastat can be used to treat Japanese patients with Fabry disease with GLA mutations amenable to migalastat according to the dosage and administration approved in other countries." | ( Efficacy and safety of migalastat in a Japanese population: a subgroup analysis of the ATTRACT study. Barth, JA; Castelli, JP; Hamazaki, T; Lagast, H; Narita, I; Ohashi, T; Sakai, N; Skuban, N, 2020) | 0.56 |
| "05) at lucerastat peak plasma concentration after dosing with 1000 mg (5." | ( The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects. Darpo, B; Dingemanse, J; Mueller, MS; Sidharta, PN; Voors-Pette, C; Xue, H, 2020) | 0.56 |
| " UV-4 was rapidly absorbed and distributed after dosing with the oral solution formulation used in this study." | ( Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects. Callahan, M; Duchars, M; Evans DeWald, L; Kaufman, B; Khaliq, M; Lin, G; Lowe, P; Ramstedt, U; Sampath, A; Smith, M; Spurgers, K; Treston, AM; Warfield, KL, 2022) | 0.72 |
| " Model-informed drug development optimized dosing and design of clinical studies and supported that no dose adjustments were needed in patients with mild to moderate renal impairment or in adolescent patients ≥45 kg." | ( Population Pharmacokinetics of Oral Migalastat in Adolescents and Adults With and Without Renal Impairment. Ivaturi, V; Johnson, FK; Leonowens, C; Schmith, V; Wu, YS; Zhou, J, 2022) | 0.72 |
| Role | Description |
|---|---|
| EC 3.2.1.20 (alpha-glucosidase) inhibitor | An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-glucosidase (EC 3.2.1.20). |
| anti-HIV agent | An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. |
| anti-obesity agent | Any substance which is used to reduce or control weight. |
| bacterial metabolite | Any prokaryotic metabolite produced during a metabolic reaction in bacteria. |
| hypoglycemic agent | A drug which lowers the blood glucose level. |
| hepatoprotective agent | Any compound that is able to prevent damage to the liver. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| 2-(hydroxymethyl)piperidine-3,4,5-triol | A hydroxypiperidine that has three hydroxy groups located at positions 3, 4 and 5 as well as a hydroxymethyl substituent at position 2. |
| piperidine alkaloid | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.8489 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 12.5893 | 0.0126 | 8.1569 | 44.6684 | AID2101 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 39.8107 | 4.4668 | 18.3916 | 35.4813 | AID2107 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 0.0580 | 0.0366 | 19.6376 | 50.1187 | AID2110; AID2111; AID2112; AID2113; AID2115 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.9811 | 0.0096 | 10.5250 | 35.4813 | AID1479145 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Trehalase | Sus scrofa (pig) | IC50 (µMol) | 41.0000 | 2.5000 | 2.5000 | 2.5000 | AID338569; AID711095 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 (µMol) | 34.7614 | 0.0400 | 3.4652 | 9.0000 | AID104667; AID1373189; AID1381559; AID1770333; AID1816865; AID240862; AID466668 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | IC50 (µMol) | 280.3333 | 0.0300 | 2.3589 | 8.8000 | AID1797728; AID1884450; AID342801; AID40425; AID456165; AID711099 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | Ki | 68.3333 | 0.0210 | 1.5288 | 6.3000 | AID1152618; AID1797728; AID40442 |
| Alpha-glucosidase MAL62 | Saccharomyces cerevisiae (brewer's yeast) | IC50 (µMol) | 212,855.0000 | 0.8400 | 1.4200 | 2.0000 | AID338567; AID729970 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 (µMol) | 39.2600 | 0.0600 | 2.2889 | 7.8000 | AID1373189; AID1381559; AID342799; AID342811; AID437995; AID466672 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | Ki | 12.5295 | 0.0590 | 1.7530 | 7.3000 | AID1819245; AID36805 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 (µMol) | 77.8333 | 0.0490 | 2.7294 | 7.8000 | AID1373189; AID1381559; AID466667 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1.3000 | 0.0002 | 1.8742 | 10.0000 | AID37439 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.3479 | 0.0400 | 1.8483 | 10.0000 | AID1770307; AID1770308; AID208985; AID240843; AID241685; AID241686; AID241781; AID342795; AID342797; AID613047; AID613048; AID711102; AID711103; AID91639 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1.3000 | 0.0002 | 1.2704 | 10.0000 | AID37439 |
| Beta-glucosidase | Agrobacterium tumefaciens | Ki | 12.0000 | 0.0070 | 0.0070 | 0.0070 | AID1152621; AID263086 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 (µMol) | 1.0000 | 0.0100 | 1.1970 | 5.0000 | AID1797728 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | Ki | 79.0000 | 0.3000 | 0.3000 | 0.3000 | AID1797728 |
| Glycogen debranching enzyme | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 8.4000 | 9.5143 | 10.0000 | AID466673 |
| Glycogen debranching enzyme | Oryctolagus cuniculus (rabbit) | IC50 (µMol) | 0.1900 | 0.1100 | 0.6975 | 2.1000 | AID342805 |
| Alpha-glucosidase MAL32 | Saccharomyces cerevisiae S288C | IC50 (µMol) | 175.0000 | 4.8000 | 7.1000 | 9.9000 | AID1798364 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1.3000 | 0.0000 | 1.8194 | 10.0000 | AID37439 |
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 (µMol) | 330.0000 | 9.3700 | 9.3700 | 9.3700 | AID397843 |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | IC50 (µMol) | 150.0000 | 0.0079 | 0.9285 | 9.9000 | AID1798364; AID328048 |
| Alpha-amylase | Geobacillus stearothermophilus | IC50 (µMol) | 1.6700 | 1.6700 | 1.6700 | 1.6700 | AID314025 |
| Trehalose synthase/amylase TreS | Mycobacterium tuberculosis CDC1551 | Ki | 0.2500 | 0.2500 | 1.3750 | 2.5000 | AID1799775 |
| Lactase-phlorizin hydrolase | Rattus norvegicus (Norway rat) | IC50 (µMol) | 36.3333 | 0.1200 | 2.9867 | 4.4000 | AID613041; AID711098; AID99232 |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | IC50 (µMol) | 137.5000 | 0.0090 | 1.0604 | 9.9000 | AID1798364; AID1798365; AID328047 |
| Neutral alpha-glucosidase AB | Homo sapiens (human) | IC50 (µMol) | 472.8250 | 1.3000 | 1.3000 | 1.3000 | AID33281; AID35813; AID37439 |
| Neutral alpha-glucosidase AB | Homo sapiens (human) | Ki | 410.0000 | 0.0300 | 0.0300 | 0.0300 | AID35817 |
| Ceramide glucosyltransferase | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0900 | 0.1325 | 0.2000 | AID466666 |
| Lysosomal acid glucosylceramidase | Bos taurus (cattle) | IC50 (µMol) | 210.0000 | 5.6000 | 5.6000 | 5.6000 | AID711100 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | IC50 (µMol) | 115.7500 | 0.5400 | 4.0244 | 7.8000 | AID1373189; AID1381559 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.3125 | 0.0800 | 2.5061 | 9.8500 | AID342793; AID397844; AID397845; AID711104 |
| Non-lysosomal glucosylceramidase | Homo sapiens (human) | IC50 (µMol) | 24.9500 | 0.0003 | 0.0897 | 0.3000 | AID437994; AID456166; AID466671; AID700852 |
| Putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | IC50 (µMol) | 0.0400 | 0.0300 | 0.1667 | 0.4200 | AID240826; AID240928 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1798364 | alpha-Glucosidase Inhibition Assay from Article 10.1016/j.bmc.2008.02.078: \\Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.\\ | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID1797728 | In Vitro Enzyme Inhibition from Article 10.1016/j.bmc.2006.08.003: \\Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.\\ | 2006 | Bioorganic & medicinal chemistry, Dec-01, Volume: 14, Issue:23 | Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. |
| AID1799390 | Btman2A from Article 10.1038/nchembio.81: \\Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.\\ | 2008 | Nature chemical biology, May, Volume: 4, Issue:5 | Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. |
| AID1799638 | Inhibition Assay from Article 10.1002/cbic.201000376: \\A novel competitive class of u00CEu00B1-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives.\\ | 2010 | Chembiochem : a European journal of chemical biology, Oct-18, Volume: 11, Issue:15 | A novel competitive class of α-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives. |
| AID1798365 | Reporter Gene Assay from Article 10.1016/j.bmc.2008.02.078: \\Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.\\ | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID1803326 | α-glucosidase Inhibitory Activity Assay from Article 10.3109/14756366.2012.719503: \\Structure-activity relationships of bergenin derivatives effect on a-glucosidase inhibition.\\ | 2013 | Journal of enzyme inhibition and medicinal chemistry, Dec, Volume: 28, Issue:6 | Structure-activity relationships of bergenin derivatives effect on α-glucosidase inhibition. |
| AID1799775 | Inhibition Assay from Article 10.1074/jbc.M111.280362: \\Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis.\\ | 2011 | The Journal of biological chemistry, Oct-14, Volume: 286, Issue:41 | Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis. |
| AID1577556 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Weis-sella level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID404676 | Increase in FITC-labeled concanavalin A binding to BAEC at 50 uM after 24 hrs by flow cytometer | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. |
| AID1409614 | Overall antiviral activity against SARS-CoV-2 (isolate France/IDF0372/2020) in the Vero E6 cell line at 48 h based on three assays 1) detection of viral RNA by qRT-PCR (targeting the N-gene), 2) plaque assay using lysate 3 days after addition of compound | 2020 | Nature, 07, Volume: 583, Issue:7816 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. |
| AID240854 | Inhibitory activity against alpha-Glucosidase from Yeast | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID1577528 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in glucose tolerance 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks and measured on day 26 followed by glucose challenge after 30 mins du | |||
| AID1816867 | Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID40176 | Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1816879 | Cell cycle arrest in human MCF7 cells assessed as accumulation of cells at S phase at 20 uM measured after 24 hrs by PI staining based flow cytometry assay (Rvb = 25.64%) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID315180 | Inhibition of concanavalin A-induced BALB/c mouse splenocyte proliferation at 30 uM by MTT assay | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-gamma and IL-4. |
| AID499646 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase after 10 mins | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase. |
| AID1577541 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in GK expression level in liver at 62.5 to 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID210968 | Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID35370 | Inhibition of soluble Alpha-mannosidase II in rat liver | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID729970 | Inhibition of yeast alpha-glucosidase using para-nitrophenyl alpha-D-glucopyranoside as substrate by spectrophotometric analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Fungal transformation of cedryl acetate and α-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites. |
| AID328046 | Inhibition of Saccharomyces sp. alpha-glucosidase | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID1770305 | Inhibition of rice alpha-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID710955 | Inhibition of bovine liver beta-galactosidase at 1000 uM | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID36810 | Competitive Inhibitory activity against Endoplasmic reticulum Alpha-Glucosidase II | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID338567 | Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometrically | 2002 | Journal of natural products, Feb, Volume: 65, Issue:2 | New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. |
| AID577333 | Binding affinity to recombinant Gcase assessed as change in melting temperature by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4 | Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1577535 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in TC level at 125 m/kg, po administered QD administered via gavage for 4 weeks | |||
| AID466671 | Inhibition of GBA2 by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID40274 | Concentration that causes 50% inhibition of mammalian lysosomal beta-galactosidase was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1577552 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Oscillibacter level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID40438 | Concentration that causes 50% inhibition of mammalian lysosomal beta-glucosidase was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID37266 | Inhibition of alpha-glucosidase activity | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Structure-activity relationships of trans-cinnamic acid derivatives on alpha-glucosidase inhibition. |
| AID1770329 | Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID613049 | Inhibition of almond beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID404665 | Inhibition of angiogenesis in BAEC assessed as inhibition of endothelial tube formation at 0.2 mM after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. |
| AID1816878 | Cell cycle arrest in human MCF7 cells assessed as accumulation of cells at G1 phase at 20 uM measured after 24 hrs by PI staining based flow cytometry assay (Rvb = 59.45%) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID379720 | Inhibition of Saccharomyces sp. alpha glucosidase by spectrophotometry | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis. |
| AID648433 | Immunosuppressant activity in human CD4+ T cells assessed as Con A-induced intracellular IL4 level at 90 uM after 72 hrs by flow cytometry (Rvb = 4.2+/-0.9%) | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID36815 | Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID613044 | Inhibition of bovine epididymis alpha-L-fucosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID437993 | Inhibition of human GBA1 | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID403149 | Inhibition of rat intestinal sucrase expressed in human Caco-2 cells at 21 uM | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11 | Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. |
| AID342811 | Inhibition of maltase in human Caco-2 cell model system after 2 hrs | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID1770314 | Inhibition of coffee beans alpha-galactosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID243638 | Percent inhibition of human alpha-fucosidase at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID398019 | Inhibition of bovine liver beta-galactosidase assessed as p-nitrophenol release at 1000 uM after 30 mins by spectrophotometry | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID1373195 | Competitive inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using P-NPP as substrate after 10 mins by Lineweaver-Burk plot analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. |
| AID711098 | Inhibition of rat intestinal lactase using lactose as substrate | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID617700 | Inhibition of rat liver Alpha-glucosidase II using p-nitrophenyl alpha D-glucopyranoside substrate | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. |
| AID37277 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1577527 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as reduction in serum glucose level 125 mg/kg, po administered QD administered via gavage for 4 weeks and measured 4 weeks during compound dosing | |||
| AID1577536 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in LDL-C level at 62.5 to 125 m/kg, po administered QD administered via gavage for 4 weeks | |||
| AID1770306 | Inhibition of rat intestinal maltase using maltose as substrate assessed as release of D-glucose measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID613045 | Inhibition of Penicillium decumbens alpha-L-rhamnosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1480924 | Inhibition of alpha-glucosidase (unknown origin) using PNP glycoside as substrate pretreated for 30 mins followed by substrate addition after 60 secs by spectrophotometric method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Analogues of xanthones--Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates. |
| AID40148 | Concentration that causes 50% inhibition of mammalian lysosomal beta-galactosidase was determined in bovine liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1816864 | Lipophilicity, logP of compound by shake flask method | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID105266 | Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID210966 | Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1816871 | Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID1816880 | Cell cycle arrest in human MCF7 cells assessed as accumulation of cells at G2 phase at 20 uM measured after 24 hrs by PI staining based flow cytometry assay (Rvb = 14.91%) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID35369 | Inhibition of lysosomal Alpha-mannosidase II in rat liver | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID501842 | Inhibition of rat liver glucosidase 2 assessed as inhibition of conversion of G1M9 to M9 | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | The action of bromoconduritol on ER glucosidase II. |
| AID33277 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (golgi I) was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID33283 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase was determined in rat epididymis | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID37435 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (endoplasmic reticulum glucosidase II) was determined in rat liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID437997 | Inhibition of Saccharomyces cerevisiae alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID1770322 | Inhibition of bovine kidney alpha-L-fucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1577551 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Lackno-spiraceae NK4A136 level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID1577554 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Bifidobacterium level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID328047 | Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID711104 | Inhibition of rat intestinal maltase using moltose as substrate | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID241685 | Inhibitory activity against rat intestinal maltase using disaccharide | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID342793 | Inhibition of rat intestinal brush border membrane maltase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID33274 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi II) was determined in rat liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1373194 | Mixed type inhibition of alpha-glucosidase (unknown origin) using PNP-G as substrate by Lineweaver-Burk plot analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. |
| AID241781 | Inhibitory activity against rat intestinal isomaltase using disaccharide | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID577523 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 10 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4 | Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID243665 | Percent inhibition of human alpha-galactosidase at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1577557 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Ruminococcus level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID1819254 | Inhibition of Endoplasmic reticulum alpha-glucosidase (unknown origin) | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | 5- |
| AID404677 | Decrease in FITC-labeled phytohemagglutininin-L binding to BAEC at 50 uM after 24 hrs by flow cytometer | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. |
| AID104771 | Concentration giving 50% inhibition of growth of mock-infected MT-4 cells | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID241686 | Inhibitory activity against rat intestinal sucrase using disaccharide | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID1577545 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as down regulation of PEPCK expression level in liver at 62.5 to 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID33282 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (lysosomal) was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1770323 | Inhibition of porcine kidney alpha-trehalase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID40146 | Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1770325 | Inhibition of Aspergillus niger amyloglucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1462636 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase using 4-nitrophenyl alpha-D-glucopyranoside as substrate preincubated for 5 mins followed by substrate addition measured after 10 mins | 2017 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17 | Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition. |
| AID540009 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells. |
| AID467031 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as p-nitrophenol release by colorimetry | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. |
| AID52058 | Inhibition of Cellobiase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID466669 | Inhibition of lactase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID648436 | Inhibition of ConA-induced phospho-JAK1 expression in human PBMC at 90 uM after 72 hrs by flow cytometry | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID40169 | Concentration that causes 50% inhibition of mammalian beta-galactosidase was determined in rat epididymis; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID467032 | Inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as p-nitrophenol release by colorimetry | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. |
| AID33285 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase was determined in rat epididymis; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID404660 | Inhibition of Bacillus stearothermophilus alpha glucosidase | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. |
| AID397844 | Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID648437 | Inhibition of Con A-induced phospho-GATA3 expression in human PBMC at 90 uM after 72 hrs by flow cytometry | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID1577543 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in PFK expression level in liver at 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID1816869 | Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID700852 | Inhibition of non-lysosomal glucosylceramidase | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | The many faces of the adamantyl group in drug design. |
| AID37272 | Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1816874 | Antimigratory activity against human MCF7 cells at 10 uM after 24 hrs by inverted fluorescence microscope analysis relative to control (Rvb = 82.9%). | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID613037 | Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID210963 | Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID711096 | Inhibition of rat intestinal trehalase | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID33281 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (lysosomal) was determined in rat liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID711102 | Inhibition of rat intestinal sucrase using sucrose as substrate | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID1770330 | Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID731125 | Induction of acid alpha glucosidase activity in fibroblasts derived from patient relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7 | Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID456167 | Displacement of PNPG from almond beta-glucosidase by UV spectroscopy | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1 | Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. |
| AID1152621 | Inhibition of Agrobacterium sp. beta glucosidase | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy. |
| AID1770307 | Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID613040 | Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID37428 | Inhibition of Alpha-glucosidase activity. | 2000 | Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10 | Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton. |
| AID1577544 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as down regulation of PCB expression level in liver at 62.5 to 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID240843 | Inhibitory concentration against rat intestinal maltase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID263086 | Inhibition of Agrobacterium sp. beta-glucosidase | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols. |
| AID243762 | Percent inhibition of alpha-L-fucosidase of bovine epididymis at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1067178 | Inhibition of alpha-glucosidase (unknown origin) assessed as hydrolysis of pNP-alpha-Glu into pNP measured for 10 mins by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5 | Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives. |
| AID35816 | Concentration that causes 50% inhibition of soluble mammalian alpha-mannosidase was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID466667 | Inhibition of sucrase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1577540 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in pyruvic acid level at 31.25 to 125 m/kg, po administered QD administered via gavage for 4 weeks | |||
| AID1460459 | Inhibition of endoplasmic reticulum alpha-glucosidase in HEK293 cells infected with DENV assessed as reduction in viral infection | 2017 | ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2 | Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction. |
| AID1770321 | Inhibition of bovine kidney alpha-L-fucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID37436 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (endoplasmic reticulum glucosidase II) was determined in rat liver NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID613046 | Inhibition of rat intestinal maltase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID397846 | Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID711100 | Inhibition of bovine liver beta-glucosidase | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID501841 | Inhibition of rat liver glucosidase 2 assessed as inhibition of conversion of G2M9 to G1M9 | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | The action of bromoconduritol on ER glucosidase II. |
| AID37284 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1816887 | Induction of apoptosis in human MCF7 cells assessed as viable cells at 20 uM measured after 24 hrs by AnnexinV/FTC-PI staining based flow cytometry method (Rvb =97 %) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID437996 | Inhibition of rice alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID36813 | Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1373190 | Inhibition of alpha-glucosidase (unknown origin) using PNP-G as substrate by Dixon plot analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. |
| AID397850 | Inhibition of Penicillium decumbens alpha-L-rhamnosidase assessed as p-nitrophenol release after 30 mins by spectrophotometry | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID1577547 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as down regulation of fructose-1-6-phosphatase expression level in liver at 31.25 to 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID437995 | Inhibition of human lysosomal alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID613041 | Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID99231 | Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID33279 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (golgi II) was determined in rat liver NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID40145 | Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liver NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID731124 | Induction of lysosomal alpha-glucosidase S529V/S619R mutant activity in fibroblasts derived from Pompe patient relative to healthy control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7 | Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID314027 | Growth inhibition of HUVEC cells by MTT assay | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. |
| AID35812 | Concentration that causes 50% inhibition of soluble mammalian alpha mannosidase was determined in rat liver; Ni is less than 50%inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID33280 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (golgi II) was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID489424 | Inhibition of Agrobacterium sp. beta-glucosidase | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | Synthesis and biological evaluation of novel biotin-iminoalditol conjugates. |
| AID243740 | Percent inhibition of alpha-mannosidase of rat epididymis 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID731127 | Induction of lysosomal alpha-glucosidase L552P mutant activity in fibroblasts derived from patient after 9 days relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7 | Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID1577533 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as reduction in TG level at 31.25 to 125 m/kg, po administered QD administered via gavage for 4 weeks | |||
| AID1334876 | Inhibition of almond beta-glucosidase assessed as reduction in production of D-glucose using disaccharides as substrate incubated for 10 to 30 mins | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition. |
| AID1816870 | Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID40437 | Concentration that causes 50% inhibition of mammalian lysosomal beta-glucosidase was determined in rat liver NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1770316 | Inhibition of bovine liver beta-galactosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID240828 | Inhibitory activity against trehalase from porcine kidney | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID37278 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID105269 | Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID403152 | Inhibition of human intestinal sucrase in human Caco-2 cell membrane at 21 uM | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11 | Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. |
| AID1577564 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Prevo-tellaceae UCG-001 level in feces at 62.5 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID1770315 | Inhibition of bovine liver beta-galactosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID342801 | Inhibition of human lysosomal beta-glucosidase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID648438 | Inhibition of PMA-induced JAK1 phosphorylation in human PBMC at 90 uM after 15 mins by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID1577534 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in HDL-C level at 31.25 to 125 m/kg, po administered QD administered via gavage for 4 weeks | |||
| AID648432 | Immunosuppressant activity in human PBMC assessed as reduction in Con A-induced extracellular IL4 level at 90 uM after 72 hrs by ELISA relative to untreated control | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID1816890 | Induction of apoptosis in human MCF7 cells assessed as necrotic cells at 20 uM measured after 24 hrs by AnnexinV/FTC-PI staining based flow cytometry method (Rvb =1.28 %) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID648448 | Inhibition of CD4 expression in human CD4+ T cells | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID711101 | Inhibition of rat intestinal cellobiase using cellobiose as substrate | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID1334875 | Inhibition of rat small intestinal brush border membrane cellobiase assessed as reduction in production of D-glucose using disaccharides as substrate incubated for 10 to 30 mins | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition. |
| AID40436 | Concentration that causes 50% inhibition of mammalian cellobiase beta-glucosidase was determined in rat intestine; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID404663 | Growth inhibition of BAEC after 48 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. |
| AID711099 | Inhibition of human beta-glucocerebrosidase | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID613038 | Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID613042 | Inhibition of jack beans alpha-mannosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1770311 | Inhibition of bovine liver beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID648435 | Inhibition of Con-A-induced phospho-STAT6 expression in human PBMC at 90 uM after 72 hrs by flow cytometry (Rvb = 10.52+/-1.9%) | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID338568 | Inhibition of yeast isomaltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometrically | 2002 | Journal of natural products, Feb, Volume: 65, Issue:2 | New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. |
| AID240826 | Inhibitory activity against alpha-Glucosidase from rice | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID1480933 | Effect on glucose uptake in human HepG2 cells at 1 uM measured after 24 hrs | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Analogues of xanthones--Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates. |
| AID40435 | Concentration that causes 50% inhibition of mammalian cellobiase beta-glucosidase was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID342804 | Inhibition of rabbit glycogen phosphorylase B at 400 uM | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID1577550 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Lactobacillus level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID1577565 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Bacteroidales S24-7 level in feces at 62.5 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID36805 | Inhibitory activity against alpha-glucosidase of yeast | 1999 | Bioorganic & medicinal chemistry letters, Feb-22, Volume: 9, Issue:4 | Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors. |
| AID1293689 | Uncompetitive inhibition of baker's yeast alpha-glucosidase using pNPG as substrate by Cornish-Bowden plot analysis | 2016 | European journal of medicinal chemistry, May-23, Volume: 114 | Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition. |
| AID1330659 | Inhibition of Bakers yeast alpha-glucosidase using p-Nitrophenyl alpha-D-glucopyranoside as substrate | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Selenoureido-iminosugars: A new family of multitarget drugs. |
| AID240688 | Inhibitory concentration against beta-glucosidase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1577529 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as reduction in fasting serum insulin level administered QD administered via gavage for 4 weeks | |||
| AID33273 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi I) was determined in rat liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID241236 | Inhibitory concentration against alpha-galactosidase of coffee bean | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID37437 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (endoplasmic reticulum glucosidase II) was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID243997 | Percent inhibition against Bovine liver galactosidase at 0.24 mM; n>=3 | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles. |
| AID40172 | Concentration that causes 50% inhibition of mammalian beta-galactosidase was determined in rat intestine; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID437994 | Inhibition of human GBA2 | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID1381559 | Inhibition of human alpha-glucosidase expressed in Saccharomyces cerevisiae using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 15 mins | |||
| AID155303 | Effect on proliferation of human peripheral blood mononuclear cells (PMBC) at 72 hr using MTT assay | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Specific inhibition effects of N-pentafluorobenzyl-1-deoxynojirimycin on human CD4+ T cells. |
| AID243739 | Percent inhibition of alpha-mannosidase of jack bean tree at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID409518 | Inhibition of yeast alpha-D-glucosidase | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties. |
| AID1770313 | Inhibition of coffee beans alpha-galactosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID40144 | Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID314026 | Growth inhibition of bovine BAEC by MTT assay | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. |
| AID577521 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 50 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4 | Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID540008 | Effect on surface oligosaccharide expression in human A549 cells assessed as inhibition of binding of L-PHA-FIPC to cell surface at 50 uM after 24 hrs by flow cytometry | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells. |
| AID36814 | Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID456165 | Displacement of 4-methylumbelliferyl from human GBA by fluorimetry | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1 | Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. |
| AID342795 | Inhibition of rat intestinal brush border membrane isomaltase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID1330658 | Inhibition of almond beta-glucosidase using p-Nitrophenyl beta-D-glucopyranoside as substrate | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Selenoureido-iminosugars: A new family of multitarget drugs. |
| AID1819245 | Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and measured after 30 min by fluorescence spectrophotometer analysis | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | 5- |
| AID437998 | Inhibition of Bacillus stearothermophilus alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID397842 | Inhibition of rice alpha-glucosidase assessed as D-glucose release after 10 mins by Glucose B-test | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID1695062 | Inhibition of almonds beta-glucosidase using p-nitrophenyl-beta-o-D-glucopyranoside as substrate measured for 10 mins | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Arylsulfonyl histamine derivatives as powerful and selective α-glucosidase inhibitors. |
| AID40178 | Concentration that causes 50% inhibition of mammalian lysosomal beta-galactosidase was determined in rat liver | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID40170 | Concentration that causes 50% inhibition of mammalian epididymal beta-galactosidase was determined in rat epididymis NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID36809 | Inhibition of lysosomal Alpha-Glucosidase II in rat liver | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID541338 | Inhibition of alpha-glucosidase using para-nitrophenyl substrate | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23 | Hydroxycoumarin derivatives: novel and potent α-glucosidase inhibitors. |
| AID1816888 | Induction of apoptosis in human MCF7 cells assessed as early apoptotic cells at 20 uM measured after 24 hrs by AnnexinV/FTC-PI staining based flow cytometry method (Rvb =0.466 %) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID1293688 | Inhibition of baker's yeast alpha-glucosidase using pNPG as substrate by spectrophotometry | 2016 | European journal of medicinal chemistry, May-23, Volume: 114 | Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition. |
| AID577522 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 25 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4 | Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1770333 | Inhibition of human alpha-glucosidase | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID614207 | Inhibition of yeast alpha-glucosidase using p-nitrophenyl a-D-glucopyranoside as substrate by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Dimerization of piceatannol by Momordica charantia peroxidase and α-glucosidase inhibitory activity of the biotransformation products. |
| AID35817 | Tested for competitive inhibition of golgi alpha mannosidase II | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1884450 | Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate preincubated with enzyme for 10 mins followed by substrate addition by fluorescence spectrophotometry | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease. |
| AID1816866 | Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID400363 | Antihyperglycemic effect in STZ-diabetic ddY mouse assessed as reduction in blood glucose level at 150 umol/kg, ip by glucose oxidase method | 1998 | Journal of natural products, Mar, Volume: 61, Issue:3 | Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice. |
| AID1816889 | Induction of apoptosis in human MCF7 cells assessed as late apoptotic cells at 20 uM measured after 24 hrs by AnnexinV/FTC-PI staining based flow cytometry method (Rvb =1.28 %) | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID613055 | Inhibition of rice alpha-glucosidase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID397845 | Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID37430 | Compound was evaluated for binding affinity towards Alpha-glucosidase analyzed by the surface plasma resonance (SPR) method | 2000 | Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10 | Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton. |
| AID317575 | Inhibition of yeast alpha-glucosidase | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5 | Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors. |
| AID35262 | Inhibition of golgi Alpha-mannosidase II in rat liver | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID1577561 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Lachnospiraceae level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID397843 | Inhibition of yeast alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID73762 | Binding affinity against Glucoamylase | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | SMall Molecule Growth 2001 (SMoG2001): an improved knowledge-based scoring function for protein-ligand interactions. |
| AID613043 | Inhibition of snail beta-mannosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID731123 | Induction of lysosomal alpha-glucosidase R432C/R432C mutant activity in fibroblasts derived from Pompe patient relative to healthy control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7 | Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID1577531 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as increase in IR phosphorylation at (Tyr 999 residues) expression in liver administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID1577562 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Alistipes level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID40173 | Concentration that causes 50% inhibition of mammalian beta-galactosidase (lactase ) was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID210962 | Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID243774 | Percent inhibition of alpha-galactosidase of Aspergillus niger at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1577559 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Anaer-ostipes level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID1577549 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as increase in Bacteroidetes level in feces administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID1152618 | Inhibition of human lysosomal beta-glucocerebrosidase | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy. |
| AID37286 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID342805 | Inhibition of rabbit muscle amylo-1,6-glucosidase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID240928 | Inhibitory concentration against rice alpha-glucosidase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID35813 | Concentration that causes 50% inhibition of soluble mammalian alpha-mannosidase in rat liver. NI is less than 50 % inhibition at 1000 micro M | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID37285 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID1577537 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in LPL mRNA level at 31.25 to 125 m/kg, po administered QD administered via gavage for 4 weeks by RT-PCR analysis | |||
| AID466673 | Inhibition of glycogen glycogen de-branching enzyme by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID314025 | Inhibition of alpha glucosidase from bacillus stearothermophilus | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. |
| AID1330688 | Inhibition of jack bean alpha-mannosidase using p-nitrophenyl-mannopyranoside as substrate measured every 2 mins | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Selenoureido-iminosugars: A new family of multitarget drugs. |
| AID648440 | Inhibition of PMA-induced JAK1 expression in human PBMC at 90 uM after 15 mins by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID1577563 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Klebsiella level in feces at 62.5 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID1435970 | Inhibition of human alpha-glucosidase expressed in Saccharomyces cerevisiae using p-nitophenyl-alpha-glucopyranoside as substrate pretreated with substrate for 15 mins followed by enzyme addition measured after 15 mins | |||
| AID37439 | Tested for competitive inhibition of endoplasmic reticulum alpha-glucosidase II. | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID613047 | Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1770310 | Inhibition of almond beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID210969 | Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID1770308 | Inhibition of rat intestinal isomaltase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1770327 | Inhibition of Penicillium decumbens alpha-L-rhamnosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1770312 | Inhibition of bovine liver beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID37406 | Inhibition of yeast Alpha-glucosidase | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship. |
| AID1440005 | Inhibition of alpha-glucosidase in human PBMC using 4-methylumbelliferyl alpha-D-glucopyranoside as substrate at pH 4.3 after 2 hrs by fluorescence assay | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. |
| AID342808 | Inhibition of glucagon-induced glucose production in rat primary hepatocytes at 100 uM | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID40425 | Inhibition of Beta-glucosidase activity. | 2000 | Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10 | Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton. |
| AID1577530 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as reduction in HOMA-IR index level administered QD administered via gavage for 4 weeks | |||
| AID243658 | Percent inhibition of human beta-galactosidase at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1770317 | Inhibition of jack bean alpha-mannosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID40147 | Concentration that causes 50% inhibition of mammalian lysosomal beta-galactosidase was determined in bovine liver NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID456166 | Displacement of 4-methylumbelliferyl from non-lysosomal GBA2 by fluorimetry | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1 | Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. |
| AID105142 | Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID40275 | Concentration that causes 50% inhibition of mammalian lysosomal beta-galactosidase was determined in rat liverNI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID731126 | Induction of lysosomal alpha-glucosidase G549R mutant activity in fibroblasts derived from patient after 9 days relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7 | Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID40442 | Inhibitory activity against beta-glucosidase of sweet almond | 1999 | Bioorganic & medicinal chemistry letters, Feb-22, Volume: 9, Issue:4 | Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors. |
| AID1577548 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as increase in Firmicutes level in feces administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID208985 | Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID466672 | Inhibition of lysosomal alpha-glucosidase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID613053 | Inhibition of coffee beans alpha-galactosidase assessed as production of p-nitrophenol by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID91639 | Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID37274 | Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID648439 | Inhibition of JAK1-mediated GATA3 phosphorylation in PMA-stimulated human PBMC at 90 uM after 30 mins by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID1577558 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Prevo-tellaceae Ga6A1 level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID1541366 | Inhibition of yeast alpha-glucosidase at 50 uM using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by microplate reader analysis | |||
| AID1373191 | Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using P-NPP as substrate after 10 mins by spectrophotometry | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. |
| AID241519 | Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticum | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID383183 | Inhibition of Saccharomyces sp. alpha-glucosidase | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus. |
| AID243651 | Percent inhibition of human alpha-mannosidase at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID40175 | Concentration that causes 50% inhibition of mammalian epididymal beta-galactosidase was determined in rat epididymis; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID241082 | Inhibitory activity against beta-Glucosidase from sweet almond | 2004 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24 | Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. |
| AID1496399 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNP glycoside as substrate preincubated for 30 mins followed by substrate addition measured after 60 secs by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Novel oxazolxanthone derivatives as a new type of α-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect. |
| AID328049 | Agonist activity at LXR | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID1577539 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in hepatic glycogen level at 31.25 to 125 m/kg, po administered QD administered via gavage for 4 weeks | |||
| AID277824 | Inhibition of alpha-glucosidase in 1.20 mg/200 uL | 2007 | Journal of natural products, Feb, Volume: 70, Issue:2 | Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa. |
| AID466668 | Inhibition of maltase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID36808 | Inhibition of endoplasmic reticulum Alpha-Glucosidase II in rat liver | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID243640 | Percent inhibition of human beta-mannosidase at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID314028 | Growth inhibition of mouse MS1 cells by MTT assay | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. |
| AID1577546 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as down regulation of glucose-6-phosphatase expression level in liver at 62.5 to 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID1275955 | Inhibition of yeast alpha-glucosidase using PNP glycoside as substrate preincubated for 30 mins followed by substrate addition measured for 60 secs by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, Apr-01, Volume: 24, Issue:7 | Synthesis of 3-acyloxyxanthone derivatives as α-glucosidase inhibitors: A further insight into the 3-substituents' effect. |
| AID1816868 | Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID1819248 | Stabilization of recombinant human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate assessed as residual activity at 56 degC temperature at 1 uM measured up to 60 mins by heat-shock experiment | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | 5- |
| AID1373192 | Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using P-NPP as substrate after 10 mins by Dixon plot analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. |
| AID398018 | Inhibition of rat epididymis beta-mannosidase assessed as p-nitrophenol release at 1000 uM after 30 mins by spectrophotometry | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID104667 | Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID613050 | Inhibition of rat intestinal cellobiase assessed as production of p-nitrophenol by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1577555 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Rumino-coccaceae UCG-014 level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID342799 | Inhibition of human lysosomal alpha-glucosidase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID338569 | Inhibition of pig kidney trehalase assessed as p-nitrophenol release by spectrophotometrically | 2002 | Journal of natural products, Feb, Volume: 65, Issue:2 | New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. |
| AID398020 | Inhibition of bovine epididymis alpha-L-fucosidase assessed as p-nitrophenol release at 1000 uM after 30 mins by spectrophotometry | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. |
| AID35368 | Competitive Inhibitory activity against Golgi Alpha-mannosidase II | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID466666 | Inhibition of GCS by cell-based assay | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1334871 | Inhibition of rice alpha-glucosidase assessed as reduction in production of D-glucose using disaccharides as substrate incubated for 10 to 30 mins | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition. |
| AID437999 | Inhibition of sweet almond beta glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID1541367 | Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by microplate reader analysis | |||
| AID577525 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 0.1 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4 | Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1480931 | Inhibition of alpha-glucosidase in human HepG2 cells assessed as reduction in glucose level at 5 uM measured after 24 hrs relative to control | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Analogues of xanthones--Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates. |
| AID1290567 | Inhibition of alpha glucosidase (unknown origin) preincubated for 15 mins followed by p-nitrophenyl-alpha-D-glucopyranoside addition measured after 30 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Study on the synthesis and biological activities of α-substituted arylacetates derivatives. |
| AID1816865 | Inhibition of alpha-glucosidase (unknown origin) preincubated for 5 mins followed by addition of pNPG substrate and measured after 30 mins by spectrophotometric method | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway. |
| AID1577538 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as reduction in ALT activity administered QD administered via gavage for 4 weeks | |||
| AID1373189 | Inhibition of alpha-glucosidase (unknown origin) using PNP-G as substrate measured for 15 mins by spectrophotometry | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. |
| AID1819256 | Stabilization of recombinant human GAA M519V mutant in pompe patient derived fibroblast using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate assessed as fold increase in intracellular enzyme activity at 10 uM incubated for 7 days relative to co | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | 5- |
| AID1770318 | Inhibition of jack bean alpha-mannosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID328048 | Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID37111 | Compound tested for inhibition of alpha-galactosidase from Aspergillus niger | 2004 | Bioorganic & medicinal chemistry letters, Jan-05, Volume: 14, Issue:1 | Novel O-glycosyl amino acid mimetics as building blocks for O-glycopeptides act as inhibitors of galactosidases. |
| AID1770332 | Inhibition of beta-glucosidase (unknown origin) | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID40174 | Concentration that causes 50% inhibition of mammalian epididymal beta-galactosidase was determined in rat epididymis | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID342797 | Inhibition of rat intestinal brush border membrane sucrase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 | In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID711103 | Inhibition of rat intestinal isomaltase using isomaltase as substrate | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID711095 | Inhibition of porcine kidney trehalase | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23 | α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia. |
| AID1577542 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in PK expression level in liver at 62.5 to 125 m/kg, po administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID466670 | Inhibition of GBA1 by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1577532 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as decrease in IRS-1 (Ser 307 residues) expression in liver administered QD administered via gavage for 4 weeks by Western blot analysis | |||
| AID243969 | Percent inhibition against sweet Almond glucosidase at 0.24 mM; n>=3 | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles. |
| AID648441 | Inhibition of PMA-induced GATA3 expression in human PBMC at 90 uM after 15 mins by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. |
| AID33284 | Concentration that causes 50% inhibition of mammalian alpha-mannosidase was determined in rat epididymis NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID497872 | Inhibition of wild type Bacteroides thetaiotaomicron beta-mannosidase 2A expressed in Escherichia coli BL21 (DE3) at 37 degC and Ph 5.6 by 2,4-dinitrophenolate release assay | 2008 | Nature chemical biology, May, Volume: 4, Issue:5 | Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. |
| AID1288652 | Competitive inhibition of recombinant Mycobacterium smegmatis trehalose synthase using DNPGlc as substrate by Dixon plot analysis | |||
| AID243745 | Percent inhibition of beta galactosidase of rat epididymis at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID243725 | Percent inhibition of beta galactosidase of bovine liver at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID240840 | Inhibitory concentration against human beta-glucosidase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID37287 | Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine; NI is less than 50 % inhibition at 1000 uM | 1994 | Journal of medicinal chemistry, Oct-28, Volume: 37, Issue:22 | Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. |
| AID613048 | Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1770319 | Inhibition of snail beta-mannosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID615825 | Inhibition of yeast alpha-glucosidase using PNP glycoside as substrate after 30 mins by spectrophotometry | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Toward potent α-glucosidase inhibitors based on xanthones: a closer look into the structure-activity correlations. |
| AID1577560 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as increase in Lactococcus level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based DNA sequencing analysis | |||
| AID1577553 | Antidiabetic activity in STZ-induced Kunming mouse model of diabetes assessed as decrease in Escherichia-Shigella level in feces at 31.25 to 125 mg/kg, po administered QD administered via gavage for 4 weeks by 16S rDNA based Illumina sequencing method | |||
| AID540016 | Inhibition of human A549 cell migration at 100 uM after 24 hrs by wound-healing assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells. |
| AID99232 | Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13 | N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. |
| AID240862 | Inhibitory concentration against human alpha-glucosidase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1770309 | Inhibition of almond beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1290566 | Inhibition of alpha glucosidase (unknown origin) at 100 uM preincubated for 15 mins followed by p-nitrophenyl-alpha-D-glucopyranoside addition measured after 30 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Study on the synthesis and biological activities of α-substituted arylacetates derivatives. |
| AID1577526 | Antidiabetic activity in po dosed STZ-induced Kunming mouse model of diabetes assessed as reduction in fasting serum glucose level administered QD administered via gavage for 4 weeks and measured 2 weeks during compound dosing | |||
| AID577524 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 1 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4 | Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1770328 | Inhibition of Penicillium decumbens alpha-L-rhamnosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1577525 | Antidiabetic activity in STZ-induced diabetic Kunming mouse assessed as reduction in body weight gain at 62.5 to 125 mg/kg, po QD administered via gavage for 4 weeks and measured every 3 days for 28 day | |||
| AID244000 | Percent inhibition against Escherichia coli galactosidase at 0.24 mM; n>=3 | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles. |
| AID243727 | Percent inhibition of beta-mannosidase of rat epididymis at 1000 uM | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6 | Biological properties of D- and L-1-deoxyazasugars. |
| AID1770320 | Inhibition of snail beta-mannosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives. |
| AID1508627 | Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1508628 | Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1508629 | Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 166 (10.96) | 18.7374 |
| 1990's | 305 (20.13) | 18.2507 |
| 2000's | 413 (27.26) | 29.6817 |
| 2010's | 506 (33.40) | 24.3611 |
| 2020's | 125 (8.25) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (35.82) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 141 (9.11%) | 5.53% |
| Reviews | 127 (8.20%) | 6.00% |
| Case Studies | 55 (3.55%) | 4.05% |
| Observational | 10 (0.65%) | 0.25% |
| Other | 1,215 (78.49%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single Center, Double-blind, Randomized, Placebo-controlled, Two-period/Two-treatment Crossover, Proof-of-mechanism Study Investigating the Effect of Miglustat on the Nasal Potential Difference in Adult Patients With Cystic Fibrosis Homozygous for the F50 [NCT02325362] | Phase 2/Phase 3 | 16 participants (Actual) | Interventional | 2015-03-17 | Completed | ||
| A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Dose Escalation Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of Migalastat Hydrochloride Given Intravenously to Healthy Volunteers With an Open-Label, Randomized, Two-Way C [NCT02082327] | Phase 1 | 31 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| An Open-Label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Three Dosing Regimens of Oral AT2220 in Patients With Pompe Disease [NCT00688597] | Phase 2 | 3 participants (Actual) | Interventional | 2008-12-08 | Terminated(stopped due to Per protocol, 3 sequential dose cohorts were planned. Study discontinued by Sponsor based upon serious adverse events in first 2 of 3 participants in Cohort 1.) | ||
| A Phase I, Randomized, Single-Blind, Four-Period Cross-Over, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Single Oral Doses of GR181413A/AT1001 in Healthy Japanese Subjects [NCT01853852] | Phase 1 | 14 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| A Randomized, Open-Label, 5-Period Crossover Study to Evaluate the Effect of Meal Type and Timing on the Pharmacokinetics of Migalastat Hydrochloride in Healthy Volunteers. [NCT01489995] | Phase 1 | 20 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| An Open-Label, Multi-Center, International Study to Investigate Drug-Drug Interactions Between AT2220 and Alglucosidase Alfa in Patients With Pompe Disease [NCT01380743] | Phase 2 | 25 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| A Single-center, Double-blind, Randomized, Placebo-controlled, Two Period / Two Treatment Cross-over Study to Assess the Effect of Florastor® (Saccharomyces Boulardii Lyo) on Gastrointestinal Tolerability, Safety, and Pharmacokinetics of Zavesca® (Miglust [NCT01822028] | Phase 1 | 42 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Prospective, Single-center, Randomized, Double-blind, Placebo-controlled, Two-part Phase 1 Study to Assess the Effect of Single Therapeutic and Supra-therapeutic Doses of Lucerastat on the QT/QTc Interval Duration in Healthy Subjects [NCT03832452] | Phase 1 | 44 participants (Actual) | Interventional | 2019-02-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||