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nitrate ester
Any member of the class of nitrates resulting from the esterification of nitric acid with an alcohol.
ChEBI ID: 51080
Members (9)
| Member | Definition | Role |
|---|---|---|
| erythrityl tetranitrate | Erythritol in which each of the hydroxy groups has been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to nitroglycerin. It is usually used diluted with lactose or other suitable inert excipients, in order to minimise the risk of explosion; undiluted erythrityl tetranitrate can be exploded by percussion or excessive heat. | erythrityl tetranitrate |
| isosorbide dinitrate | isosorbide dinitrate | |
| isosorbide-5-mononitrate | isosorbide mononitrate | |
| naproxen-n-butyl nitrate | A carboxylic ester obtained by formal condensation of the carboxy group of naproxen with the hydroxy group of 4-(nitrooxy)butanol. A cyclooxygenase-inhibiting nitric oxide donator that is metabolised to naproxen and a nitric oxide donating moiety, effective in treatment of osteoarthritis. | naproxcinod |
| nicorandil | A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris. | nicorandil |
| nitroflurbiprofen | A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2. | nitroflurbiprofen |
| pentrinitrol | pentrinitrol | |
| propatyl nitrate | propatylnitrate | |
| trolnitrate | trolnitrate |
Research
Studies (4,943)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,708 (34.55) | 18.7374 |
| 1990's | 1,308 (26.46) | 18.2507 |
| 2000's | 1,114 (22.54) | 29.6817 |
| 2010's | 649 (13.13) | 24.3611 |
| 2020's | 164 (3.32) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,688 (27.24%) | 5.53% |
| Reviews | 493 (7.96%) | 6.00% |
| Case Studies | 372 (6.00%) | 4.05% |
| Observational | 13 (0.21%) | 0.25% |
| Other | 3,631 (58.59%) | 84.16% |