ascorbic-acid and Anaphylaxis

Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Cardiovascular System; Female; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Inflammation; Male; Rats

Topics: Adult; Anaphylaxis; Animals; Antibody Formation; Ascorbic Acid; Autoimmune Diseases; Bacterial Infections; Chemotaxis; Common Cold; Female; Humans; Immunity, Cellular; Male; Phagocytes; Phagocytosis; T-Lymphocytes; Virus Diseases

Topics: Adult; Anaphylaxis; Ascorbic Acid; Drug Combinations; Female; Humans; Injections, Intravenous; Vitamin B Complex

Male and female guinea pigs receiving, respectively, 100 and 280 mg/day Vitamin C throughout the duration of immunization showed enhanced humoral antibody production to bovine serum albumin (BSA) and, in castrated females, to penicilloyl-coupled guinea pig gamma-globulin. A significant degree of protection was afforded against fatal anaphylactic shock in passively sensitized males. Under appropriate conditions of sensitization with rabbit anti-HGG and challenge with human gamma-globulin, 8 of 20 unsupplemented animals died of shock, whereas in the group receiving 280 mg Na ascorbate/day for 4 days preceding passive transfer and again 60' before challenge, only 2 of 18 died. The rate of dose-dependent mortality observed when groups of passively sensitized animals were challenged with increasing doses of antigen was reduced in animals supplemented as above. Actively immunized guinea pigs were not protected by 5 daily doses of 280 mg Na ascorbate given prior to challenge. There were no significant differences in the total hemolytic activity of the serum nor in the C3 and C4 components of complement in immunized animals. There was no change in the concentration of Cl esterase in non-immunized controls, but immunization with BSA was followed by a rapid decline in Cl concentration, the decrease being greater in the ascorbate-treated group than in the unsupplemented controls, possibly reflecting a higher level of circulating immune complexes in the former case.

Topics: Anaphylaxis; Animals; Antibody Formation; Antigen-Antibody Reactions; Ascorbic Acid; Complement System Proteins; Female; Guinea Pigs; Immunization; Immunization, Passive; Male; Sex Factors

Two vitamins, ascorbic acid (AA) and pyridoxine have been suggested by others as useful drugs for the treatment of bronchial asthma, although the views concerning AA or controversial. We have tested both vitamins in some models of histamine release and experimental anaphylaxis. AA does not inhibit mast cell degranulation induced by phospholipase A and histamine release from isolated rat mast cells induced by compound 48/80 or antigen (egg albumin). On the contrary, in the latter tests pyridoxine exerts inhibition in a range of concentrations from 10(-3)-10(-2) M. We conclude: 1. There is no experimental basis for considering ascorbic acid as a prophylactic antiasthmatic drug as is disodium cromoglycate. 2. Pyridoxine must receive additional basic and clinical investigations in this field.

Topics: Anaphylaxis; Animals; Ascorbic Acid; Cromolyn Sodium; Cytoplasmic Granules; Histamine Release; Mast Cells; p-Methoxy-N-methylphenethylamine; Phospholipases A; Pyridoxine; Rats

The author, on the basis of his personal work, proposes a classification of the mechanisms of histamine liberation: a metabolic mechanism (acting like anaphylaxis) and a mechanism by amine displacement. Subsequently, the action on histamine of two hydrosoluble vitamins: ascorbic acid and nicotinamide is considered, in the animal as a whole and on the mastocytes of rat peritoneum.

Topics: Anaphylaxis; Ascorbic Acid; Histamine Release; Humans; Niacinamide; Oxygen Consumption

Topics: Adult; Anaphylaxis; Ascorbic Acid; Drug Hypersensitivity; Female; Humans; Periodontal Diseases

Topics: Aminocaproates; Aminopyrine; Anaphylaxis; Animals; Aprotinin; Ascorbic Acid; Bordetella pertussis; Drug Synergism; Fever; Histamine H1 Antagonists; Hypothermia; Methysergide; Mice; Phenylbutazone; Temperature

1. Sodium phenylbutazone, soya bean trypsin inhibitor, or the concomitant administration of ascorbic acid and mepyramine protected rats against anaphylactic shock at 10 days after sensitization but gave no protection against anaphylaxis at 20 days.2. During anaphylactic shock in rats at 10 days after sensitization, the plasma bradykinin and bradykininogen levels, as well as those in the intestinal lumen and peritoneal cavity, were markedly raised.3. The results support the hypothesis that there are two phases in anaphylaxis in the rat-an early phase in which bradykinin is a mediator and against which phenylbutazone or soya bean trypsin inhibitor or the mixture of ascorbic acid and mepyramine, give protection, and a late phase which does not involve bradykinin.

Topics: Anaphylaxis; Animals; Ascorbic Acid; Body Fluids; Bradykinin; Female; Histamine H1 Antagonists; Intestine, Small; Liver; Lung; Male; Myocardium; Phenylbutazone; Rats; Time Factors; Trypsin Inhibitors

Topics: Anaphylaxis; Ascorbic Acid; Drug Hypersensitivity; Humans; Iatrogenic Disease; Male; Medication Errors; Middle Aged; Penicillin G; Skin Tests; Urticaria

Topics: Anaphylaxis; Animals; Ascorbic Acid; Dogs; Histamine

Topics: Anaphylaxis; Animals; Ascorbic Acid; Aspirin; Bradykinin; Enzymes; Heart; Heart Ventricles; Histamine H1 Antagonists; Horses; Intestine, Small; Lung; Pertussis Vaccine; Rats

Topics: Anaphylaxis; Ascorbic Acid; Guinea Pigs; Pharmacology; Research; Vitamins

Topics: Amino Alcohols; Anaphylaxis; Animals; Anti-Allergic Agents; Ascorbic Acid; Ethanolamine; Ethanolamines; Guinea Pigs; Histamine H1 Antagonists; Ileum; Metabolism; Pharmacology; Pyrilamine; Research

Topics: Aerosols; Anaphylaxis; Animals; Anti-Allergic Agents; Antigens; Ascorbic Acid; Ascorbic Acid Deficiency; Dextrans; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Histidine; Lung; Metabolism; Pharmacology; Research; Urine

Topics: Adrenal Glands; Anaphylaxis; Animals; Ascorbic Acid; Guinea Pigs; Histamine; In Vitro Techniques; Scurvy

Topics: Adrenal Glands; Anaphylaxis; Animals; Antibodies; Antigens; Ascorbic Acid; Autoantibodies; Dogs; Immunization; Intestine, Small; Liver; Skin Tests

Topics: Adrenal Glands; Anaphylaxis; Animals; Ascorbic Acid; Cortisone; Guinea Pigs; Hypersensitivity; Immune System Diseases; Lactic Acid; Potassium; Sodium Salicylate

Topics: Adrenal Cortex Hormones; Anaphylaxis; Ascorbic Acid; Desoxycorticosterone; Premedication; Vitamins

Topics: Anaphylaxis; Ascorbic Acid; Flavonoids; Histamine; Hypersensitivity; Immune System Diseases; Skin; Vitamins

Topics: Adrenal Glands; Anaphylaxis; Ascorbic Acid; Humans; Hypersensitivity

Topics: Anaphylaxis; Ascorbic Acid; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Imidazoles