A reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner.
ChEBI ID: 59739
| Member | Definition | Class |
|---|---|---|
| 15-deoxy-delta(12,14)-prostaglandin j2 | A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. | 15-deoxy-Delta(12,14)-prostaglandin J2 |
| ozone | An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs. | ozone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,119 (12.97) | 18.7374 |
| 1990's | 1,583 (9.69) | 18.2507 |
| 2000's | 4,775 (29.24) | 29.6817 |
| 2010's | 5,401 (33.07) | 24.3611 |
| 2020's | 2,455 (15.03) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 426 (2.49%) | 5.53% |
| Reviews | 1,242 (7.25%) | 6.00% |
| Case Studies | 104 (0.61%) | 4.05% |
| Observational | 34 (0.20%) | 0.25% |
| Other | 15,327 (89.46%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 20.1590 | 2 | 4 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 35.4813 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 24.8033 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 28.7968 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 7.1912 | 1 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 21.1699 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 26.8088 | 2 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 67.8334 | 1 | 2 |
| prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | Potency | 41.7629 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 2.9935 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 15.5346 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Kd | 2.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 5.6000 | 1 | 1 |